Anethole trithione_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.291043
MYH9 myosin, heavy chain 9, non-muscle 0.120846
SMOC1 SPARC related modular calcium binding 1 0.104012
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0988534
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.08584
MCL1 myeloid cell leukemia 1 0.0831516
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0826633
BASP1 brain abundant, membrane attached signal protein 1 0.0823594
RPL3 ribosomal protein L3 0.0813291
FAM107B family with sequence similarity 107, member B 0.0762432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0722006
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0702808
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0670561
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0666962
TM4SF1 transmembrane 4 L six family member 1 0.0640876
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0636633
EIF1 eukaryotic translation initiation factor 1 0.059422
FNDC3B fibronectin type III domain containing 3B 0.0589128
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0576267
APP amyloid beta (A4) precursor protein 0.0564499
TPM3 tropomyosin 3 0.0551892
SOD2 superoxide dismutase 2, mitochondrial 0.0549713
STC1 stanniocalcin 1 0.0534087
HYOU1 hypoxia up-regulated 1 0.0533148
APLP2 amyloid beta (A4) precursor-like protein 2 0.0518062
SFTPA2 surfactant protein A2 0.0512931
FMNL2 formin-like 2 0.0508576
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0505952
RAB1A RAB1A, member RAS oncogene family 0.0488336
KYNU kynureninase 0.0485241
HDAC9 histone deacetylase 9 0.0483485
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0481825
RPL19 ribosomal protein L19 0.0473911
RPLP0 ribosomal protein, large, P0 0.0470276
HSPA8 heat shock 70kDa protein 8 0.0469066
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0457138
RPS4Y1 ribosomal protein S4, Y-linked 1 0.0448907
MT1X metallothionein 1X 0.0447818
CALR calreticulin 0.0440698
CCL5 chemokine (C-C motif) ligand 5 0.0427725
PLEC plectin 0.0424565
ANGPTL4 angiopoietin-like 4 0.0422661
LAMC2 laminin, gamma 2 0.0415373
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.037748
BRD2 bromodomain containing 2 0.0376947
RPL4 ribosomal protein L4 0.0374553
EIF4A1 eukaryotic translation initiation factor 4A1 0.0368019
C15ORF48 chromosome 15 open reading frame 48 0.0362166
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0354384
NRG1 neuregulin 1 0.0352798
ZSWIM6 zinc finger, SWIM-type containing 6 0.0346463
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0344965
EGR1 early growth response 1 0.0343829
TNIP1 TNFAIP3 interacting protein 1 0.034248
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0338577
RAB7A RAB7A, member RAS oncogene family 0.0336851
MSN moesin 0.0335771
SMAD2 SMAD family member 2 0.0332366
NAP1L1 nucleosome assembly protein 1-like 1 0.0330999
H1-2 H1.2 linker histone, cluster member 0.032998
PUM1 pumilio RNA-binding family member 1 0.0327417
EEF2 eukaryotic translation elongation factor 2 0.0324102
ANKRD11 ankyrin repeat domain 11 0.0322731
HLA-B major histocompatibility complex, class I, B 0.0318733
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0314005
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0312849
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0301727
MACF1 microtubule-actin crosslinking factor 1 0.0301671
RPL26 ribosomal protein L26 0.0298399
DOCK4 dedicator of cytokinesis 4 0.0297239
AKAP12 A kinase (PRKA) anchor protein 12 0.0290215
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0287724
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0287499
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0286673
COPA coatomer protein complex, subunit alpha 0.0286077
PRELID3B PRELI domain containing 3B 0.0284521
JUN jun proto-oncogene 0.0284362
TPI1 triosephosphate isomerase 1 0.0281952
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0280351
ARHGAP26 Rho GTPase activating protein 26 0.0279926
TXNRD1 thioredoxin reductase 1 0.0277931
ZNF644 zinc finger protein 644 0.0277817
SYAP1 synapse associated protein 1 0.0276015
PARD3 par-3 family cell polarity regulator 0.0275202
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0274106
SQSTM1 sequestosome 1 0.027391
CLU clusterin 0.0273293
BMP6 bone morphogenetic protein 6 0.0272814
MRTFA myocardin related transcription factor A 0.0267636
RPL11 ribosomal protein L11 0.0267069
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0266533
H1-0 H1.0 linker histone 0.0264553
RPS12 ribosomal protein S12 0.0261674
TRA2A transformer 2 alpha homolog (Drosophila) 0.0260658
H1-4 H1.4 linker histone, cluster member 0.0260271
MAML3 mastermind-like 3 (Drosophila) 0.0258009
KAT6B K(lysine) acetyltransferase 6B 0.025781
AHNAK AHNAK nucleoprotein 0.0257193
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0256835
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.0255098

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.142436
VIM vimentin -0.125424
IGF2 insulin-like growth factor 2 -0.108643
CMIP c-Maf inducing protein -0.0709793
SLC38A1 solute carrier family 38, member 1 -0.0636249
RPS29 ribosomal protein S29 -0.0630038
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0623781
SAMD4A sterile alpha motif domain containing 4A -0.0620111
TFPI2 tissue factor pathway inhibitor 2 -0.0617483
TPM4 tropomyosin 4 -0.0583338
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0553063
FTH1 ferritin, heavy polypeptide 1 -0.0548739
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0532506
RPL35A ribosomal protein L35a -0.051385
NEBL nebulette -0.0465981
RPS19 ribosomal protein S19 -0.0449335
ERBIN erbb2 interacting protein -0.0449244
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0439864
RBM25 RNA binding motif protein 25 -0.0439841
EGFR epidermal growth factor receptor -0.0417004
GRAMD1B GRAM domain containing 1B -0.0409995
RPLP1 ribosomal protein, large, P1 -0.0407496
BIRC3 baculoviral IAP repeat containing 3 -0.0406529
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0399912
MT2A metallothionein 2A -0.0397835
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0394095
NHSL1 NHS-like 1 -0.0383102
POTEF POTE ankyrin domain family, member F -0.0380896
PTMA prothymosin, alpha -0.0374762
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0373174
PKM pyruvate kinase, muscle -0.0360064
KPNB1 karyopherin (importin) beta 1 -0.035364
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0350889
S100A11 S100 calcium binding protein A11 -0.0347982
CENPF centromere protein F, 350/400kDa -0.034621
MKI67 marker of proliferation Ki-67 -0.0337264
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0331952
SMC4 structural maintenance of chromosomes 4 -0.0328982
IER3 immediate early response 3 -0.032778
HMGB1 high mobility group box 1 -0.032549
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0320134
UPP1 uridine phosphorylase 1 -0.031692
RAD51B RAD51 paralog B -0.0311687
PNISR PNN-interacting serine/arginine-rich protein -0.0308984
VDAC1 voltage-dependent anion channel 1 -0.0308409
ZNF638 zinc finger protein 638 -0.0300229
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0294915
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 -0.0292414
KLF6 Kruppel-like factor 6 -0.0290095
USP34 ubiquitin specific peptidase 34 -0.0287898
CFLAR CASP8 and FADD-like apoptosis regulator -0.0286799
PCNX1 pecanex 1 -0.0286748
NAV3 neuron navigator 3 -0.0285766
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.027609
CENPE centromere protein E, 312kDa -0.0275795
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.02742
CBX3 chromobox homolog 3 -0.0271064
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0268469
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0268054
PRKCE protein kinase C, epsilon -0.026472
RPL36 ribosomal protein L36 -0.0261742
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0261069
WWOX WW domain containing oxidoreductase -0.0261012
SNX14 sorting nexin 14 -0.0260641
IFITM3 interferon induced transmembrane protein 3 -0.0259488
CBX5 chromobox homolog 5 -0.0257196
TAS2R14 taste receptor, type 2, member 14 -0.0255819
NEMF nuclear export mediator factor -0.0252568
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) -0.0251745
AKAP10 A kinase (PRKA) anchor protein 10 -0.0250111
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0250006
BHLHE40 basic helix-loop-helix family, member e40 -0.0248592
TMSB10 thymosin beta 10 -0.0246051
ITSN1 intersectin 1 (SH3 domain protein) -0.0244733
DST dystonin -0.024373
HMGA1 high mobility group AT-hook 1 -0.0242817
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.0241817
KTN1 kinectin 1 (kinesin receptor) -0.0241001
RASAL2 RAS protein activator like 2 -0.0236852
RGS20 regulator of G-protein signaling 20 -0.0236397
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0236007
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0235906
KDM5B lysine (K)-specific demethylase 5B -0.0233759
SRSF11 serine/arginine-rich splicing factor 11 -0.0232539
RAN RAN, member RAS oncogene family -0.0231988
DLG1 discs, large homolog 1 (Drosophila) -0.0231908
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0230494
EIF5B eukaryotic translation initiation factor 5B -0.022826
RPL31 ribosomal protein L31 -0.0228108
CDCP1 CUB domain containing protein 1 -0.0227993
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0227583
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0226634
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0219057
CHD9 chromodomain helicase DNA binding protein 9 -0.0217934
NEGR1 neuronal growth regulator 1 -0.0217924
PDE8A phosphodiesterase 8A -0.0214748
BRWD1 bromodomain and WD repeat domain containing 1 -0.0214702
RPL38 ribosomal protein L38 -0.0214206
RIN2 Ras and Rab interactor 2 -0.0213837
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0212233