Anastrozole_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anastrozole_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.198376
CXCL8 chemokine (C-X-C motif) ligand 8 0.110437
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0960313
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0900183
MCL1 myeloid cell leukemia 1 0.0890628
MYH9 myosin, heavy chain 9, non-muscle 0.0879576
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0861742
GRAMD1B GRAM domain containing 1B 0.0857995
PKM pyruvate kinase, muscle 0.0819067
INTS6 integrator complex subunit 6 0.0718402
RPS3 ribosomal protein S3 0.0709832
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0689945
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0643682
HYOU1 hypoxia up-regulated 1 0.063418
HOMER1 homer scaffolding protein 1 0.0619983
EIF1 eukaryotic translation initiation factor 1 0.0598758
HSPA8 heat shock 70kDa protein 8 0.0586277
RPS12 ribosomal protein S12 0.055812
ENO1 enolase 1, (alpha) 0.0555379
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0541801
MT2A metallothionein 2A 0.0535301
SRRM2 serine/arginine repetitive matrix 2 0.0515949
AREG amphiregulin 0.0513478
DSCAM Down syndrome cell adhesion molecule 0.0504508
GOLGB1 golgin B1 0.050176
CEMIP cell migration inducing protein, hyaluronan binding 0.0474692
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0464595
MSN moesin 0.0457184
LOC112694756 uncharaterized LOC112694756 0.0449974
RPL37A ribosomal protein L37a 0.0444391
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0439047
FTL ferritin, light polypeptide 0.0438208
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0433906
ZSWIM6 zinc finger, SWIM-type containing 6 0.0423202
NSUN6 NOP2/Sun domain family, member 6 0.0406371
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0403691
RPS2 ribosomal protein S2 0.0403501
PLEC plectin 0.0396979
RPS6 ribosomal protein S6 0.039663
RPL3 ribosomal protein L3 0.039212
BRD2 bromodomain containing 2 0.0384399
PTMA prothymosin, alpha 0.0373552
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0370019
MYOF myoferlin 0.0368983
RPS8 ribosomal protein S8 0.0366151
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0363568
APLP2 amyloid beta (A4) precursor-like protein 2 0.036265
RPS17 ribosomal protein S17 0.0352704
PDIA3 protein disulfide isomerase family A, member 3 0.0344998
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0344892
SLTM SAFB-like, transcription modulator 0.0344752
TPI1 triosephosphate isomerase 1 0.0342914
SLC38A2 solute carrier family 38, member 2 0.0334807
EXT1 exostosin glycosyltransferase 1 0.0334253
ACTG1 actin gamma 1 0.0331992
SIK3 SIK family kinase 3 0.032957
MYO1E myosin IE 0.0325069
NQO1 NAD(P)H dehydrogenase, quinone 1 0.0316457
CALR calreticulin 0.0301083
EGR1 early growth response 1 0.0295977
EEF2 eukaryotic translation elongation factor 2 0.0291885
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0288551
BMP6 bone morphogenetic protein 6 0.0282442
RPL31 ribosomal protein L31 0.0280034
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0278933
RPS27A ribosomal protein S27a 0.0278518
TPM3 tropomyosin 3 0.0274341
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0273189
PCBP2 poly(rC) binding protein 2 0.0271984
NFE2L1 nuclear factor, erythroid 2-like 1 0.0267354
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.026474
NAP1L1 nucleosome assembly protein 1-like 1 0.026426
DSPP dentin sialophosphoprotein 0.0260939
SAMD4A sterile alpha motif domain containing 4A 0.0259003
TMCO3 transmembrane and coiled-coil domains 3 0.0257036
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0255512
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0254616
KTN1 kinectin 1 (kinesin receptor) 0.025385
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0251538
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0250953
RPL7 ribosomal protein L7 0.0250396
PYGL phosphorylase, glycogen, liver 0.0248968
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0248552
RPL11 ribosomal protein L11 0.0244776
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0237116
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) 0.02339
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0233024
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0228958
EEF1G eukaryotic translation elongation factor 1 gamma 0.0228612
RPL23 ribosomal protein L23 0.0228416
AKAP12 A kinase (PRKA) anchor protein 12 0.022764
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0224453
ATF6 activating transcription factor 6 0.0224407
PDIA6 protein disulfide isomerase family A, member 6 0.0223142
JUN jun proto-oncogene 0.0220905
RACK1 receptor for activated C kinase 1 0.0220085
RPS27 ribosomal protein S27 0.021998
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0217272
ASPH aspartate beta-hydroxylase 0.0217123
IER2 immediate early response 2 0.0217032

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.322595
TXNRD1 thioredoxin reductase 1 -0.10164
OSMR oncostatin M receptor -0.0873286
NAMPT nicotinamide phosphoribosyltransferase -0.0865751
PTPRM protein tyrosine phosphatase, receptor type, M -0.0770053
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0708669
LRP1B low density lipoprotein receptor-related protein 1B -0.0677501
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0677249
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0649773
EFNA5 ephrin-A5 -0.0619098
RAB27B RAB27B, member RAS oncogene family -0.0604048
ZMYND8 zinc finger, MYND-type containing 8 -0.0590064
NDRG1 N-myc downstream regulated 1 -0.057656
TMEM165 transmembrane protein 165 -0.0553651
H1-0 H1.0 linker histone -0.0543888
CAV1 caveolin 1, caveolae protein, 22kDa -0.0535294
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0519261
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0502871
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0478946
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0460632
BRWD3 bromodomain and WD repeat domain containing 3 -0.0443958
ANXA2 annexin A2 -0.0437646
FAM13A family with sequence similarity 13, member A -0.0434802
PDE4D phosphodiesterase 4D, cAMP-specific -0.0422025
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0395915
TBC1D22A TBC1 domain family, member 22A -0.0381487
BRWD1 bromodomain and WD repeat domain containing 1 -0.0369342
PATJ PATJ crumbs cell polarity complex component -0.0363222
ZMYM2 zinc finger, MYM-type 2 -0.0360531
FTH1 ferritin, heavy polypeptide 1 -0.0357756
GPC6 glypican 6 -0.0331719
NGLY1 N-glycanase 1 -0.0326383
KCMF1 potassium channel modulatory factor 1 -0.0324
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0315899
TMSB10 thymosin beta 10 -0.0315294
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0312401
BIRC6 baculoviral IAP repeat containing 6 -0.0308511
AKR1C1 aldo-keto reductase family 1, member C1 -0.0304444
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0302364
ANKRD10 ankyrin repeat domain 10 -0.0292747
ARHGAP32 Rho GTPase activating protein 32 -0.0292279
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0292207
CES1 carboxylesterase 1 -0.0289578
TPD52 tumor protein D52 -0.028656
LAMC2 laminin, gamma 2 -0.0284196
NPC1 Niemann-Pick disease, type C1 -0.028223
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0274551
WDR45B WD repeat domain 45B -0.0271005
RIN2 Ras and Rab interactor 2 -0.026868
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0266494
KDM2A lysine (K)-specific demethylase 2A -0.0265391
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0259137
AHNAK AHNAK nucleoprotein -0.0259068
NCOA3 nuclear receptor coactivator 3 -0.0257156
RNF145 ring finger protein 145 -0.0252691
NT5C2 5'-nucleotidase, cytosolic II -0.0248669
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0248191
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.024777
MGAT4C MGAT4 family, member C -0.0246808
RASA2 RAS p21 protein activator 2 -0.0245758
UVRAG UV radiation resistance associated -0.0245729
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0243041
BTG1 B-cell translocation gene 1, anti-proliferative -0.0241852
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.024072
LAMA4 laminin, alpha 4 -0.0239649
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0238255
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0238076
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0237015
STRN3 striatin, calmodulin binding protein 3 -0.0234758
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0234732
ELF2 E74-like factor 2 (ets domain transcription factor) -0.023111
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0230888
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0226403
OGA O-GlcNAcase -0.0223743
CAMTA1 calmodulin binding transcription activator 1 -0.0223334
PDE8A phosphodiesterase 8A -0.0221602
SREBF2 sterol regulatory element binding transcription factor 2 -0.0218687
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0216129
ZFAND6 zinc finger, AN1-type domain 6 -0.0215344
PCED1B PC-esterase domain containing 1B -0.0213532
NRIP1 nuclear receptor interacting protein 1 -0.0213241
MT1X metallothionein 1X -0.0212527
NDE1 nudE neurodevelopment protein 1 -0.0212397
ANKRD12 ankyrin repeat domain 12 -0.0211373
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) -0.0210949
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0207939
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0205696
SLMAP sarcolemma associated protein -0.0205562
RAP1B RAP1B, member of RAS oncogene family -0.0203233
SBF2 SET binding factor 2 -0.02026
TSC22D2 TSC22 domain family, member 2 -0.0202065
PUM2 pumilio RNA-binding family member 2 -0.0199336
GM2A GM2 ganglioside activator -0.0197231
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0196803
CAB39 calcium binding protein 39 -0.0196126
TENT5A terminal nucleotidyltransferase 5A -0.019535
FRMD4B FERM domain containing 4B -0.0194598
TLK1 tousled-like kinase 1 -0.0192589
IGFBP5 insulin-like growth factor binding protein 5 -0.0192122
RAB1A RAB1A, member RAS oncogene family -0.0190301