Anastrozole_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Anastrozole_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.193548
FN1 fibronectin 1 0.152713
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.138752
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.132421
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.130583
GRB10 growth factor receptor-bound protein 10 0.12003
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0962659
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0911506
CD44 CD44 molecule (Indian blood group) 0.089151
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0861507
HMGA2 high mobility group AT-hook 2 0.0834911
VIM vimentin 0.0809267
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0693247
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0674432
CDH13 cadherin 13 0.0663601
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0650727
MYH9 myosin, heavy chain 9, non-muscle 0.0640087
PKM pyruvate kinase, muscle 0.0633152
SDK1 sidekick cell adhesion molecule 1 0.0631145
EXT1 exostosin glycosyltransferase 1 0.0625292
ANGPTL4 angiopoietin-like 4 0.0615782
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0614944
ASPH aspartate beta-hydroxylase 0.0609227
AADAC arylacetamide deacetylase 0.0603208
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0586575
MACF1 microtubule-actin crosslinking factor 1 0.0584824
NAV2 neuron navigator 2 0.05763
TIMP1 TIMP metallopeptidase inhibitor 1 0.054962
SEPTIN9 septin 9 0.0539515
DST dystonin 0.0537685
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.053638
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0528662
LOX lysyl oxidase 0.0525117
ZSWIM6 zinc finger, SWIM-type containing 6 0.0505169
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0504694
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0480056
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0478972
MYO10 myosin X 0.0477479
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0476732
MAML3 mastermind-like 3 (Drosophila) 0.0463049
PSD3 pleckstrin and Sec7 domain containing 3 0.0460474
NAV1 neuron navigator 1 0.0454482
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0447849
SQSTM1 sequestosome 1 0.0436094
RAI14 retinoic acid induced 14 0.0431963
CA12 carbonic anhydrase XII 0.0425661
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0423009
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0415193
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0412421
B2M beta-2-microglobulin 0.0412261
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0411921
PLIN2 perilipin 2 0.0406437
ECE1 endothelin converting enzyme 1 0.0402441
MTSS1 metastasis suppressor 1 0.0400954
NCOR2 nuclear receptor corepressor 2 0.0398887
LRMDA leucine rich melanocyte differentiation associated 0.0395749
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0395478
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0390205
LOXL2 lysyl oxidase-like 2 0.0385283
AHNAK AHNAK nucleoprotein 0.0383593
IFI44L interferon-induced protein 44-like 0.0382495
ENO1 enolase 1, (alpha) 0.0381896
WLS wntless Wnt ligand secretion mediator 0.0374046
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0368299
IFI6 interferon, alpha-inducible protein 6 0.0366779
SFTPA2 surfactant protein A2 0.0366102
KTN1 kinectin 1 (kinesin receptor) 0.0364925
PYGL phosphorylase, glycogen, liver 0.0360043
IRAK2 interleukin-1 receptor-associated kinase 2 0.0357833
ATXN1 ataxin 1 0.0357708
EDIL3 EGF-like repeats and discoidin I-like domains 3 0.0355061
TMSB4X thymosin beta 4, X-linked 0.0351866
INTS6 integrator complex subunit 6 0.0348502
PCBP2 poly(rC) binding protein 2 0.0347381
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0346541
PLEC plectin 0.0345833
RNF213 ring finger protein 213 0.0345719
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0342189
SYT1 synaptotagmin I 0.0340655
PRSS23 protease, serine, 23 0.0335647
ERRFI1 ERBB receptor feedback inhibitor 1 0.0335579
PDGFA platelet-derived growth factor alpha polypeptide 0.0334261
SOD2 superoxide dismutase 2, mitochondrial 0.0328847
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0326735
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0324686
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0318839
PDLIM5 PDZ and LIM domain 5 0.031877
SAMD9 sterile alpha motif domain containing 9 0.0317284
PRKCA protein kinase C, alpha 0.0315842
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0313724
APLP2 amyloid beta (A4) precursor-like protein 2 0.0310359
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0310328
MBNL1 muscleblind-like splicing regulator 1 0.0309216
EFNA5 ephrin-A5 0.0308648
RASAL2 RAS protein activator like 2 0.0305792
TGFB1 transforming growth factor, beta 1 0.0304349
NTN4 netrin 4 0.029688
CLIC4 chloride intracellular channel 4 0.0295399
FNDC3B fibronectin type III domain containing 3B 0.0292868
GPATCH2L G patch domain containing 2-like 0.0291901

decreased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase -0.243125
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.107893
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.10034
GOLGA4 golgin A4 -0.0964616
RBM39 RNA binding motif protein 39 -0.0946107
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.089924
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0606371
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0591727
OSMR oncostatin M receptor -0.0540703
NPC1 Niemann-Pick disease, type C1 -0.0525522
OGA O-GlcNAcase -0.0490065
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.047099
KMT2C lysine (K)-specific methyltransferase 2C -0.0449439
NCOA7 nuclear receptor coactivator 7 -0.0424792
KDM3A lysine (K)-specific demethylase 3A -0.0415114
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0398685
ZMYND8 zinc finger, MYND-type containing 8 -0.039517
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0391223
PDE4D phosphodiesterase 4D, cAMP-specific -0.0386875
KDM2A lysine (K)-specific demethylase 2A -0.0381652
USP34 ubiquitin specific peptidase 34 -0.0365033
PID1 phosphotyrosine interaction domain containing 1 -0.0364135
SRP54 signal recognition particle 54kDa -0.0349993
MON2 MON2 homolog (S. cerevisiae) -0.0341223
DLG1 discs, large homolog 1 (Drosophila) -0.0336787
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0321709
LMAN1 lectin, mannose-binding, 1 -0.0320863
GCC2 GRIP and coiled-coil domain containing 2 -0.0320738
FAM13A family with sequence similarity 13, member A -0.0316537
COG5 component of oligomeric golgi complex 5 -0.0309148
ZNF292 zinc finger protein 292 -0.0307291
USP3 ubiquitin specific peptidase 3 -0.0303067
BIRC6 baculoviral IAP repeat containing 6 -0.0302598
ELL2 elongation factor, RNA polymerase II, 2 -0.030185
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0297964
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0296751
BASP1 brain abundant, membrane attached signal protein 1 -0.0292281
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0292119
LRRC49 leucine rich repeat containing 49 -0.0291491
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0285545
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0285196
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0284238
MIS18BP1 MIS18 binding protein 1 -0.0275607
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0275026
VRK2 vaccinia related kinase 2 -0.0274752
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0274021
WSB1 WD repeat and SOCS box containing 1 -0.0273228
RUNX2 runt-related transcription factor 2 -0.0273132
FRMD5 FERM domain containing 5 -0.0270357
MARCHF6 membrane associated ring-CH-type finger 6 -0.0265502
RNF149 ring finger protein 149 -0.0264572
STRN3 striatin, calmodulin binding protein 3 -0.0264416
NBAS neuroblastoma amplified sequence -0.0263555
PTPRR protein tyrosine phosphatase, receptor type, R -0.0262702
UGCG UDP-glucose ceramide glucosyltransferase -0.0262157
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0261839
SEC23A Sec23 homolog A (S. cerevisiae) -0.0261271
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0261266
ZBTB20 zinc finger and BTB domain containing 20 -0.0256583
ZFC3H1 zinc finger, C3H1-type containing -0.0256469
METTL15 methyltransferase like 15 -0.0256268
AKAP9 A kinase (PRKA) anchor protein 9 -0.0255293
MORF4L2 mortality factor 4 like 2 -0.0250823
P4HB prolyl 4-hydroxylase, beta polypeptide -0.024952
POU2F1 POU class 2 homeobox 1 -0.024653
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0245231
CANX calnexin -0.0243252
LCORL ligand dependent nuclear receptor corepressor-like -0.024312
TTLL10 tubulin tyrosine ligase-like family member 10 -0.0242278
WDPCP WD repeat containing planar cell polarity effector -0.0241498
COL12A1 collagen, type XII, alpha 1 -0.0241257
COPB1 coatomer protein complex, subunit beta 1 -0.0240185
TMEM263 transmembrane protein 263 -0.024003
PCNX1 pecanex 1 -0.0237056
WDR45B WD repeat domain 45B -0.0235583
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0234852
FBXL13 F-box and leucine-rich repeat protein 13 -0.0232247
DENND4A DENN/MADD domain containing 4A -0.0232181
GARS1 glycyl-tRNA synthetase 1 -0.0231221
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0230024
NPEPPS aminopeptidase puromycin sensitive -0.0228401
RNF145 ring finger protein 145 -0.0228362
TBC1D15 TBC1 domain family, member 15 -0.0227366
CDK17 cyclin-dependent kinase 17 -0.0226835
ACBD3 acyl-CoA binding domain containing 3 -0.0226482
CEP95 centrosomal protein 95kDa -0.0226396
CENPE centromere protein E, 312kDa -0.0224533
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0222091
AFTPH aftiphilin -0.0220924
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0218249
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0217899
NGLY1 N-glycanase 1 -0.0217856
SBF2 SET binding factor 2 -0.021648
TM9SF3 transmembrane 9 superfamily member 3 -0.021236
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.021168
ARF4 ADP-ribosylation factor 4 -0.0211357
THOC2 THO complex 2 -0.0210424
SUCO SUN domain containing ossification factor -0.0208886
COPA coatomer protein complex, subunit alpha -0.0208216
RB1CC1 RB1-inducible coiled-coil 1 -0.020812