Anastrozole_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anastrozole perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anastrozole_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ASPH aspartate beta-hydroxylase 0.106968
MYH9 myosin, heavy chain 9, non-muscle 0.102089
EXT1 exostosin glycosyltransferase 1 0.0870167
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0719401
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0653727
SMAD3 SMAD family member 3 0.0602053
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0588772
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0544096
HMGA2 high mobility group AT-hook 2 0.0498235
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0478469
HIPK2 homeodomain interacting protein kinase 2 0.0474856
FAT1 FAT atypical cadherin 1 0.045069
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0420673
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0416353
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0410418
LTBP1 latent transforming growth factor beta binding protein 1 0.0409164
DST dystonin 0.0403802
RASAL2 RAS protein activator like 2 0.0385785
FNDC3B fibronectin type III domain containing 3B 0.038345
SVIL supervillin 0.0368316
SHB Src homology 2 domain containing adaptor protein B 0.0361027
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0359532
ERRFI1 ERBB receptor feedback inhibitor 1 0.0357679
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0356571
NTN4 netrin 4 0.0350445
SEPTIN9 septin 9 0.0338474
EREG epiregulin 0.0328346
NFE2L1 nuclear factor, erythroid 2-like 1 0.0328067
PLEC plectin 0.0324999
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0320439
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0319661
TMEM156 transmembrane protein 156 0.0312077
TPM3 tropomyosin 3 0.0311126
HSPA8 heat shock 70kDa protein 8 0.0298226
GPATCH2L G patch domain containing 2-like 0.02965
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0295846
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0293396
VCL vinculin 0.02889
MAP1B microtubule-associated protein 1B 0.0286878
ZC3H12C zinc finger CCCH-type containing 12C 0.0285074
IL6ST interleukin 6 signal transducer 0.027681
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0274387
DOCK5 dedicator of cytokinesis 5 0.0273648
MACF1 microtubule-actin crosslinking factor 1 0.027137
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0270848
TRIO trio Rho guanine nucleotide exchange factor 0.0268147
FLNA filamin A, alpha 0.0265842
AHR aryl hydrocarbon receptor 0.0262126
CLIP2 CAP-GLY domain containing linker protein 2 0.0260735
PDLIM5 PDZ and LIM domain 5 0.0259422
ZSWIM6 zinc finger, SWIM-type containing 6 0.0247917
LYST lysosomal trafficking regulator 0.024784
PALLD palladin, cytoskeletal associated protein 0.0245567
VEGFC vascular endothelial growth factor C 0.0240126
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.023939
ANKRD28 ankyrin repeat domain 28 0.0235928
FNDC3A fibronectin type III domain containing 3A 0.0231487
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0230752
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0230627
AHNAK AHNAK nucleoprotein 0.0227775
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0227677
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4 0.0220264
AKAP12 A kinase (PRKA) anchor protein 12 0.0217712
NRIP1 nuclear receptor interacting protein 1 0.0217498
MLPH melanophilin 0.0215657
ELL2 elongation factor, RNA polymerase II, 2 0.0215528
SRRM2 serine/arginine repetitive matrix 2 0.0211184
KTN1 kinectin 1 (kinesin receptor) 0.0209399
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0207879
ATXN1 ataxin 1 0.020574
ITGA1 integrin, alpha 1 0.0203218
WWTR1 WW domain containing transcription regulator 1 0.0202709
HYOU1 hypoxia up-regulated 1 0.0202626
SMYD3 SET and MYND domain containing 3 0.0200844
RNF213 ring finger protein 213 0.0200345
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0196292
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0194713
ZEB2 zinc finger E-box binding homeobox 2 0.0193567
SGMS2 sphingomyelin synthase 2 0.0192631
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0188235
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0184016
NPAS2 neuronal PAS domain protein 2 0.0183826
NUMA1 nuclear mitotic apparatus protein 1 0.0177899
LIMCH1 LIM and calponin homology domains 1 0.0177664
RPL3 ribosomal protein L3 0.0177018
NRP1 neuropilin 1 0.0176743
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0173967
ANXA5 annexin A5 0.0173642
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0171248
ANO6 anoctamin 6 0.0171151
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0170697
LOXL2 lysyl oxidase-like 2 0.0170455
SOX9 SRY (sex determining region Y)-box 9 0.0170402
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0169031
MSN moesin 0.0165121
SH3KBP1 SH3-domain kinase binding protein 1 0.0164754
APLP2 amyloid beta (A4) precursor-like protein 2 0.01645
RUNX1 runt-related transcription factor 1 0.0164488
SAMD4A sterile alpha motif domain containing 4A 0.0161869
SYNJ2 synaptojanin 2 0.0161733

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.372646
PTMA prothymosin, alpha -0.229639
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.146391
TMSB10 thymosin beta 10 -0.145957
HLA-B major histocompatibility complex, class I, B -0.124291
NDRG1 N-myc downstream regulated 1 -0.102673
TPT1 tumor protein, translationally-controlled 1 -0.101749
FTL ferritin, light polypeptide -0.0990021
VIM vimentin -0.0806249
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0791739
RPS6 ribosomal protein S6 -0.0709726
IFI27 interferon, alpha-inducible protein 27 -0.0699197
S100A6 S100 calcium binding protein A6 -0.0691214
RPL35A ribosomal protein L35a -0.0668494
MT2A metallothionein 2A -0.0664755
RPS24 ribosomal protein S24 -0.0582225
RPL31 ribosomal protein L31 -0.0575681
RPLP1 ribosomal protein, large, P1 -0.057279
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0571375
NRG1 neuregulin 1 -0.0539249
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.052066
RPS25 ribosomal protein S25 -0.0493672
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0484178
SQSTM1 sequestosome 1 -0.048049
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0476899
IER3 immediate early response 3 -0.0462426
RPL9 ribosomal protein L9 -0.0461696
RPS29 ribosomal protein S29 -0.0452491
FTH1 ferritin, heavy polypeptide 1 -0.044734
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0445669
RPS23 ribosomal protein S23 -0.0440743
ACTG1 actin gamma 1 -0.0436374
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0423297
RPS19 ribosomal protein S19 -0.0417946
RPS11 ribosomal protein S11 -0.0416188
RPL37A ribosomal protein L37a -0.0411144
GNAS GNAS complex locus -0.0410807
CANX calnexin -0.0407098
RPS21 ribosomal protein S21 -0.0405563
TMEM165 transmembrane protein 165 -0.0399453
RPS16 ribosomal protein S16 -0.0391349
LOC102724023 ES1 protein homolog, mitochondrial -0.0387975
RPS8 ribosomal protein S8 -0.037794
RPL37 ribosomal protein L37 -0.037181
ENO2 enolase 2 (gamma, neuronal) -0.0369563
RPL34 ribosomal protein L34 -0.0355498
S100A9 S100 calcium binding protein A9 -0.035298
SOX4 SRY (sex determining region Y)-box 4 -0.0350378
RPL19 ribosomal protein L19 -0.0350337
RPL38 ribosomal protein L38 -0.0348881
EGR1 early growth response 1 -0.0348404
GOLGA4 golgin A4 -0.0348141
KPNB1 karyopherin (importin) beta 1 -0.0345386
RPLP2 ribosomal protein, large, P2 -0.0340698
RPL26 ribosomal protein L26 -0.0331237
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0330033
RPL28 ribosomal protein L28 -0.0329543
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0326894
RPL11 ribosomal protein L11 -0.0319422
HLA-A major histocompatibility complex, class I, A -0.0319049
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0314456
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0309058
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0304279
RPS3 ribosomal protein S3 -0.030149
HMGA1 high mobility group AT-hook 1 -0.0297694
RAB7A RAB7A, member RAS oncogene family -0.029688
WSB1 WD repeat and SOCS box containing 1 -0.0296786
HILPDA hypoxia inducible lipid droplet-associated -0.0296428
RPL12 ribosomal protein L12 -0.0292301
RPS27A ribosomal protein S27a -0.0290858
PGK1 phosphoglycerate kinase 1 -0.0283805
RPS27 ribosomal protein S27 -0.0279536
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.027751
B2M beta-2-microglobulin -0.0276643
CTSD cathepsin D -0.0275175
RPL23 ribosomal protein L23 -0.0274671
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0272982
MTDH metadherin -0.0272011
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0271841
RPL30 ribosomal protein L30 -0.0270672
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0270149
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0267388
PDE4D phosphodiesterase 4D, cAMP-specific -0.0266774
RPLP0 ribosomal protein, large, P0 -0.0264441
RPL8 ribosomal protein L8 -0.0264109
TMEM263 transmembrane protein 263 -0.0258816
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0257334
SERF2 small EDRK-rich factor 2 -0.0257149
RPS13 ribosomal protein S13 -0.0257065
UBE2K ubiquitin-conjugating enzyme E2K -0.0255344
RPS12 ribosomal protein S12 -0.0250629
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0249532
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0249492
KRT81 keratin 81, type II -0.024761
CD63 CD63 molecule -0.0246291
RPS5 ribosomal protein S5 -0.0244022
RPS14 ribosomal protein S14 -0.0242693
EIF5B eukaryotic translation initiation factor 5B -0.0242612
WDR45B WD repeat domain 45B -0.0242424
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0241541