Anastrozole_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Anastrozole_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.294877
NTM neurotrimin 0.120528
CADM2 cell adhesion molecule 2 0.110519
PCLO piccolo presynaptic cytomatrix protein 0.106851
MYH9 myosin, heavy chain 9, non-muscle 0.08887
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0834607
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0803557
DST dystonin 0.0751703
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.071686
ADGRV1 adhesion G protein-coupled receptor V1 0.0691088
TENM3 teneurin transmembrane protein 3 0.0637283
SRRM2 serine/arginine repetitive matrix 2 0.0628204
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0617511
DOCK5 dedicator of cytokinesis 5 0.0585232
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0576067
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0573778
RPS2 ribosomal protein S2 0.0569097
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0561155
ENO1 enolase 1, (alpha) 0.0532246
RPS12 ribosomal protein S12 0.0530453
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0526012
CALR calreticulin 0.0521025
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0501123
RPS8 ribosomal protein S8 0.0485698
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0478967
EIF1 eukaryotic translation initiation factor 1 0.0471442
SFTPA2 surfactant protein A2 0.0461975
CDH19 cadherin 19, type 2 0.0461005
COL3A1 collagen, type III, alpha 1 0.0456376
LDHA lactate dehydrogenase A 0.0452073
PDIA6 protein disulfide isomerase family A, member 6 0.0450956
SQSTM1 sequestosome 1 0.044457
ACTG1 actin gamma 1 0.044231
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0431267
RPL23 ribosomal protein L23 0.0431108
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0429598
RPS6 ribosomal protein S6 0.0426674
PTMA prothymosin, alpha 0.0426234
NFE2L1 nuclear factor, erythroid 2-like 1 0.0425631
HYOU1 hypoxia up-regulated 1 0.0417371
PCDH18 protocadherin 18 0.0400607
SLC38A2 solute carrier family 38, member 2 0.0379984
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0379555
PARD3B par-3 family cell polarity regulator beta 0.0371042
ASPH aspartate beta-hydroxylase 0.0366919
FOXP2 forkhead box P2 0.0364311
RPL3 ribosomal protein L3 0.0355819
AKAP12 A kinase (PRKA) anchor protein 12 0.0353
XPO1 exportin 1 0.0346246
PCDH7 protocadherin 7 0.0345599
RPL31 ribosomal protein L31 0.0340693
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0334654
TBC1D5 TBC1 domain family, member 5 0.0332028
TMSB4X thymosin beta 4, X-linked 0.0331381
DSCAM Down syndrome cell adhesion molecule 0.0326786
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0325283
OSBPL10 oxysterol binding protein-like 10 0.0324242
DDIT4 DNA-damage-inducible transcript 4 0.0321413
ANKRD11 ankyrin repeat domain 11 0.0318415
THBS1 thrombospondin 1 0.0316785
KTN1 kinectin 1 (kinesin receptor) 0.0315523
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0314587
BPTF bromodomain PHD finger transcription factor 0.0314512
CKAP5 cytoskeleton associated protein 5 0.031172
TPI1 triosephosphate isomerase 1 0.0307699
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0305485
B2M beta-2-microglobulin 0.0291698
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0287944
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0283914
NCAM2 neural cell adhesion molecule 2 0.0282697
RPS19 ribosomal protein S19 0.0280054
EGFR epidermal growth factor receptor 0.0276578
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.027589
FBXL17 F-box and leucine-rich repeat protein 17 0.0275312
CHD7 chromodomain helicase DNA binding protein 7 0.0274169
WWC2 WW and C2 domain containing 2 0.0273381
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0273327
APLP2 amyloid beta (A4) precursor-like protein 2 0.0273157
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0272551
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0272431
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0271101
WWOX WW domain containing oxidoreductase 0.0269783
SLIT2 slit homolog 2 (Drosophila) 0.0267002
PEG10 paternally expressed 10 0.0263301
RPL7 ribosomal protein L7 0.0262989
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 0.0262784
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.02621
COL5A2 collagen, type V, alpha 2 0.0260885
TSC22D1 TSC22 domain family, member 1 0.0259723
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0259065
GREB1L growth regulation by estrogen in breast cancer-like 0.0258087
RAD51B RAD51 paralog B 0.0257744
NCOR2 nuclear receptor corepressor 2 0.0257018
ASXL2 additional sex combs like transcriptional regulator 2 0.0256774
PRKCSH protein kinase C substrate 80K-H 0.0256166
ZNF638 zinc finger protein 638 0.0254989
RPS3 ribosomal protein S3 0.0253764
SCRN1 secernin 1 0.0251563
ATF4 activating transcription factor 4 0.0250837
SAMD4A sterile alpha motif domain containing 4A 0.0247227

decreased expression

Symbol Name Standardized Value
TSC22D2 TSC22 domain family, member 2 -0.107473
ZNF292 zinc finger protein 292 -0.106588
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0979884
NRG1 neuregulin 1 -0.0633112
ADGRL2 adhesion G protein-coupled receptor L2 -0.0606971
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0602385
CDC73 cell division cycle 73 -0.0589031
RHEB Ras homolog enriched in brain -0.0572481
STRN3 striatin, calmodulin binding protein 3 -0.0568626
MARCHF6 membrane associated ring-CH-type finger 6 -0.0555823
GPC3 glypican 3 -0.0554186
RTN4 reticulon 4 -0.0552148
ZEB2 zinc finger E-box binding homeobox 2 -0.0548641
PGAP1 post-GPI attachment to proteins 1 -0.0530329
WDR43 WD repeat domain 43 -0.0516314
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0510293
ADAM9 ADAM metallopeptidase domain 9 -0.0499741
FAM171B family with sequence similarity 171, member B -0.0493858
KMT2C lysine (K)-specific methyltransferase 2C -0.0458273
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0446596
ATP5F1B ATP synthase F1 subunit beta -0.0435475
ADGRL3 adhesion G protein-coupled receptor L3 -0.042824
ZFAND3 zinc finger, AN1-type domain 3 -0.0417374
CHD1 chromodomain helicase DNA binding protein 1 -0.0415931
SPAG9 sperm associated antigen 9 -0.0412374
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0409491
FBXO11 F-box protein 11 -0.0405398
LRRN3 leucine rich repeat neuronal 3 -0.0403941
NOP58 NOP58 ribonucleoprotein -0.0400543
CAMTA1 calmodulin binding transcription activator 1 -0.0399865
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0391246
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0381936
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0377813
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0376512
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0365266
KMT2E lysine (K)-specific methyltransferase 2E -0.0365089
TUT4 terminal uridylyl transferase 4 -0.036503
AKAP9 A kinase (PRKA) anchor protein 9 -0.0363413
FNDC3B fibronectin type III domain containing 3B -0.035014
RYBP RING1 and YY1 binding protein -0.0349795
MAP4 microtubule-associated protein 4 -0.0348226
TNRC6B trinucleotide repeat containing 6B -0.0347766
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0343176
TBC1D12 TBC1 domain family, member 12 -0.0342362
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0342232
MTF2 metal response element binding transcription factor 2 -0.0338057
ZMYM2 zinc finger, MYM-type 2 -0.0337467
NUP153 nucleoporin 153kDa -0.0335032
RFX7 regulatory factor X, 7 -0.0332956
URI1 URI1, prefoldin-like chaperone -0.0331815
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0331466
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0330403
POU2F1 POU class 2 homeobox 1 -0.0329021
QKI QKI, KH domain containing, RNA binding -0.0326719
RAB7A RAB7A, member RAS oncogene family -0.032539
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0324599
PUM1 pumilio RNA-binding family member 1 -0.0324519
PDS5A PDS5 cohesin associated factor A -0.032239
MRPS30 mitochondrial ribosomal protein S30 -0.0319506
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0319116
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0313171
MEF2A myocyte enhancer factor 2A -0.0309984
MEMO1 mediator of cell motility 1 -0.0308555
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0308464
KMT2A lysine (K)-specific methyltransferase 2A -0.0307293
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0303551
POTEF POTE ankyrin domain family, member F -0.0296046
PCDH9 protocadherin 9 -0.0295263
PICALM phosphatidylinositol binding clathrin assembly protein -0.0295091
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0292715
PDS5B PDS5 cohesin associated factor B -0.0292572
ANK2 ankyrin 2, neuronal -0.0292209
LYPLA1 lysophospholipase I -0.0292062
PHIP pleckstrin homology domain interacting protein -0.0291433
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0291431
PFN1 profilin 1 -0.0291383
EP300 E1A binding protein p300 -0.0290183
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0288751
SIK3 SIK family kinase 3 -0.0282646
BTG3 BTG family, member 3 -0.0279794
DMD dystrophin -0.0277137
HMGA1 high mobility group AT-hook 1 -0.0274942
CAPNS1 calpain, small subunit 1 -0.0270947
SRP54 signal recognition particle 54kDa -0.0269903
BIRC6 baculoviral IAP repeat containing 6 -0.0268798
RAI1 retinoic acid induced 1 -0.0267696
LUC7L2 LUC7-like 2 (S. cerevisiae) -0.0267044
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0266139
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0265827
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0263484
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0259584
HS6ST2 heparan sulfate 6-O-sulfotransferase 2 -0.0259173
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0256936
RAD21 RAD21 homolog (S. pombe) -0.0254492
NCOR1 nuclear receptor corepressor 1 -0.0252529
KDM5B lysine (K)-specific demethylase 5B -0.0251606
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0251097
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0250141
MRPS6 mitochondrial ribosomal protein S6 -0.0249922
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0247156