| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Anastrozole_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.224009 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.217286 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.175999 |
| LAMC2 | laminin, gamma 2 | 0.156985 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.153801 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.15142 |
| EXT1 | exostosin glycosyltransferase 1 | 0.12552 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.115752 |
| ASPH | aspartate beta-hydroxylase | 0.114135 |
| PLEC | plectin | 0.107849 |
| DSPP | dentin sialophosphoprotein | 0.0951121 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0940553 |
| LAMB3 | laminin, beta 3 | 0.0927351 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0865239 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0757403 |
| LMO7 | LIM domain 7 | 0.0742613 |
| AHNAK | AHNAK nucleoprotein | 0.0735983 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0702367 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0676535 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0651682 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0647611 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0612808 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0600507 |
| NAV2 | neuron navigator 2 | 0.0597564 |
| EFNA5 | ephrin-A5 | 0.0581673 |
| FN1 | fibronectin 1 | 0.0574243 |
| SMAD3 | SMAD family member 3 | 0.0563819 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0560817 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0557683 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0548023 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.051233 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0500769 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0493819 |
| HMGB2 | high mobility group box 2 | 0.0484789 |
| MSN | moesin | 0.0482481 |
| TMSB4X | thymosin beta 4, X-linked | 0.0475122 |
| BRD2 | bromodomain containing 2 | 0.0466354 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0458716 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0451844 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0447944 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.0429073 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0417318 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0410785 |
| SDC4 | syndecan 4 | 0.0408493 |
| RPS2 | ribosomal protein S2 | 0.0406842 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0405367 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0404428 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0399024 |
| RPL3 | ribosomal protein L3 | 0.0393423 |
| GOLGB1 | golgin B1 | 0.0391026 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0383171 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0382615 |
| DST | dystonin | 0.0378371 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.0377782 |
| SQSTM1 | sequestosome 1 | 0.0377677 |
| EGFR | epidermal growth factor receptor | 0.0377257 |
| ANO6 | anoctamin 6 | 0.0368628 |
| MYO5B | myosin VB | 0.0366141 |
| INTS6 | integrator complex subunit 6 | 0.0366042 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0365329 |
| RPL4 | ribosomal protein L4 | 0.0363252 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0359837 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0355272 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0350357 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0346931 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0346757 |
| ACTG1 | actin gamma 1 | 0.0346755 |
| RUNX1 | runt-related transcription factor 1 | 0.0342379 |
| VCL | vinculin | 0.0337785 |
| CANX | calnexin | 0.0337595 |
| APP | amyloid beta (A4) precursor protein | 0.0327767 |
| SGMS2 | sphingomyelin synthase 2 | 0.0320959 |
| RPS3 | ribosomal protein S3 | 0.0318925 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0318073 |
| ATXN1 | ataxin 1 | 0.0316657 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0315664 |
| PALLD | palladin, cytoskeletal associated protein | 0.0311872 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0305991 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0305607 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0298871 |
| TJP1 | tight junction protein 1 | 0.0298854 |
| TPM3 | tropomyosin 3 | 0.02931 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0290222 |
| VGLL3 | vestigial-like family member 3 | 0.0289829 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0289323 |
| CD44 | CD44 molecule (Indian blood group) | 0.0289063 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.028673 |
| CALR | calreticulin | 0.0283741 |
| ENO1 | enolase 1, (alpha) | 0.0283544 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0282326 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0280238 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0279028 |
| FHIT | fragile histidine triad | 0.0277988 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.027711 |
| ERBIN | erbb2 interacting protein | 0.0276164 |
| KIAA1217 | KIAA1217 | 0.027585 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.027458 |
| OCLN | occludin | 0.0274302 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.027418 |
| SEPTIN9 | septin 9 | 0.0273965 |
| Symbol | Name | Standardized Value |
|---|---|---|
| POTEF | POTE ankyrin domain family, member F | -0.191825 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.140316 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.10759 |
| TMSB10 | thymosin beta 10 | -0.106282 |
| FTL | ferritin, light polypeptide | -0.0961615 |
| NDRG1 | N-myc downstream regulated 1 | -0.0868047 |
| PTMA | prothymosin, alpha | -0.0802464 |
| S100A6 | S100 calcium binding protein A6 | -0.076661 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0592377 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0590848 |
| IFI27 | interferon, alpha-inducible protein 27 | -0.0568942 |
| HMGA1 | high mobility group AT-hook 1 | -0.0537466 |
| CSTB | cystatin B (stefin B) | -0.0499006 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0471533 |
| RPL35A | ribosomal protein L35a | -0.0425665 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0421804 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0418503 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0416459 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0412144 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0409985 |
| CCND1 | cyclin D1 | -0.0403773 |
| LY6E | lymphocyte antigen 6 complex, locus E | -0.0398752 |
| TMEM165 | transmembrane protein 165 | -0.0388784 |
| S100A10 | S100 calcium binding protein A10 | -0.0373044 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.036827 |
| HLA-B | major histocompatibility complex, class I, B | -0.0365161 |
| RPLP1 | ribosomal protein, large, P1 | -0.0353424 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0346998 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0345643 |
| RAB1A | RAB1A, member RAS oncogene family | -0.03428 |
| IFITM1 | interferon induced transmembrane protein 1 | -0.0323079 |
| TPM4 | tropomyosin 4 | -0.0320839 |
| RNF145 | ring finger protein 145 | -0.0318731 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0318663 |
| RBM25 | RNA binding motif protein 25 | -0.0311533 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0309621 |
| CTSD | cathepsin D | -0.0302208 |
| S100A9 | S100 calcium binding protein A9 | -0.0300799 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0300764 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0300636 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0296223 |
| MDK | midkine (neurite growth-promoting factor 2) | -0.0296006 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0295877 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0293966 |
| FAM162A | family with sequence similarity 162, member A | -0.0292764 |
| IFITM3 | interferon induced transmembrane protein 3 | -0.0291236 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | -0.0290444 |
| TMEM123 | transmembrane protein 123 | -0.0287648 |
| FAM13A | family with sequence similarity 13, member A | -0.0287602 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0287555 |
| TFG | TRK-fused gene | -0.0283432 |
| WASF2 | WAS protein family, member 2 | -0.0280651 |
| CCNL1 | cyclin L1 | -0.0279417 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0278831 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.02777 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0275138 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0274995 |
| GNAS | GNAS complex locus | -0.0273293 |
| USP3 | ubiquitin specific peptidase 3 | -0.0269443 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0268823 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0264252 |
| KRT7 | keratin 7, type II | -0.0258339 |
| HLA-A | major histocompatibility complex, class I, A | -0.0257956 |
| RPS23 | ribosomal protein S23 | -0.0256768 |
| UBC | ubiquitin C | -0.0255492 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0250127 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0247326 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0245271 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0245109 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0244516 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0240889 |
| SLMAP | sarcolemma associated protein | -0.0239008 |
| TOP1 | topoisomerase (DNA) I | -0.0234034 |
| PSMA6 | proteasome (prosome, macropain) subunit, alpha type, 6 | -0.0233993 |
| RPS24 | ribosomal protein S24 | -0.0230833 |
| FUT8 | fucosyltransferase 8 (alpha (1,6) fucosyltransferase) | -0.0229882 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0229163 |
| ZNF292 | zinc finger protein 292 | -0.0225983 |
| PFN1 | profilin 1 | -0.0223964 |
| KHDRBS1 | KH domain containing, RNA binding, signal transduction associated 1 | -0.0222783 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0221632 |
| H3-3B | H3.3 histone B | -0.0218888 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0217656 |
| FOSL1 | FOS-like antigen 1 | -0.0214312 |
| VIM | vimentin | -0.0212546 |
| RNASE3 | ribonuclease, RNase A family, 3 | -0.0212322 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0211163 |
| RPL8 | ribosomal protein L8 | -0.0210747 |
| RPLP2 | ribosomal protein, large, P2 | -0.0210746 |
| RLF | rearranged L-myc fusion | -0.0207323 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0206416 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.020629 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0205444 |
| NDFIP1 | Nedd4 family interacting protein 1 | -0.019895 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0198268 |
| SPINT2 | serine peptidase inhibitor, Kunitz type, 2 | -0.0198085 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.0197703 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0196662 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0195653 |
| JUP | junction plakoglobin | -0.0193139 |
