Anethole trithione_HT-29 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in HT-29 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_HT-29 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.208547
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.183108
SMAD3 SMAD family member 3 0.175949
KRT18 keratin 18, type I 0.160447
KRT8 keratin 8, type II 0.160154
FTL ferritin, light polypeptide 0.157794
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.14562
EXT1 exostosin glycosyltransferase 1 0.129364
MYH14 myosin, heavy chain 14, non-muscle 0.108537
MYH9 myosin, heavy chain 9, non-muscle 0.103976
TJP1 tight junction protein 1 0.102494
MYO1E myosin IE 0.088086
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0872493
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0862506
LOC112694756 uncharaterized LOC112694756 0.0830657
TPT1 tumor protein, translationally-controlled 1 0.0809196
PLEC plectin 0.0786137
ERRFI1 ERBB receptor feedback inhibitor 1 0.0779857
BCL2L1 BCL2-like 1 0.0762735
DST dystonin 0.0709807
AREG amphiregulin 0.0692277
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 0.0655377
MYO5B myosin VB 0.0648322
RPS3 ribosomal protein S3 0.0647929
NTN4 netrin 4 0.0634805
CTBP2 C-terminal binding protein 2 0.0629586
FAT1 FAT atypical cadherin 1 0.0616393
PLK2 polo-like kinase 2 0.0607167
ARHGAP32 Rho GTPase activating protein 32 0.0587748
KRT20 keratin 20, type I 0.0582993
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0578048
KLF5 Kruppel-like factor 5 (intestinal) 0.056906
PDZD8 PDZ domain containing 8 0.0564584
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0544732
ATXN1 ataxin 1 0.053632
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.05329
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0530223
AHNAK AHNAK nucleoprotein 0.053
SEPTIN9 septin 9 0.0515403
RPL3 ribosomal protein L3 0.0514863
ACTN4 actinin, alpha 4 0.0514818
AKAP13 A kinase (PRKA) anchor protein 13 0.0513985
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0511054
EPS8 epidermal growth factor receptor pathway substrate 8 0.0506668
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0494875
EZR ezrin 0.0491598
NCEH1 neutral cholesterol ester hydrolase 1 0.0485603
TM4SF1 transmembrane 4 L six family member 1 0.0478339
ITPRID2 ITPR interacting domain containing 2 0.0459031
FOXO1 forkhead box O1 0.0458597
NCOR2 nuclear receptor corepressor 2 0.045666
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0452114
ACTG1 actin gamma 1 0.044449
RPL4 ribosomal protein L4 0.0439135
ASPH aspartate beta-hydroxylase 0.0432859
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0428347
LIMA1 LIM domain and actin binding 1 0.0426722
ETV6 ets variant 6 0.0426109
EEF2 eukaryotic translation elongation factor 2 0.0422352
TRAPPC9 trafficking protein particle complex 9 0.0420851
PDE4D phosphodiesterase 4D, cAMP-specific 0.0415004
SLC45A4 solute carrier family 45, member 4 0.0414094
RPL19 ribosomal protein L19 0.0413683
DSPP dentin sialophosphoprotein 0.0413589
UBC ubiquitin C 0.0405746
RPS12 ribosomal protein S12 0.0405673
SRRM2 serine/arginine repetitive matrix 2 0.0401521
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0399593
CCNYL1 cyclin Y-like 1 0.0399022
KLF6 Kruppel-like factor 6 0.0394389
NUMA1 nuclear mitotic apparatus protein 1 0.0391896
ZSWIM6 zinc finger, SWIM-type containing 6 0.0389318
PTPRK protein tyrosine phosphatase, receptor type, K 0.0370684
RPS5 ribosomal protein S5 0.0364288
ARHGAP23 Rho GTPase activating protein 23 0.0359568
PTPRF protein tyrosine phosphatase, receptor type, F 0.0356867
MACF1 microtubule-actin crosslinking factor 1 0.0354648
VMP1 vacuole membrane protein 1 0.0350404
ARHGAP42 Rho GTPase activating protein 42 0.0349961
TMEM65 transmembrane protein 65 0.0340533
TXNRD1 thioredoxin reductase 1 0.0338157
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0336659
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0334506
MACC1 metastasis associated in colon cancer 1 0.0333127
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0330734
RPL7A ribosomal protein L7a 0.0329594
EIF1 eukaryotic translation initiation factor 1 0.0319016
FHL2 four and a half LIM domains 2 0.0318691
HSPA8 heat shock 70kDa protein 8 0.0316743
CD2AP CD2-associated protein 0.0315511
LDHA lactate dehydrogenase A 0.0315294
B2M beta-2-microglobulin 0.0314967
SGMS2 sphingomyelin synthase 2 0.03118
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.030995
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0309389
CTTN cortactin 0.0308138
MYEOV myeloma overexpressed 0.0308083
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0305671
RPLP0 ribosomal protein, large, P0 0.030544
MYO10 myosin X 0.0305318

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.0898261
FRY furry homolog (Drosophila) -0.0797742
FTH1 ferritin, heavy polypeptide 1 -0.0784391
ITPKC inositol-trisphosphate 3-kinase C -0.0587373
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0507738
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0404537
NAMPT nicotinamide phosphoribosyltransferase -0.0399572
GMDS GDP-mannose 4,6-dehydratase -0.0323504
JUP junction plakoglobin -0.0322504
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0322025
GARS1 glycyl-tRNA synthetase 1 -0.0313047
ZNF292 zinc finger protein 292 -0.0307801
RSF1 remodeling and spacing factor 1 -0.0304458
LOC102724023 ES1 protein homolog, mitochondrial -0.0300244
ACACA acetyl-CoA carboxylase alpha -0.0287655
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.028258
SAMD12 sterile alpha motif domain containing 12 -0.0279282
MAP3K8 mitogen-activated protein kinase kinase kinase 8 -0.0270624
DIAPH2 diaphanous-related formin 2 -0.0262971
RPL35A ribosomal protein L35a -0.0259841
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0258193
NECTIN2 nectin cell adhesion molecule 2 -0.0248846
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.024847
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0248003
FAM13A family with sequence similarity 13, member A -0.0241043
WASF2 WAS protein family, member 2 -0.0239555
ZMYM2 zinc finger, MYM-type 2 -0.0238546
CHD9 chromodomain helicase DNA binding protein 9 -0.0234453
GGNBP2 gametogenetin binding protein 2 -0.0233165
KLK10 kallikrein-related peptidase 10 -0.0231718
RTN3 reticulon 3 -0.0231235
CCNL1 cyclin L1 -0.0229463
SKIL SKI-like proto-oncogene -0.022542
VASP vasodilator-stimulated phosphoprotein -0.0216066
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0211636
TRA2A transformer 2 alpha homolog (Drosophila) -0.0209935
GOLGA4 golgin A4 -0.0206808
THOC2 THO complex 2 -0.0206737
RBM39 RNA binding motif protein 39 -0.0200762
BIRC6 baculoviral IAP repeat containing 6 -0.0199371
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0198773
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0190243
PDIA3 protein disulfide isomerase family A, member 3 -0.0188638
CALU calumenin -0.0187012
FBXO32 F-box protein 32 -0.0186754
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0186738
PTEN phosphatase and tensin homolog -0.0186564
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0185813
TM4SF4 transmembrane 4 L six family member 4 -0.0184634
ZMYND8 zinc finger, MYND-type containing 8 -0.0184328
PIAS1 protein inhibitor of activated STAT, 1 -0.0181372
ANXA2 annexin A2 -0.01813
KDM5B lysine (K)-specific demethylase 5B -0.0177364
RLF rearranged L-myc fusion -0.0175532
CDK19 cyclin-dependent kinase 19 -0.0173921
NPC1 Niemann-Pick disease, type C1 -0.0172881
ZNF148 zinc finger protein 148 -0.0171888
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0171701
SLC38A1 solute carrier family 38, member 1 -0.0171363
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0171314
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.017048
PDS5B PDS5 cohesin associated factor B -0.0169874
PRELID2 PRELI domain containing 2 -0.0167154
ZNF207 zinc finger protein 207 -0.0161883
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0160817
DYNC2I1 dynein 2 intermediate chain 1 -0.0160125
FBXO11 F-box protein 11 -0.0158926
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0158748
KDM3A lysine (K)-specific demethylase 3A -0.0158032
KLHL24 kelch-like family member 24 -0.0157099
CHKA choline kinase alpha -0.0156802
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0156123
ERBIN erbb2 interacting protein -0.015454
LSR lipolysis stimulated lipoprotein receptor -0.0154505
CEP95 centrosomal protein 95kDa -0.0153918
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0153786
PNISR PNN-interacting serine/arginine-rich protein -0.0153562
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0152433
SOX4 SRY (sex determining region Y)-box 4 -0.0152262
TSC22D2 TSC22 domain family, member 2 -0.0150904
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0149825
ZNF638 zinc finger protein 638 -0.0149333
WSB1 WD repeat and SOCS box containing 1 -0.0148342
LCORL ligand dependent nuclear receptor corepressor-like -0.0147468
ABHD12 abhydrolase domain containing 12 -0.0146739
TMEM165 transmembrane protein 165 -0.0145951
TRPS1 trichorhinophalangeal syndrome I -0.0144821
MICU1 mitochondrial calcium uptake 1 -0.0144603
CDK8 cyclin-dependent kinase 8 -0.0143508
HMGA1 high mobility group AT-hook 1 -0.014341
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0143022
ANKRD12 ankyrin repeat domain 12 -0.0140808
HMGB1 high mobility group box 1 -0.0140357
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0140198
GCC2 GRIP and coiled-coil domain containing 2 -0.013775
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0137178
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0135252
ARF4 ADP-ribosylation factor 4 -0.0133657
MXI1 MAX interactor 1, dimerization protein -0.0132849
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0132213