| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Anastrozole_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EIF1 | eukaryotic translation initiation factor 1 | 0.144522 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.140182 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.101559 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0992308 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0919834 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0869571 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0806366 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0775146 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0749975 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0678497 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0666568 |
| RPL3 | ribosomal protein L3 | 0.0635018 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0634931 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0622614 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0615362 |
| MCL1 | myeloid cell leukemia 1 | 0.0612158 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0612064 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0593623 |
| BRD2 | bromodomain containing 2 | 0.0588413 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0575884 |
| IER3 | immediate early response 3 | 0.056449 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0562375 |
| FAM107B | family with sequence similarity 107, member B | 0.0561212 |
| PM20D1 | peptidase M20 domain containing 1 | 0.052776 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0527746 |
| USP36 | ubiquitin specific peptidase 36 | 0.0521697 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0519764 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0516284 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0507132 |
| TPI1 | triosephosphate isomerase 1 | 0.0488387 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0484312 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0471088 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.045842 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0450512 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0449035 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0436727 |
| RBM39 | RNA binding motif protein 39 | 0.0429558 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0427847 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0425511 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0417906 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0407362 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0406122 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0398588 |
| CALR | calreticulin | 0.039788 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0396885 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0388534 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0387982 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0383293 |
| ANGPTL4 | angiopoietin-like 4 | 0.0376574 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.037182 |
| SFTPA2 | surfactant protein A2 | 0.0365163 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0362259 |
| APP | amyloid beta (A4) precursor protein | 0.0357083 |
| RPL4 | ribosomal protein L4 | 0.0343654 |
| JUN | jun proto-oncogene | 0.0336472 |
| STC1 | stanniocalcin 1 | 0.0332976 |
| PDE10A | phosphodiesterase 10A | 0.0331413 |
| RPS2 | ribosomal protein S2 | 0.033008 |
| IL6 | interleukin 6 | 0.0329416 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0327444 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0325338 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0324942 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0321232 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0314964 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0314062 |
| PLEC | plectin | 0.0311569 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0311378 |
| EGFR | epidermal growth factor receptor | 0.0310907 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0310318 |
| ADM | adrenomedullin | 0.0305459 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | 0.0304605 |
| SPAG9 | sperm associated antigen 9 | 0.0304447 |
| YME1L1 | YME1-like 1 ATPase | 0.0301629 |
| ASPH | aspartate beta-hydroxylase | 0.0295166 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0294707 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0294553 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0294336 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0294198 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0294048 |
| SIK3 | SIK family kinase 3 | 0.0291932 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0289779 |
| CYTH1 | cytohesin 1 | 0.0287867 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0286242 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0283332 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0282867 |
| LAMC2 | laminin, gamma 2 | 0.0281891 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0279818 |
| DSPP | dentin sialophosphoprotein | 0.0275455 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0275453 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.027451 |
| HYOU1 | hypoxia up-regulated 1 | 0.0273418 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0273337 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0272227 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0271479 |
| TPM3 | tropomyosin 3 | 0.0270983 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0270222 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0266518 |
| IER2 | immediate early response 2 | 0.026575 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.0263165 |
| WWOX | WW domain containing oxidoreductase | 0.0262194 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.323332 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.239392 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.150637 |
| VIM | vimentin | -0.142126 |
| TMSB10 | thymosin beta 10 | -0.134409 |
| FTL | ferritin, light polypeptide | -0.104103 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0772795 |
| IGF2 | insulin-like growth factor 2 | -0.0717678 |
| HMGA1 | high mobility group AT-hook 1 | -0.0704374 |
| PFN1 | profilin 1 | -0.0698998 |
| S100A6 | S100 calcium binding protein A6 | -0.0639243 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | -0.05903 |
| CMIP | c-Maf inducing protein | -0.0566595 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0505464 |
| POTEF | POTE ankyrin domain family, member F | -0.0499205 |
| RPLP0 | ribosomal protein, large, P0 | -0.0491231 |
| TPM4 | tropomyosin 4 | -0.0486283 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0474411 |
| TXNRD1 | thioredoxin reductase 1 | -0.0467772 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0448336 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0448081 |
| TAGLN2 | transgelin 2 | -0.0442568 |
| ERBIN | erbb2 interacting protein | -0.0438808 |
| CFDP1 | craniofacial development protein 1 | -0.0421773 |
| RTN4 | reticulon 4 | -0.042118 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0418285 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0406622 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0395526 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0365014 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0349032 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0346966 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0346289 |
| PTMA | prothymosin, alpha | -0.0339117 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0328482 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0326185 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0313584 |
| RPL19 | ribosomal protein L19 | -0.0300214 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0299147 |
| S100A10 | S100 calcium binding protein A10 | -0.0296972 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0291223 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.028544 |
| TMEM123 | transmembrane protein 123 | -0.0283112 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0281659 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0280821 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0277614 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0277255 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0274207 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0269846 |
| RPS21 | ribosomal protein S21 | -0.0262223 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0259672 |
| RPLP1 | ribosomal protein, large, P1 | -0.0259265 |
| CAPNS1 | calpain, small subunit 1 | -0.0256264 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0255197 |
| RPL30 | ribosomal protein L30 | -0.0254677 |
| LDHB | lactate dehydrogenase B | -0.025148 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0249498 |
| RPS25 | ribosomal protein S25 | -0.0249006 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0241464 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0240732 |
| RPS23 | ribosomal protein S23 | -0.0234222 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.023255 |
| HDAC9 | histone deacetylase 9 | -0.0231355 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0230515 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0226461 |
| RPL8 | ribosomal protein L8 | -0.0223198 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0222924 |
| RPL36 | ribosomal protein L36 | -0.0222571 |
| AK1 | adenylate kinase 1 | -0.021917 |
| MYADM | myeloid-associated differentiation marker | -0.021916 |
| GNAS | GNAS complex locus | -0.0215786 |
| YY1 | YY1 transcription factor | -0.0212994 |
| LYPLA1 | lysophospholipase I | -0.0209223 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0207156 |
| PLS3 | plastin 3 | -0.02053 |
| HMGB1 | high mobility group box 1 | -0.0204782 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0203951 |
| CD99 | CD99 molecule | -0.0202788 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0201579 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0201545 |
| SLC25A6 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 | -0.0194294 |
| EGR1 | early growth response 1 | -0.0193749 |
| YBX1 | Y box binding protein 1 | -0.019242 |
| NLN | neurolysin (metallopeptidase M3 family) | -0.0192168 |
| FDPS | farnesyl diphosphate synthase | -0.0191755 |
| TUBA1B | tubulin, alpha 1b | -0.0189633 |
| SERINC3 | serine incorporator 3 | -0.0187998 |
| HSPB1 | heat shock 27kDa protein 1 | -0.01861 |
| KIFC3 | kinesin family member C3 | -0.018608 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0185094 |
| MORF4L1 | mortality factor 4 like 1 | -0.01849 |
| PAWR | PRKC, apoptosis, WT1, regulator | -0.018401 |
| USP34 | ubiquitin specific peptidase 34 | -0.0183973 |
| RPS24 | ribosomal protein S24 | -0.0183915 |
| DENND4A | DENN/MADD domain containing 4A | -0.0183117 |
| MFF | mitochondrial fission factor | -0.0181887 |
| RAI1 | retinoic acid induced 1 | -0.0179617 |
| RPL35A | ribosomal protein L35a | -0.0179477 |
| NTN4 | netrin 4 | -0.0179411 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | -0.0177838 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0177416 |
