Anethole trithione_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PABPC1 poly(A) binding protein, cytoplasmic 1 0.20252
FRMD6 FERM domain containing 6 0.118523
MYH9 myosin, heavy chain 9, non-muscle 0.0756796
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0753063
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0752733
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0712728
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.066981
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0664281
MT2A metallothionein 2A 0.0640692
RPL7A ribosomal protein L7a 0.0640538
SAMD4A sterile alpha motif domain containing 4A 0.0633494
TPT1 tumor protein, translationally-controlled 1 0.0617355
RPL3 ribosomal protein L3 0.0607658
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0605593
MCTP1 multiple C2 domains, transmembrane 1 0.0579243
EIF4A1 eukaryotic translation initiation factor 4A1 0.0555112
SRRM2 serine/arginine repetitive matrix 2 0.0549722
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0525569
EEF2 eukaryotic translation elongation factor 2 0.0515322
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0513194
NDRG1 N-myc downstream regulated 1 0.0497745
RPS8 ribosomal protein S8 0.0483111
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0481832
RPS3 ribosomal protein S3 0.0473852
PTMA prothymosin, alpha 0.0462148
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0461062
RPS12 ribosomal protein S12 0.0456077
NAP1L1 nucleosome assembly protein 1-like 1 0.0438596
RPL8 ribosomal protein L8 0.0438562
APLP2 amyloid beta (A4) precursor-like protein 2 0.0435441
INTS6 integrator complex subunit 6 0.0428571
SGMS2 sphingomyelin synthase 2 0.0421613
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0420908
CALR calreticulin 0.0419749
TMSB10 thymosin beta 10 0.0418484
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0418043
SET SET nuclear proto-oncogene 0.0414966
RRBP1 ribosome binding protein 1 0.0409779
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0409634
DSCAM Down syndrome cell adhesion molecule 0.0404431
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0403458
HMGA2 high mobility group AT-hook 2 0.0398474
CORO1C coronin, actin binding protein, 1C 0.0394795
RPL11 ribosomal protein L11 0.0379588
RPS4X ribosomal protein S4, X-linked 0.037377
FTL ferritin, light polypeptide 0.0373457
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0363005
RPS19 ribosomal protein S19 0.0360903
H1-4 H1.4 linker histone, cluster member 0.0356528
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0347493
PFN1 profilin 1 0.034386
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0342017
NABP1 nucleic acid binding protein 1 0.0341989
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0337387
WNT2B wingless-type MMTV integration site family, member 2B 0.0337287
RPS21 ribosomal protein S21 0.0336683
PDIA6 protein disulfide isomerase family A, member 6 0.033647
TRIP12 thyroid hormone receptor interactor 12 0.0335601
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0335581
AGO2 argonaute RISC catalytic component 2 0.0335095
EXT1 exostosin glycosyltransferase 1 0.033083
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.033057
PUM1 pumilio RNA-binding family member 1 0.0327292
TM4SF19 transmembrane 4 L six family member 19 0.0324688
LRMDA leucine rich melanocyte differentiation associated 0.032101
FKBP15 FK506 binding protein 15, 133kDa 0.0319235
TPM3 tropomyosin 3 0.0318976
PTPRG protein tyrosine phosphatase, receptor type, G 0.0318066
HSPA8 heat shock 70kDa protein 8 0.0315288
RPS6 ribosomal protein S6 0.0311081
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0306961
CPNE1 copine I 0.0301498
ANKRD11 ankyrin repeat domain 11 0.0298803
RCOR1 REST corepressor 1 0.0297904
PRELID2 PRELI domain containing 2 0.0290759
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0289746
HYOU1 hypoxia up-regulated 1 0.028884
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.028751
FLNA filamin A, alpha 0.0283466
ASPH aspartate beta-hydroxylase 0.0282627
IFRD1 interferon-related developmental regulator 1 0.028093
RAB7A RAB7A, member RAS oncogene family 0.0280707
FUS FUS RNA binding protein 0.0279011
RAP1B RAP1B, member of RAS oncogene family 0.0276496
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0271822
SND1 staphylococcal nuclease and tudor domain containing 1 0.0268553
CTTN cortactin 0.026719
MCL1 myeloid cell leukemia 1 0.0266873
FNDC3B fibronectin type III domain containing 3B 0.0266546
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0266114
RPLP0 ribosomal protein, large, P0 0.026458
NUDC nudC nuclear distribution protein 0.0262593
RPL19 ribosomal protein L19 0.0260169
ZFP36L1 ZFP36 ring finger protein-like 1 0.0258382
ANK2 ankyrin 2, neuronal 0.0258288
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0257345
FLNB filamin B, beta 0.0255488
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.025466
STC1 stanniocalcin 1 0.0253241
SFPQ splicing factor proline/glutamine-rich 0.0252973

decreased expression

Symbol Name Standardized Value
DLC1 DLC1 Rho GTPase activating protein -0.273141
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.124752
NAV3 neuron navigator 3 -0.094428
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0775983
TXNRD1 thioredoxin reductase 1 -0.0733828
TTR transthyretin -0.0618846
RBM25 RNA binding motif protein 25 -0.0559338
ZNF438 zinc finger protein 438 -0.0524815
ANTXR2 anthrax toxin receptor 2 -0.0512944
HMGA1 high mobility group AT-hook 1 -0.0502399
LAMB3 laminin, beta 3 -0.0418838
PTK2 protein tyrosine kinase 2 -0.0402295
C2CD2 C2 calcium-dependent domain containing 2 -0.0352421
PCNX4 pecanex 4 -0.0348404
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0346647
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.0342578
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0340136
CDK6 cyclin-dependent kinase 6 -0.033807
CALD1 caldesmon 1 -0.0337759
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0336823
POTEF POTE ankyrin domain family, member F -0.0331896
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0318828
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0318521
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.031823
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0307534
BIRC3 baculoviral IAP repeat containing 3 -0.0296266
SPRED1 sprouty-related, EVH1 domain containing 1 -0.0288453
FHL2 four and a half LIM domains 2 -0.0284976
TAS2R14 taste receptor, type 2, member 14 -0.0283951
RPL13A ribosomal protein L13a -0.0283906
NSMAF neutral sphingomyelinase (N-SMase) activation associated factor -0.0279523
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0276366
RASA2 RAS p21 protein activator 2 -0.0262853
CREB5 cAMP responsive element binding protein 5 -0.0259677
CD44 CD44 molecule (Indian blood group) -0.0257283
ELL2 elongation factor, RNA polymerase II, 2 -0.0256419
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.025542
TPM4 tropomyosin 4 -0.0251916
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0245726
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0245433
GPHN gephyrin -0.0245374
RAB3IP RAB3A interacting protein -0.0242977
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0242787
TM9SF3 transmembrane 9 superfamily member 3 -0.0242498
METAP1 methionyl aminopeptidase 1 -0.0240981
KIF5B kinesin family member 5B -0.0239514
NRIP1 nuclear receptor interacting protein 1 -0.0239304
TRPS1 trichorhinophalangeal syndrome I -0.0239094
BHLHE40 basic helix-loop-helix family, member e40 -0.0238047
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.023699
SBF2 SET binding factor 2 -0.0235473
DIAPH3 diaphanous-related formin 3 -0.0230505
TCERG1 transcription elongation regulator 1 -0.0230163
CCDC50 coiled-coil domain containing 50 -0.0228306
PTBP2 polypyrimidine tract binding protein 2 -0.0224937
UBXN4 UBX domain protein 4 -0.0224609
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0224528
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0222755
MTDH metadherin -0.0216082
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0215292
NF1 neurofibromin 1 -0.0213183
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0211595
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0211371
BNC2 basonuclin 2 -0.0209733
BRWD1 bromodomain and WD repeat domain containing 1 -0.0209303
RIC1 RAB6A GEF complex partner 1 -0.0207146
POU2F1 POU class 2 homeobox 1 -0.020644
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0204815
SOS1 son of sevenless homolog 1 (Drosophila) -0.0202761
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0202604
SLC38A1 solute carrier family 38, member 1 -0.0200573
MTAP methylthioadenosine phosphorylase -0.0200506
EFR3A EFR3 homolog A (S. cerevisiae) -0.0199128
SPRY4 sprouty homolog 4 (Drosophila) -0.0196375
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 -0.0196053
TMEM156 transmembrane protein 156 -0.0195439
SMC5 structural maintenance of chromosomes 5 -0.0194375
PALS1 protein associated with LIN7 1, MAGUK p55 family member -0.0194185
ANKRD28 ankyrin repeat domain 28 -0.0192835
RB1CC1 RB1-inducible coiled-coil 1 -0.0192578
CASP4 caspase 4, apoptosis-related cysteine peptidase -0.019179
CSNK1G3 casein kinase 1, gamma 3 -0.0191757
CAPN2 calpain 2, (m/II) large subunit -0.0191013
ELOVL6 ELOVL fatty acid elongase 6 -0.0190862
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0189966
TCF12 transcription factor 12 -0.0188779
ALCAM activated leukocyte cell adhesion molecule -0.0188645
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0187559
ERBIN erbb2 interacting protein -0.0186469
GNAS GNAS complex locus -0.0185824
EIF5B eukaryotic translation initiation factor 5B -0.0185811
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0184246
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 -0.0184055
SLC38A2 solute carrier family 38, member 2 -0.0184032
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0180175
URI1 URI1, prefoldin-like chaperone -0.0179583
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0179041
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0179041
PRMT3 protein arginine methyltransferase 3 -0.0178841
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0178782