Anethole trithione_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.225025
MYH9 myosin, heavy chain 9, non-muscle 0.101801
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0887882
MT2A metallothionein 2A 0.0878512
ASPH aspartate beta-hydroxylase 0.0846811
ACTN1 actinin, alpha 1 0.0789144
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0788262
PABPC1 poly(A) binding protein, cytoplasmic 1 0.073676
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0699962
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0696621
APLP2 amyloid beta (A4) precursor-like protein 2 0.0672844
SPTBN1 spectrin, beta, non-erythrocytic 1 0.061482
SFTPA2 surfactant protein A2 0.0613153
SETBP1 SET binding protein 1 0.0564638
ZYX zyxin 0.0516618
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0513108
VCL vinculin 0.0512601
WWTR1 WW domain containing transcription regulator 1 0.0500211
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0497256
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0486411
MSN moesin 0.0486069
APP amyloid beta (A4) precursor protein 0.0464246
PLEC plectin 0.0463181
CLIC4 chloride intracellular channel 4 0.0458868
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0453675
AKAP12 A kinase (PRKA) anchor protein 12 0.0444796
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0437679
TLE4 transducin-like enhancer of split 4 0.0434799
ACTN4 actinin, alpha 4 0.042922
CTNND1 catenin (cadherin-associated protein), delta 1 0.0419079
SEPTIN9 septin 9 0.0413122
CEMIP2 cell migration inducing hyaluronidase 2 0.0409109
MACF1 microtubule-actin crosslinking factor 1 0.040438
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0402868
TPR translocated promoter region, nuclear basket protein 0.0394262
PRRC2C proline-rich coiled-coil 2C 0.0386689
LOC112694756 uncharaterized LOC112694756 0.0386164
BRD2 bromodomain containing 2 0.0377931
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.037334
ZSWIM6 zinc finger, SWIM-type containing 6 0.0372451
RPL3 ribosomal protein L3 0.0366107
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0362606
PDIA4 protein disulfide isomerase family A, member 4 0.036219
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0360255
CALU calumenin 0.0355799
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0355281
PDLIM5 PDZ and LIM domain 5 0.0347486
VEGFA vascular endothelial growth factor A 0.034213
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0341707
COPA coatomer protein complex, subunit alpha 0.034162
SRPK2 SRSF protein kinase 2 0.0341284
LMNA lamin A/C 0.0337309
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0334038
PI15 peptidase inhibitor 15 0.032973
FLNB filamin B, beta 0.0328533
IFRD1 interferon-related developmental regulator 1 0.0325744
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0323413
NUMA1 nuclear mitotic apparatus protein 1 0.0321384
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0312923
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0312513
ACTG1 actin gamma 1 0.0310707
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0310078
EGR1 early growth response 1 0.0307675
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0307413
SRRM2 serine/arginine repetitive matrix 2 0.0306779
WNK1 WNK lysine deficient protein kinase 1 0.029923
GLS2 glutaminase 2 (liver, mitochondrial) 0.0299112
TMF1 TATA element modulatory factor 1 0.0296597
RPS2 ribosomal protein S2 0.0296467
CUL3 cullin 3 0.0295852
NAP1L1 nucleosome assembly protein 1-like 1 0.0292072
CSNK1A1 casein kinase 1, alpha 1 0.0291388
DST dystonin 0.0287992
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0285897
CALD1 caldesmon 1 0.028314
AFDN afadin, adherens junction formation factor 0.0278252
MRTFA myocardin related transcription factor A 0.0277391
MYO1E myosin IE 0.0275591
IL6ST interleukin 6 signal transducer 0.0274963
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0274517
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0273549
VMP1 vacuole membrane protein 1 0.0272675
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0271681
MCL1 myeloid cell leukemia 1 0.0271623
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0270653
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 0.026986
NAV1 neuron navigator 1 0.026777
UBC ubiquitin C 0.0264319
SET SET nuclear proto-oncogene 0.0264105
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0262463
CYTH3 cytohesin 3 0.025962
WDR1 WD repeat domain 1 0.0258616
TMEM178B transmembrane protein 178B 0.0258505
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0257851
FERMT2 fermitin family member 2 0.0256543
EFCAB13 EF-hand calcium binding domain 13 0.0256237
SOX13 SRY (sex determining region Y)-box 13 0.0255648
WASL Wiskott-Aldrich syndrome-like 0.0253562
PAX3 paired box 3 0.0251093
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0250447

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.123373
NLGN1 neuroligin 1 -0.107172
CD109 CD109 molecule -0.0855797
IGFBP3 insulin-like growth factor binding protein 3 -0.082649
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.079494
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0793014
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0761977
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0672723
IGFBP5 insulin-like growth factor binding protein 5 -0.0658122
PDE10A phosphodiesterase 10A -0.0623787
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0607628
FN1 fibronectin 1 -0.0577561
NAV3 neuron navigator 3 -0.0573927
MACROD2 MACRO domain containing 2 -0.0570831
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0470928
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0465369
TMEM123 transmembrane protein 123 -0.0460483
DCT dopachrome tautomerase -0.0458866
RUNX1 runt-related transcription factor 1 -0.0447702
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0440896
NPAS2 neuronal PAS domain protein 2 -0.0421376
HMCN1 hemicentin 1 -0.0419803
SCFD2 sec1 family domain containing 2 -0.0367059
VDAC1 voltage-dependent anion channel 1 -0.0366694
CLMN calmin (calponin-like, transmembrane) -0.0366615
PGK1 phosphoglycerate kinase 1 -0.0362039
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0360507
OXR1 oxidation resistance 1 -0.0351202
MRPS6 mitochondrial ribosomal protein S6 -0.0342391
CDK14 cyclin-dependent kinase 14 -0.0336776
FRMD4A FERM domain containing 4A -0.0326121
CHSY1 chondroitin sulfate synthase 1 -0.0316101
NAV2 neuron navigator 2 -0.031071
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0310222
GDF15 growth differentiation factor 15 -0.0298586
PTPRD protein tyrosine phosphatase, receptor type, D -0.0295912
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0292439
EHBP1 EH domain binding protein 1 -0.0292164
SOX5 SRY (sex determining region Y)-box 5 -0.0291557
WDR45B WD repeat domain 45B -0.02875
RPL35A ribosomal protein L35a -0.0280793
FHIT fragile histidine triad -0.0278461
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0274134
SSH1 slingshot protein phosphatase 1 -0.0272962
GNAS GNAS complex locus -0.0270187
PLIN2 perilipin 2 -0.0269184
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0265256
NAMPT nicotinamide phosphoribosyltransferase -0.0264084
HILPDA hypoxia inducible lipid droplet-associated -0.0263987
CPEB2 cytoplasmic polyadenylation element binding protein 2 -0.0256182
ZNF292 zinc finger protein 292 -0.0253803
A2M alpha-2-macroglobulin -0.025031
NPR2 natriuretic peptide receptor 2 -0.0249459
OSMR oncostatin M receptor -0.0247734
RNF24 ring finger protein 24 -0.0247578
HSPG2 heparan sulfate proteoglycan 2 -0.0245332
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0243561
CTTNBP2 cortactin binding protein 2 -0.0243183
RFX7 regulatory factor X, 7 -0.0238998
LSAMP limbic system-associated membrane protein -0.0230805
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0228761
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.022183
GHR growth hormone receptor -0.0221767
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0215462
WSB1 WD repeat and SOCS box containing 1 -0.0212371
FYN FYN proto-oncogene, Src family tyrosine kinase -0.0212134
FTH1 ferritin, heavy polypeptide 1 -0.021183
IER3 immediate early response 3 -0.0208265
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0207584
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0207216
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0203948
PDIA3 protein disulfide isomerase family A, member 3 -0.0200372
FCRLA Fc receptor-like A -0.0196076
PYGB phosphorylase, glycogen; brain -0.0193789
USP3 ubiquitin specific peptidase 3 -0.0187132
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0185745
SYPL1 synaptophysin-like 1 -0.0182384
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) -0.0179174
MAML3 mastermind-like 3 (Drosophila) -0.0179158
TRIM2 tripartite motif containing 2 -0.0176867
S100A6 S100 calcium binding protein A6 -0.0176795
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0176548
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0176525
ZMYND8 zinc finger, MYND-type containing 8 -0.0176049
C1ORF21 chromosome 1 open reading frame 21 -0.0173667
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0173345
LNPK lunapark, ER junction formation factor -0.0171921
NBAS neuroblastoma amplified sequence -0.0169218
NPEPPS aminopeptidase puromycin sensitive -0.0168676
ANXA5 annexin A5 -0.0168033
MOXD1 monooxygenase, DBH-like 1 -0.0164012
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0163412
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0160731
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0160581
ZNF638 zinc finger protein 638 -0.0160013
PPP2R2B protein phosphatase 2, regulatory subunit B, beta -0.0158949
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0158301
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.0157912
ADAM19 ADAM metallopeptidase domain 19 -0.0157414
IL1RAP interleukin 1 receptor accessory protein -0.0156667