Anethole trithione_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.149994
NRG1 neuregulin 1 0.131321
ASPH aspartate beta-hydroxylase 0.116321
ZSWIM6 zinc finger, SWIM-type containing 6 0.0860867
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0854053
MYH9 myosin, heavy chain 9, non-muscle 0.0800893
RASAL2 RAS protein activator like 2 0.078039
TRIO trio Rho guanine nucleotide exchange factor 0.0730804
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0703682
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0682952
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0674783
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0636334
GLIS3 GLIS family zinc finger 3 0.0595659
AKAP12 A kinase (PRKA) anchor protein 12 0.0583214
PLEC plectin 0.0581289
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.056779
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0565678
PDLIM5 PDZ and LIM domain 5 0.0564646
LOXL2 lysyl oxidase-like 2 0.0561658
FNDC3A fibronectin type III domain containing 3A 0.0560256
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0554956
FLNA filamin A, alpha 0.0552576
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0537084
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0532993
EPS8 epidermal growth factor receptor pathway substrate 8 0.0532153
SMAD3 SMAD family member 3 0.0530228
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0522969
RNF213 ring finger protein 213 0.0515295
HMGA2 high mobility group AT-hook 2 0.050824
CTBP2 C-terminal binding protein 2 0.050349
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0502831
AHNAK AHNAK nucleoprotein 0.0498906
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0493875
SHB Src homology 2 domain containing adaptor protein B 0.0488966
RAB10 RAB10, member RAS oncogene family 0.0487873
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0480417
DST dystonin 0.0476766
INTS6 integrator complex subunit 6 0.0476511
SLC35F3 solute carrier family 35, member F3 0.0468744
PRKCA protein kinase C, alpha 0.0467159
VCL vinculin 0.0465962
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0444918
SAMD4A sterile alpha motif domain containing 4A 0.0444829
AEBP2 AE binding protein 2 0.0444657
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0441977
LTBP1 latent transforming growth factor beta binding protein 1 0.042454
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0406878
HIPK2 homeodomain interacting protein kinase 2 0.0400981
PALLD palladin, cytoskeletal associated protein 0.0399804
AHNAK2 AHNAK nucleoprotein 2 0.0395719
FNDC3B fibronectin type III domain containing 3B 0.0390456
NPAS2 neuronal PAS domain protein 2 0.0386444
UBC ubiquitin C 0.0381059
PARD3 par-3 family cell polarity regulator 0.0380174
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0380142
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0375059
SEPTIN9 septin 9 0.0368716
DOCK5 dedicator of cytokinesis 5 0.0368247
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0360595
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0355891
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0355847
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0346195
JMJD1C jumonji domain containing 1C 0.0345948
TOP1 topoisomerase (DNA) I 0.0343678
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0342116
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0342027
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0342006
UBASH3B ubiquitin associated and SH3 domain containing B 0.0337619
CANX calnexin 0.033739
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0334912
CUL3 cullin 3 0.0333166
GRB10 growth factor receptor-bound protein 10 0.0331296
OGA O-GlcNAcase 0.0329623
MLPH melanophilin 0.0325354
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0319901
SVIL supervillin 0.0316512
SDC2 syndecan 2 0.0314911
CORO1C coronin, actin binding protein, 1C 0.0314553
NTN4 netrin 4 0.030962
PTK2 protein tyrosine kinase 2 0.0305985
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0304426
PDIA4 protein disulfide isomerase family A, member 4 0.0304133
AGO2 argonaute RISC catalytic component 2 0.0303996
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0299621
TUFT1 tuftelin 1 0.0298474
ANKRD17 ankyrin repeat domain 17 0.0297955
MACF1 microtubule-actin crosslinking factor 1 0.0295249
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0294588
RAB31 RAB31, member RAS oncogene family 0.0293691
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0289726
CLIP2 CAP-GLY domain containing linker protein 2 0.0288118
QSOX1 quiescin Q6 sulfhydryl oxidase 1 0.0287995
ACTN4 actinin, alpha 4 0.0286587
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.02857
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0283879
EFNA5 ephrin-A5 0.0282784
CNKSR3 CNKSR family member 3 0.0282103
PDE4D phosphodiesterase 4D, cAMP-specific 0.0281426
ELL2 elongation factor, RNA polymerase II, 2 0.0275837
MYO10 myosin X 0.0274152

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.223227
FN1 fibronectin 1 -0.209184
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.178545
FTH1 ferritin, heavy polypeptide 1 -0.125726
MT2A metallothionein 2A -0.109487
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0967134
FTL ferritin, light polypeptide -0.0783975
NAMPT nicotinamide phosphoribosyltransferase -0.0729258
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0690107
ITGA1 integrin, alpha 1 -0.064622
NDRG1 N-myc downstream regulated 1 -0.0546287
RPS6 ribosomal protein S6 -0.0484626
RPLP1 ribosomal protein, large, P1 -0.0470775
RPL35A ribosomal protein L35a -0.0462179
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0415729
B2M beta-2-microglobulin -0.0398629
CENPF centromere protein F, 350/400kDa -0.0397716
VIM vimentin -0.0394753
RPS8 ribosomal protein S8 -0.0394282
RPS19 ribosomal protein S19 -0.0389616
PTMA prothymosin, alpha -0.0389594
PLIN2 perilipin 2 -0.0384905
HMGA1 high mobility group AT-hook 1 -0.0370875
PELO pelota homolog (Drosophila) -0.0361017
MRPS6 mitochondrial ribosomal protein S6 -0.0348715
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0346826
CDCP1 CUB domain containing protein 1 -0.0342879
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0328851
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0326334
RPS27 ribosomal protein S27 -0.0326221
CD109 CD109 molecule -0.0325484
ZMYND8 zinc finger, MYND-type containing 8 -0.0323914
RPS29 ribosomal protein S29 -0.0315581
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0313521
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.030651
ACBD3 acyl-CoA binding domain containing 3 -0.0302191
IGFBP3 insulin-like growth factor binding protein 3 -0.0295336
PDIA3 protein disulfide isomerase family A, member 3 -0.0291631
ENO2 enolase 2 (gamma, neuronal) -0.0290823
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0290329
FOSL1 FOS-like antigen 1 -0.0284491
RPS20 ribosomal protein S20 -0.0275765
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.027262
POTEF POTE ankyrin domain family, member F -0.027052
RPL37A ribosomal protein L37a -0.026289
LOC102724023 ES1 protein homolog, mitochondrial -0.0259328
EIF1 eukaryotic translation initiation factor 1 -0.025368
RPS23 ribosomal protein S23 -0.0253529
RPLP2 ribosomal protein, large, P2 -0.0245916
CDC27 cell division cycle 27 -0.0245492
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0241651
TXNRD1 thioredoxin reductase 1 -0.0241643
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0240876
TTC3 tetratricopeptide repeat domain 3 -0.0236786
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0235872
GCC2 GRIP and coiled-coil domain containing 2 -0.0234252
RAI14 retinoic acid induced 14 -0.023343
RPS25 ribosomal protein S25 -0.0229404
VDAC1 voltage-dependent anion channel 1 -0.0224249
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.022402
PKM pyruvate kinase, muscle -0.0220665
RPS14 ribosomal protein S14 -0.0219153
RPL34 ribosomal protein L34 -0.0214687
HLA-B major histocompatibility complex, class I, B -0.0213997
RPS11 ribosomal protein S11 -0.0213284
BTG1 B-cell translocation gene 1, anti-proliferative -0.0212896
DCAF7 DDB1 and CUL4 associated factor 7 -0.0211636
TPM4 tropomyosin 4 -0.0207098
LRP5 low density lipoprotein receptor-related protein 5 -0.0206179
RPL9 ribosomal protein L9 -0.0204273
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0204184
RTN4 reticulon 4 -0.0203551
S100A6 S100 calcium binding protein A6 -0.0202046
TMEM165 transmembrane protein 165 -0.0200018
KPNB1 karyopherin (importin) beta 1 -0.0198742
SQSTM1 sequestosome 1 -0.0198446
RPL37 ribosomal protein L37 -0.0197857
MIS18BP1 MIS18 binding protein 1 -0.0193872
IER3 immediate early response 3 -0.0189764
RPL23 ribosomal protein L23 -0.0188527
RNF24 ring finger protein 24 -0.0187843
KDM5B lysine (K)-specific demethylase 5B -0.0187724
RPL8 ribosomal protein L8 -0.0186833
NACA nascent polypeptide-associated complex alpha subunit -0.0186768
SFXN1 sideroflexin 1 -0.0186027
WTAP Wilms tumor 1 associated protein -0.0183072
RPS15 ribosomal protein S15 -0.0181921
RPL36 ribosomal protein L36 -0.0178913
RPL26 ribosomal protein L26 -0.0176559
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0175373
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0173993
PIM3 Pim-3 proto-oncogene, serine/threonine kinase -0.0173312
HILPDA hypoxia inducible lipid droplet-associated -0.017188
GOLGA4 golgin A4 -0.0171805
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0171665
RPS16 ribosomal protein S16 -0.0171162
RPL28 ribosomal protein L28 -0.0170941
RPL27 ribosomal protein L27 -0.0170605
AKAP9 A kinase (PRKA) anchor protein 9 -0.0170426
RPLP0 ribosomal protein, large, P0 -0.0169762