Anethole trithione_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.250673
SPTBN1 spectrin, beta, non-erythrocytic 1 0.141561
GMDS GDP-mannose 4,6-dehydratase 0.114028
MYH9 myosin, heavy chain 9, non-muscle 0.108366
HYOU1 hypoxia up-regulated 1 0.0910154
EZR ezrin 0.0891423
EMP1 epithelial membrane protein 1 0.0887972
BCL2L1 BCL2-like 1 0.0758572
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0751115
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0745329
TJP1 tight junction protein 1 0.068287
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0678307
UBE2H ubiquitin-conjugating enzyme E2H 0.0655655
APLP2 amyloid beta (A4) precursor-like protein 2 0.0649286
ANXA1 annexin A1 0.0640757
PLEC plectin 0.0640718
KRT18 keratin 18, type I 0.0629176
MYOF myoferlin 0.0627761
KRT8 keratin 8, type II 0.0618151
DSPP dentin sialophosphoprotein 0.0615503
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0611073
ACTN4 actinin, alpha 4 0.060335
AKAP13 A kinase (PRKA) anchor protein 13 0.0590265
TMSB10 thymosin beta 10 0.0589324
ATXN1 ataxin 1 0.0585292
SNX9 sorting nexin 9 0.0580644
PTPRK protein tyrosine phosphatase, receptor type, K 0.0580413
MYO1E myosin IE 0.0567949
VMP1 vacuole membrane protein 1 0.0566851
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0563441
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0552114
SEPTIN9 septin 9 0.0549487
H1-0 H1.0 linker histone 0.0527119
RAB7A RAB7A, member RAS oncogene family 0.0526032
SIK3 SIK family kinase 3 0.0522488
SMAD3 SMAD family member 3 0.0512543
KLHL29 kelch-like family member 29 0.0486552
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0485448
FNDC3B fibronectin type III domain containing 3B 0.0483164
GCLC glutamate-cysteine ligase, catalytic subunit 0.047111
TMC5 transmembrane channel-like 5 0.0466386
EPS8 epidermal growth factor receptor pathway substrate 8 0.0465476
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0450985
ZSWIM6 zinc finger, SWIM-type containing 6 0.0446848
MPRIP myosin phosphatase Rho interacting protein 0.0443909
MYO5B myosin VB 0.0428566
MBNL2 muscleblind-like splicing regulator 2 0.0425286
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0424874
ASPH aspartate beta-hydroxylase 0.0424549
EFNA5 ephrin-A5 0.0423024
KLF6 Kruppel-like factor 6 0.0420179
PDIA4 protein disulfide isomerase family A, member 4 0.0407087
BAIAP2L1 BAI1-associated protein 2-like 1 0.0407035
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0406897
CLTC clathrin, heavy chain (Hc) 0.0405836
LAMA4 laminin, alpha 4 0.0402986
MACC1 metastasis associated in colon cancer 1 0.0390357
ATP11A ATPase, class VI, type 11A 0.0379969
SGMS2 sphingomyelin synthase 2 0.0379086
CYSTM1 cysteine-rich transmembrane module containing 1 0.0378689
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0378486
MORF4L2 mortality factor 4 like 2 0.0372856
PMM2 phosphomannomutase 2 0.0370394
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0368821
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 0.0364616
LOC102724023 ES1 protein homolog, mitochondrial 0.0357808
SH3RF1 SH3 domain containing ring finger 1 0.0354678
TMSB4X thymosin beta 4, X-linked 0.0353592
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0350296
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0341865
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0341425
UGCG UDP-glucose ceramide glucosyltransferase 0.0339679
CTBP2 C-terminal binding protein 2 0.0337886
NCEH1 neutral cholesterol ester hydrolase 1 0.0337308
TXNRD1 thioredoxin reductase 1 0.033683
ITGA6 integrin, alpha 6 0.0336794
SQSTM1 sequestosome 1 0.033634
FOXO3 forkhead box O3 0.0329066
CSNK1A1 casein kinase 1, alpha 1 0.0326889
COBL cordon-bleu WH2 repeat protein 0.0325417
CLDN4 claudin 4 0.0322959
LIPH lipase, member H 0.0321795
CTNND1 catenin (cadherin-associated protein), delta 1 0.0321427
SPATA13 spermatogenesis associated 13 0.0315933
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0311903
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 0.0310987
HDLBP high density lipoprotein binding protein 0.0308601
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.030587
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0297268
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 0.0295873
CEMIP cell migration inducing protein, hyaluronan binding 0.0295399
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 0.0292105
SLC38A2 solute carrier family 38, member 2 0.029189
MAL2 mal, T-cell differentiation protein 2 (gene/pseudogene) 0.0290964
CUX1 cut-like homeobox 1 0.0286987
GDA guanine deaminase 0.0284984
FNIP1 folliculin interacting protein 1 0.0284729
MCU mitochondrial calcium uniporter 0.0284457
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.028323
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0282465

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.237259
RPL35A ribosomal protein L35a -0.104903
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0886694
TPT1 tumor protein, translationally-controlled 1 -0.0794785
PTMA prothymosin, alpha -0.0780546
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0734902
FGFR2 fibroblast growth factor receptor 2 -0.0534736
PGK1 phosphoglycerate kinase 1 -0.053408
RPS25 ribosomal protein S25 -0.0523025
SAMD12 sterile alpha motif domain containing 12 -0.0490908
RPLP1 ribosomal protein, large, P1 -0.0486577
WDR45B WD repeat domain 45B -0.048056
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0475947
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0456995
ZMYND8 zinc finger, MYND-type containing 8 -0.04417
KDM3A lysine (K)-specific demethylase 3A -0.0438677
MAML2 mastermind-like 2 (Drosophila) -0.0415833
ACSS2 acyl-CoA synthetase short-chain family member 2 -0.0415751
FDFT1 farnesyl-diphosphate farnesyltransferase 1 -0.0396791
HLA-E major histocompatibility complex, class I, E -0.0396531
RPS3 ribosomal protein S3 -0.0393842
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.03915
ACACA acetyl-CoA carboxylase alpha -0.0388435
FLNB filamin B, beta -0.0378733
RPS8 ribosomal protein S8 -0.0374513
RPL38 ribosomal protein L38 -0.0371845
EHBP1 EH domain binding protein 1 -0.0357038
KPNB1 karyopherin (importin) beta 1 -0.034063
WSB1 WD repeat and SOCS box containing 1 -0.0322854
EPCAM epithelial cell adhesion molecule -0.0321
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0303859
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0301821
RPS29 ribosomal protein S29 -0.0297948
HLA-B major histocompatibility complex, class I, B -0.0290713
AGR2 anterior gradient 2 -0.0287173
FDPS farnesyl diphosphate synthase -0.028715
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0286337
DLG1 discs, large homolog 1 (Drosophila) -0.0284985
S100A10 S100 calcium binding protein A10 -0.028061
RPL13A ribosomal protein L13a -0.028061
RAD51B RAD51 paralog B -0.0279923
ANLN anillin, actin binding protein -0.027943
RPL34 ribosomal protein L34 -0.0278057
RPL31 ribosomal protein L31 -0.0277439
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0275546
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0270744
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0270154
RPL37A ribosomal protein L37a -0.0268435
RNF43 ring finger protein 43 -0.0263342
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0255923
S100P S100 calcium binding protein P -0.0255557
VDAC1 voltage-dependent anion channel 1 -0.0252868
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0251238
GNAS GNAS complex locus -0.0250157
RPS27A ribosomal protein S27a -0.0249889
RPS24 ribosomal protein S24 -0.0247491
HLA-C major histocompatibility complex, class I, C -0.0245512
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0245188
CD46 CD46 molecule, complement regulatory protein -0.0244648
TPM4 tropomyosin 4 -0.0240062
TMEM135 transmembrane protein 135 -0.0239484
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0236264
TMBIM1 transmembrane BAX inhibitor motif containing 1 -0.0235642
IFITM3 interferon induced transmembrane protein 3 -0.0234649
HLA-A major histocompatibility complex, class I, A -0.0231637
RPL23 ribosomal protein L23 -0.0228749
FAM13A family with sequence similarity 13, member A -0.0225659
PKM pyruvate kinase, muscle -0.0221799
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0221168
INSIG1 insulin induced gene 1 -0.0220647
RSF1 remodeling and spacing factor 1 -0.021948
RPL9 ribosomal protein L9 -0.021705
FASN fatty acid synthase -0.0215704
ACTG1 actin gamma 1 -0.0212491
RPS19 ribosomal protein S19 -0.0211673
SSH2 slingshot protein phosphatase 2 -0.0209203
PPARG peroxisome proliferator-activated receptor gamma -0.0208919
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0208726
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0208609
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.020604
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0204535
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 -0.0204084
RPS16 ribosomal protein S16 -0.0201542
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.019646
WARS1 tryptophanyl-tRNA synthetase 1 -0.0195872
KRT7 keratin 7, type II -0.0195083
HMGB1 high mobility group box 1 -0.0194806
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0188379
PHF14 PHD finger protein 14 -0.0187205
DDIT4 DNA-damage-inducible transcript 4 -0.0185988
ACSL1 acyl-CoA synthetase long-chain family member 1 -0.0183996
DYNLT3 dynein, light chain, Tctex-type 3 -0.0183426
BTG1 B-cell translocation gene 1, anti-proliferative -0.0181978
USP3 ubiquitin specific peptidase 3 -0.0180119
IER3 immediate early response 3 -0.0178454
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.017753
S100A11 S100 calcium binding protein A11 -0.0176668
TMEM123 transmembrane protein 123 -0.0176503
ARHGAP6 Rho GTPase activating protein 6 -0.0175235
SKAP1 src kinase associated phosphoprotein 1 -0.0174969