Anethole trithione_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Anethole trithione perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Anethole trithione_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.158248
ACTG1 actin gamma 1 0.145351
HMGA2 high mobility group AT-hook 2 0.120416
LAMB3 laminin, beta 3 0.115481
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.115253
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.105578
HSPA8 heat shock 70kDa protein 8 0.0982416
MYH9 myosin, heavy chain 9, non-muscle 0.0913968
DSPP dentin sialophosphoprotein 0.0829475
AHNAK AHNAK nucleoprotein 0.0759665
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0742738
SEPTIN9 septin 9 0.0741266
EGFR epidermal growth factor receptor 0.0738698
PTMA prothymosin, alpha 0.0712192
LAMC2 laminin, gamma 2 0.069296
LAMA4 laminin, alpha 4 0.0658873
MPRIP myosin phosphatase Rho interacting protein 0.0658408
TPT1 tumor protein, translationally-controlled 1 0.0624209
IER3 immediate early response 3 0.0596061
MACF1 microtubule-actin crosslinking factor 1 0.0585011
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0571707
TMSB10 thymosin beta 10 0.0570315
RCOR1 REST corepressor 1 0.0528965
NUP50 nucleoporin 50kDa 0.0514526
SNX9 sorting nexin 9 0.0486625
MYO5B myosin VB 0.0468714
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.046755
OSBPL10 oxysterol binding protein-like 10 0.0463742
SMAD3 SMAD family member 3 0.0463187
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0445764
RPL3 ribosomal protein L3 0.0441491
KRT18 keratin 18, type I 0.0417759
ZHX2 zinc fingers and homeoboxes 2 0.0417512
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0408594
USP9X ubiquitin specific peptidase 9, X-linked 0.0406431
AKAP13 A kinase (PRKA) anchor protein 13 0.0400562
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0397369
DOCK5 dedicator of cytokinesis 5 0.0391105
CLIP2 CAP-GLY domain containing linker protein 2 0.0380478
KLF5 Kruppel-like factor 5 (intestinal) 0.0370838
HDAC4 histone deacetylase 4 0.0361075
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0358293
PLEC plectin 0.0357631
SRRM2 serine/arginine repetitive matrix 2 0.0355847
ABR active BCR-related 0.0353231
HDLBP high density lipoprotein binding protein 0.0350724
PLAUR plasminogen activator, urokinase receptor 0.034885
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.03448
JARID2 jumonji, AT rich interactive domain 2 0.0344211
SQSTM1 sequestosome 1 0.0340296
FLNA filamin A, alpha 0.0339862
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0337507
AKAP12 A kinase (PRKA) anchor protein 12 0.0332917
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.033111
DSCAM Down syndrome cell adhesion molecule 0.0328313
IGSF9B immunoglobulin superfamily, member 9B 0.0325761
EFNB2 ephrin-B2 0.0325616
PDIA4 protein disulfide isomerase family A, member 4 0.0324507
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0323751
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0322551
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0322169
KLF6 Kruppel-like factor 6 0.0321904
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0314977
CDC42BPB CDC42 binding protein kinase beta (DMPK-like) 0.0313695
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0313438
EXT1 exostosin glycosyltransferase 1 0.0311859
ZSWIM6 zinc finger, SWIM-type containing 6 0.0311435
LMNA lamin A/C 0.0303648
H1-4 H1.4 linker histone, cluster member 0.0302551
KLC1 kinesin light chain 1 0.0300361
EZR ezrin 0.0297024
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0290522
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0288951
GPC5 glypican 5 0.0288201
MYH14 myosin, heavy chain 14, non-muscle 0.0286271
EMP1 epithelial membrane protein 1 0.0282318
CMIP c-Maf inducing protein 0.0279178
CREB5 cAMP responsive element binding protein 5 0.0269405
RASAL2 RAS protein activator like 2 0.0268879
HOMER1 homer scaffolding protein 1 0.0261507
APLP2 amyloid beta (A4) precursor-like protein 2 0.0255919
ENO1 enolase 1, (alpha) 0.0255733
CTTN cortactin 0.0255402
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0255397
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0254314
LPP LIM domain containing preferred translocation partner in lipoma 0.0253495
FHL2 four and a half LIM domains 2 0.0252606
KRT8 keratin 8, type II 0.0250897
SERBP1 SERPINE1 mRNA binding protein 1 0.0243042
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0242914
ACTN4 actinin, alpha 4 0.0242849
CTSB cathepsin B 0.0237629
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0237153
SMYD3 SET and MYND domain containing 3 0.0235136
CALR calreticulin 0.0234986
SDC4 syndecan 4 0.0234503
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0233399
FERMT1 fermitin family member 1 0.0232822
ACTN1 actinin, alpha 1 0.0232383
RAP1GAP2 RAP1 GTPase activating protein 2 0.0232376

decreased expression

Symbol Name Standardized Value
CD36 CD36 molecule (thrombospondin receptor) -0.145282
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.135344
OXR1 oxidation resistance 1 -0.0688786
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0614239
RUNX2 runt-related transcription factor 2 -0.0596748
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0553955
RPL35A ribosomal protein L35a -0.0459124
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0451531
STRN3 striatin, calmodulin binding protein 3 -0.0448478
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0442853
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0431456
COG5 component of oligomeric golgi complex 5 -0.0428574
RAD51B RAD51 paralog B -0.0408295
HDAC2 histone deacetylase 2 -0.0401437
PUM2 pumilio RNA-binding family member 2 -0.0395243
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0393746
PDLIM5 PDZ and LIM domain 5 -0.0388805
TOP1 topoisomerase (DNA) I -0.0388045
RBM25 RNA binding motif protein 25 -0.038435
GARS1 glycyl-tRNA synthetase 1 -0.037255
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0364674
PTBP2 polypyrimidine tract binding protein 2 -0.0320477
BRWD1 bromodomain and WD repeat domain containing 1 -0.0316874
RNF145 ring finger protein 145 -0.0304265
NFIA nuclear factor I/A -0.0300615
FAR1 fatty acyl CoA reductase 1 -0.0290127
NEK7 NIMA-related kinase 7 -0.0290053
GOLGA4 golgin A4 -0.0288393
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0281465
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0279369
IGFBP3 insulin-like growth factor binding protein 3 -0.0276246
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0268618
WDR43 WD repeat domain 43 -0.026803
KDM6A lysine (K)-specific demethylase 6A -0.026403
WAC WW domain containing adaptor with coiled-coil -0.0260736
PCBP2 poly(rC) binding protein 2 -0.0257354
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0256502
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0255959
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0255404
VCL vinculin -0.0252315
USP3 ubiquitin specific peptidase 3 -0.0249583
EREG epiregulin -0.0249329
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0243372
PNISR PNN-interacting serine/arginine-rich protein -0.0241951
FTH1 ferritin, heavy polypeptide 1 -0.0238451
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0236114
GPHN gephyrin -0.0235996
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0233354
TXNRD1 thioredoxin reductase 1 -0.0231766
SRSF11 serine/arginine-rich splicing factor 11 -0.0230334
IARS1 isoleucyl-tRNA synthetase 1 -0.022846
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0227544
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0227434
FNDC3A fibronectin type III domain containing 3A -0.0225869
CD46 CD46 molecule, complement regulatory protein -0.0224504
FAT1 FAT atypical cadherin 1 -0.0223484
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0219241
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.021861
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0214972
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0213038
ANAPC5 anaphase promoting complex subunit 5 -0.0212372
NCEH1 neutral cholesterol ester hydrolase 1 -0.021162
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0211502
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0210909
MBNL1 muscleblind-like splicing regulator 1 -0.0210011
ECT2 epithelial cell transforming 2 -0.0208161
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0206744
PARD3 par-3 family cell polarity regulator -0.020669
RPS29 ribosomal protein S29 -0.0206393
TCERG1 transcription elongation regulator 1 -0.0200383
PCNX1 pecanex 1 -0.0199054
PHF14 PHD finger protein 14 -0.0195262
MIPEP mitochondrial intermediate peptidase -0.01951
KMT2E lysine (K)-specific methyltransferase 2E -0.0193848
RAB6A RAB6A, member RAS oncogene family -0.0192892
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0192574
PKP4 plakophilin 4 -0.0191531
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0189691
RFX7 regulatory factor X, 7 -0.0189218
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0188792
SCFD1 sec1 family domain containing 1 -0.0187763
UBE2K ubiquitin-conjugating enzyme E2K -0.0185058
ITCH itchy E3 ubiquitin protein ligase -0.018446
METTL15 methyltransferase like 15 -0.0184178
SLMAP sarcolemma associated protein -0.0182681
NAMPT nicotinamide phosphoribosyltransferase -0.0177963
CEP152 centrosomal protein 152kDa -0.0176244
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0175884
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0175605
ZMYM2 zinc finger, MYM-type 2 -0.0175435
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0175052
EDAR ectodysplasin A receptor -0.0173207
PHC3 polyhomeotic homolog 3 (Drosophila) -0.0173162
MED13L mediator complex subunit 13-like -0.0173066
SEC24B SEC24 family member B -0.0172853
TSC22D2 TSC22 domain family, member 2 -0.0172753
PTEN phosphatase and tensin homolog -0.0171746
ERBIN erbb2 interacting protein -0.0171657
NFXL1 nuclear transcription factor, X-box binding-like 1 -0.0170832
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0170057