| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Anastrozole_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.177768 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.160047 |
| MYO1E | myosin IE | 0.108816 |
| NDRG1 | N-myc downstream regulated 1 | 0.0917298 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0835159 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0828596 |
| DTNA | dystrobrevin, alpha | 0.0717882 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0705691 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0704727 |
| PDE10A | phosphodiesterase 10A | 0.0681115 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0615335 |
| FTL | ferritin, light polypeptide | 0.0614337 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0613874 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0612934 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0609859 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0591857 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0560684 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0551394 |
| SVIL | supervillin | 0.0542147 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0530403 |
| LAMB3 | laminin, beta 3 | 0.0529227 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0526949 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0526426 |
| ANXA1 | annexin A1 | 0.0522053 |
| MYO5B | myosin VB | 0.0520874 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0501974 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0491593 |
| PTK2 | protein tyrosine kinase 2 | 0.0491371 |
| RPL13A | ribosomal protein L13a | 0.0484401 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.048411 |
| MCL1 | myeloid cell leukemia 1 | 0.0483879 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0482791 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0480074 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0477689 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0468974 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0457784 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | 0.0450664 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0448115 |
| PCBP3 | poly(rC) binding protein 3 | 0.0443638 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0439497 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0436299 |
| CPE | carboxypeptidase E | 0.0430759 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0430384 |
| RPL23 | ribosomal protein L23 | 0.0420677 |
| MXD1 | MAX dimerization protein 1 | 0.0418707 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0415124 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0415009 |
| SBF2 | SET binding factor 2 | 0.041443 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0410462 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.040716 |
| MT2A | metallothionein 2A | 0.0405359 |
| RASAL2 | RAS protein activator like 2 | 0.0399934 |
| TSC22D2 | TSC22 domain family, member 2 | 0.0395066 |
| TJP2 | tight junction protein 2 | 0.0382443 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0377153 |
| MED13 | mediator complex subunit 13 | 0.0372496 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 0.0371009 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0369099 |
| MYO10 | myosin X | 0.036306 |
| NPTN | neuroplastin | 0.0351986 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0351543 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.034993 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0340268 |
| DUSP10 | dual specificity phosphatase 10 | 0.0337985 |
| FMNL2 | formin-like 2 | 0.0332936 |
| LAMC2 | laminin, gamma 2 | 0.033281 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.033081 |
| MSN | moesin | 0.033055 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0325585 |
| RPS3 | ribosomal protein S3 | 0.0325471 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0324609 |
| HELZ | helicase with zinc finger | 0.0323476 |
| RORA | RAR-related orphan receptor A | 0.032151 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.032113 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0321106 |
| AREG | amphiregulin | 0.0321085 |
| FNDC3B | fibronectin type III domain containing 3B | 0.031562 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0315069 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | 0.0312115 |
| JAK1 | Janus kinase 1 | 0.0305034 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0300183 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0297835 |
| SLK | STE20-like kinase | 0.029679 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0295626 |
| BRD2 | bromodomain containing 2 | 0.0289219 |
| HDLBP | high density lipoprotein binding protein | 0.0284673 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0282813 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0281545 |
| DUSP5 | dual specificity phosphatase 5 | 0.0280473 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0280054 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0276493 |
| PTEN | phosphatase and tensin homolog | 0.0276243 |
| TJP1 | tight junction protein 1 | 0.0275928 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0275294 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0271698 |
| ANO6 | anoctamin 6 | 0.0269946 |
| ATOSA | atos homolog A | 0.0267201 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0266288 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.026566 |
| PDIA5 | protein disulfide isomerase family A, member 5 | 0.026557 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.110231 |
| S100A9 | S100 calcium binding protein A9 | -0.0887665 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.085598 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.08149 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0763012 |
| EZR | ezrin | -0.070749 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0689689 |
| FLNB | filamin B, beta | -0.0655793 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0654334 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.063817 |
| TMSB10 | thymosin beta 10 | -0.0629391 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0629388 |
| FN1 | fibronectin 1 | -0.0628273 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0618783 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0600161 |
| EFNA5 | ephrin-A5 | -0.0599516 |
| PGK1 | phosphoglycerate kinase 1 | -0.0563617 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0534345 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.052308 |
| ADNP | activity-dependent neuroprotector homeobox | -0.051486 |
| PTMA | prothymosin, alpha | -0.0514804 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0501519 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0498125 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.048371 |
| ASPH | aspartate beta-hydroxylase | -0.0466052 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0464647 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0463587 |
| INHBA | inhibin, beta A | -0.0459037 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0454852 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0452014 |
| BPTF | bromodomain PHD finger transcription factor | -0.0449792 |
| THBS1 | thrombospondin 1 | -0.044298 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0440902 |
| TBL1X | transducin (beta)-like 1X-linked | -0.0438386 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0437637 |
| IGF2 | insulin-like growth factor 2 | -0.0429134 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0422366 |
| TPM4 | tropomyosin 4 | -0.0421968 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0418373 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0403184 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0403108 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0401511 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0401398 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0398822 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.03908 |
| VMP1 | vacuole membrane protein 1 | -0.0389692 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0381909 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0377064 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0373101 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0371326 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0369209 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0368697 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0367143 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.03633 |
| KDM1A | lysine (K)-specific demethylase 1A | -0.0362317 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0352831 |
| DIDO1 | death inducer-obliterator 1 | -0.0350665 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0346229 |
| IER3 | immediate early response 3 | -0.0345935 |
| RAI14 | retinoic acid induced 14 | -0.0344686 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0342465 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0340149 |
| ARHGAP21 | Rho GTPase activating protein 21 | -0.0339906 |
| KCNK1 | potassium channel, two pore domain subfamily K, member 1 | -0.0337698 |
| PRELID2 | PRELI domain containing 2 | -0.033535 |
| EXOC4 | exocyst complex component 4 | -0.0328325 |
| MAP7 | microtubule-associated protein 7 | -0.0328205 |
| NEK7 | NIMA-related kinase 7 | -0.0320877 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.0317316 |
| KIF13B | kinesin family member 13B | -0.0317185 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0313222 |
| RBM47 | RNA binding motif protein 47 | -0.0312318 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.0310381 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0309793 |
| ANKIB1 | ankyrin repeat and IBR domain containing 1 | -0.0306863 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0306662 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | -0.0304453 |
| KYNU | kynureninase | -0.0304076 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0303643 |
| PARD3 | par-3 family cell polarity regulator | -0.0303531 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0292975 |
| CDK6 | cyclin-dependent kinase 6 | -0.0290264 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0290084 |
| RNF213 | ring finger protein 213 | -0.02893 |
| PERP | PERP, TP53 apoptosis effector | -0.0285304 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0279624 |
| NF1 | neurofibromin 1 | -0.0277642 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0277211 |
| DSPP | dentin sialophosphoprotein | -0.0275392 |
| HMGB1 | high mobility group box 1 | -0.0275284 |
| GOLGB1 | golgin B1 | -0.0273569 |
| GNAS | GNAS complex locus | -0.0268906 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.026788 |
| C6ORF132 | chromosome 6 open reading frame 132 | -0.0263101 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.0263076 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0262603 |
| HMGA2 | high mobility group AT-hook 2 | -0.0262001 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0260635 |
| MED13L | mediator complex subunit 13-like | -0.0254249 |
| GPC6 | glypican 6 | -0.0253706 |
