| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Anastrozole_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.244843 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.100275 |
| ANXA1 | annexin A1 | 0.0991356 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0943142 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.093869 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.086784 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0840248 |
| TPM3 | tropomyosin 3 | 0.083484 |
| TPI1 | triosephosphate isomerase 1 | 0.0823695 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0804372 |
| RPS12 | ribosomal protein S12 | 0.0795375 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0784796 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0776501 |
| RPS2 | ribosomal protein S2 | 0.0747964 |
| RPL3 | ribosomal protein L3 | 0.0742991 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0735679 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0722449 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.071183 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0696209 |
| RRM2 | ribonucleotide reductase M2 | 0.0658617 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0590274 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.058369 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.058122 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0577713 |
| RPS3 | ribosomal protein S3 | 0.0560449 |
| CALR | calreticulin | 0.0555581 |
| ASPH | aspartate beta-hydroxylase | 0.0540879 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0530012 |
| SLC38A2 | solute carrier family 38, member 2 | 0.050054 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.049164 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0490078 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0486683 |
| CPNE1 | copine I | 0.0481844 |
| INTS6 | integrator complex subunit 6 | 0.0474275 |
| DSPP | dentin sialophosphoprotein | 0.0469833 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0467263 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.046432 |
| CPOX | coproporphyrinogen oxidase | 0.0457042 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0448143 |
| BRD2 | bromodomain containing 2 | 0.0448035 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0443469 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0442716 |
| XPOT | exportin, tRNA | 0.0439238 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0437307 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | 0.0432772 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0422235 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0417569 |
| SET | SET nuclear proto-oncogene | 0.0415666 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0414115 |
| HMGA2 | high mobility group AT-hook 2 | 0.0407689 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0403481 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0397713 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0384073 |
| GOLGB1 | golgin B1 | 0.0379575 |
| EZR | ezrin | 0.0378224 |
| IPO7 | importin 7 | 0.0374727 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0363609 |
| ACTG1 | actin gamma 1 | 0.0360624 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0349155 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0348927 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0342464 |
| DENND5A | DENN/MADD domain containing 5A | 0.0340641 |
| WWOX | WW domain containing oxidoreductase | 0.0339414 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0336923 |
| AHNAK | AHNAK nucleoprotein | 0.0332809 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0330276 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0329099 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0327679 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.03274 |
| DST | dystonin | 0.0324459 |
| ADIPOR2 | adiponectin receptor 2 | 0.0320991 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0320587 |
| SQSTM1 | sequestosome 1 | 0.0318625 |
| CLTC | clathrin, heavy chain (Hc) | 0.0318372 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0318365 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0311635 |
| FAT1 | FAT atypical cadherin 1 | 0.0310742 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0307881 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0307457 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0306927 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0306474 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0304689 |
| YAP1 | Yes-associated protein 1 | 0.0303879 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0303387 |
| TXNRD1 | thioredoxin reductase 1 | 0.0301157 |
| RPL37A | ribosomal protein L37a | 0.0299466 |
| ZNF638 | zinc finger protein 638 | 0.0298555 |
| MSN | moesin | 0.0298265 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0293326 |
| IGF2R | insulin-like growth factor 2 receptor | 0.0293309 |
| PDGFC | platelet derived growth factor C | 0.0293141 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0289482 |
| PLEC | plectin | 0.0288214 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0285731 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0285355 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0285213 |
| RNF213 | ring finger protein 213 | 0.0282549 |
| SF3B1 | splicing factor 3b, subunit 1, 155kDa | 0.028069 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0279441 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0278498 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.304509 |
| VIM | vimentin | -0.176834 |
| TMSB10 | thymosin beta 10 | -0.09861 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0873486 |
| PFN1 | profilin 1 | -0.0626169 |
| HMGA1 | high mobility group AT-hook 1 | -0.0611513 |
| MGAT4C | MGAT4 family, member C | -0.0578072 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0571639 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0571454 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0567318 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0553014 |
| TUBA1B | tubulin, alpha 1b | -0.0510249 |
| MMP12 | matrix metallopeptidase 12 | -0.0508426 |
| HSPB1 | heat shock 27kDa protein 1 | -0.050079 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.046979 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0469008 |
| S100A6 | S100 calcium binding protein A6 | -0.0439377 |
| ALDH1A1 | aldehyde dehydrogenase 1 family, member A1 | -0.0435288 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.04193 |
| MYL12B | myosin, light chain 12B, regulatory | -0.041275 |
| CLDN1 | claudin 1 | -0.0400869 |
| NR5A2 | nuclear receptor subfamily 5, group A, member 2 | -0.0399129 |
| RPLP1 | ribosomal protein, large, P1 | -0.0395088 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0393017 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0390545 |
| BCHE | butyrylcholinesterase | -0.0381932 |
| NHSL1 | NHS-like 1 | -0.0380029 |
| TMEM123 | transmembrane protein 123 | -0.0377421 |
| GCG | glucagon | -0.0365225 |
| RPS24 | ribosomal protein S24 | -0.0360006 |
| DTNA | dystrobrevin, alpha | -0.034314 |
| RPS16 | ribosomal protein S16 | -0.0341317 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0327892 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0326032 |
| RPL35A | ribosomal protein L35a | -0.0322383 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | -0.032238 |
| KLHL24 | kelch-like family member 24 | -0.0321356 |
| SYT1 | synaptotagmin I | -0.0318184 |
| YBX3 | Y box binding protein 3 | -0.0315609 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.031013 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -0.0309881 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0309753 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0306517 |
| WDR45B | WD repeat domain 45B | -0.030595 |
| ZNF804A | zinc finger protein 804A | -0.0305745 |
| RPS21 | ribosomal protein S21 | -0.0291148 |
| RPLP0 | ribosomal protein, large, P0 | -0.0285337 |
| S100A10 | S100 calcium binding protein A10 | -0.027576 |
| RPLP2 | ribosomal protein, large, P2 | -0.0274331 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0258302 |
| HMGB1 | high mobility group box 1 | -0.0251366 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0249583 |
| RPL32 | ribosomal protein L32 | -0.0247785 |
| RASAL2 | RAS protein activator like 2 | -0.0246624 |
| FTL | ferritin, light polypeptide | -0.0244753 |
| CHCHD2 | coiled-coil-helix-coiled-coil-helix domain containing 2 | -0.0243602 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | -0.0242924 |
| NDUFV2 | NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa | -0.0242732 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0242677 |
| RAB1A | RAB1A, member RAS oncogene family | -0.024235 |
| NAV3 | neuron navigator 3 | -0.0238715 |
| LARP1 | La ribonucleoprotein domain family, member 1 | -0.0237979 |
| RPL8 | ribosomal protein L8 | -0.0237869 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0237376 |
| THOC2 | THO complex 2 | -0.0236997 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0233731 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.023072 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0226078 |
| PRR11 | proline rich 11 | -0.0226077 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0225026 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0224261 |
| CBX3 | chromobox homolog 3 | -0.0222131 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0216563 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0216099 |
| RPS14 | ribosomal protein S14 | -0.0215498 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0214418 |
| LDHB | lactate dehydrogenase B | -0.0211695 |
| RPS23 | ribosomal protein S23 | -0.0207788 |
| RPL28 | ribosomal protein L28 | -0.0205776 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0205557 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0205172 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0203989 |
| RPL27A | ribosomal protein L27a | -0.0203164 |
| FAM162A | family with sequence similarity 162, member A | -0.0201609 |
| RPS25 | ribosomal protein S25 | -0.0201479 |
| H1-0 | H1.0 linker histone | -0.0200267 |
| CCT4 | chaperonin containing TCP1, subunit 4 (delta) | -0.019998 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0199704 |
| RPS15 | ribosomal protein S15 | -0.019792 |
| RPL19 | ribosomal protein L19 | -0.0195928 |
| RPL36A | ribosomal protein L36a | -0.0195871 |
| USP34 | ubiquitin specific peptidase 34 | -0.0194422 |
| CAPNS1 | calpain, small subunit 1 | -0.0193989 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0192764 |
| KIF18B | kinesin family member 18B | -0.0192623 |
| ASTN2 | astrotactin 2 | -0.0191214 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0190011 |
| GNAS | GNAS complex locus | -0.0189084 |
| DDB2 | damage-specific DNA binding protein 2, 48kDa | -0.0185542 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0185541 |
