Anastrozole_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

79 genes differentially expressed following the Anastrozole_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP5 insulin-like growth factor binding protein 5 0.241708
EGFR epidermal growth factor receptor 0.230293
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.214455
UBE2H ubiquitin-conjugating enzyme E2H 0.180905
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.17342
GPC6 glypican 6 0.152204
SMAD3 SMAD family member 3 0.14376
EHBP1 EH domain binding protein 1 0.135049
JMJD1C jumonji domain containing 1C 0.134775
LPP LIM domain containing preferred translocation partner in lipoma 0.128399
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.117259
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.112863
KMT2E lysine (K)-specific methyltransferase 2E 0.108759
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0901063
KMT2C lysine (K)-specific methyltransferase 2C 0.0873413
ASPH aspartate beta-hydroxylase 0.0791819
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0791535
ATXN1 ataxin 1 0.074485
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0622261
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0598829
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0530616
RPS6 ribosomal protein S6 0.052271
CALD1 caldesmon 1 0.0522552
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0475717
PTK2 protein tyrosine kinase 2 0.0449673
AKAP12 A kinase (PRKA) anchor protein 12 0.0430101
COL6A3 collagen, type VI, alpha 3 0.041214
FNDC3B fibronectin type III domain containing 3B 0.0404408
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0396336
RPL12 ribosomal protein L12 0.0348786
RPS12 ribosomal protein S12 0.0249939
RPLP1 ribosomal protein, large, P1 0.0247591
THSD4 thrombospondin, type I, domain containing 4 0.0220961
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0220003
ESYT2 extended synaptotagmin-like protein 2 0.0213025
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0210072
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0151538
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0137877
PTMA prothymosin, alpha 0.0124833
FN1 fibronectin 1 0.0111846
CD44 CD44 molecule (Indian blood group) 0.0070266
LDHA lactate dehydrogenase A 0.00223583
MYOF myoferlin 0.00124603

decreased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor -0.312404
EXT1 exostosin glycosyltransferase 1 -0.205298
NALF1 NALCN channel auxiliary factor 1 -0.189189
HMGA2 high mobility group AT-hook 2 -0.155694
PSD3 pleckstrin and Sec7 domain containing 3 -0.122077
WSB1 WD repeat and SOCS box containing 1 -0.120444
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.115317
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.108319
TMSB10 thymosin beta 10 -0.107881
CADM2 cell adhesion molecule 2 -0.103417
PDE10A phosphodiesterase 10A -0.0995697
PDE4D phosphodiesterase 4D, cAMP-specific -0.0913076
CDH13 cadherin 13 -0.0878266
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0800453
MAML3 mastermind-like 3 (Drosophila) -0.0759612
STC1 stanniocalcin 1 -0.0756178
DST dystonin -0.068054
MT2A metallothionein 2A -0.061953
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0609064
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0580699
VIM vimentin -0.0579498
NDRG1 N-myc downstream regulated 1 -0.0561134
IGFBP3 insulin-like growth factor binding protein 3 -0.0479428
EFNA5 ephrin-A5 -0.0400131
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0375042
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0369763
TPT1 tumor protein, translationally-controlled 1 -0.0327204
MED13L mediator complex subunit 13-like -0.0321558
RPS8 ribosomal protein S8 -0.0303688
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.029534
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0273917
INHBA inhibin, beta A -0.0193555
COL6A1 collagen, type VI, alpha 1 -0.0162981
RPL23 ribosomal protein L23 -0.00919707
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0089516
SAMD4A sterile alpha motif domain containing 4A -0.00637494