Anethole trithione_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AHNAK AHNAK nucleoprotein 0.0726604
SSBP2 single-stranded DNA binding protein 2 0.0617544
CTBP2 C-terminal binding protein 2 0.0613201
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0602503
CAMTA1 calmodulin binding transcription activator 1 0.0554338
TPT1 tumor protein, translationally-controlled 1 0.0514181
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0486392
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0466626
RPL34 ribosomal protein L34 0.0465841
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0448567
ZNF608 zinc finger protein 608 0.043922
MYOF myoferlin 0.0404874
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0401661
H1-4 H1.4 linker histone, cluster member 0.040031
TRIO trio Rho guanine nucleotide exchange factor 0.0396993
HSPH1 heat shock 105kDa/110kDa protein 1 0.0393605
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0391726
EML4 echinoderm microtubule associated protein like 4 0.038623
RPS8 ribosomal protein S8 0.0384015
EBNA1BP2 EBNA1 binding protein 2 0.0382731
ITGA6 integrin, alpha 6 0.0381919
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0369844
ZFAND3 zinc finger, AN1-type domain 3 0.0353545
TM4SF1 transmembrane 4 L six family member 1 0.0351358
ENO1 enolase 1, (alpha) 0.0347295
IFI16 interferon, gamma-inducible protein 16 0.0346818
FAT1 FAT atypical cadherin 1 0.0345604
HSPA8 heat shock 70kDa protein 8 0.0341779
RPL4 ribosomal protein L4 0.0336881
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0326284
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 0.0326247
KDM3A lysine (K)-specific demethylase 3A 0.0321986
RPL5 ribosomal protein L5 0.0309377
S100A9 S100 calcium binding protein A9 0.0309214
N4BP2L2 NEDD4 binding protein 2-like 2 0.0301354
PGK1 phosphoglycerate kinase 1 0.0296381
JMJD1C jumonji domain containing 1C 0.0293904
KMT2C lysine (K)-specific methyltransferase 2C 0.0293654
MAPK1 mitogen-activated protein kinase 1 0.0291906
BMP2K BMP2 inducible kinase 0.0282356
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0281897
PFN1 profilin 1 0.0279716
RPS21 ribosomal protein S21 0.0278327
TOP1 topoisomerase (DNA) I 0.0274774
MRTFA myocardin related transcription factor A 0.0274516
GSE1 Gse1 coiled-coil protein 0.0273356
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0272798
PABPN1 poly(A) binding protein, nuclear 1 0.0272102
RPL12 ribosomal protein L12 0.0270302
RTN4 reticulon 4 0.0262992
FUS FUS RNA binding protein 0.0256282
EGFR epidermal growth factor receptor 0.025305
TNRC6B trinucleotide repeat containing 6B 0.0252453
USP47 ubiquitin specific peptidase 47 0.0248517
SDK1 sidekick cell adhesion molecule 1 0.024619
KIAA2026 KIAA2026 0.0244584
S100A4 S100 calcium binding protein A4 0.0242684
GMDS GDP-mannose 4,6-dehydratase 0.0240614
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0239628
MYO5C myosin VC 0.0238739
HSPB1 heat shock 27kDa protein 1 0.0238208
LATS2 large tumor suppressor kinase 2 0.0237614
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0237297
MATR3 matrin 3 0.0236939
XPO1 exportin 1 0.0236546
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0236393
MACF1 microtubule-actin crosslinking factor 1 0.0235831
STX18 syntaxin 18 0.0233693
UBQLN1 ubiquilin 1 0.0233603
SGMS1 sphingomyelin synthase 1 0.0232335
TRERF1 transcriptional regulating factor 1 0.0232169
RPL35A ribosomal protein L35a 0.0230074
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.022943
RPL23 ribosomal protein L23 0.0225712
USP3 ubiquitin specific peptidase 3 0.0225558
SFTPA2 surfactant protein A2 0.0224438
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0223788
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0221595
CTTN cortactin 0.022065
MSI2 musashi RNA-binding protein 2 0.0220447
RPLP2 ribosomal protein, large, P2 0.021984
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0219163
RPS17 ribosomal protein S17 0.0218938
TSC22D2 TSC22 domain family, member 2 0.021609
RPS25 ribosomal protein S25 0.0215556
RPL36A ribosomal protein L36a 0.0212458
SEPTIN9 septin 9 0.021179
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0210247
RYBP RING1 and YY1 binding protein 0.0209778
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0209185
KLHDC4 kelch domain containing 4 0.0207602
HOOK2 hook microtubule-tethering protein 2 0.0207136
RHEB Ras homolog enriched in brain 0.0206627
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0204943
UIMC1 ubiquitin interaction motif containing 1 0.0203278
UBR3 ubiquitin protein ligase E3 component n-recognin 3 (putative) 0.0202715
CSNK1D casein kinase 1, delta 0.0200951
RPL31 ribosomal protein L31 0.0198498
RPS19 ribosomal protein S19 0.0197904
TAF4 TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa 0.0197641

decreased expression

Symbol Name Standardized Value
VCL vinculin -0.169546
NBEA neurobeachin -0.159869
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.123245
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0825061
ZBTB20 zinc finger and BTB domain containing 20 -0.0784778
TMSB4X thymosin beta 4, X-linked -0.0698676
ADAM10 ADAM metallopeptidase domain 10 -0.0678837
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0648787
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.064156
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.064013
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0592928
DPYD dihydropyrimidine dehydrogenase -0.0576646
SOX6 SRY (sex determining region Y)-box 6 -0.0551959
SBF2 SET binding factor 2 -0.0534254
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0527459
TAS2R14 taste receptor, type 2, member 14 -0.0522786
MKI67 marker of proliferation Ki-67 -0.0516424
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0498622
ANK2 ankyrin 2, neuronal -0.0493377
LDHA lactate dehydrogenase A -0.0486291
LPP LIM domain containing preferred translocation partner in lipoma -0.0478354
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0477353
PKM pyruvate kinase, muscle -0.0476606
METTL15 methyltransferase like 15 -0.0470248
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0469958
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.0466642
SQSTM1 sequestosome 1 -0.0458895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0455989
TMEM65 transmembrane protein 65 -0.0450741
CENPF centromere protein F, 350/400kDa -0.0448152
HDLBP high density lipoprotein binding protein -0.04329
ZEB1 zinc finger E-box binding homeobox 1 -0.0430812
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0420023
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.041921
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0417906
TXNRD1 thioredoxin reductase 1 -0.0417366
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0403173
DENND1A DENN/MADD domain containing 1A -0.0397526
VPS13B vacuolar protein sorting 13 homolog B (yeast) -0.0391442
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0384205
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.038348
EFNA5 ephrin-A5 -0.0379515
TPM4 tropomyosin 4 -0.0375108
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0374523
TJP1 tight junction protein 1 -0.0374065
PLCE1 phospholipase C, epsilon 1 -0.0371484
NAV2 neuron navigator 2 -0.0349079
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0346932
PHF3 PHD finger protein 3 -0.0343427
LARS1 leucyl-tRNA synthetase 1 -0.0343271
YEATS2 YEATS domain containing 2 -0.0340789
FER fer (fps/fes related) tyrosine kinase -0.0330954
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0329189
AHI1 Abelson helper integration site 1 -0.0325944
SLC38A2 solute carrier family 38, member 2 -0.0324688
DGKH diacylglycerol kinase, eta -0.0321584
BABAM2 BRISC and BRCA1 A complex member 2 -0.0321392
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0320841
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -0.0314383
MEIS2 Meis homeobox 2 -0.031366
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0309622
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.03082
PNISR PNN-interacting serine/arginine-rich protein -0.0306953
NSD1 nuclear receptor binding SET domain protein 1 -0.0306838
B2M beta-2-microglobulin -0.0304563
EXOC4 exocyst complex component 4 -0.0304191
PKP4 plakophilin 4 -0.0304037
ADNP activity-dependent neuroprotector homeobox -0.0303681
TTC3 tetratricopeptide repeat domain 3 -0.0303297
DIAPH3 diaphanous-related formin 3 -0.0301908
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0299518
MLIP muscular LMNA-interacting protein -0.0297248
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.029295
RAB6A RAB6A, member RAS oncogene family -0.0292363
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L -0.0291462
CYFIP1 cytoplasmic FMR1 interacting protein 1 -0.0289518
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0289363
CEP350 centrosomal protein 350kDa -0.0288484
DIAPH2 diaphanous-related formin 2 -0.0288326
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0286891
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0284078
MLLT3 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3 -0.0281377
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0281084
TCF12 transcription factor 12 -0.0280753
ZMYM2 zinc finger, MYM-type 2 -0.0280249
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0280155
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0275951
DSTN destrin (actin depolymerizing factor) -0.0275939
OSMR oncostatin M receptor -0.0274685
PATJ PATJ crumbs cell polarity complex component -0.0272531
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0269971
RFX3 regulatory factor X, 3 (influences HLA class II expression) -0.0267348
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0266882
TMEM41B transmembrane protein 41B -0.0266281
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.0265205
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.026377
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0263748
CCNL1 cyclin L1 -0.0263694
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0263083
CDC73 cell division cycle 73 -0.0263026