| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| Description | A 1,2,4-triazole compound having a 3,5-bis(2-cyano-2-propyl)benzyl group at the 1-position. (Chemical Entities of Biological Interest Ontology, CHEBI_2704) |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/2187 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in Anastrozole relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB3P | heat shock protein 90kDa alpha (cytosolic), class B member 3, pseudogene | 2.48 |
| HSP90AB4P | heat shock protein 90kDa alpha (cytosolic), class B member 4, pseudogene | 2.04 |
| C17ORF80 | chromosome 17 open reading frame 80 | 1.73 |
| CENPP | centromere protein P | 1.48 |
| FGB | fibrinogen beta chain | 0.93 |
| PTMA | prothymosin, alpha | 0.86 |
| SLC30A5 | solute carrier family 30 (zinc transporter), member 5 | 0.73 |
| H1-0 | H1.0 linker histone | 0.65 |
| CIAO2B | cytosolic iron-sulfur assembly component 2B | 0.57 |
| SP100 | SP100 nuclear antigen | 0.57 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | 0.57 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.56 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.55 |
| RPL37 | ribosomal protein L37 | 0.51 |
| UTP14C | UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast) | 0.51 |
| EWSR1 | EWS RNA-binding protein 1 | 0.5 |
| ZNF600 | zinc finger protein 600 | 0.49 |
| MED10 | mediator complex subunit 10 | 0.49 |
| BANF1 | barrier to autointegration factor 1 | 0.49 |
| PTRHD1 | peptidyl-tRNA hydrolase domain containing 1 | 0.49 |
| NUDCD2 | NudC domain containing 2 | 0.48 |
| ANKRD10 | ankyrin repeat domain 10 | 0.47 |
| ALG14 | ALG14, UDP-N-acetylglucosaminyltransferase subunit | 0.47 |
| ERH | enhancer of rudimentary homolog (Drosophila) | 0.46 |
| MRPS24 | mitochondrial ribosomal protein S24 | 0.46 |
| PTMS | parathymosin | 0.45 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.44 |
| TRIR | telomerase RNA component interacting RNase | 0.43 |
| RPS26P11 | ribosomal protein S26 pseudogene 11 | 0.42 |
| H1-3 | H1.3 linker histone, cluster member | 0.42 |
| RIC8B | RIC8 guanine nucleotide exchange factor B | 0.41 |
| DYNLL1 | dynein, light chain, LC8-type 1 | 0.41 |
| RPS27A | ribosomal protein S27a | 0.4 |
| DOCK11 | dedicator of cytokinesis 11 | 0.4 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.4 |
| ZNF317 | zinc finger protein 317 | 0.4 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.39 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.39 |
| S100A2 | S100 calcium binding protein A2 | 0.39 |
| TANGO2 | transport and golgi organization 2 homolog (Drosophila) | 0.39 |
| NOVA1 | neuro-oncological ventral antigen 1 | 0.38 |
| SPC24 | SPC24, NDC80 kinetochore complex component | 0.38 |
| NFIA | nuclear factor I/A | 0.38 |
| ZC3HAV1L | zinc finger CCCH-type, antiviral 1-like | 0.38 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.38 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.37 |
| H1-4 | H1.4 linker histone, cluster member | 0.37 |
| RNF141 | ring finger protein 141 | 0.37 |
| NPM3 | nucleophosmin/nucleoplasmin 3 | 0.37 |
| YWHAQ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta | 0.36 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.36 |
| POLR2I | polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa | 0.35 |
| HPCAL4 | hippocalcin like 4 | 0.35 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.35 |
| ZNRF1 | zinc and ring finger 1, E3 ubiquitin protein ligase | 0.35 |
| SLC25A21 | solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 | 0.35 |
| PLEKHA2 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2 | 0.34 |
| ZNF428 | zinc finger protein 428 | 0.34 |
| FAM117A | family with sequence similarity 117, member A | 0.34 |
| RNF220 | ring finger protein 220 | 0.33 |
| RHOB | ras homolog family member B | 0.33 |
| COPS8 | COP9 signalosome subunit 8 | 0.33 |
| CDCA7 | cell division cycle associated 7 | 0.33 |
| PGGHG | protein-glucosylgalactosylhydroxylysine glucosidase | 0.33 |
| COA7 | cytochrome c oxidase assembly factor 7 (putative) | 0.33 |
| CLCN6 | chloride channel, voltage-sensitive 6 | 0.33 |
| CDC34 | cell division cycle 34 | 0.33 |
| METAP1 | methionyl aminopeptidase 1 | 0.33 |
| RBM23 | RNA binding motif protein 23 | 0.32 |
| NPHP4 | nephronophthisis 4 | 0.32 |
| ONECUT2 | one cut homeobox 2 | 0.32 |
| MAPK8IP3 | mitogen-activated protein kinase 8 interacting protein 3 | 0.32 |
| CENPO | centromere protein O | 0.32 |
| SARDH | sarcosine dehydrogenase | 0.31 |
| VWDE | von Willebrand factor D and EGF domains | 0.31 |
| PRMT2IP | PRMT2 interacting protein | 0.31 |
| NDRG1 | N-myc downstream regulated 1 | 0.31 |
| RMI2 | RecQ mediated genome instability 2 | 0.31 |
| GABPB1 | GA binding protein transcription factor, beta subunit 1 | 0.31 |
| KCTD18 | potassium channel tetramerization domain containing 18 | 0.31 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.31 |
| C20ORF27 | chromosome 20 open reading frame 27 | 0.3 |
| PROS1 | protein S (alpha) | 0.3 |
| ADAT3 | adenosine deaminase, tRNA-specific 3 | 0.3 |
| CACNA2D2 | calcium channel, voltage-dependent, alpha 2/delta subunit 2 | 0.3 |
| PHKG2 | phosphorylase kinase, gamma 2 (testis) | 0.3 |
| UQCRH | ubiquinol-cytochrome c reductase hinge protein | 0.3 |
| SMN1 | survival of motor neuron 1, telomeric | 0.3 |
| ZNF302 | zinc finger protein 302 | 0.3 |
| ADGRA3 | adhesion G protein-coupled receptor A3 | 0.3 |
| RAP1GAP | RAP1 GTPase activating protein | 0.3 |
| HINT2 | histidine triad nucleotide binding protein 2 | 0.3 |
| ZCCHC10 | zinc finger, CCHC domain containing 10 | 0.3 |
| RPP14 | ribonuclease P/MRP 14kDa subunit | 0.29 |
| NNT | nicotinamide nucleotide transhydrogenase | 0.29 |
| PTBP2 | polypyrimidine tract binding protein 2 | 0.29 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.29 |
| RANBP1 | RAN binding protein 1 | 0.29 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | 0.29 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.29 |
| Symbol | Name | Standardized Value |
|---|---|---|
| KMT2B | lysine (K)-specific methyltransferase 2B | -1.4 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -0.95 |
| HMBOX1 | homeobox containing 1 | -0.71 |
| PPP1R26 | protein phosphatase 1, regulatory subunit 26 | -0.69 |
| HSP90AA4P | heat shock protein 90kDa alpha (cytosolic), class A member 4, pseudogene | -0.65 |
| TBC1D32 | TBC1 domain family, member 32 | -0.65 |
| JAG2 | jagged 2 | -0.63 |
| NIPA1 | non imprinted in Prader-Willi/Angelman syndrome 1 | -0.59 |
| COL7A1 | collagen, type VII, alpha 1 | -0.58 |
| SYN2 | synapsin II | -0.58 |
| HSPA8 | heat shock 70kDa protein 8 | -0.56 |
| CEP89 | centrosomal protein 89kDa | -0.56 |
| FBXL2 | F-box and leucine-rich repeat protein 2 | -0.54 |
| NEU3 | sialidase 3 (membrane sialidase) | -0.54 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.53 |
| MSH5 | mutS homolog 5 | -0.52 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.52 |
| B4GALNT1 | beta-1,4-N-acetyl-galactosaminyl transferase 1 | -0.51 |
| TMEM64 | transmembrane protein 64 | -0.47 |
| KLHDC8B | kelch domain containing 8B | -0.46 |
| TMOD1 | tropomodulin 1 | -0.46 |
| STYX | serine/threonine/tyrosine interacting protein | -0.46 |
| COBL | cordon-bleu WH2 repeat protein | -0.45 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | -0.45 |
| TCAIM | T cell activation inhibitor, mitochondrial | -0.45 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | -0.44 |
| WHAMM | WAS protein homolog associated with actin, golgi membranes and microtubules | -0.43 |
| TOR2A | torsin family 2, member A | -0.43 |
| NAT9 | N-acetyltransferase 9 (GCN5-related, putative) | -0.43 |
| NOMO1 | NODAL modulator 1 | -0.43 |
| GAS2L1 | growth arrest-specific 2 like 1 | -0.42 |
| BTBD11 | BTB (POZ) domain containing 11 | -0.42 |
| ADCK1 | aarF domain containing kinase 1 | -0.42 |
| MCOLN1 | mucolipin 1 | -0.42 |
| CNTLN | centlein, centrosomal protein | -0.42 |
| SLC12A4 | solute carrier family 12 (potassium/chloride transporter), member 4 | -0.42 |
| SLC12A9 | solute carrier family 12, member 9 | -0.41 |
| CD63 | CD63 molecule | -0.4 |
| FHL1 | four and a half LIM domains 1 | -0.4 |
| SELENOK | selenoprotein K | -0.4 |
| LSM10 | LSM10, U7 small nuclear RNA associated | -0.4 |
| SNAPC2 | small nuclear RNA activating complex, polypeptide 2, 45kDa | -0.39 |
| AURKAIP1 | aurora kinase A interacting protein 1 | -0.39 |
| DCAF6 | DDB1 and CUL4 associated factor 6 | -0.39 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.38 |
| KIAA0930 | KIAA0930 | -0.38 |
| PIP5K1A | phosphatidylinositol-4-phosphate 5-kinase, type I, alpha | -0.38 |
| TRAPPC5 | trafficking protein particle complex 5 | -0.37 |
| CA8 | carbonic anhydrase VIII | -0.37 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -0.37 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.36 |
| NR1D2 | nuclear receptor subfamily 1, group D, member 2 | -0.36 |
| DES | desmin | -0.36 |
| PRKD1 | protein kinase D1 | -0.36 |
| ANK2 | ankyrin 2, neuronal | -0.36 |
| FOXRED2 | FAD-dependent oxidoreductase domain containing 2 | -0.35 |
| DUOX1 | dual oxidase 1 | -0.35 |
| SLC38A1 | solute carrier family 38, member 1 | -0.35 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.35 |
| TAPT1 | transmembrane anterior posterior transformation 1 | -0.35 |
| STX4 | syntaxin 4 | -0.34 |
| VCPKMT | valosin containing protein lysine (K) methyltransferase | -0.34 |
| SCO1 | SCO1 cytochrome c oxidase assembly protein | -0.34 |
| NIN | ninein (GSK3B interacting protein) | -0.34 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.34 |
| GDF15 | growth differentiation factor 15 | -0.33 |
| ICOSLG | inducible T-cell co-stimulator ligand | -0.33 |
| C1GALT1C1 | C1GALT1-specific chaperone 1 | -0.33 |
| DXO | decapping exoribonuclease | -0.33 |
| XIRP2 | xin actin binding repeat containing 2 | -0.33 |
| SLC44A2 | solute carrier family 44 (choline transporter), member 2 | -0.32 |
| RBX1 | ring-box 1, E3 ubiquitin protein ligase | -0.32 |
| PDXK | pyridoxal (pyridoxine, vitamin B6) kinase | -0.32 |
| MPV17L2 | MPV17 mitochondrial membrane protein-like 2 | -0.32 |
| TTYH2 | tweety family member 2 | -0.31 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.31 |
| SPPL2A | signal peptide peptidase like 2A | -0.31 |
| BAK1 | BCL2-antagonist/killer 1 | -0.31 |
| SLC7A6OS | solute carrier family 7, member 6 opposite strand | -0.31 |
| CKM | creatine kinase, muscle | -0.31 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.31 |
| TP53I11 | tumor protein p53 inducible protein 11 | -0.31 |
| F2 | coagulation factor II (thrombin) | -0.31 |
| VMP1 | vacuole membrane protein 1 | -0.3 |
| FBXO45 | F-box protein 45 | -0.3 |
| RFT1 | RFT1 homolog (S. cerevisiae) | -0.3 |
| STARD3NL | STARD3 N-terminal like | -0.3 |
| PRR36 | proline rich 36 | -0.3 |
| VSIG10 | V-set and immunoglobulin domain containing 10 | -0.3 |
| SRPX | sushi-repeat containing protein, X-linked | -0.3 |
| VAMP3 | vesicle-associated membrane protein 3 | -0.29 |
| KIF16B | kinesin family member 16B | -0.29 |
| SEMA4D | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D | -0.29 |
| CCDC117 | coiled-coil domain containing 117 | -0.29 |
| SEC11C | SEC11 homolog C (S. cerevisiae) | -0.29 |
| EIF2B4 | eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa | -0.29 |
| HOXA7 | homeobox A7 | -0.29 |
| SHKBP1 | SH3KBP1 binding protein 1 | -0.29 |
| CAB39L | calcium binding protein 39-like | -0.29 |
| AGO3 | argonaute RISC catalytic component 3 | -0.28 |
