Anethole trithione_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FMN1 formin 1 0.137386
DST dystonin 0.100028
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0914876
SEPTIN9 septin 9 0.0812314
ASPH aspartate beta-hydroxylase 0.0808414
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0754029
MYH9 myosin, heavy chain 9, non-muscle 0.0699903
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.06713
HDAC4 histone deacetylase 4 0.0593861
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0586242
ATXN1 ataxin 1 0.0585218
ANGPTL4 angiopoietin-like 4 0.0584548
PLEC plectin 0.0580134
FLNA filamin A, alpha 0.0563481
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0545055
SFTPA2 surfactant protein A2 0.0531758
ZMIZ1 zinc finger, MIZ-type containing 1 0.0499901
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0498618
RUNX1 runt-related transcription factor 1 0.0497112
RASAL2 RAS protein activator like 2 0.0491592
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0459743
SP100 SP100 nuclear antigen 0.0453455
KDM4C lysine (K)-specific demethylase 4C 0.0451512
PDE4D phosphodiesterase 4D, cAMP-specific 0.0449208
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0447743
TRIO trio Rho guanine nucleotide exchange factor 0.0436678
HDAC9 histone deacetylase 9 0.0433591
LRMDA leucine rich melanocyte differentiation associated 0.0430151
IFI44L interferon-induced protein 44-like 0.0417918
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0413865
MELTF melanotransferrin 0.0412835
IFI6 interferon, alpha-inducible protein 6 0.0412541
SLC39A11 solute carrier family 39, member 11 0.0410762
MACF1 microtubule-actin crosslinking factor 1 0.0401057
ACTN4 actinin, alpha 4 0.0397072
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0391017
FLNB filamin B, beta 0.0390766
AKAP13 A kinase (PRKA) anchor protein 13 0.0385105
MSN moesin 0.0381911
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0374547
LINGO2 leucine rich repeat and Ig domain containing 2 0.0373462
CDH13 cadherin 13 0.0366602
RPL3 ribosomal protein L3 0.0366556
CTTN cortactin 0.0366361
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0366278
ANKRD11 ankyrin repeat domain 11 0.0362062
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0357193
NAV1 neuron navigator 1 0.0356447
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0355401
COMMD10 COMM domain containing 10 0.035405
SRRM2 serine/arginine repetitive matrix 2 0.0352783
ACTN1 actinin, alpha 1 0.0352687
SMAD3 SMAD family member 3 0.0351677
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0347023
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0343206
TAS2R14 taste receptor, type 2, member 14 0.0342029
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0341812
NLGN1 neuroligin 1 0.0341104
FUS FUS RNA binding protein 0.0340678
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0340303
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 0.033787
STK10 serine/threonine kinase 10 0.0337148
CUX1 cut-like homeobox 1 0.0334297
NAV2 neuron navigator 2 0.0333755
KLC1 kinesin light chain 1 0.0333673
HMG20B high mobility group 20B 0.033289
CTBP2 C-terminal binding protein 2 0.0332766
EFCAB13 EF-hand calcium binding domain 13 0.0329682
PTPRG protein tyrosine phosphatase, receptor type, G 0.0329672
EXOC4 exocyst complex component 4 0.0327381
SON SON DNA binding protein 0.032568
PRELID2 PRELI domain containing 2 0.0323601
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 0.0322518
PTPRM protein tyrosine phosphatase, receptor type, M 0.0316214
CFAP20DC CFAP20 domain containing 0.0315163
DOCK5 dedicator of cytokinesis 5 0.0314364
CYTH3 cytohesin 3 0.0307807
LMNA lamin A/C 0.0307419
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0306084
LINC02798 long intergenic non-protein coding RNA 2798 0.0305593
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0303516
PLAT plasminogen activator, tissue 0.0303195
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0299237
TBC1D22A TBC1 domain family, member 22A 0.02972
IGF1R insulin-like growth factor 1 receptor 0.0296654
CLIC4 chloride intracellular channel 4 0.0291332
MAML3 mastermind-like 3 (Drosophila) 0.029056
MCL1 myeloid cell leukemia 1 0.0288874
GPHN gephyrin 0.0286416
PTK2 protein tyrosine kinase 2 0.0286183
NCOR2 nuclear receptor corepressor 2 0.0285549
SFPQ splicing factor proline/glutamine-rich 0.0284766
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.02816
RNF213 ring finger protein 213 0.0281274
AHNAK AHNAK nucleoprotein 0.0276687
EHBP1 EH domain binding protein 1 0.0274922
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0274173
AUTS2 autism susceptibility candidate 2 0.0273471
ZFAND3 zinc finger, AN1-type domain 3 0.0272988
FOXP1 forkhead box P1 0.0272741

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.228629
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143568
VIM vimentin -0.142276
LSAMP limbic system-associated membrane protein -0.109107
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0954888
GOLGA4 golgin A4 -0.0736514
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0704829
VDAC1 voltage-dependent anion channel 1 -0.0657312
FTL ferritin, light polypeptide -0.0644092
PGK1 phosphoglycerate kinase 1 -0.0629933
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0586683
EIF1 eukaryotic translation initiation factor 1 -0.0568947
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0556279
SREBF2 sterol regulatory element binding transcription factor 2 -0.0533725
CANX calnexin -0.051637
MT2A metallothionein 2A -0.0472391
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0460933
WSB1 WD repeat and SOCS box containing 1 -0.0429153
SEPTIN7 septin 7 -0.0424896
WDR45B WD repeat domain 45B -0.0423539
PDIA3 protein disulfide isomerase family A, member 3 -0.0420287
SPAG9 sperm associated antigen 9 -0.0417093
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0416594
RPL35A ribosomal protein L35a -0.0416341
KMT2E lysine (K)-specific methyltransferase 2E -0.0414673
ENO1 enolase 1, (alpha) -0.0394498
LDHA lactate dehydrogenase A -0.0383205
IL1RAP interleukin 1 receptor accessory protein -0.0379929
NAMPT nicotinamide phosphoribosyltransferase -0.037931
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0376123
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0371957
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0354995
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0350134
AKAP10 A kinase (PRKA) anchor protein 10 -0.0343431
POTEF POTE ankyrin domain family, member F -0.0341548
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0340816
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0321135
ADAM17 ADAM metallopeptidase domain 17 -0.0309354
LMAN1 lectin, mannose-binding, 1 -0.0304071
RPLP1 ribosomal protein, large, P1 -0.0304035
HMGA1 high mobility group AT-hook 1 -0.0299679
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0298449
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0292829
LOC112694756 uncharaterized LOC112694756 -0.0290312
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0289769
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0286887
ACBD3 acyl-CoA binding domain containing 3 -0.0286881
USP3 ubiquitin specific peptidase 3 -0.0286661
FAM162A family with sequence similarity 162, member A -0.0284099
KLHDC10 kelch domain containing 10 -0.0283857
ZNF292 zinc finger protein 292 -0.0283346
UBC ubiquitin C -0.0282215
WAC WW domain containing adaptor with coiled-coil -0.0281834
CADM1 cell adhesion molecule 1 -0.0280136
ZC3H15 zinc finger CCCH-type containing 15 -0.0279027
KPNB1 karyopherin (importin) beta 1 -0.0270123
S100A6 S100 calcium binding protein A6 -0.026657
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0264898
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0259262
CCNL1 cyclin L1 -0.0259246
SKIC3 SKI3 subunit of superkiller complex -0.0251446
GARS1 glycyl-tRNA synthetase 1 -0.0248092
BRWD3 bromodomain and WD repeat domain containing 3 -0.0242457
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0240096
RNF145 ring finger protein 145 -0.0237913
USP53 ubiquitin specific peptidase 53 -0.0235618
SRP54 signal recognition particle 54kDa -0.0235212
FNDC3B fibronectin type III domain containing 3B -0.0234932
RTN4 reticulon 4 -0.02345
GMPS guanine monphosphate synthase -0.0231782
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0231574
FOXO3 forkhead box O3 -0.0231423
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0229905
CLIP4 CAP-GLY domain containing linker protein family, member 4 -0.0228794
TFG TRK-fused gene -0.0227461
CSNK1G3 casein kinase 1, gamma 3 -0.0225926
NPEPPS aminopeptidase puromycin sensitive -0.022047
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0220065
SEC62 SEC62 homolog (S. cerevisiae) -0.0219908
DDIT4 DNA-damage-inducible transcript 4 -0.0213194
RLF rearranged L-myc fusion -0.0211445
GNS glucosamine (N-acetyl)-6-sulfatase -0.020749
RAD21 RAD21 homolog (S. pombe) -0.0207062
CALR calreticulin -0.0206462
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0206037
ZMYM2 zinc finger, MYM-type 2 -0.0204316
UGCG UDP-glucose ceramide glucosyltransferase -0.0202824
ERLEC1 endoplasmic reticulum lectin 1 -0.0202415
CLINT1 clathrin interactor 1 -0.0201673
FHIT fragile histidine triad -0.0200716
HELZ helicase with zinc finger -0.0200078
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0198695
KIF5B kinesin family member 5B -0.0197083
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0197012
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0196506
TRIM33 tripartite motif containing 33 -0.0194215
PRRC1 proline-rich coiled-coil 1 -0.0192653
NRN1 neuritin 1 -0.0192225
BTG1 B-cell translocation gene 1, anti-proliferative -0.0191769