| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Anastrozole_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DST | dystonin | 0.157695 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.153786 |
| CAPRIN2 | caprin family member 2 | 0.138038 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.114776 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.103092 |
| MT2A | metallothionein 2A | 0.0999038 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0935864 |
| FMNL2 | formin-like 2 | 0.083177 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0782455 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0782084 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0755439 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.066991 |
| ANGPTL4 | angiopoietin-like 4 | 0.066371 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0628012 |
| RUNX1 | runt-related transcription factor 1 | 0.0603006 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0582322 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.057804 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0576242 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0552698 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.054815 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.054774 |
| HOMER1 | homer scaffolding protein 1 | 0.0547285 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0542278 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0534331 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0529556 |
| TMSB4X | thymosin beta 4, X-linked | 0.0519651 |
| JUN | jun proto-oncogene | 0.0517498 |
| PLK2 | polo-like kinase 2 | 0.049278 |
| PLEC | plectin | 0.0485313 |
| PYGL | phosphorylase, glycogen, liver | 0.0484732 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0478837 |
| SQSTM1 | sequestosome 1 | 0.0471827 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0463186 |
| HSPA8 | heat shock 70kDa protein 8 | 0.045741 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0450371 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0428013 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0422978 |
| VCL | vinculin | 0.0417441 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0417394 |
| RPS12 | ribosomal protein S12 | 0.0410505 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0406505 |
| RPL3 | ribosomal protein L3 | 0.040066 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0398017 |
| PRELID2 | PRELI domain containing 2 | 0.0386117 |
| AREG | amphiregulin | 0.0378046 |
| NEK10 | NIMA-related kinase 10 | 0.0374795 |
| TPI1 | triosephosphate isomerase 1 | 0.0374624 |
| RCOR1 | REST corepressor 1 | 0.0370554 |
| MCL1 | myeloid cell leukemia 1 | 0.0366812 |
| ITPR3 | inositol 1,4,5-trisphosphate receptor, type 3 | 0.0362435 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0361258 |
| RPS2 | ribosomal protein S2 | 0.0357403 |
| CMIP | c-Maf inducing protein | 0.035679 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0353501 |
| SPAG9 | sperm associated antigen 9 | 0.0352475 |
| PDE10A | phosphodiesterase 10A | 0.0351996 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0350073 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0348313 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | 0.0343168 |
| EZR | ezrin | 0.0340953 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0340808 |
| SVIL | supervillin | 0.0327519 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0326348 |
| NT5E | 5'-nucleotidase, ecto (CD73) | 0.0325358 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0324397 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0320237 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0319288 |
| SMAD3 | SMAD family member 3 | 0.0316098 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0315028 |
| ENO1 | enolase 1, (alpha) | 0.0313917 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0308642 |
| SP100 | SP100 nuclear antigen | 0.0304532 |
| TPM3 | tropomyosin 3 | 0.030335 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0298643 |
| RPS18 | ribosomal protein S18 | 0.0295998 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0295914 |
| PKM | pyruvate kinase, muscle | 0.0292509 |
| SDC4 | syndecan 4 | 0.0290398 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.029016 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0287916 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0287183 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0282663 |
| BRD2 | bromodomain containing 2 | 0.0279337 |
| SYAP1 | synapse associated protein 1 | 0.0278755 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0275003 |
| B2M | beta-2-microglobulin | 0.0274697 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0274586 |
| INTS6 | integrator complex subunit 6 | 0.0270298 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0270262 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0269562 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0267158 |
| USP12 | ubiquitin specific peptidase 12 | 0.0264072 |
| EREG | epiregulin | 0.0262401 |
| LOC112694756 | uncharaterized LOC112694756 | 0.026175 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | 0.0258111 |
| IER2 | immediate early response 2 | 0.0257299 |
| RNF213 | ring finger protein 213 | 0.0255549 |
| F2R | coagulation factor II (thrombin) receptor | 0.0252652 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.02483 |
| ADAR | adenosine deaminase, RNA-specific | 0.0247503 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.131989 |
| VIM | vimentin | -0.118068 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0998626 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0883672 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0680752 |
| RAI1 | retinoic acid induced 1 | -0.0631423 |
| PTMA | prothymosin, alpha | -0.0548516 |
| EFNA5 | ephrin-A5 | -0.0547638 |
| TMSB10 | thymosin beta 10 | -0.0521444 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0514303 |
| HMGA1 | high mobility group AT-hook 1 | -0.0514003 |
| CADM2 | cell adhesion molecule 2 | -0.0492761 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0486271 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0454216 |
| TNS3 | tensin 3 | -0.0428957 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0412612 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0400573 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0389988 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0368543 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0362895 |
| RPL35A | ribosomal protein L35a | -0.036067 |
| RPS24 | ribosomal protein S24 | -0.0356576 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0348322 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0329554 |
| CFAP299 | cilia and flagella associated protein 299 | -0.0329163 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.031195 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0295693 |
| APP | amyloid beta (A4) precursor protein | -0.0292554 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.0291365 |
| TMEM123 | transmembrane protein 123 | -0.0289712 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0282486 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0281642 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0281296 |
| ZNF292 | zinc finger protein 292 | -0.0280094 |
| RBM25 | RNA binding motif protein 25 | -0.0265288 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0264862 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0261953 |
| DOCK11 | dedicator of cytokinesis 11 | -0.0260771 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0260454 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0259118 |
| EHBP1 | EH domain binding protein 1 | -0.0256817 |
| THOC2 | THO complex 2 | -0.0256432 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0252478 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0245257 |
| GCNT2 | glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) | -0.0245084 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0239333 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0238422 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0235169 |
| EPB41 | erythrocyte membrane protein band 4.1 | -0.0233345 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0230893 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0230069 |
| POTEF | POTE ankyrin domain family, member F | -0.0227318 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0226859 |
| PAFAH1B1 | platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) | -0.022345 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0220834 |
| OLA1 | Obg-like ATPase 1 | -0.02159 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0214096 |
| SBF2 | SET binding factor 2 | -0.0211975 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0210444 |
| URI1 | URI1, prefoldin-like chaperone | -0.0210102 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0209566 |
| CFDP1 | craniofacial development protein 1 | -0.0208802 |
| NOP58 | NOP58 ribonucleoprotein | -0.0207478 |
| EPHA4 | EPH receptor A4 | -0.0206535 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | -0.0206095 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0204714 |
| CENPF | centromere protein F, 350/400kDa | -0.0204204 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0201031 |
| TAPBP | TAP binding protein (tapasin) | -0.0200475 |
| BSG | basigin (Ok blood group) | -0.0199568 |
| AMBRA1 | autophagy/beclin-1 regulator 1 | -0.0198998 |
| SINHCAF | SIN3-HDAC complex associated factor | -0.0196666 |
| CELF1 | CUGBP, Elav-like family member 1 | -0.0196235 |
| RAB27B | RAB27B, member RAS oncogene family | -0.0195401 |
| RLF | rearranged L-myc fusion | -0.019481 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0194134 |
| ZFR | zinc finger RNA binding protein | -0.0193115 |
| RPL28 | ribosomal protein L28 | -0.0192852 |
| EPS15 | epidermal growth factor receptor pathway substrate 15 | -0.0192632 |
| OSMR | oncostatin M receptor | -0.0190208 |
| RPL38 | ribosomal protein L38 | -0.0189133 |
| CANX | calnexin | -0.0187971 |
| FLNB | filamin B, beta | -0.0187644 |
| SRGN | serglycin | -0.0187393 |
| HSPG2 | heparan sulfate proteoglycan 2 | -0.0186588 |
| SBNO1 | strawberry notch homolog 1 (Drosophila) | -0.0185927 |
| COL5A2 | collagen, type V, alpha 2 | -0.0185017 |
| WDR45B | WD repeat domain 45B | -0.0183861 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0183774 |
| LRRC49 | leucine rich repeat containing 49 | -0.0183617 |
| XPO7 | exportin 7 | -0.0182834 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0182557 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0182095 |
| CAPNS1 | calpain, small subunit 1 | -0.0180432 |
| PTK2 | protein tyrosine kinase 2 | -0.0179995 |
| EXOC4 | exocyst complex component 4 | -0.017996 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0179417 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0179259 |
| ANXA2 | annexin A2 | -0.0179148 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.017815 |
