| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Anastrozole_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DSPP | dentin sialophosphoprotein | 0.197739 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.193828 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.160506 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | 0.154564 |
| SVIL | supervillin | 0.147724 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.132667 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.128041 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.118811 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.115222 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.111477 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.110848 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.107774 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.106732 |
| FAM107B | family with sequence similarity 107, member B | 0.099158 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0951512 |
| ASPH | aspartate beta-hydroxylase | 0.0887193 |
| DST | dystonin | 0.082683 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0823495 |
| FAT1 | FAT atypical cadherin 1 | 0.080393 |
| FN1 | fibronectin 1 | 0.0780807 |
| FOXP1 | forkhead box P1 | 0.0767163 |
| SLC38A2 | solute carrier family 38, member 2 | 0.075635 |
| KYNU | kynureninase | 0.0695584 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0659294 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0645443 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0612918 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0570961 |
| RPL3 | ribosomal protein L3 | 0.0528038 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0527505 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0497467 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0491693 |
| ITGAV | integrin, alpha V | 0.0487429 |
| ATXN1 | ataxin 1 | 0.0483178 |
| FRMD5 | FERM domain containing 5 | 0.0480771 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0466598 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0465769 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0438574 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0438335 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0433813 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0420084 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0404569 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0399522 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0399005 |
| ENO1 | enolase 1, (alpha) | 0.0390864 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0385879 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0382538 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.038026 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0370932 |
| LOC112694756 | uncharaterized LOC112694756 | 0.037048 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0369744 |
| BCL2L1 | BCL2-like 1 | 0.0367444 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0365033 |
| DIAPH1 | diaphanous-related formin 1 | 0.0362804 |
| TNS1 | tensin 1 | 0.0362711 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0341312 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.033854 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0329787 |
| C3 | complement component 3 | 0.0329777 |
| PLEC | plectin | 0.0327125 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0326212 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0325972 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0325444 |
| KRT23 | keratin 23, type I | 0.0325294 |
| TCIM | transcriptional and immune response regulator | 0.0322149 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0321467 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0319047 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0316779 |
| CANX | calnexin | 0.0315268 |
| USP47 | ubiquitin specific peptidase 47 | 0.0309703 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0307605 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0306873 |
| CRY1 | cryptochrome circadian clock 1 | 0.0306475 |
| MYO5B | myosin VB | 0.030338 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0302464 |
| FLNB | filamin B, beta | 0.0300464 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0296713 |
| LMO7 | LIM domain 7 | 0.0295275 |
| RAD51B | RAD51 paralog B | 0.0289117 |
| PALLD | palladin, cytoskeletal associated protein | 0.0288951 |
| BRD2 | bromodomain containing 2 | 0.0286281 |
| PKM | pyruvate kinase, muscle | 0.0281522 |
| KRT8 | keratin 8, type II | 0.027855 |
| CLIC4 | chloride intracellular channel 4 | 0.0271243 |
| RASA2 | RAS p21 protein activator 2 | 0.0269511 |
| JMJD1C | jumonji domain containing 1C | 0.02664 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.02653 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0264393 |
| HDAC4 | histone deacetylase 4 | 0.0264247 |
| MYO1E | myosin IE | 0.0262343 |
| PEG3 | paternally expressed 3 | 0.0262232 |
| ACTG1 | actin gamma 1 | 0.0262157 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0261149 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0257161 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.025367 |
| OPTN | optineurin | 0.0252158 |
| MCL1 | myeloid cell leukemia 1 | 0.0249834 |
| RAB3B | RAB3B, member RAS oncogene family | 0.024903 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0248209 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0244508 |
| TPM1 | tropomyosin 1 (alpha) | 0.0241314 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.228483 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.163132 |
| IGF2 | insulin-like growth factor 2 | -0.14291 |
| APOA2 | apolipoprotein A-II | -0.129558 |
| GPC3 | glypican 3 | -0.10015 |
| RPS24 | ribosomal protein S24 | -0.0946825 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0902982 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0744012 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0742492 |
| RPL11 | ribosomal protein L11 | -0.0732053 |
| RPL35A | ribosomal protein L35a | -0.0713218 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0709274 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0677711 |
| CP | ceruloplasmin (ferroxidase) | -0.0651855 |
| FTL | ferritin, light polypeptide | -0.0623156 |
| RPS6 | ribosomal protein S6 | -0.0559325 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0549441 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0533928 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0531951 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0531315 |
| APOB | apolipoprotein B | -0.0487759 |
| RPLP1 | ribosomal protein, large, P1 | -0.0485005 |
| RPS8 | ribosomal protein S8 | -0.0475877 |
| RPLP2 | ribosomal protein, large, P2 | -0.0457424 |
| APOE | apolipoprotein E | -0.0433543 |
| RPS23 | ribosomal protein S23 | -0.0418035 |
| RPL34 | ribosomal protein L34 | -0.039982 |
| RPS19 | ribosomal protein S19 | -0.0395849 |
| RPL31 | ribosomal protein L31 | -0.0391672 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0384198 |
| RPL9 | ribosomal protein L9 | -0.038341 |
| RPS29 | ribosomal protein S29 | -0.0382692 |
| RPS27A | ribosomal protein S27a | -0.0373938 |
| TRIM26 | tripartite motif containing 26 | -0.0371597 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0368745 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0365629 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0363012 |
| GNAS | GNAS complex locus | -0.0359631 |
| GDF15 | growth differentiation factor 15 | -0.0359189 |
| RPS13 | ribosomal protein S13 | -0.0358104 |
| RPS21 | ribosomal protein S21 | -0.0352261 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0346306 |
| RPL12 | ribosomal protein L12 | -0.0343128 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0322465 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0318304 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0316026 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0315745 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0313762 |
| RPLP0 | ribosomal protein, large, P0 | -0.0310899 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0302528 |
| APOC1 | apolipoprotein C-I | -0.0293052 |
| PTMA | prothymosin, alpha | -0.0287997 |
| RPL38 | ribosomal protein L38 | -0.028482 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.028368 |
| RBM25 | RNA binding motif protein 25 | -0.0281692 |
| PERP | PERP, TP53 apoptosis effector | -0.0279536 |
| RPS25 | ribosomal protein S25 | -0.0278201 |
| RPL27A | ribosomal protein L27a | -0.0273399 |
| TMEM123 | transmembrane protein 123 | -0.0272367 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0269424 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0268123 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0267519 |
| RPL28 | ribosomal protein L28 | -0.0264863 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0264422 |
| RPS16 | ribosomal protein S16 | -0.0264301 |
| RBM39 | RNA binding motif protein 39 | -0.0264232 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0259737 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0259619 |
| A2M | alpha-2-macroglobulin | -0.0259117 |
| EGR1 | early growth response 1 | -0.0257277 |
| SBF2 | SET binding factor 2 | -0.0256759 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0253856 |
| NPR2 | natriuretic peptide receptor 2 | -0.0252329 |
| RPL37A | ribosomal protein L37a | -0.0249715 |
| TMEM51 | transmembrane protein 51 | -0.0245542 |
| IER3 | immediate early response 3 | -0.0243658 |
| RPS14 | ribosomal protein S14 | -0.0234945 |
| LYZ | lysozyme | -0.0232954 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0231655 |
| ARID3A | AT rich interactive domain 3A (BRIGHT-like) | -0.0229611 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0228721 |
| RPL26 | ribosomal protein L26 | -0.0227292 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0225917 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0225563 |
| APOA1 | apolipoprotein A-I | -0.0221077 |
| DOK6 | docking protein 6 | -0.0219573 |
| RPL32 | ribosomal protein L32 | -0.0219312 |
| TMSB10 | thymosin beta 10 | -0.0218178 |
| RNF149 | ring finger protein 149 | -0.0216311 |
| USP3 | ubiquitin specific peptidase 3 | -0.0215911 |
| RPL36 | ribosomal protein L36 | -0.0215016 |
| H3-3B | H3.3 histone B | -0.0214769 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0213607 |
| RPL19 | ribosomal protein L19 | -0.0211391 |
| RPL36A | ribosomal protein L36a | -0.0210058 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | -0.0207948 |
| ANGPTL8 | angiopoietin like 8 | -0.0204807 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0204677 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0202912 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0202849 |
