Anethole trithione_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.154786
BACE2 beta-site APP-cleaving enzyme 2 0.133624
MYO1E myosin IE 0.12448
PDE4D phosphodiesterase 4D, cAMP-specific 0.103655
LIMCH1 LIM and calponin homology domains 1 0.0942898
SVIL supervillin 0.0843429
ABHD17C abhydrolase domain containing 17C 0.0780385
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0771436
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0749661
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0739249
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0732409
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0699686
SAMD4A sterile alpha motif domain containing 4A 0.0694978
IGF1R insulin-like growth factor 1 receptor 0.0673521
GRB10 growth factor receptor-bound protein 10 0.0650023
ESYT2 extended synaptotagmin-like protein 2 0.0638604
ELL2 elongation factor, RNA polymerase II, 2 0.0630271
ARHGAP21 Rho GTPase activating protein 21 0.059577
DSPP dentin sialophosphoprotein 0.0555674
ZSWIM6 zinc finger, SWIM-type containing 6 0.0538227
MXD1 MAX dimerization protein 1 0.052893
DSCAM Down syndrome cell adhesion molecule 0.0525085
ATOSA atos homolog A 0.0514283
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0512781
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0512215
SMOC1 SPARC related modular calcium binding 1 0.0499078
MUC16 mucin 16, cell surface associated 0.0488656
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0475177
HSPA8 heat shock 70kDa protein 8 0.0457365
AKAP13 A kinase (PRKA) anchor protein 13 0.0456962
MTUS1 microtubule associated tumor suppressor 1 0.0455743
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0452647
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0452342
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0441829
PTPRM protein tyrosine phosphatase, receptor type, M 0.0419823
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0416248
ITPRID2 ITPR interacting domain containing 2 0.04127
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0409564
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 0.0408866
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0389611
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0381961
MCTP2 multiple C2 domains, transmembrane 2 0.0377911
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0376299
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.037561
FOXO1 forkhead box O1 0.0374957
NCKAP1 NCK-associated protein 1 0.0363515
PPARD peroxisome proliferator-activated receptor delta 0.0353402
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0350787
TOP1 topoisomerase (DNA) I 0.0335543
EPS8 epidermal growth factor receptor pathway substrate 8 0.0323645
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0323604
NPTN neuroplastin 0.0316526
MYO6 myosin VI 0.0316108
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0313262
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0311221
MYO5B myosin VB 0.0310966
SMAD3 SMAD family member 3 0.031075
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0308802
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0308619
EFNA1 ephrin-A1 0.0304035
DUSP16 dual specificity phosphatase 16 0.0303414
NCOR2 nuclear receptor corepressor 2 0.0298998
ARHGAP5 Rho GTPase activating protein 5 0.0294847
PKM pyruvate kinase, muscle 0.0293865
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0289745
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0285654
PSD3 pleckstrin and Sec7 domain containing 3 0.0283477
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.027904
SUN1 Sad1 and UNC84 domain containing 1 0.0277551
ARHGAP26 Rho GTPase activating protein 26 0.0276402
SESTD1 SEC14 and spectrin domains 1 0.027488
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0274448
SPNS2 spinster homolog 2 (Drosophila) 0.0272243
BRD9 bromodomain containing 9 0.0271482
EFNA5 ephrin-A5 0.0270942
RSAD2 radical S-adenosyl methionine domain containing 2 0.0269913
DAAM1 dishevelled associated activator of morphogenesis 1 0.0269386
NUMB numb homolog (Drosophila) 0.0266956
PUM2 pumilio RNA-binding family member 2 0.0265401
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0263013
F3 coagulation factor III (thromboplastin, tissue factor) 0.0259916
ABHD3 abhydrolase domain containing 3 0.0256716
PRKG1 protein kinase, cGMP-dependent, type I 0.0253426
THRB thyroid hormone receptor, beta 0.0248592
PPP2R2C protein phosphatase 2, regulatory subunit B, gamma 0.0248343
ZBTB43 zinc finger and BTB domain containing 43 0.0247929
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0245018
H1-0 H1.0 linker histone 0.024486
EZR ezrin 0.0241368
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 0.0241326
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0240796
RAB27B RAB27B, member RAS oncogene family 0.0239129
ERRFI1 ERBB receptor feedback inhibitor 1 0.0238982
ANXA1 annexin A1 0.0237468
BCL2L11 BCL2-like 11 (apoptosis facilitator) 0.0236566
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0235755
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.023332
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0232407
LARP4B La ribonucleoprotein domain family, member 4B 0.0231511
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0231466

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.109017
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0939568
TXNRD1 thioredoxin reductase 1 -0.090528
STC1 stanniocalcin 1 -0.0656912
FN1 fibronectin 1 -0.0644863
FTL ferritin, light polypeptide -0.0578186
LSAMP limbic system-associated membrane protein -0.0568059
ENO1 enolase 1, (alpha) -0.0540036
GPC6 glypican 6 -0.0531555
ZBTB20 zinc finger and BTB domain containing 20 -0.051507
TRIO trio Rho guanine nucleotide exchange factor -0.0466643
ASPH aspartate beta-hydroxylase -0.0463504
SPAG9 sperm associated antigen 9 -0.0459344
NDRG1 N-myc downstream regulated 1 -0.0453348
RTN4 reticulon 4 -0.0436527
FTH1 ferritin, heavy polypeptide 1 -0.0424977
PTMA prothymosin, alpha -0.0421561
AK1 adenylate kinase 1 -0.0401494
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0387473
INHBA inhibin, beta A -0.0384827
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0379548
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.037307
TNPO1 transportin 1 -0.0371579
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0371149
TMSB10 thymosin beta 10 -0.0367913
STRN3 striatin, calmodulin binding protein 3 -0.0366034
B2M beta-2-microglobulin -0.0363272
KRT17 keratin 17, type I -0.0356785
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0355985
AKAP12 A kinase (PRKA) anchor protein 12 -0.035404
ZXDC ZXD family zinc finger C -0.0347526
EGR1 early growth response 1 -0.0347291
POTEF POTE ankyrin domain family, member F -0.0346081
NBAS neuroblastoma amplified sequence -0.0345029
ZEB1 zinc finger E-box binding homeobox 1 -0.0344375
RPL12 ribosomal protein L12 -0.0342435
CHD9 chromodomain helicase DNA binding protein 9 -0.0330775
USP3 ubiquitin specific peptidase 3 -0.0327089
RIGI RNA sensor RIG-I -0.0325204
GLS2 glutaminase 2 (liver, mitochondrial) -0.0323289
ACTG1 actin gamma 1 -0.0322129
KLHL24 kelch-like family member 24 -0.0316054
ADNP activity-dependent neuroprotector homeobox -0.0314817
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0311872
NLGN1 neuroligin 1 -0.0311495
NALF1 NALCN channel auxiliary factor 1 -0.0308908
MORF4L2 mortality factor 4 like 2 -0.0304897
LDHA lactate dehydrogenase A -0.0303889
PGK1 phosphoglycerate kinase 1 -0.0303103
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0300995
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0299595
LDHB lactate dehydrogenase B -0.0298866
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0297759
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0296318
COL6A3 collagen, type VI, alpha 3 -0.0296172
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0293532
LOXL2 lysyl oxidase-like 2 -0.0293366
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.029297
SRP54 signal recognition particle 54kDa -0.0285242
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0285036
RAI14 retinoic acid induced 14 -0.0284481
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0282444
PTK2 protein tyrosine kinase 2 -0.0280913
DCAF7 DDB1 and CUL4 associated factor 7 -0.028064
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0278297
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0278072
FMNL2 formin-like 2 -0.0277348
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0276307
CHD1 chromodomain helicase DNA binding protein 1 -0.0276047
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.0273377
SBF2 SET binding factor 2 -0.0272738
SSH2 slingshot protein phosphatase 2 -0.0272258
FRMD4A FERM domain containing 4A -0.0271577
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0267766
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB -0.026686
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0263635
GATAD2B GATA zinc finger domain containing 2B -0.0262896
VPS26A vacuolar protein sorting 26 homolog A (S. pombe) -0.0262593
TTC17 tetratricopeptide repeat domain 17 -0.0260835
RPL31 ribosomal protein L31 -0.0259755
ARL15 ADP-ribosylation factor-like 15 -0.0258457
ZMYM2 zinc finger, MYM-type 2 -0.0257707
CD44 CD44 molecule (Indian blood group) -0.0256729
JUN jun proto-oncogene -0.0256678
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.0252802
TRIP12 thyroid hormone receptor interactor 12 -0.025269
RAD51B RAD51 paralog B -0.0251019
KPNB1 karyopherin (importin) beta 1 -0.0248593
CYRIB CYFIP related Rac1 interactor B -0.0245805
WDFY2 WD repeat and FYVE domain containing 2 -0.0241968
RPL35A ribosomal protein L35a -0.0238676
S100A10 S100 calcium binding protein A10 -0.0238485
PIAS1 protein inhibitor of activated STAT, 1 -0.0238087
MSN moesin -0.0236888
LTN1 listerin E3 ubiquitin protein ligase 1 -0.023227
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0232134
NAMPT nicotinamide phosphoribosyltransferase -0.0231956
EXT1 exostosin glycosyltransferase 1 -0.0231705
HLA-B major histocompatibility complex, class I, B -0.0230446
AKAP9 A kinase (PRKA) anchor protein 9 -0.0227796