Anastrozole_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anastrozole_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.194005
LMO7 LIM domain 7 0.162766
PLEC plectin 0.125209
MSN moesin 0.106908
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0900755
RPS12 ribosomal protein S12 0.0856887
MT2A metallothionein 2A 0.0814532
RPS2 ribosomal protein S2 0.0773507
RPS3 ribosomal protein S3 0.0680548
CD44 CD44 molecule (Indian blood group) 0.0675868
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0658151
PRSS23 protease, serine, 23 0.0641259
EIF1 eukaryotic translation initiation factor 1 0.0632705
PDLIM5 PDZ and LIM domain 5 0.0624738
LOC112694756 uncharaterized LOC112694756 0.0616859
RPS8 ribosomal protein S8 0.0614804
SRRM2 serine/arginine repetitive matrix 2 0.0600758
RPS6 ribosomal protein S6 0.0589496
KTN1 kinectin 1 (kinesin receptor) 0.0586653
TPM3 tropomyosin 3 0.0585431
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0573795
LAMC2 laminin, gamma 2 0.0571132
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0558094
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0534375
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0509316
HSPA8 heat shock 70kDa protein 8 0.0508095
B2M beta-2-microglobulin 0.0502499
CLU clusterin 0.0498052
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0496884
RAI14 retinoic acid induced 14 0.0492639
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0488811
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0476861
SQSTM1 sequestosome 1 0.0470011
TMSB4X thymosin beta 4, X-linked 0.0468041
RPL37 ribosomal protein L37 0.0466469
MT1E metallothionein 1E 0.0458536
RPS19 ribosomal protein S19 0.0448276
CPNE1 copine I 0.0408616
ANXA1 annexin A1 0.0403265
SET SET nuclear proto-oncogene 0.0399861
MYOF myoferlin 0.0398486
ITPRID2 ITPR interacting domain containing 2 0.0397243
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.039201
PRELID3B PRELI domain containing 3B 0.0386866
MBNL1 muscleblind-like splicing regulator 1 0.0385135
EGFR epidermal growth factor receptor 0.0379253
ENO1 enolase 1, (alpha) 0.03767
CUL4B cullin 4B 0.0371438
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0371236
ANKRD11 ankyrin repeat domain 11 0.0370675
FAM107B family with sequence similarity 107, member B 0.0367895
DSPP dentin sialophosphoprotein 0.0367375
ASPH aspartate beta-hydroxylase 0.0366544
RPL3 ribosomal protein L3 0.0366461
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0362972
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0359619
FLNA filamin A, alpha 0.0358536
BHLHE40 basic helix-loop-helix family, member e40 0.0358519
EEF2 eukaryotic translation elongation factor 2 0.0357232
DST dystonin 0.0356331
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0347093
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.034592
ANGPTL4 angiopoietin-like 4 0.0345142
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0343875
SEPTIN9 septin 9 0.0342357
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0338814
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0334617
PSD3 pleckstrin and Sec7 domain containing 3 0.0330892
GOLGB1 golgin B1 0.0324265
NFE2L1 nuclear factor, erythroid 2-like 1 0.0323236
PKM pyruvate kinase, muscle 0.0321329
SLC35F3 solute carrier family 35, member F3 0.0319812
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0316079
SLK STE20-like kinase 0.0313898
CDCP1 CUB domain containing protein 1 0.031246
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0309001
RPL23 ribosomal protein L23 0.0308114
SIK3 SIK family kinase 3 0.0307603
TJP1 tight junction protein 1 0.0306241
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0304281
SMAD3 SMAD family member 3 0.0304078
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0303607
RPL37A ribosomal protein L37a 0.0301085
EXT1 exostosin glycosyltransferase 1 0.0300438
RAB2A RAB2A, member RAS oncogene family 0.0298708
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0297977
SLC38A2 solute carrier family 38, member 2 0.0296881
NUMA1 nuclear mitotic apparatus protein 1 0.0294759
RPL35 ribosomal protein L35 0.0294427
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0293738
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0292001
EFNB2 ephrin-B2 0.0290638
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0286403
ATM ATM serine/threonine kinase 0.0283928
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0282021
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0278293
FNDC3B fibronectin type III domain containing 3B 0.0277972
TMF1 TATA element modulatory factor 1 0.0277451
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0275556
BRD2 bromodomain containing 2 0.0274746

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.165761
PTMA prothymosin, alpha -0.120541
NDRG1 N-myc downstream regulated 1 -0.110496
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.11036
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.109443
ZMYND8 zinc finger, MYND-type containing 8 -0.0805733
IGF2 insulin-like growth factor 2 -0.0744115
RPS24 ribosomal protein S24 -0.0667002
PODXL podocalyxin-like -0.0640124
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0639943
TPT1 tumor protein, translationally-controlled 1 -0.0541712
S100A10 S100 calcium binding protein A10 -0.053288
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.050823
ABI3BP ABI family, member 3 (NESH) binding protein -0.0504525
POTEF POTE ankyrin domain family, member F -0.0468945
ANXA2 annexin A2 -0.0463604
HLA-B major histocompatibility complex, class I, B -0.0463413
BLCAP bladder cancer associated protein -0.0460498
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0458044
GNAS GNAS complex locus -0.0438185
EMP1 epithelial membrane protein 1 -0.0406347
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0402122
RPS21 ribosomal protein S21 -0.0398645
RPL36A ribosomal protein L36a -0.0397374
RBM39 RNA binding motif protein 39 -0.0395755
MEF2A myocyte enhancer factor 2A -0.0394096
DLG1 discs, large homolog 1 (Drosophila) -0.0389207
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0385832
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.038282
KIAA1217 KIAA1217 -0.0376361
SEC31A SEC31 homolog A (S. cerevisiae) -0.0361762
RPS25 ribosomal protein S25 -0.0356283
CEMIP cell migration inducing protein, hyaluronan binding -0.0353157
NT5C2 5'-nucleotidase, cytosolic II -0.0350659
CAVIN1 caveolae associated protein 1 -0.0349552
LDLR low density lipoprotein receptor -0.0343983
STAU1 staufen double-stranded RNA binding protein 1 -0.0343766
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0342364
TMEM165 transmembrane protein 165 -0.0340272
BCL2L1 BCL2-like 1 -0.034001
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0331203
CAV1 caveolin 1, caveolae protein, 22kDa -0.0330956
HM13 histocompatibility (minor) 13 -0.032828
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.032779
VDAC1 voltage-dependent anion channel 1 -0.0327197
WSB1 WD repeat and SOCS box containing 1 -0.0326054
MT1X metallothionein 1X -0.0325132
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0324443
ANLN anillin, actin binding protein -0.0312722
EPB41L1 erythrocyte membrane protein band 4.1-like 1 -0.0312664
KDM3A lysine (K)-specific demethylase 3A -0.0312134
CD99 CD99 molecule -0.0310753
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0307046
RIN2 Ras and Rab interactor 2 -0.0304323
PLTP phospholipid transfer protein -0.0303669
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0301058
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0297286
TRA2A transformer 2 alpha homolog (Drosophila) -0.0296911
RPL27A ribosomal protein L27a -0.0295522
EGR1 early growth response 1 -0.0290641
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0289204
ITCH itchy E3 ubiquitin protein ligase -0.028275
LOXL2 lysyl oxidase-like 2 -0.0276974
ATP5F1B ATP synthase F1 subunit beta -0.0276416
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0275538
NCOA3 nuclear receptor coactivator 3 -0.0275092
HSPG2 heparan sulfate proteoglycan 2 -0.0274471
CNTNAP3 contactin associated protein-like 3 -0.0274089
BRWD3 bromodomain and WD repeat domain containing 3 -0.0273499
IFIH1 interferon induced with helicase C domain 1 -0.0269885
SP100 SP100 nuclear antigen -0.0268303
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0266232
NPEPPS aminopeptidase puromycin sensitive -0.026623
MDK midkine (neurite growth-promoting factor 2) -0.026621
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0261305
HLA-E major histocompatibility complex, class I, E -0.0260417
MARCHF6 membrane associated ring-CH-type finger 6 -0.0260046
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0258013
RPL35A ribosomal protein L35a -0.0255517
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0250671
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0249244
CLIC4 chloride intracellular channel 4 -0.0248156
RHEB Ras homolog enriched in brain -0.0244195
CYRIB CYFIP related Rac1 interactor B -0.0243898
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0243277
DENND4C DENN/MADD domain containing 4C -0.024208
DPYD dihydropyrimidine dehydrogenase -0.0240289
ITGA6 integrin, alpha 6 -0.0237588
DENND4A DENN/MADD domain containing 4A -0.0235594
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0234353
WARS1 tryptophanyl-tRNA synthetase 1 -0.0233496
RPLP1 ribosomal protein, large, P1 -0.0233405
C4BPB complement component 4 binding protein, beta -0.0232086
NAMPT nicotinamide phosphoribosyltransferase -0.023141
LITAF lipopolysaccharide-induced TNF factor -0.0229129
LAMA5 laminin, alpha 5 -0.0228995
IFI16 interferon, gamma-inducible protein 16 -0.0226796
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0226635
RPLP2 ribosomal protein, large, P2 -0.0226407
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0225896