Anethole trithione_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTL ferritin, light polypeptide 0.187203
PTMA prothymosin, alpha 0.176012
PABPC1 poly(A) binding protein, cytoplasmic 1 0.152224
BCL2L1 BCL2-like 1 0.138317
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.133433
KRT18 keratin 18, type I 0.0874312
EZR ezrin 0.086762
RPS6 ribosomal protein S6 0.0855651
TMSB10 thymosin beta 10 0.0830729
TPT1 tumor protein, translationally-controlled 1 0.0829467
NCEH1 neutral cholesterol ester hydrolase 1 0.0759009
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0756286
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0707874
RPS21 ribosomal protein S21 0.069768
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0687703
MYH9 myosin, heavy chain 9, non-muscle 0.0663521
DSPP dentin sialophosphoprotein 0.0642934
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0621069
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0620129
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0610154
MYO1E myosin IE 0.0609637
RPL19 ribosomal protein L19 0.0589745
VCL vinculin 0.0586103
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0585957
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0569477
KRT8 keratin 8, type II 0.0563639
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0544541
MYH14 myosin, heavy chain 14, non-muscle 0.0525966
APLP2 amyloid beta (A4) precursor-like protein 2 0.0525723
RPL12 ribosomal protein L12 0.0524941
RPLP2 ribosomal protein, large, P2 0.0522091
RPS3 ribosomal protein S3 0.0508391
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0494519
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0484502
RPLP1 ribosomal protein, large, P1 0.0479878
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0476631
IFRD1 interferon-related developmental regulator 1 0.0470996
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0468677
PLEC plectin 0.0467975
EPCAM epithelial cell adhesion molecule 0.0465759
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0465201
RPL35A ribosomal protein L35a 0.0449977
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0441669
CSNK1A1 casein kinase 1, alpha 1 0.044007
TRIO trio Rho guanine nucleotide exchange factor 0.0438823
EIF1 eukaryotic translation initiation factor 1 0.0437995
RPLP0 ribosomal protein, large, P0 0.0437264
RPS8 ribosomal protein S8 0.0437122
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0425703
LOC102724023 ES1 protein homolog, mitochondrial 0.0423396
RPL37A ribosomal protein L37a 0.0422041
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like 0.0421302
SAMD4A sterile alpha motif domain containing 4A 0.0420911
RPS5 ribosomal protein S5 0.0412254
LPP LIM domain containing preferred translocation partner in lipoma 0.0405274
TJP1 tight junction protein 1 0.04025
RPS13 ribosomal protein S13 0.0402342
SMAD3 SMAD family member 3 0.0401875
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0401243
CEMIP cell migration inducing protein, hyaluronan binding 0.0399948
ETV6 ets variant 6 0.0398578
AKAP12 A kinase (PRKA) anchor protein 12 0.0397216
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0396903
ACTG1 actin gamma 1 0.0395764
HSPA8 heat shock 70kDa protein 8 0.0391394
ACTN4 actinin, alpha 4 0.0388795
RPS12 ribosomal protein S12 0.0387128
EGR1 early growth response 1 0.0373965
WWC1 WW and C2 domain containing 1 0.0373069
OSBPL10 oxysterol binding protein-like 10 0.0372339
FNDC3B fibronectin type III domain containing 3B 0.0371374
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0369086
RPL37 ribosomal protein L37 0.0367737
NEBL nebulette 0.0367409
MACC1 metastasis associated in colon cancer 1 0.0360759
RPL23 ribosomal protein L23 0.0359623
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0359083
RPL31 ribosomal protein L31 0.0356973
RPL35 ribosomal protein L35 0.0356195
CUX1 cut-like homeobox 1 0.0354644
TMSB4X thymosin beta 4, X-linked 0.0353752
RPS19 ribosomal protein S19 0.0353368
MKI67 marker of proliferation Ki-67 0.0352672
B2M beta-2-microglobulin 0.0350638
RPL28 ribosomal protein L28 0.0348158
FRMD5 FERM domain containing 5 0.034694
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0344702
FAT1 FAT atypical cadherin 1 0.0344239
PGK1 phosphoglycerate kinase 1 0.0343893
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0343425
SHB Src homology 2 domain containing adaptor protein B 0.0338632
ACTN1 actinin, alpha 1 0.0335971
CTBP2 C-terminal binding protein 2 0.0333653
RPL32 ribosomal protein L32 0.0332577
ZNFX1 zinc finger, NFX1-type containing 1 0.0330923
LMO7 LIM domain 7 0.0329429
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0329345
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0327761
RPL8 ribosomal protein L8 0.0326511
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0326492

decreased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 -0.0473689
KMT2E lysine (K)-specific methyltransferase 2E -0.0391367
PCBP2 poly(rC) binding protein 2 -0.0280285
UBC ubiquitin C -0.0278722
POTEF POTE ankyrin domain family, member F -0.0204654
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.0198936
CCNL1 cyclin L1 -0.0197793
USP3 ubiquitin specific peptidase 3 -0.0189227
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0171429
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0159693
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0155304
ARHGAP12 Rho GTPase activating protein 12 -0.0155257
TFG TRK-fused gene -0.0155174
RRAS2 related RAS viral (r-ras) oncogene homolog 2 -0.0150097
ZNF207 zinc finger protein 207 -0.0147055
PELI1 pellino E3 ubiquitin protein ligase 1 -0.0147038
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0133698
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0133149
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0128959
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -0.0128612
SRP54 signal recognition particle 54kDa -0.0123018
ZFP36 ZFP36 ring finger protein -0.0122299
NDFIP1 Nedd4 family interacting protein 1 -0.0120618
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0120582
RYK receptor-like tyrosine kinase -0.0118912
MTF2 metal response element binding transcription factor 2 -0.0118452
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0118427
RASA2 RAS p21 protein activator 2 -0.011798
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0113844
TRA2A transformer 2 alpha homolog (Drosophila) -0.0113789
VPS41 vacuolar protein sorting 41 homolog (S. cerevisiae) -0.0113732
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0112981
MEF2A myocyte enhancer factor 2A -0.0112242
UGCG UDP-glucose ceramide glucosyltransferase -0.0110636
LMTK2 lemur tyrosine kinase 2 -0.0110274
CAPN5 calpain 5 -0.010978
KDM6A lysine (K)-specific demethylase 6A -0.0107977
DHFR dihydrofolate reductase -0.0105563
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0102314
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0101852
PDS5B PDS5 cohesin associated factor B -0.0100304
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.00998546
NAMPT nicotinamide phosphoribosyltransferase -0.00996456
AMBRA1 autophagy/beclin-1 regulator 1 -0.00991434
ALG9 ALG9, alpha-1,2-mannosyltransferase -0.0098912
ARL8B ADP-ribosylation factor-like 8B -0.00987035
GLS2 glutaminase 2 (liver, mitochondrial) -0.00968009
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.00966721
RNASE3 ribonuclease, RNase A family, 3 -0.00963027
PHKB phosphorylase kinase, beta -0.00961057
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.00957565
U2SURP U2 snRNP-associated SURP domain containing -0.00946921
NUAK2 NUAK family, SNF1-like kinase, 2 -0.00944733
KCTD3 potassium channel tetramerization domain containing 3 -0.00939612
WAC WW domain containing adaptor with coiled-coil -0.00934411
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -0.00933277
ARRDC3 arrestin domain containing 3 -0.00933124
AZIN1 antizyme inhibitor 1 -0.0093034
ZNF654 zinc finger protein 654 -0.00915426
RAB22A RAB22A, member RAS oncogene family -0.00909875
ATP11B ATPase, class VI, type 11B -0.00906168
TBC1D23 TBC1 domain family, member 23 -0.00903656
FAR1 fatty acyl CoA reductase 1 -0.00902988
PER1 period circadian clock 1 -0.00900728
HBP1 HMG-box transcription factor 1 -0.00899654
JUP junction plakoglobin -0.00897234
RBM25 RNA binding motif protein 25 -0.00877606
JAK1 Janus kinase 1 -0.00877163
H2AC6 H2A clustered histone 6 -0.00873362
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta -0.00872169
NBAS neuroblastoma amplified sequence -0.00869307
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing -0.00857885
RNF145 ring finger protein 145 -0.00855957
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.00850906
MSMO1 methylsterol monooxygenase 1 -0.0083906
NCKAP1 NCK-associated protein 1 -0.00829049
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.00826485
UBE2D1 ubiquitin-conjugating enzyme E2D 1 -0.00825028
FAM133B family with sequence similarity 133, member B -0.00816949
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.00809909
ANKRD13C ankyrin repeat domain 13C -0.00805305
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.00804677
NEK7 NIMA-related kinase 7 -0.00803647
BTBD10 BTB (POZ) domain containing 10 -0.00800094
SREBF2 sterol regulatory element binding transcription factor 2 -0.00799942
MARCHF7 membrane associated ring-CH-type finger 7 -0.00799834
PTEN phosphatase and tensin homolog -0.00795282
LATS1 large tumor suppressor kinase 1 -0.00795038
HYCC2 hyccin PI4KA lipid kinase complex subunit 2 -0.00792467
HIPK3 homeodomain interacting protein kinase 3 -0.00791261
TXNRD1 thioredoxin reductase 1 -0.00783932
ELMO2 engulfment and cell motility 2 -0.00781482
RYBP RING1 and YY1 binding protein -0.00779949
PATL1 protein associated with topoisomerase II homolog 1 (yeast) -0.00778197
FANCL Fanconi anemia, complementation group L -0.00772595
MTMR2 myotubularin related protein 2 -0.00771215
WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules -0.00766642
PAQR3 progestin and adipoQ receptor family member III -0.00756715
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00755801
PRRC1 proline-rich coiled-coil 1 -0.00742917