Anethole trithione_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

98 genes differentially expressed following the Anethole trithione_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.200782
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.171592
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.164896
NIPBL Nipped-B homolog (Drosophila) 0.13975
ASPH aspartate beta-hydroxylase 0.13485
PRKCA protein kinase C, alpha 0.112805
FTL ferritin, light polypeptide 0.105044
PICALM phosphatidylinositol binding clathrin assembly protein 0.103821
DOCK4 dedicator of cytokinesis 4 0.0980872
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0969881
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0939105
ELL2 elongation factor, RNA polymerase II, 2 0.0917136
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0867415
COL5A1 collagen, type V, alpha 1 0.0822795
HMGA2 high mobility group AT-hook 2 0.068023
SMYD3 SET and MYND domain containing 3 0.0626081
GSK3B glycogen synthase kinase 3 beta 0.0614702
OGA O-GlcNAcase 0.0591183
FRMD5 FERM domain containing 5 0.0576084
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 0.0555555
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0545976
RPL37A ribosomal protein L37a 0.054182
EFNA5 ephrin-A5 0.0531075
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0524798
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0519092
UBE3C ubiquitin protein ligase E3C 0.050915
FNBP4 formin binding protein 4 0.050078
SAMD4A sterile alpha motif domain containing 4A 0.0495268
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0492106
ANKRD28 ankyrin repeat domain 28 0.0466531
LPP LIM domain containing preferred translocation partner in lipoma 0.0458106
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0446391
PDLIM5 PDZ and LIM domain 5 0.0441814
WDFY2 WD repeat and FYVE domain containing 2 0.0388059
MT2A metallothionein 2A 0.0355087
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0334695
KDM6A lysine (K)-specific demethylase 6A 0.0333362
TOP1 topoisomerase (DNA) I 0.0307936
INSIG2 insulin induced gene 2 0.0266468
P4HB prolyl 4-hydroxylase, beta polypeptide 0.02588
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0254798
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0242291
ESYT2 extended synaptotagmin-like protein 2 0.022452
MAML3 mastermind-like 3 (Drosophila) 0.0200464
FAT1 FAT atypical cadherin 1 0.0197294
RAD51B RAD51 paralog B 0.0195771
PDE4D phosphodiesterase 4D, cAMP-specific 0.0182914
CD44 CD44 molecule (Indian blood group) 0.0120461
NEBL nebulette 0.0116366
MYOF myoferlin 0.0115379
PHF21A PHD finger protein 21A 0.0111316
FNDC3B fibronectin type III domain containing 3B 0.0102139
PTMA prothymosin, alpha 0.00819584
PRRC2C proline-rich coiled-coil 2C 0.00553453
WSB1 WD repeat and SOCS box containing 1 0.00520887
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.00487567
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.00439465
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.00435187
FN1 fibronectin 1 6.16227E-4
NKD1 naked cuticle homolog 1 (Drosophila) 6.00202E-4

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.246499
VIM vimentin -0.238973
VMP1 vacuole membrane protein 1 -0.185537
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.17046
DST dystonin -0.140064
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.136479
IGFBP3 insulin-like growth factor binding protein 3 -0.102427
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0926673
TENM3 teneurin transmembrane protein 3 -0.0811594
TPT1 tumor protein, translationally-controlled 1 -0.0784203
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0773812
PDE10A phosphodiesterase 10A -0.0686514
PSD3 pleckstrin and Sec7 domain containing 3 -0.0545495
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0541019
CANX calnexin -0.0530259
STC1 stanniocalcin 1 -0.0495978
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0484003
GNAS GNAS complex locus -0.0481622
AKAP12 A kinase (PRKA) anchor protein 12 -0.0430272
CDH13 cadherin 13 -0.0427978
RBM39 RNA binding motif protein 39 -0.0403902
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0393218
NAMPT nicotinamide phosphoribosyltransferase -0.0367078
INHBA inhibin, beta A -0.0354387
COL6A3 collagen, type VI, alpha 3 -0.0348713
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0324117
EXT1 exostosin glycosyltransferase 1 -0.0293162
IFRD1 interferon-related developmental regulator 1 -0.0255232
TMSB10 thymosin beta 10 -0.0251824
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.021232
FMNL2 formin-like 2 -0.0200383
NALF1 NALCN channel auxiliary factor 1 -0.0182121
DSCAM Down syndrome cell adhesion molecule -0.0132187
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0120246
KDM3A lysine (K)-specific demethylase 3A -0.0111138
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.00817059
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.00520479
TRIO trio Rho guanine nucleotide exchange factor -6.75857E-4