Anethole trithione_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TRIO trio Rho guanine nucleotide exchange factor 0.139942
ZFAND3 zinc finger, AN1-type domain 3 0.0973985
VEGFA vascular endothelial growth factor A 0.0955762
USP9X ubiquitin specific peptidase 9, X-linked 0.0859463
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0810614
CTBP2 C-terminal binding protein 2 0.0776476
SFTPA2 surfactant protein A2 0.077599
MED13L mediator complex subunit 13-like 0.0762886
HMGA2 high mobility group AT-hook 2 0.0672543
IGF2R insulin-like growth factor 2 receptor 0.0656759
JMJD1C jumonji domain containing 1C 0.0654196
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0653368
OGA O-GlcNAcase 0.0637689
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0629151
MYH9 myosin, heavy chain 9, non-muscle 0.0626545
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0611588
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0579655
ZMIZ1 zinc finger, MIZ-type containing 1 0.0551264
KDM6A lysine (K)-specific demethylase 6A 0.0548139
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0532991
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0526685
PARD3 par-3 family cell polarity regulator 0.0515761
TMSB4X thymosin beta 4, X-linked 0.0515677
H1-4 H1.4 linker histone, cluster member 0.0508618
SPAG9 sperm associated antigen 9 0.0506813
EEF2 eukaryotic translation elongation factor 2 0.0503049
SPPL3 signal peptide peptidase like 3 0.0471838
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.046997
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0460845
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0455126
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0447317
CAMTA1 calmodulin binding transcription activator 1 0.0443566
APP amyloid beta (A4) precursor protein 0.0438507
RPL3 ribosomal protein L3 0.0436995
RPL4 ribosomal protein L4 0.0434334
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0434243
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0433703
SIK3 SIK family kinase 3 0.0433386
ZNF608 zinc finger protein 608 0.0431571
MYOF myoferlin 0.0427431
ANO6 anoctamin 6 0.0424128
FRMD6 FERM domain containing 6 0.0423825
QKI QKI, KH domain containing, RNA binding 0.0419093
MB21D2 Mab-21 domain containing 2 0.0418958
DENND5A DENN/MADD domain containing 5A 0.0401921
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0396899
SSBP2 single-stranded DNA binding protein 2 0.0388507
TOP2B topoisomerase (DNA) II beta 180kDa 0.0380788
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0377569
ANKRD11 ankyrin repeat domain 11 0.0366896
FGFR1 fibroblast growth factor receptor 1 0.036555
APLP2 amyloid beta (A4) precursor-like protein 2 0.0363723
SFPQ splicing factor proline/glutamine-rich 0.0359309
ANKHD1 ankyrin repeat and KH domain containing 1 0.0357599
ATP11A ATPase, class VI, type 11A 0.0352781
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0350527
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.034928
PHF3 PHD finger protein 3 0.0347376
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0346381
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.034595
AFF4 AF4/FMR2 family, member 4 0.0345949
RHEB Ras homolog enriched in brain 0.0335523
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0333284
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0330819
KMT2C lysine (K)-specific methyltransferase 2C 0.0329751
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0327878
KANK1 KN motif and ankyrin repeat domains 1 0.0326503
FNIP1 folliculin interacting protein 1 0.0321988
HYOU1 hypoxia up-regulated 1 0.0321847
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0321791
TNIP1 TNFAIP3 interacting protein 1 0.031857
TRA2A transformer 2 alpha homolog (Drosophila) 0.031841
SAMD4A sterile alpha motif domain containing 4A 0.0317796
XPO1 exportin 1 0.0314588
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0313788
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0312684
CERT1 ceramide transporter 1 0.0310097
ZEB1 zinc finger E-box binding homeobox 1 0.0304713
BCOR BCL6 corepressor 0.0302017
EWSR1 EWS RNA-binding protein 1 0.0301651
PICALM phosphatidylinositol binding clathrin assembly protein 0.0301225
RBM33 RNA binding motif protein 33 0.0301105
EP300 E1A binding protein p300 0.0297755
ELOVL5 ELOVL fatty acid elongase 5 0.0293981
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0291327
GNAQ guanine nucleotide binding protein (G protein), q polypeptide 0.0288235
NCOR2 nuclear receptor corepressor 2 0.0286471
SON SON DNA binding protein 0.0286385
MYH10 myosin, heavy chain 10, non-muscle 0.0284238
LPP LIM domain containing preferred translocation partner in lipoma 0.028395
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0283648
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0282163
SSBP3 single stranded DNA binding protein 3 0.0281174
NUMA1 nuclear mitotic apparatus protein 1 0.028023
TPD52 tumor protein D52 0.0279672
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0278703
SREBF2 sterol regulatory element binding transcription factor 2 0.0278299
TFRC transferrin receptor 0.0277924
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0277248
PRKCE protein kinase C, epsilon 0.0276174

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.0853465
PRKG1 protein kinase, cGMP-dependent, type I -0.0804135
PEG10 paternally expressed 10 -0.0584716
TPK1 thiamin pyrophosphokinase 1 -0.0538876
MT2A metallothionein 2A -0.0497389
DLG1 discs, large homolog 1 (Drosophila) -0.0467201
CENPF centromere protein F, 350/400kDa -0.0448289
RPL35A ribosomal protein L35a -0.0443517
BCAS3 breast carcinoma amplified sequence 3 -0.0435673
RPS23 ribosomal protein S23 -0.0397603
MKI67 marker of proliferation Ki-67 -0.0393667
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0383832
RPS29 ribosomal protein S29 -0.0378831
RPL37A ribosomal protein L37a -0.0376119
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0367777
RPLP1 ribosomal protein, large, P1 -0.0362576
RPLP2 ribosomal protein, large, P2 -0.0362211
SOX4 SRY (sex determining region Y)-box 4 -0.0346176
TIMP1 TIMP metallopeptidase inhibitor 1 -0.03378
RPL31 ribosomal protein L31 -0.0335977
TPM4 tropomyosin 4 -0.0327517
FTH1 ferritin, heavy polypeptide 1 -0.0326604
COL1A2 collagen, type I, alpha 2 -0.0322926
FTL ferritin, light polypeptide -0.0319753
AKAP12 A kinase (PRKA) anchor protein 12 -0.0311696
IER3 immediate early response 3 -0.0311009
PDIA3 protein disulfide isomerase family A, member 3 -0.030812
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0306942
DCAF7 DDB1 and CUL4 associated factor 7 -0.0303035
VDAC1 voltage-dependent anion channel 1 -0.0301494
SEPTIN7 septin 7 -0.0299539
CHD9 chromodomain helicase DNA binding protein 9 -0.0295507
RPL36 ribosomal protein L36 -0.0290994
CENPE centromere protein E, 312kDa -0.0289953
LARS1 leucyl-tRNA synthetase 1 -0.0287599
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0285772
SEPTIN11 septin 11 -0.0265788
RPL37 ribosomal protein L37 -0.0264357
RPS25 ribosomal protein S25 -0.0261277
TMSB10 thymosin beta 10 -0.0261172
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0260278
MEOX2 mesenchyme homeobox 2 -0.0260191
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0256175
RPS27 ribosomal protein S27 -0.025366
VIM vimentin -0.0250592
RPL38 ribosomal protein L38 -0.0247382
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0246685
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0245422
CCDC88A coiled-coil domain containing 88A -0.0242297
RPS8 ribosomal protein S8 -0.0242261
RPL34 ribosomal protein L34 -0.0241841
RPL23 ribosomal protein L23 -0.0241523
TAPBP TAP binding protein (tapasin) -0.0241392
HMGB1 high mobility group box 1 -0.0237713
RPS19 ribosomal protein S19 -0.0236772
DEK DEK proto-oncogene -0.0235008
THOC2 THO complex 2 -0.0234088
RPS20 ribosomal protein S20 -0.0230043
NDUFA4 NDUFA4, mitochondrial complex associated -0.0228521
CDC27 cell division cycle 27 -0.0227812
RPS15 ribosomal protein S15 -0.0225752
RPL8 ribosomal protein L8 -0.0220255
CBX3 chromobox homolog 3 -0.0215781
RAD51B RAD51 paralog B -0.0214088
RPS14 ribosomal protein S14 -0.0211567
RPL36A ribosomal protein L36a -0.0210715
AKR1C1 aldo-keto reductase family 1, member C1 -0.0210354
MGP matrix Gla protein -0.0210147
RPS3 ribosomal protein S3 -0.0209758
GNAS GNAS complex locus -0.0208497
RSRC2 arginine/serine-rich coiled-coil 2 -0.0207911
SMC4 structural maintenance of chromosomes 4 -0.0204738
PGK1 phosphoglycerate kinase 1 -0.020162
ALCAM activated leukocyte cell adhesion molecule -0.0201434
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0197776
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0196301
MEST mesoderm specific transcript -0.0196297
CKAP2 cytoskeleton associated protein 2 -0.0194991
EFNA5 ephrin-A5 -0.0194693
HLA-B major histocompatibility complex, class I, B -0.0194499
IARS1 isoleucyl-tRNA synthetase 1 -0.0193112
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0191809
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 -0.0189584
B2M beta-2-microglobulin -0.0187952
RPS6 ribosomal protein S6 -0.0186954
WSB1 WD repeat and SOCS box containing 1 -0.0184949
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -0.0184769
IGF2 insulin-like growth factor 2 -0.0184307
ZNF680 zinc finger protein 680 -0.0184014
NUCB2 nucleobindin 2 -0.0182818
TUBA1B tubulin, alpha 1b -0.0181976
SOS2 son of sevenless homolog 2 (Drosophila) -0.0181324
TPT1 tumor protein, translationally-controlled 1 -0.0181172
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0178354
TMEM45A transmembrane protein 45A -0.0177696
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0174653
BPTF bromodomain PHD finger transcription factor -0.0172415
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0171262
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0171104
GPM6B glycoprotein M6B -0.0168238