| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Anastrozole_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.262539 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.15245 |
| VEGFA | vascular endothelial growth factor A | 0.130364 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.128884 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.113658 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.106425 |
| PLEC | plectin | 0.0860717 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0832186 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0752802 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0729407 |
| CDH13 | cadherin 13 | 0.0642486 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0636345 |
| SQSTM1 | sequestosome 1 | 0.0604046 |
| MYO10 | myosin X | 0.0531651 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0529444 |
| RPS2 | ribosomal protein S2 | 0.0519554 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0498648 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0487033 |
| HYOU1 | hypoxia up-regulated 1 | 0.0475775 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0474303 |
| HDAC9 | histone deacetylase 9 | 0.0472257 |
| BRD2 | bromodomain containing 2 | 0.0451224 |
| RPL3 | ribosomal protein L3 | 0.0447047 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0429986 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0425258 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0423537 |
| NAV2 | neuron navigator 2 | 0.0423107 |
| EGFR | epidermal growth factor receptor | 0.0421216 |
| GOLGB1 | golgin B1 | 0.0418754 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0412867 |
| MSN | moesin | 0.0412036 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0406413 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0391083 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0377225 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0373042 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0363892 |
| RND3 | Rho family GTPase 3 | 0.0363044 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0357688 |
| B2M | beta-2-microglobulin | 0.0353551 |
| RPS6 | ribosomal protein S6 | 0.0338741 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0334574 |
| SP100 | SP100 nuclear antigen | 0.0329842 |
| ANGPTL4 | angiopoietin-like 4 | 0.0323895 |
| SDC2 | syndecan 2 | 0.0320469 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0319786 |
| APP | amyloid beta (A4) precursor protein | 0.0317201 |
| CALR | calreticulin | 0.0314377 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0312692 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.031086 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0302146 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0300911 |
| ASPH | aspartate beta-hydroxylase | 0.0294103 |
| FAT1 | FAT atypical cadherin 1 | 0.0293188 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0287568 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0285281 |
| RPS12 | ribosomal protein S12 | 0.0283188 |
| CD44 | CD44 molecule (Indian blood group) | 0.0282272 |
| FAM107B | family with sequence similarity 107, member B | 0.0281986 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0278996 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0276327 |
| IER2 | immediate early response 2 | 0.0274918 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0273324 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0270896 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0268842 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0267157 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0264985 |
| ACTG1 | actin gamma 1 | 0.0260287 |
| RUNX1 | runt-related transcription factor 1 | 0.0258563 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.025808 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.025562 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.0254944 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0253858 |
| RPS8 | ribosomal protein S8 | 0.0252262 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0251692 |
| FLNA | filamin A, alpha | 0.0249367 |
| ANO6 | anoctamin 6 | 0.024749 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.024654 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0244074 |
| PKM | pyruvate kinase, muscle | 0.0239057 |
| CADM1 | cell adhesion molecule 1 | 0.023664 |
| JAG1 | jagged 1 | 0.0236272 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0234874 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0234751 |
| ATF4 | activating transcription factor 4 | 0.0233566 |
| LRRC59 | leucine rich repeat containing 59 | 0.0233536 |
| TPM3 | tropomyosin 3 | 0.0232709 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0231713 |
| SFTPA2 | surfactant protein A2 | 0.0228981 |
| SEPTIN9 | septin 9 | 0.0227056 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0226743 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0224484 |
| ATXN1 | ataxin 1 | 0.0222222 |
| DSPP | dentin sialophosphoprotein | 0.0221395 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0221189 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.0219778 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0219243 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0219234 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0218991 |
| RPS3 | ribosomal protein S3 | 0.0217287 |
| PGM3 | phosphoglucomutase 3 | 0.0215687 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -0.33182 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.233465 |
| VIM | vimentin | -0.164891 |
| COL1A2 | collagen, type I, alpha 2 | -0.157843 |
| FN1 | fibronectin 1 | -0.136104 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.116924 |
| TPM4 | tropomyosin 4 | -0.115656 |
| DPYD | dihydropyrimidine dehydrogenase | -0.109603 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.106438 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.1062 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.102179 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.09636 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0961654 |
| LOX | lysyl oxidase | -0.0909043 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0738525 |
| TMSB10 | thymosin beta 10 | -0.0730299 |
| HMGA2 | high mobility group AT-hook 2 | -0.0697675 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0693566 |
| ATP13A3 | ATPase type 13A3 | -0.068853 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0647163 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0638128 |
| VCAN | versican | -0.0561501 |
| CANX | calnexin | -0.0512374 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0499511 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0487974 |
| PTMA | prothymosin, alpha | -0.0475023 |
| LOXL2 | lysyl oxidase-like 2 | -0.0453431 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0430138 |
| ANXA2 | annexin A2 | -0.0413998 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.0412556 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0393014 |
| PALLD | palladin, cytoskeletal associated protein | -0.0391126 |
| MT1X | metallothionein 1X | -0.0373003 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0361561 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0357004 |
| CAVIN1 | caveolae associated protein 1 | -0.0354634 |
| UBC | ubiquitin C | -0.0351165 |
| FBN1 | fibrillin 1 | -0.0350657 |
| S100A6 | S100 calcium binding protein A6 | -0.0347388 |
| RRBP1 | ribosome binding protein 1 | -0.0345725 |
| ZNF292 | zinc finger protein 292 | -0.0345442 |
| GOLGA4 | golgin A4 | -0.033484 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0334191 |
| PRR16 | proline rich 16 | -0.0329644 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0326415 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0323418 |
| RLF | rearranged L-myc fusion | -0.0316956 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0312457 |
| SBF2 | SET binding factor 2 | -0.0306606 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0306026 |
| PRELID2 | PRELI domain containing 2 | -0.030422 |
| EBF1 | early B-cell factor 1 | -0.0304217 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0302325 |
| SMYD3 | SET and MYND domain containing 3 | -0.0297829 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0294167 |
| CALU | calumenin | -0.0290594 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0288664 |
| SQLE | squalene epoxidase | -0.0288663 |
| FRMD4A | FERM domain containing 4A | -0.0288036 |
| USP3 | ubiquitin specific peptidase 3 | -0.0285961 |
| SULF1 | sulfatase 1 | -0.0285631 |
| VEGFC | vascular endothelial growth factor C | -0.0285048 |
| EHD2 | EH-domain containing 2 | -0.0281085 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0280722 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0279714 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0278825 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0273752 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0272282 |
| CLIC4 | chloride intracellular channel 4 | -0.0270476 |
| TPM1 | tropomyosin 1 (alpha) | -0.0270254 |
| PRRC1 | proline-rich coiled-coil 1 | -0.026687 |
| CLINT1 | clathrin interactor 1 | -0.0265962 |
| QKI | QKI, KH domain containing, RNA binding | -0.0263084 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0262508 |
| RBMS1 | RNA binding motif, single stranded interacting protein 1 | -0.0261382 |
| OGA | O-GlcNAcase | -0.0261295 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0259489 |
| TMEM263 | transmembrane protein 263 | -0.0259177 |
| CALD1 | caldesmon 1 | -0.0248043 |
| RASAL2 | RAS protein activator like 2 | -0.0247823 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0246554 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0246045 |
| POSTN | periostin, osteoblast specific factor | -0.0244074 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0243699 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0242407 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0241599 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0240814 |
| BNC2 | basonuclin 2 | -0.0240531 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0239264 |
| PXDN | peroxidasin | -0.0238821 |
| ATM | ATM serine/threonine kinase | -0.0237013 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0236786 |
| RTN4 | reticulon 4 | -0.0236743 |
| FOXP1 | forkhead box P1 | -0.0234366 |
| PTK2 | protein tyrosine kinase 2 | -0.0233377 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0232804 |
| CD109 | CD109 molecule | -0.0232653 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0230762 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0229539 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0229103 |
