Anastrozole_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anastrozole_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.249068
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.16286
RPS12 ribosomal protein S12 0.102301
RPS8 ribosomal protein S8 0.0856394
MYH9 myosin, heavy chain 9, non-muscle 0.0772519
RPS6 ribosomal protein S6 0.0750208
RPS2 ribosomal protein S2 0.0688486
EXT1 exostosin glycosyltransferase 1 0.0678293
DSPP dentin sialophosphoprotein 0.067818
CALR calreticulin 0.0672436
RPL37A ribosomal protein L37a 0.0665193
ACTG1 actin gamma 1 0.0651728
FTL ferritin, light polypeptide 0.0649156
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0619936
KRT18 keratin 18, type I 0.0604984
RPS3 ribosomal protein S3 0.0604608
RPL3 ribosomal protein L3 0.0538687
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0537909
HSPA8 heat shock 70kDa protein 8 0.0528535
SRRM2 serine/arginine repetitive matrix 2 0.0520457
FAT1 FAT atypical cadherin 1 0.0491124
EGFR epidermal growth factor receptor 0.0472914
RPS19 ribosomal protein S19 0.0460777
LMO7 LIM domain 7 0.0452358
SLC38A2 solute carrier family 38, member 2 0.0451877
EIF1 eukaryotic translation initiation factor 1 0.0445108
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.044387
ASPH aspartate beta-hydroxylase 0.044322
RPS17 ribosomal protein S17 0.0442593
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0442216
RPL23 ribosomal protein L23 0.0426596
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0420026
TMSB4X thymosin beta 4, X-linked 0.0410933
RPS27A ribosomal protein S27a 0.0398309
EEF1G eukaryotic translation elongation factor 1 gamma 0.0397889
RPL9 ribosomal protein L9 0.0396632
TPT1 tumor protein, translationally-controlled 1 0.0391347
B2M beta-2-microglobulin 0.0389887
PLEC plectin 0.038442
MT2A metallothionein 2A 0.0383345
RPL7A ribosomal protein L7a 0.0377023
PDIA3 protein disulfide isomerase family A, member 3 0.0376762
TPM4 tropomyosin 4 0.0375698
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0369979
VEGFA vascular endothelial growth factor A 0.0364994
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.036449
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0362474
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0356743
PTMA prothymosin, alpha 0.035657
KTN1 kinectin 1 (kinesin receptor) 0.0349926
RPL35A ribosomal protein L35a 0.0348768
TPM3 tropomyosin 3 0.03475
KRT8 keratin 8, type II 0.0347152
PKM pyruvate kinase, muscle 0.0345086
RPL31 ribosomal protein L31 0.0343763
RPL26 ribosomal protein L26 0.0342511
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0339916
HYOU1 hypoxia up-regulated 1 0.0334625
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0325017
GOLGB1 golgin B1 0.0322388
BRD2 bromodomain containing 2 0.0310462
EZR ezrin 0.0296814
NUCB2 nucleobindin 2 0.0288398
RPS27 ribosomal protein S27 0.02845
TPI1 triosephosphate isomerase 1 0.0283992
AREG amphiregulin 0.0271599
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0271229
ERRFI1 ERBB receptor feedback inhibitor 1 0.0267051
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0260721
RPL36 ribosomal protein L36 0.025466
SET SET nuclear proto-oncogene 0.0250649
UNC13B unc-13 homolog B (C. elegans) 0.0243397
MUC13 mucin 13, cell surface associated 0.0240484
LOC102724023 ES1 protein homolog, mitochondrial 0.0231671
MYH14 myosin, heavy chain 14, non-muscle 0.023163
SQSTM1 sequestosome 1 0.0229568
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0224363
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0222231
NUMA1 nuclear mitotic apparatus protein 1 0.0220111
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.022009
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0219407
MYO5B myosin VB 0.0218358
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0218245
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0217417
H1-4 H1.4 linker histone, cluster member 0.0215048
WNK1 WNK lysine deficient protein kinase 1 0.0214381
RPL35 ribosomal protein L35 0.0214007
RPS29 ribosomal protein S29 0.0212607
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0212005
ENO2 enolase 2 (gamma, neuronal) 0.0210457
RPS18 ribosomal protein S18 0.0207378
PNN pinin, desmosome associated protein 0.0206976
RPLP2 ribosomal protein, large, P2 0.0206722
PDIA6 protein disulfide isomerase family A, member 6 0.0206496
SMC1A structural maintenance of chromosomes 1A 0.0206135
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0205865
RPS10 ribosomal protein S10 0.0205629
SVIL supervillin 0.0205277
ZSWIM6 zinc finger, SWIM-type containing 6 0.0204739
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0204671

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.148808
ANXA2 annexin A2 -0.124769
NPSR1 neuropeptide S receptor 1 -0.117128
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.10947
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0911648
GPHN gephyrin -0.0860256
CEMIP cell migration inducing protein, hyaluronan binding -0.0780453
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0739989
RNF43 ring finger protein 43 -0.0716736
NALF1 NALCN channel auxiliary factor 1 -0.0678582
PRSS3 protease, serine, 3 -0.0572556
TNS4 tensin 4 -0.0562435
ANTXR2 anthrax toxin receptor 2 -0.0561538
NFIA nuclear factor I/A -0.0555194
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0522825
MED13L mediator complex subunit 13-like -0.0522061
NCOR1 nuclear receptor corepressor 1 -0.0520475
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0516493
FAM13A family with sequence similarity 13, member A -0.0508828
ZFAND3 zinc finger, AN1-type domain 3 -0.0498575
NDRG1 N-myc downstream regulated 1 -0.0485102
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0473482
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0468596
RBM39 RNA binding motif protein 39 -0.0467125
BIRC6 baculoviral IAP repeat containing 6 -0.0453821
MON2 MON2 homolog (S. cerevisiae) -0.0453109
OGA O-GlcNAcase -0.0447566
EPCAM epithelial cell adhesion molecule -0.0444185
NF1 neurofibromin 1 -0.0441606
TRIM2 tripartite motif containing 2 -0.0422474
GSK3B glycogen synthase kinase 3 beta -0.0414541
PTPRR protein tyrosine phosphatase, receptor type, R -0.0406262
ZNF292 zinc finger protein 292 -0.040457
KDM7A lysine (K)-specific demethylase 7A -0.0403982
PTBP3 polypyrimidine tract binding protein 3 -0.0402139
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0398331
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0394724
ESYT2 extended synaptotagmin-like protein 2 -0.0392087
KDM3A lysine (K)-specific demethylase 3A -0.0391603
MBD5 methyl-CpG binding domain protein 5 -0.0391544
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0388521
ETNK1 ethanolamine kinase 1 -0.0388122
ARHGAP32 Rho GTPase activating protein 32 -0.03853
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0382072
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0381363
FLNB filamin B, beta -0.0380896
ITGA6 integrin, alpha 6 -0.0379685
PPARG peroxisome proliferator-activated receptor gamma -0.0376729
H1-0 H1.0 linker histone -0.0376177
WDR45B WD repeat domain 45B -0.0374575
MUC6 mucin 6, oligomeric mucus/gel-forming -0.0370924
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0366606
SETD5 SET domain containing 5 -0.0365341
RAB1A RAB1A, member RAS oncogene family -0.0361038
FERMT1 fermitin family member 1 -0.0360534
CD46 CD46 molecule, complement regulatory protein -0.0358704
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0355985
CADPS Ca++-dependent secretion activator -0.0353472
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0349681
DLG1 discs, large homolog 1 (Drosophila) -0.0348581
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.034797
DERA deoxyribose-phosphate aldolase (putative) -0.0347492
IARS1 isoleucyl-tRNA synthetase 1 -0.0346064
PUM2 pumilio RNA-binding family member 2 -0.0343285
ZMYM2 zinc finger, MYM-type 2 -0.034238
RNF145 ring finger protein 145 -0.0340209
SREBF2 sterol regulatory element binding transcription factor 2 -0.0338099
GDF15 growth differentiation factor 15 -0.0337428
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0335996
EXOC1 exocyst complex component 1 -0.0331719
FTH1 ferritin, heavy polypeptide 1 -0.0330574
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0329229
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0328018
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.032508
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0324526
ANKRD17 ankyrin repeat domain 17 -0.032418
USP34 ubiquitin specific peptidase 34 -0.0323218
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.032169
PNISR PNN-interacting serine/arginine-rich protein -0.03214
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0317642
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.03133
ARHGAP5 Rho GTPase activating protein 5 -0.0312591
SBF2 SET binding factor 2 -0.0310225
GOLGA4 golgin A4 -0.0309782
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0307707
COG5 component of oligomeric golgi complex 5 -0.0307276
PIGR polymeric immunoglobulin receptor -0.0306928
SHROOM3 shroom family member 3 -0.0304995
TBC1D22A TBC1 domain family, member 22A -0.0302621
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 -0.0299968
GREB1L growth regulation by estrogen in breast cancer-like -0.0298608
GCC2 GRIP and coiled-coil domain containing 2 -0.0297516
USP3 ubiquitin specific peptidase 3 -0.0294261
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0293892
METTL15 methyltransferase like 15 -0.0291079
STRN3 striatin, calmodulin binding protein 3 -0.0289499
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0288181
UBE2H ubiquitin-conjugating enzyme E2H -0.0287444
LCORL ligand dependent nuclear receptor corepressor-like -0.0282196
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0281464