| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Anastrozole_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.382457 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.195944 |
| GRAMD1B | GRAM domain containing 1B | 0.124832 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.12159 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.113335 |
| TPI1 | triosephosphate isomerase 1 | 0.108969 |
| YBX3 | Y box binding protein 3 | 0.103904 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.10384 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0965332 |
| TPM3 | tropomyosin 3 | 0.0898541 |
| TXNRD1 | thioredoxin reductase 1 | 0.089844 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0795631 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0749033 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0693562 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0660386 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0653098 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0651655 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0626622 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0615031 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0606149 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0602277 |
| KRT18 | keratin 18, type I | 0.0596942 |
| ACTG1 | actin gamma 1 | 0.0593442 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0573363 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0568191 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0529578 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0526706 |
| RPL3 | ribosomal protein L3 | 0.0510477 |
| DST | dystonin | 0.0508978 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0497762 |
| DSPP | dentin sialophosphoprotein | 0.0485934 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0481175 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0480406 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0475133 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0474395 |
| MCL1 | myeloid cell leukemia 1 | 0.0470661 |
| CTTN | cortactin | 0.0466885 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0450814 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0450517 |
| UBR4 | ubiquitin protein ligase E3 component n-recognin 4 | 0.0443161 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0431883 |
| TLN1 | talin 1 | 0.0429762 |
| AHNAK | AHNAK nucleoprotein | 0.0423349 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0417614 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0415577 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0408204 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0401478 |
| ATP11A | ATPase, class VI, type 11A | 0.0399334 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0392988 |
| PLEC | plectin | 0.0389109 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0386761 |
| STC1 | stanniocalcin 1 | 0.0383426 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0380606 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0363748 |
| SPAG9 | sperm associated antigen 9 | 0.0362311 |
| SET | SET nuclear proto-oncogene | 0.0356068 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0352273 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0347297 |
| CPNE1 | copine I | 0.0346788 |
| TPM2 | tropomyosin 2 (beta) | 0.0346329 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0341046 |
| BRD2 | bromodomain containing 2 | 0.0338183 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0337417 |
| HOMER1 | homer scaffolding protein 1 | 0.0333899 |
| DDX39B | DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B | 0.033062 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0326985 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0326891 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0326805 |
| ENO1 | enolase 1, (alpha) | 0.0324717 |
| JMJD1C | jumonji domain containing 1C | 0.0324495 |
| PGK1 | phosphoglycerate kinase 1 | 0.0324262 |
| ADAR | adenosine deaminase, RNA-specific | 0.0320655 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0319806 |
| ATP13A3 | ATPase type 13A3 | 0.0317758 |
| PKM | pyruvate kinase, muscle | 0.0317024 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0316104 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0308646 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0308475 |
| CLTC | clathrin, heavy chain (Hc) | 0.030587 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0305124 |
| MARCHF4 | membrane associated ring-CH-type finger 4 | 0.0301335 |
| IL6ST | interleukin 6 signal transducer | 0.0298021 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0291315 |
| CEP250 | centrosomal protein 250kDa | 0.0291294 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0290546 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0288995 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0287636 |
| CAVIN1 | caveolae associated protein 1 | 0.0283306 |
| PPME1 | protein phosphatase methylesterase 1 | 0.0282592 |
| ANO6 | anoctamin 6 | 0.0281821 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.027898 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0278711 |
| MYO10 | myosin X | 0.0278376 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0274978 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0274625 |
| IER2 | immediate early response 2 | 0.0273353 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0272584 |
| VCP | valosin containing protein | 0.0272178 |
| RPL4 | ribosomal protein L4 | 0.0271563 |
| JUN | jun proto-oncogene | 0.0266834 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.157164 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0772973 |
| RAD51B | RAD51 paralog B | -0.0730412 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0638389 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0598479 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0564279 |
| EGR1 | early growth response 1 | -0.0553294 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0501481 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.044385 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0439696 |
| RPL35A | ribosomal protein L35a | -0.0417451 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0416769 |
| PFN1 | profilin 1 | -0.0410466 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0407305 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0394317 |
| TMSB10 | thymosin beta 10 | -0.0362774 |
| RSF1 | remodeling and spacing factor 1 | -0.0362363 |
| HMGA2 | high mobility group AT-hook 2 | -0.0359007 |
| RYR3 | ryanodine receptor 3 | -0.0354787 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0348579 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0330631 |
| ATXN1 | ataxin 1 | -0.0326437 |
| USP34 | ubiquitin specific peptidase 34 | -0.0326395 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0321763 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0318716 |
| BBX | bobby sox homolog (Drosophila) | -0.0318553 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.030845 |
| TMEM165 | transmembrane protein 165 | -0.0306791 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.0300539 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0290256 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0282781 |
| AEBP2 | AE binding protein 2 | -0.0278881 |
| TNRC6B | trinucleotide repeat containing 6B | -0.0276641 |
| FMN1 | formin 1 | -0.0275587 |
| HDAC8 | histone deacetylase 8 | -0.0274084 |
| SBF2 | SET binding factor 2 | -0.0265265 |
| TAPBP | TAP binding protein (tapasin) | -0.0262541 |
| CCNL1 | cyclin L1 | -0.0259745 |
| RPL9 | ribosomal protein L9 | -0.0258538 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0254651 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0251761 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0246405 |
| HMGA1 | high mobility group AT-hook 1 | -0.0245591 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0236829 |
| NF1 | neurofibromin 1 | -0.0235493 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0234923 |
| RPL37 | ribosomal protein L37 | -0.0222674 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.022211 |
| POTEF | POTE ankyrin domain family, member F | -0.0220709 |
| FTL | ferritin, light polypeptide | -0.0217776 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0216922 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0216 |
| RPS21 | ribosomal protein S21 | -0.0215539 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0212996 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0209047 |
| GOLGA4 | golgin A4 | -0.0208005 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0207693 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0204742 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | -0.0204006 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0202999 |
| EHBP1 | EH domain binding protein 1 | -0.0202127 |
| THOC2 | THO complex 2 | -0.0201889 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0199548 |
| RPS24 | ribosomal protein S24 | -0.019844 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.019636 |
| PPHLN1 | periphilin 1 | -0.0196053 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.01921 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | -0.0192031 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0191537 |
| RYK | receptor-like tyrosine kinase | -0.0189997 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0189911 |
| EGFR | epidermal growth factor receptor | -0.0189879 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0188255 |
| RPL26 | ribosomal protein L26 | -0.0188158 |
| RPL11 | ribosomal protein L11 | -0.018616 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | -0.0185368 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0183018 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0180821 |
| TRMT11 | tRNA methyltransferase 11 homolog (S. cerevisiae) | -0.0180466 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0176846 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0175581 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0174397 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0173696 |
| RPL37A | ribosomal protein L37a | -0.0172563 |
| CCDC91 | coiled-coil domain containing 91 | -0.0172342 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.0171057 |
| TAOK1 | TAO kinase 1 | -0.0170594 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0167581 |
| DCAF10 | DDB1 and CUL4 associated factor 10 | -0.0166108 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0162929 |
| ATXN2 | ataxin 2 | -0.0159969 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0159831 |
| HM13 | histocompatibility (minor) 13 | -0.0158948 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0158379 |
| RSU1 | Ras suppressor protein 1 | -0.0157551 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.015642 |
| FCHSD2 | FCH and double SH3 domains 2 | -0.0156126 |
| SCMH1 | sex comb on midleg homolog 1 (Drosophila) | -0.015505 |
| ZNF292 | zinc finger protein 292 | -0.0154682 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0154301 |
