Anethole trithione_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF608 zinc finger protein 608 0.140556
JMJD1C jumonji domain containing 1C 0.132375
VCL vinculin 0.111418
COL5A2 collagen, type V, alpha 2 0.0944596
VMP1 vacuole membrane protein 1 0.0902767
CELF2 CUGBP, Elav-like family member 2 0.0815307
DST dystonin 0.0799138
SLIT2 slit homolog 2 (Drosophila) 0.0770333
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0753788
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.072314
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0687188
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0630517
SMYD3 SET and MYND domain containing 3 0.0624893
MED13 mediator complex subunit 13 0.0613398
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0597846
USP9X ubiquitin specific peptidase 9, X-linked 0.0554747
ZFAND3 zinc finger, AN1-type domain 3 0.054497
TENM3 teneurin transmembrane protein 3 0.0525831
DENND5A DENN/MADD domain containing 5A 0.0524008
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0522724
PDE4D phosphodiesterase 4D, cAMP-specific 0.0522432
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0521675
CABIN1 calcineurin binding protein 1 0.05184
SOX5 SRY (sex determining region Y)-box 5 0.0505096
EXT1 exostosin glycosyltransferase 1 0.0500867
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0497753
RPS21 ribosomal protein S21 0.0493488
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0493395
APLP2 amyloid beta (A4) precursor-like protein 2 0.0488018
NALF1 NALCN channel auxiliary factor 1 0.0477371
TMSB10 thymosin beta 10 0.047236
ZSWIM6 zinc finger, SWIM-type containing 6 0.0467585
DSCAM Down syndrome cell adhesion molecule 0.0463567
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0462921
ANKRD17 ankyrin repeat domain 17 0.0460898
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0449996
SIK3 SIK family kinase 3 0.0448211
KMT2C lysine (K)-specific methyltransferase 2C 0.04448
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0442364
CTNND1 catenin (cadherin-associated protein), delta 1 0.0440728
NAP1L1 nucleosome assembly protein 1-like 1 0.0425279
BNC2 basonuclin 2 0.0416085
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0408455
TBL1X transducin (beta)-like 1X-linked 0.040407
SFPQ splicing factor proline/glutamine-rich 0.0399375
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0396069
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0395479
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0385054
AUTS2 autism susceptibility candidate 2 0.0384883
HDAC4 histone deacetylase 4 0.0383998
MLIP muscular LMNA-interacting protein 0.0380936
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.03802
MACF1 microtubule-actin crosslinking factor 1 0.0378995
DOCK3 dedicator of cytokinesis 3 0.0376526
ZNF644 zinc finger protein 644 0.0375258
PRRC2B proline-rich coiled-coil 2B 0.0364199
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0362975
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0361268
UBAP2 ubiquitin associated protein 2 0.0360608
FUS FUS RNA binding protein 0.0359672
EEF1G eukaryotic translation elongation factor 1 gamma 0.0354209
NFIB nuclear factor I/B 0.0348437
RPL3 ribosomal protein L3 0.0346549
CUX1 cut-like homeobox 1 0.034625
WLS wntless Wnt ligand secretion mediator 0.0345133
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0344458
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0335281
RPS12 ribosomal protein S12 0.0334569
USP34 ubiquitin specific peptidase 34 0.0330953
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0328938
BTBD9 BTB (POZ) domain containing 9 0.032687
SSH2 slingshot protein phosphatase 2 0.0326542
PDE7A phosphodiesterase 7A 0.0326488
ANKRD11 ankyrin repeat domain 11 0.0325642
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0324186
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0322113
WDR1 WD repeat domain 1 0.0321773
SMAD6 SMAD family member 6 0.0315602
RPS6 ribosomal protein S6 0.0315204
PCNX4 pecanex 4 0.0311691
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.031049
ARFGEF3 ARFGEF family member 3 0.0309923
KDM6A lysine (K)-specific demethylase 6A 0.0309578
INTS6 integrator complex subunit 6 0.0308259
SNX14 sorting nexin 14 0.0307734
RCC1 regulator of chromosome condensation 1 0.0306586
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0305266
SETX senataxin 0.0303852
LCOR ligand dependent nuclear receptor corepressor 0.0302396
HSPA8 heat shock 70kDa protein 8 0.0299391
PARD3B par-3 family cell polarity regulator beta 0.0296402
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0294206
PHF3 PHD finger protein 3 0.029231
EXOC6B exocyst complex component 6B 0.0291479
FAM193A family with sequence similarity 193, member A 0.0291099
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0290804
SRSF4 serine/arginine-rich splicing factor 4 0.0288542
RPL35 ribosomal protein L35 0.0285588
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0284269
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0283145

decreased expression

Symbol Name Standardized Value
NPAS3 neuronal PAS domain protein 3 -0.139356
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.134086
RAD51B RAD51 paralog B -0.130487
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0856194
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0630661
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0592138
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0578036
CADM2 cell adhesion molecule 2 -0.0502437
PTMA prothymosin, alpha -0.0455191
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0441926
KTN1 kinectin 1 (kinesin receptor) -0.0400579
KPNB1 karyopherin (importin) beta 1 -0.038309
ZNF292 zinc finger protein 292 -0.03534
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0352241
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0347786
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0330166
OSBPL10 oxysterol binding protein-like 10 -0.0325308
NOP58 NOP58 ribonucleoprotein -0.032128
GJA1 gap junction protein, alpha 1, 43kDa -0.0306763
RFX7 regulatory factor X, 7 -0.0294872
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0290008
HMGA1 high mobility group AT-hook 1 -0.0284872
LDHA lactate dehydrogenase A -0.0281458
ZFP64 ZFP64 zinc finger protein -0.0276934
NAMPT nicotinamide phosphoribosyltransferase -0.0273043
SLF1 SMC5-SMC6 complex localization factor 1 -0.0272141
RLF rearranged L-myc fusion -0.0268202
PDIA3 protein disulfide isomerase family A, member 3 -0.0255852
VDAC1 voltage-dependent anion channel 1 -0.0255173
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0254082
LARS1 leucyl-tRNA synthetase 1 -0.0253881
KDM1A lysine (K)-specific demethylase 1A -0.0251127
ADAM10 ADAM metallopeptidase domain 10 -0.0242829
AKAP10 A kinase (PRKA) anchor protein 10 -0.0242119
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0235981
SINHCAF SIN3-HDAC complex associated factor -0.0231031
KDM5B lysine (K)-specific demethylase 5B -0.0227622
FNBP1L formin binding protein 1-like -0.0224816
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0222189
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0219761
THOC2 THO complex 2 -0.0219439
ACACA acetyl-CoA carboxylase alpha -0.0219059
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0213484
RAP1B RAP1B, member of RAS oncogene family -0.0212282
PA2G4 proliferation-associated 2G4, 38kDa -0.021188
PGAP1 post-GPI attachment to proteins 1 -0.0206182
RPL35A ribosomal protein L35a -0.0205019
WDR45B WD repeat domain 45B -0.0199746
POM121C POM121 transmembrane nucleoporin C -0.0199734
SOX2 SRY (sex determining region Y)-box 2 -0.0197906
USP28 ubiquitin specific peptidase 28 -0.0196922
NUDT3 nudix (nucleoside diphosphate linked moiety X)-type motif 3 -0.019533
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0195079
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0194901
MXI1 MAX interactor 1, dimerization protein -0.0194481
PTCH1 patched 1 -0.0192966
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0192538
TMEM14B transmembrane protein 14B -0.0191203
INSIG2 insulin induced gene 2 -0.0191106
ZBTB20 zinc finger and BTB domain containing 20 -0.0184588
RBM25 RNA binding motif protein 25 -0.0184416
MTDH metadherin -0.0183646
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.01836
PARD6B par-6 family cell polarity regulator beta -0.0182984
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0182436
SNX3 sorting nexin 3 -0.0180905
TOM1L2 target of myb1-like 2 (chicken) -0.0180725
LPIN2 lipin 2 -0.0179332
QSER1 glutamine and serine rich 1 -0.0177945
AFG2A AFG2 AAA ATPase homolog A -0.0176813
CHD9 chromodomain helicase DNA binding protein 9 -0.0176356
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0175932
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0172194
PUS7 pseudouridylate synthase 7 (putative) -0.0170559
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) -0.0170137
PAWR PRKC, apoptosis, WT1, regulator -0.0169808
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0169598
SREBF2 sterol regulatory element binding transcription factor 2 -0.0168465
REEP3 receptor accessory protein 3 -0.0166981
TMEM123 transmembrane protein 123 -0.0166032
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0165497
PCDHB11 protocadherin beta 11 -0.0165214
PAQR7 progestin and adipoQ receptor family member VII -0.0165206
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0164315
SEC63 SEC63 homolog (S. cerevisiae) -0.0163401
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 -0.0163207
DARS1 aspartyl-tRNA synthetase 1 -0.0163084
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.016114
ADAM9 ADAM metallopeptidase domain 9 -0.0159643
WDR75 WD repeat domain 75 -0.0159542
USO1 USO1 vesicle transport factor -0.0159156
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0158868
SERBP1 SERPINE1 mRNA binding protein 1 -0.0158438
SERPINA2 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 2 (gene/pseudogene) -0.0157949
PRKX protein kinase, X-linked -0.0157781
OSTM1 osteopetrosis associated transmembrane protein 1 -0.0157779
EHBP1 EH domain binding protein 1 -0.0157694
GRID2 glutamate receptor, ionotropic, delta 2 -0.0156611
CFAP97 cilia and flagella associated protein 97 -0.0155932
EFNA5 ephrin-A5 -0.0155573