Anethole trithione_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Anethole trithione_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.135877
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.100971
BCAR3 breast cancer anti-estrogen resistance 3 0.0987433
CAPRIN2 caprin family member 2 0.0862501
TXNRD1 thioredoxin reductase 1 0.0704165
NPAS2 neuronal PAS domain protein 2 0.0653253
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0649667
MT1X metallothionein 1X 0.062894
WWTR1 WW domain containing transcription regulator 1 0.0602861
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0584408
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.056134
RUNX1 runt-related transcription factor 1 0.0559665
DST dystonin 0.0558308
SPAG9 sperm associated antigen 9 0.0548921
TMSB4X thymosin beta 4, X-linked 0.0548422
ZBTB38 zinc finger and BTB domain containing 38 0.0531377
HOMER1 homer scaffolding protein 1 0.0515094
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0513833
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0498183
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0490858
VCL vinculin 0.0481501
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0475464
MACF1 microtubule-actin crosslinking factor 1 0.045491
TTC3 tetratricopeptide repeat domain 3 0.0454745
SON SON DNA binding protein 0.0448249
FMNL2 formin-like 2 0.044752
HDLBP high density lipoprotein binding protein 0.0442581
APLP2 amyloid beta (A4) precursor-like protein 2 0.0436374
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0424406
CMIP c-Maf inducing protein 0.0405649
LOC112694756 uncharaterized LOC112694756 0.0395766
JMJD1C jumonji domain containing 1C 0.0393667
SMAD3 SMAD family member 3 0.0391372
INTS6 integrator complex subunit 6 0.0386576
MT1E metallothionein 1E 0.0385312
ZC3H11A zinc finger CCCH-type containing 11A 0.038262
SYAP1 synapse associated protein 1 0.0378726
HLA-B major histocompatibility complex, class I, B 0.0378336
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0376118
NEK10 NIMA-related kinase 10 0.0372274
HYOU1 hypoxia up-regulated 1 0.0366277
PDIA4 protein disulfide isomerase family A, member 4 0.0362108
ERRFI1 ERBB receptor feedback inhibitor 1 0.035872
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0351584
COPA coatomer protein complex, subunit alpha 0.0345692
HSPA8 heat shock 70kDa protein 8 0.0344621
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.034254
FUS FUS RNA binding protein 0.0342238
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0338784
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0335819
MB21D2 Mab-21 domain containing 2 0.0331795
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0329107
TM4SF1 transmembrane 4 L six family member 1 0.0328982
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0328025
GOLGA3 golgin A3 0.0327098
RRBP1 ribosome binding protein 1 0.0324063
PLEC plectin 0.0321128
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0320857
ZSWIM6 zinc finger, SWIM-type containing 6 0.032051
SKI SKI proto-oncogene 0.0317824
RAB7A RAB7A, member RAS oncogene family 0.0313915
JUN jun proto-oncogene 0.0313641
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0310076
TOP1 topoisomerase (DNA) I 0.0309594
SQSTM1 sequestosome 1 0.030867
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0308622
SND1 staphylococcal nuclease and tudor domain containing 1 0.0307548
LOXL2 lysyl oxidase-like 2 0.0306282
CALU calumenin 0.0294622
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.02902
MYH9 myosin, heavy chain 9, non-muscle 0.0284611
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0282099
CFLAR CASP8 and FADD-like apoptosis regulator 0.0281861
GOLGB1 golgin B1 0.0280443
HPCAL1 hippocalcin-like 1 0.0277238
TPT1 tumor protein, translationally-controlled 1 0.0277057
ARHGAP5 Rho GTPase activating protein 5 0.0276361
ZNF644 zinc finger protein 644 0.0274185
RPL3 ribosomal protein L3 0.0273419
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0271967
PUM1 pumilio RNA-binding family member 1 0.0270825
CAMTA1 calmodulin binding transcription activator 1 0.0269467
CALR calreticulin 0.0268388
SETX senataxin 0.0267808
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0266724
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0264868
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa 0.0260147
BIRC2 baculoviral IAP repeat containing 2 0.025604
KLF6 Kruppel-like factor 6 0.0255734
MOK MOK protein kinase 0.0255717
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0254147
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0253579
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0253169
SMYD3 SET and MYND domain containing 3 0.0252659
ERCC1 excision repair cross-complementation group 1 0.025098
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0250144
AHNAK AHNAK nucleoprotein 0.0249277
EEF2 eukaryotic translation elongation factor 2 0.024638
PGM3 phosphoglucomutase 3 0.0246182
RPL35 ribosomal protein L35 0.0245545

decreased expression

Symbol Name Standardized Value
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.136058
CADM2 cell adhesion molecule 2 -0.0929629
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0911565
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0866573
VIM vimentin -0.0834932
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0806979
TP63 tumor protein p63 -0.0688509
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0658209
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0603928
FTH1 ferritin, heavy polypeptide 1 -0.060167
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0601081
RIGI RNA sensor RIG-I -0.0593365
PTMA prothymosin, alpha -0.05387
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0515455
ZMYND8 zinc finger, MYND-type containing 8 -0.0514927
WSB1 WD repeat and SOCS box containing 1 -0.0501855
RPL35A ribosomal protein L35a -0.0499659
ZNF292 zinc finger protein 292 -0.0497452
TTC28 tetratricopeptide repeat domain 28 -0.044863
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0403872
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0399408
EHBP1 EH domain binding protein 1 -0.0398395
EFNA5 ephrin-A5 -0.0374972
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0371281
HMGA1 high mobility group AT-hook 1 -0.0363106
RPS8 ribosomal protein S8 -0.036029
EPHA4 EPH receptor A4 -0.0358656
CALD1 caldesmon 1 -0.0355084
CFAP299 cilia and flagella associated protein 299 -0.0342717
POTEF POTE ankyrin domain family, member F -0.0335421
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.032945
PIAS2 protein inhibitor of activated STAT, 2 -0.0325712
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0320961
RPL31 ribosomal protein L31 -0.0319763
LPP LIM domain containing preferred translocation partner in lipoma -0.031958
DOCK11 dedicator of cytokinesis 11 -0.0316022
RBM25 RNA binding motif protein 25 -0.031475
ESYT2 extended synaptotagmin-like protein 2 -0.0310676
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0303746
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0301792
APP amyloid beta (A4) precursor protein -0.0298448
RAB27B RAB27B, member RAS oncogene family -0.0297115
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0285103
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0284672
TPRG1 tumor protein p63 regulated 1 -0.0284452
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0281774
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0281697
TNS3 tensin 3 -0.0274382
VDAC1 voltage-dependent anion channel 1 -0.0271038
MBNL2 muscleblind-like splicing regulator 2 -0.0270256
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0269865
RPL37A ribosomal protein L37a -0.0268834
CDK19 cyclin-dependent kinase 19 -0.0267281
NAV2 neuron navigator 2 -0.0264081
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0260172
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0258637
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0256527
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0255023
WASF2 WAS protein family, member 2 -0.0250193
ITGB4 integrin, beta 4 -0.0249232
SLK STE20-like kinase -0.0246052
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.024603
RSF1 remodeling and spacing factor 1 -0.0245489
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0241787
PGK1 phosphoglycerate kinase 1 -0.0240974
TPM4 tropomyosin 4 -0.0240697
NEMF nuclear export mediator factor -0.024053
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0238454
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0235198
ZNF217 zinc finger protein 217 -0.0234499
PTK2 protein tyrosine kinase 2 -0.023356
FTL ferritin, light polypeptide -0.0232324
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.023037
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0229592
ARHGAP12 Rho GTPase activating protein 12 -0.0226643
CCDC91 coiled-coil domain containing 91 -0.0226426
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.022269
DPH6 diphthamine biosynthesis 6 -0.0221255
CENPF centromere protein F, 350/400kDa -0.0220538
NDRG1 N-myc downstream regulated 1 -0.0219847
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0219789
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0219361
RPS29 ribosomal protein S29 -0.0219317
NPEPPS aminopeptidase puromycin sensitive -0.0216065
RPLP1 ribosomal protein, large, P1 -0.021465
RPL39 ribosomal protein L39 -0.0214486
KPNB1 karyopherin (importin) beta 1 -0.021388
PDE10A phosphodiesterase 10A -0.0213734
AKAP10 A kinase (PRKA) anchor protein 10 -0.0210117
PGAP1 post-GPI attachment to proteins 1 -0.0207399
RTTN rotatin -0.0206768
ATF7IP activating transcription factor 7 interacting protein -0.0206194
AGO3 argonaute RISC catalytic component 3 -0.0205258
ALDH7A1 aldehyde dehydrogenase 7 family, member A1 -0.0203593
SETD5 SET domain containing 5 -0.0200597
SRSF11 serine/arginine-rich splicing factor 11 -0.0200486
RPS6 ribosomal protein S6 -0.0199779
CFAP96 cilia and flagella associated protein 96 -0.0199452
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0197853
THSD4 thrombospondin, type I, domain containing 4 -0.0197448