Anastrozole_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anastrozole_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.168539
DST dystonin 0.165832
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.152684
COL8A1 collagen, type VIII, alpha 1 0.130161
KYNU kynureninase 0.125524
SPTBN1 spectrin, beta, non-erythrocytic 1 0.101078
ASPH aspartate beta-hydroxylase 0.0876278
MYOF myoferlin 0.0843089
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0838515
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0801809
SAMD4A sterile alpha motif domain containing 4A 0.0786838
PDLIM5 PDZ and LIM domain 5 0.075085
PM20D1 peptidase M20 domain containing 1 0.0713305
MYH9 myosin, heavy chain 9, non-muscle 0.068408
RPS2 ribosomal protein S2 0.0667724
GRAMD1B GRAM domain containing 1B 0.06627
RPL3 ribosomal protein L3 0.0626609
EIF1 eukaryotic translation initiation factor 1 0.0598579
HSPA8 heat shock 70kDa protein 8 0.0588941
SMOC1 SPARC related modular calcium binding 1 0.0578231
GDA guanine deaminase 0.0577422
CTIF CBP80/20-dependent translation initiation factor 0.0560321
EEF2 eukaryotic translation elongation factor 2 0.0541586
SH3KBP1 SH3-domain kinase binding protein 1 0.0507272
RAB3B RAB3B, member RAS oncogene family 0.0505423
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0500721
FMNL2 formin-like 2 0.0493368
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0473627
INTS6 integrator complex subunit 6 0.0471836
TRIO trio Rho guanine nucleotide exchange factor 0.0466258
ZSWIM6 zinc finger, SWIM-type containing 6 0.0460895
PSD3 pleckstrin and Sec7 domain containing 3 0.0459712
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0446736
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0445468
RPS12 ribosomal protein S12 0.0441966
PDE10A phosphodiesterase 10A 0.0425701
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0419722
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0419193
PKM pyruvate kinase, muscle 0.0415252
MSN moesin 0.0414967
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0414936
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.041361
TPM3 tropomyosin 3 0.0391566
RPL4 ribosomal protein L4 0.0390856
DOCK4 dedicator of cytokinesis 4 0.0383871
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0380383
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0378982
SLC38A2 solute carrier family 38, member 2 0.0372146
VCL vinculin 0.0358269
CXCL8 chemokine (C-X-C motif) ligand 8 0.0357814
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0354905
TGFBR1 transforming growth factor, beta receptor 1 0.0349103
HYOU1 hypoxia up-regulated 1 0.0345712
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0340213
NFE2L1 nuclear factor, erythroid 2-like 1 0.0337443
SQSTM1 sequestosome 1 0.0332453
AHNAK AHNAK nucleoprotein 0.0329747
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0323652
TXNRD1 thioredoxin reductase 1 0.0314811
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0313864
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0313726
SRRM2 serine/arginine repetitive matrix 2 0.0308082
NAP1L1 nucleosome assembly protein 1-like 1 0.0301953
COL4A5 collagen, type IV, alpha 5 0.0297808
EZR ezrin 0.0296031
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0295468
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0294562
RPS3 ribosomal protein S3 0.0292996
RPS17 ribosomal protein S17 0.029251
NFE2L2 nuclear factor, erythroid 2-like 2 0.0287036
EEF1G eukaryotic translation elongation factor 1 gamma 0.0284504
RGS2 regulator of G-protein signaling 2 0.0281366
SET SET nuclear proto-oncogene 0.0277441
PRRC2C proline-rich coiled-coil 2C 0.027071
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0269171
RPS15A ribosomal protein S15a 0.0267026
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0265622
MT2A metallothionein 2A 0.02654
EXT1 exostosin glycosyltransferase 1 0.0264254
CSNK1A1 casein kinase 1, alpha 1 0.0263095
MAML3 mastermind-like 3 (Drosophila) 0.0262835
FLRT2 fibronectin leucine rich transmembrane protein 2 0.026213
APLP2 amyloid beta (A4) precursor-like protein 2 0.0259373
RPL23 ribosomal protein L23 0.0251474
AGTPBP1 ATP/GTP binding protein 1 0.0250485
PLEC plectin 0.0249616
ATXN1 ataxin 1 0.0241233
MYO10 myosin X 0.0239674
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0237422
CALR calreticulin 0.0236495
GLCCI1 glucocorticoid induced 1 0.0234582
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0233644
LOC112694756 uncharaterized LOC112694756 0.0232574
ZC3H11A zinc finger CCCH-type containing 11A 0.0227054
ALPK2 alpha-kinase 2 0.0226008
BRD2 bromodomain containing 2 0.0224596
RPL35 ribosomal protein L35 0.0224372
RPL37A ribosomal protein L37a 0.0222901
BDNF brain-derived neurotrophic factor 0.0217794
NONO non-POU domain containing, octamer-binding 0.0215591

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.211894
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.185077
VIM vimentin -0.163523
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.145228
PDE4D phosphodiesterase 4D, cAMP-specific -0.120448
TPT1 tumor protein, translationally-controlled 1 -0.0998015
TMSB10 thymosin beta 10 -0.0954973
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0841343
NALF1 NALCN channel auxiliary factor 1 -0.0829579
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0727547
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0726132
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0689233
S100A6 S100 calcium binding protein A6 -0.0667615
SMYD3 SET and MYND domain containing 3 -0.0636027
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.06098
RPS24 ribosomal protein S24 -0.0600177
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0573907
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0561911
NAMPT nicotinamide phosphoribosyltransferase -0.0551345
HLA-B major histocompatibility complex, class I, B -0.0538468
WARS1 tryptophanyl-tRNA synthetase 1 -0.0536376
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0519111
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0505052
PTMA prothymosin, alpha -0.0496988
GNAS GNAS complex locus -0.0476042
TM4SF1 transmembrane 4 L six family member 1 -0.0467413
SPAG9 sperm associated antigen 9 -0.0430443
SOX4 SRY (sex determining region Y)-box 4 -0.042719
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0424075
WSB1 WD repeat and SOCS box containing 1 -0.0403135
TFPI2 tissue factor pathway inhibitor 2 -0.0397672
RPLP1 ribosomal protein, large, P1 -0.0397143
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0395967
STC1 stanniocalcin 1 -0.0393287
PCBP3 poly(rC) binding protein 3 -0.0371055
TGFBI transforming growth factor, beta-induced, 68kDa -0.0367386
OSMR oncostatin M receptor -0.0354645
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0348453
TENT5A terminal nucleotidyltransferase 5A -0.0344792
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0342229
BMERB1 bMERB domain containing 1 -0.0341453
RPL36A ribosomal protein L36a -0.0338683
BTG1 B-cell translocation gene 1, anti-proliferative -0.0331419
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0329581
OASL 2'-5'-oligoadenylate synthetase-like -0.0328119
HLA-A major histocompatibility complex, class I, A -0.0327775
IFIH1 interferon induced with helicase C domain 1 -0.0325973
NCKAP5 NCK-associated protein 5 -0.0324621
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0324568
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0322315
RPL35A ribosomal protein L35a -0.0319636
FTH1 ferritin, heavy polypeptide 1 -0.0315088
ZMYND8 zinc finger, MYND-type containing 8 -0.0315025
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0310302
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.030493
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0303286
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -0.0299135
VDAC1 voltage-dependent anion channel 1 -0.0297283
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0295861
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0295766
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0293209
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0290661
KMT2C lysine (K)-specific methyltransferase 2C -0.0289875
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 -0.0283016
SLC16A6 solute carrier family 16, member 6 -0.027816
CRLF2 cytokine receptor-like factor 2 -0.0276216
ATP5F1B ATP synthase F1 subunit beta -0.0274924
RPS21 ribosomal protein S21 -0.0272969
RTN4 reticulon 4 -0.0271395
S100A10 S100 calcium binding protein A10 -0.0270692
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.026769
IL6 interleukin 6 -0.0261793
KPNB1 karyopherin (importin) beta 1 -0.0260634
TENM3 teneurin transmembrane protein 3 -0.0257932
ANXA2 annexin A2 -0.0254471
CTSL cathepsin L -0.0247306
BABAM2 BRISC and BRCA1 A complex member 2 -0.0245209
STEAP1B STEAP family member 1B -0.0245084
SBF2 SET binding factor 2 -0.0243765
RPL38 ribosomal protein L38 -0.0241912
TMEM165 transmembrane protein 165 -0.0235013
ZFHX3 zinc finger homeobox 3 -0.0234957
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0234372
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0233917
PTGR1 prostaglandin reductase 1 -0.0230529
IGFBP3 insulin-like growth factor binding protein 3 -0.0230479
RPLP0 ribosomal protein, large, P0 -0.0226858
ADGRB3 adhesion G protein-coupled receptor B3 -0.0226046
RPLP2 ribosomal protein, large, P2 -0.0222961
PRKD3 protein kinase D3 -0.0220855
NPEPPS aminopeptidase puromycin sensitive -0.0220586
NBEAL1 neurobeachin-like 1 -0.0218539
RPS14 ribosomal protein S14 -0.0217701
GRB10 growth factor receptor-bound protein 10 -0.0216978
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0215347
CDH13 cadherin 13 -0.0215227
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0214375
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0213447
CA12 carbonic anhydrase XII -0.0211424
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0209834