| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Anastrozole perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Anastrozole_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MYH9 | myosin, heavy chain 9, non-muscle | 0.311467 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.184631 |
| EXT1 | exostosin glycosyltransferase 1 | 0.122269 |
| CD44 | CD44 molecule (Indian blood group) | 0.121866 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.121015 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.115549 |
| FN1 | fibronectin 1 | 0.104754 |
| AHNAK | AHNAK nucleoprotein | 0.0982155 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.092994 |
| KYNU | kynureninase | 0.0911144 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0887698 |
| ASPH | aspartate beta-hydroxylase | 0.0745241 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0744237 |
| COL6A3 | collagen, type VI, alpha 3 | 0.0716267 |
| PRSS23 | protease, serine, 23 | 0.0710121 |
| STC1 | stanniocalcin 1 | 0.0701974 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0697611 |
| CALR | calreticulin | 0.068371 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.064998 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0608458 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0603758 |
| HMGA2 | high mobility group AT-hook 2 | 0.0595232 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0593874 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0577007 |
| GOLGB1 | golgin B1 | 0.0576559 |
| FLNA | filamin A, alpha | 0.056633 |
| ENO1 | enolase 1, (alpha) | 0.0557556 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0546805 |
| PRELID2 | PRELI domain containing 2 | 0.0541517 |
| NRXN3 | neurexin 3 | 0.0537226 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0533106 |
| EXOC4 | exocyst complex component 4 | 0.0513688 |
| ATXN1 | ataxin 1 | 0.0487566 |
| GLIS3 | GLIS family zinc finger 3 | 0.0478115 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0473639 |
| HDLBP | high density lipoprotein binding protein | 0.0470135 |
| PKM | pyruvate kinase, muscle | 0.0463225 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.046122 |
| MSN | moesin | 0.0458145 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0455552 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0448633 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0447853 |
| ECE1 | endothelin converting enzyme 1 | 0.044623 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0443274 |
| WWOX | WW domain containing oxidoreductase | 0.0441339 |
| INTS6 | integrator complex subunit 6 | 0.0419811 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0413664 |
| PLEC | plectin | 0.0410409 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0406224 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0402225 |
| SMAD3 | SMAD family member 3 | 0.0402168 |
| CHD9 | chromodomain helicase DNA binding protein 9 | 0.0395933 |
| COL6A2 | collagen, type VI, alpha 2 | 0.0393581 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0390941 |
| SDC4 | syndecan 4 | 0.0389805 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0388084 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0381906 |
| VEGFC | vascular endothelial growth factor C | 0.0380351 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0373871 |
| SMYD3 | SET and MYND domain containing 3 | 0.0370911 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0369675 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0368296 |
| HDAC9 | histone deacetylase 9 | 0.0364376 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0364294 |
| MCL1 | myeloid cell leukemia 1 | 0.0353291 |
| RAD51B | RAD51 paralog B | 0.0352293 |
| FAT1 | FAT atypical cadherin 1 | 0.0351124 |
| TPM3 | tropomyosin 3 | 0.0351025 |
| ACTN1 | actinin, alpha 1 | 0.0347607 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0345625 |
| DST | dystonin | 0.0343036 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0342212 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0341022 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.033894 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0338587 |
| COG6 | component of oligomeric golgi complex 6 | 0.0336873 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0329075 |
| ADM | adrenomedullin | 0.0328847 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0326608 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0326535 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0319342 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | 0.031808 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0315289 |
| DNAH11 | dynein, axonemal, heavy chain 11 | 0.0314128 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0311804 |
| APP | amyloid beta (A4) precursor protein | 0.031176 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0311591 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0311478 |
| HYOU1 | hypoxia up-regulated 1 | 0.0309935 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0306721 |
| CANX | calnexin | 0.0304582 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0302667 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0302594 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0300619 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0299241 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0296067 |
| BPTF | bromodomain PHD finger transcription factor | 0.0294262 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0293383 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0292515 |
| EGFR | epidermal growth factor receptor | 0.0292093 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.132957 |
| NDRG1 | N-myc downstream regulated 1 | -0.124106 |
| COL1A2 | collagen, type I, alpha 2 | -0.0931001 |
| TMSB10 | thymosin beta 10 | -0.0864112 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.075335 |
| FTL | ferritin, light polypeptide | -0.0751836 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0677092 |
| GOLGA4 | golgin A4 | -0.0647141 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0630894 |
| FAM13A | family with sequence similarity 13, member A | -0.0604075 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0573554 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0569707 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.0549455 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0533379 |
| VIM | vimentin | -0.0530704 |
| TMEM165 | transmembrane protein 165 | -0.0524505 |
| HLA-B | major histocompatibility complex, class I, B | -0.049805 |
| COL1A1 | collagen, type I, alpha 1 | -0.0489718 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0460515 |
| NOP58 | NOP58 ribonucleoprotein | -0.0457118 |
| CADM1 | cell adhesion molecule 1 | -0.0451058 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0408701 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0406551 |
| ATP13A3 | ATPase type 13A3 | -0.0405029 |
| RNF145 | ring finger protein 145 | -0.0398073 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0396068 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0392784 |
| SRP54 | signal recognition particle 54kDa | -0.0384729 |
| S100A6 | S100 calcium binding protein A6 | -0.0367875 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.035152 |
| H3-3B | H3.3 histone B | -0.034782 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0344494 |
| TMEM158 | transmembrane protein 158 (gene/pseudogene) | -0.0341844 |
| ZNF292 | zinc finger protein 292 | -0.0331607 |
| CLINT1 | clathrin interactor 1 | -0.0328709 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0326075 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0324302 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0316886 |
| RTN4 | reticulon 4 | -0.0316106 |
| KAZN | kazrin, periplakin interacting protein | -0.031206 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0311808 |
| MATR3 | matrin 3 | -0.0310326 |
| UBC | ubiquitin C | -0.0306119 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.030139 |
| RBM39 | RNA binding motif protein 39 | -0.0299428 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0295204 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0290809 |
| UBE2B | ubiquitin-conjugating enzyme E2B | -0.029047 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0290186 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0289024 |
| SETD5 | SET domain containing 5 | -0.0287007 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.028675 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0285655 |
| KLHDC10 | kelch domain containing 10 | -0.0281481 |
| HLA-C | major histocompatibility complex, class I, C | -0.0280562 |
| CTSD | cathepsin D | -0.0279583 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0278155 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.027595 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.026978 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.026791 |
| RLF | rearranged L-myc fusion | -0.026739 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0265856 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0265333 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0264267 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0263746 |
| FAM162A | family with sequence similarity 162, member A | -0.0262972 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0262193 |
| WASF2 | WAS protein family, member 2 | -0.0260829 |
| ARF4 | ADP-ribosylation factor 4 | -0.0260771 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | -0.0258583 |
| HM13 | histocompatibility (minor) 13 | -0.0256527 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0255024 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0253257 |
| RHEB | Ras homolog enriched in brain | -0.0251589 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0248405 |
| MT1X | metallothionein 1X | -0.0248173 |
| POTEF | POTE ankyrin domain family, member F | -0.0247386 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.024675 |
| CD99 | CD99 molecule | -0.024614 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0245496 |
| SSBP2 | single-stranded DNA binding protein 2 | -0.0243587 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0243158 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0242997 |
| COL5A2 | collagen, type V, alpha 2 | -0.0241281 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0237967 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0234499 |
| RPS6 | ribosomal protein S6 | -0.0234334 |
| TMEM41B | transmembrane protein 41B | -0.0232439 |
| USP3 | ubiquitin specific peptidase 3 | -0.0231494 |
| SKIC3 | SKI3 subunit of superkiller complex | -0.0228799 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0228544 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0227451 |
| PTMA | prothymosin, alpha | -0.0227337 |
| UFM1 | ubiquitin-fold modifier 1 | -0.0227042 |
| NUCB2 | nucleobindin 2 | -0.0224153 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0220647 |
| SRPK2 | SRSF protein kinase 2 | -0.0220294 |
| RPL27A | ribosomal protein L27a | -0.0220069 |
| TPST1 | tyrosylprotein sulfotransferase 1 | -0.0219555 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0219139 |
