Anethole trithione_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.124251
MYH9 myosin, heavy chain 9, non-muscle 0.124161
CEMIP cell migration inducing protein, hyaluronan binding 0.103314
FLNB filamin B, beta 0.0861161
ASPH aspartate beta-hydroxylase 0.0783307
PRELID2 PRELI domain containing 2 0.0740989
SMAD3 SMAD family member 3 0.0709445
BCAR3 breast cancer anti-estrogen resistance 3 0.0709069
MBNL1 muscleblind-like splicing regulator 1 0.0683145
AHNAK AHNAK nucleoprotein 0.0678758
FNDC3B fibronectin type III domain containing 3B 0.0654331
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0634969
FOXO1 forkhead box O1 0.0628816
MYOF myoferlin 0.0563713
H1-0 H1.0 linker histone 0.0530442
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0512845
SEPTIN9 septin 9 0.0504694
MSN moesin 0.0502065
DOCK5 dedicator of cytokinesis 5 0.0492154
APLP2 amyloid beta (A4) precursor-like protein 2 0.0490166
MACF1 microtubule-actin crosslinking factor 1 0.0482479
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0465285
DST dystonin 0.0463129
INTS6 integrator complex subunit 6 0.0449979
BCL2L1 BCL2-like 1 0.043824
VCL vinculin 0.0433465
SLC45A4 solute carrier family 45, member 4 0.0427287
KRT17 keratin 17, type I 0.0421336
CUL4B cullin 4B 0.0413676
SH3PXD2A SH3 and PX domains 2A 0.0410041
ANKRD33B ankyrin repeat domain 33B 0.040964
CLU clusterin 0.0382362
CTNND1 catenin (cadherin-associated protein), delta 1 0.0379714
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0375887
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0375636
CPNE1 copine I 0.0370411
NCOR2 nuclear receptor corepressor 2 0.036939
PICALM phosphatidylinositol binding clathrin assembly protein 0.036732
AOPEP aminopeptidase O (putative) 0.0362716
CTBP2 C-terminal binding protein 2 0.0361995
TRIO trio Rho guanine nucleotide exchange factor 0.0357065
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0353351
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0346815
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0343648
KLF5 Kruppel-like factor 5 (intestinal) 0.0339944
NEK7 NIMA-related kinase 7 0.0336702
LMO7 LIM domain 7 0.0329649
RPL3 ribosomal protein L3 0.0325688
FOXP1 forkhead box P1 0.03129
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0307345
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.030541
MED13L mediator complex subunit 13-like 0.030229
FLNA filamin A, alpha 0.0287937
DSCAM Down syndrome cell adhesion molecule 0.0281893
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0279199
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.027526
AFAP1L2 actin filament associated protein 1-like 2 0.027502
ITGA6 integrin, alpha 6 0.0271629
ARHGAP29 Rho GTPase activating protein 29 0.0271068
ASXL1 additional sex combs like transcriptional regulator 1 0.0266183
CAMK2D calcium/calmodulin-dependent protein kinase II delta 0.026557
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0264836
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0261076
NCOA3 nuclear receptor coactivator 3 0.0260368
RPS21 ribosomal protein S21 0.0253542
ANLN anillin, actin binding protein 0.0252163
JAG1 jagged 1 0.0252132
OGA O-GlcNAcase 0.025152
LNPEP leucyl/cystinyl aminopeptidase 0.0249339
EXT1 exostosin glycosyltransferase 1 0.0248875
NDE1 nudE neurodevelopment protein 1 0.024519
OSBPL3 oxysterol binding protein-like 3 0.0241499
SOX13 SRY (sex determining region Y)-box 13 0.0240486
ZNF217 zinc finger protein 217 0.0240466
MT1X metallothionein 1X 0.0240266
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0237626
APP amyloid beta (A4) precursor protein 0.0237429
BARX2 BARX homeobox 2 0.0236611
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.0235792
SFTPA2 surfactant protein A2 0.0235787
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0235219
TXNIP thioredoxin interacting protein 0.023415
COG6 component of oligomeric golgi complex 6 0.0232836
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0232375
NUMA1 nuclear mitotic apparatus protein 1 0.0231053
CAPRIN2 caprin family member 2 0.0230916
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0230422
DIDO1 death inducer-obliterator 1 0.022866
ARGLU1 arginine and glutamate rich 1 0.0228201
UBE2H ubiquitin-conjugating enzyme E2H 0.0225728
ACTN1 actinin, alpha 1 0.0220847
PLAT plasminogen activator, tissue 0.0218205
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0218049
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0216514
CLIC4 chloride intracellular channel 4 0.021648
KDM6A lysine (K)-specific demethylase 6A 0.0215975
CD44 CD44 molecule (Indian blood group) 0.021594
LIFR leukemia inhibitory factor receptor alpha 0.0213131
RALGAPB Ral GTPase activating protein, beta subunit (non-catalytic) 0.0212851
ELL2 elongation factor, RNA polymerase II, 2 0.0210869

decreased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 -0.441701
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.167127
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.119216
ABI3BP ABI family, member 3 (NESH) binding protein -0.0799994
SULF1 sulfatase 1 -0.0799576
ALCAM activated leukocyte cell adhesion molecule -0.0697492
POTEF POTE ankyrin domain family, member F -0.0683683
FTH1 ferritin, heavy polypeptide 1 -0.067491
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0650103
HSPG2 heparan sulfate proteoglycan 2 -0.0641785
RAI14 retinoic acid induced 14 -0.0623156
SLC35F3 solute carrier family 35, member F3 -0.0596305
EMP1 epithelial membrane protein 1 -0.0557022
IGF2 insulin-like growth factor 2 -0.0490235
LDHA lactate dehydrogenase A -0.0471289
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0439502
RPS8 ribosomal protein S8 -0.0405635
ANO1 anoctamin 1, calcium activated chloride channel -0.0403929
HMGA1 high mobility group AT-hook 1 -0.0403009
NDRG1 N-myc downstream regulated 1 -0.0391858
SQLE squalene epoxidase -0.0388156
CALB1 calbindin 1, 28kDa -0.0384474
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0358635
S100A11 S100 calcium binding protein A11 -0.0358624
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0344114
PGK1 phosphoglycerate kinase 1 -0.0340092
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0339325
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0338558
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.033121
RPL35A ribosomal protein L35a -0.0331088
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0326707
ZMYND8 zinc finger, MYND-type containing 8 -0.0321128
PPARG peroxisome proliferator-activated receptor gamma -0.0320327
HLA-B major histocompatibility complex, class I, B -0.0316471
HM13 histocompatibility (minor) 13 -0.0315228
CSTB cystatin B (stefin B) -0.0314768
ZEB1 zinc finger E-box binding homeobox 1 -0.0306162
LAMC2 laminin, gamma 2 -0.0301688
F3 coagulation factor III (thromboplastin, tissue factor) -0.0300508
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0300364
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 -0.0298204
THBD thrombomodulin -0.0292135
RPS6 ribosomal protein S6 -0.0286638
PSD3 pleckstrin and Sec7 domain containing 3 -0.0280155
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0278888
OXR1 oxidation resistance 1 -0.027732
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0277254
ANXA1 annexin A1 -0.0277089
RABGAP1L RAB GTPase activating protein 1-like -0.0276662
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0275866
C4BPB complement component 4 binding protein, beta -0.0271122
ENO1 enolase 1, (alpha) -0.0264946
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0264737
NAV2 neuron navigator 2 -0.0264265
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 -0.0261526
NUCB2 nucleobindin 2 -0.0259988
VDAC1 voltage-dependent anion channel 1 -0.0256712
IARS1 isoleucyl-tRNA synthetase 1 -0.0255916
ABLIM3 actin binding LIM protein family, member 3 -0.0255745
RPL34 ribosomal protein L34 -0.0253715
DPYD dihydropyrimidine dehydrogenase -0.0253163
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0252858
HLA-E major histocompatibility complex, class I, E -0.0252679
MTSS1 metastasis suppressor 1 -0.0251945
ATF4 activating transcription factor 4 -0.0247735
CD9 CD9 molecule -0.0247696
GOLGA4 golgin A4 -0.0247203
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0244993
WDFY2 WD repeat and FYVE domain containing 2 -0.0243322
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0241946
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0241528
FTL ferritin, light polypeptide -0.0240035
B2M beta-2-microglobulin -0.0239689
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0239032
CDCP1 CUB domain containing protein 1 -0.0238882
FOSL1 FOS-like antigen 1 -0.0235756
PCDH1 protocadherin 1 -0.0235635
CSNK1E casein kinase 1, epsilon -0.0235454
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0233787
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0231394
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0230267
IFITM3 interferon induced transmembrane protein 3 -0.0229845
RPL39 ribosomal protein L39 -0.0226254
TPM4 tropomyosin 4 -0.0226105
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0222182
GARS1 glycyl-tRNA synthetase 1 -0.0222143
COL17A1 collagen, type XVII, alpha 1 -0.0216583
TMSB4X thymosin beta 4, X-linked -0.0216519
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0216374
ENO2 enolase 2 (gamma, neuronal) -0.021489
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0214346
SPIRE1 spire-type actin nucleation factor 1 -0.0210997
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0210396
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0209232
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0208435
RPL37A ribosomal protein L37a -0.0208428
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0208274
SYN3 synapsin III -0.020807
RPS25 ribosomal protein S25 -0.0204462
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.020417