Ankyloglossia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Short or anteriorly attached lingual frenulum, associated with limited mobility of the tongue. (Human Phenotype Ontology, HP_0010296)
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Genes

140 genes co-occuring with the disease Ankyloglossia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
TBX22 T-box 22 3.561
IRF6 interferon regulatory factor 6 2.298
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 2.174
MSX1 msh homeobox 1 2.066
LGR6 leucine-rich repeat containing G protein-coupled receptor 6 2.063
COL7A1 collagen, type VII, alpha 1 1.985
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 1.964
PAX9 paired box 9 1.902
DCAF12L2 DDB1 and CUL4 associated factor 12-like 2 1.785
OFD1 oral-facial-digital syndrome 1 1.733
ZNF157 zinc finger protein 157 1.702
CPXCR1 CPX chromosome region, candidate 1 1.689
TBX1 T-box 1 1.65
LONRF3 LON peptidase N-terminal domain and ring finger 3 1.643
RNFT1 ring finger protein, transmembrane 1 1.61
FERMT1 fermitin family member 1 1.593
RSPO1 R-spondin 1 1.538
VAX1 ventral anterior homeobox 1 1.534
BARX1 BARX homeobox 1 1.501
TBX3 T-box 3 1.49
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 1.473
RSPO2 R-spondin 2 1.462
RSPO4 R-spondin 4 1.46
MID1 midline 1 1.456
RSPO3 R-spondin 3 1.448
KLHL4 kelch-like family member 4 1.44
KRT14 keratin 14, type I 1.431
GRHL3 grainyhead-like 3 (Drosophila) 1.423
TTC28 tetratricopeptide repeat domain 28 1.416
BMP4 bone morphogenetic protein 4 1.411
WLS wntless Wnt ligand secretion mediator 1.406
AXIN2 axin 2 1.402
PAX3 paired box 3 1.401
PITPNB phosphatidylinositol transfer protein, beta 1.39
COL17A1 collagen, type XVII, alpha 1 1.385
WNT5A wingless-type MMTV integration site family, member 5A 1.374
TBC1D32 TBC1 domain family, member 32 1.37
RYK receptor-like tyrosine kinase 1.358
PLEC plectin 1.355
TBX5 T-box 5 1.341
ALX4 ALX homeobox 4 1.34
TP63 tumor protein p63 1.337
DCLK2 doublecortin-like kinase 2 1.331
SHH sonic hedgehog 1.322
NECTIN1 nectin cell adhesion molecule 1 1.319
WNT10A wingless-type MMTV integration site family, member 10A 1.304
TBX10 T-box 10 1.304
TBX19 T-box 19 1.303
SMIM23 small integral membrane protein 23 1.296
TGFB3 transforming growth factor, beta 3 1.294
SOX9 SRY (sex determining region Y)-box 9 1.288
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2 1.288
TUBD1 tubulin, delta 1 1.285
ITM2A integral membrane protein 2A 1.28
NHLH1 nescient helix loop helix 1 1.279
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2 1.273
FGF8 fibroblast growth factor 8 (androgen-induced) 1.269
MYH13 myosin, heavy chain 13, skeletal muscle 1.259
DLX5 distal-less homeobox 5 1.252
LAMA3 laminin, alpha 3 1.251
KIF22 kinesin family member 22 1.25
WNT3A wingless-type MMTV integration site family, member 3A 1.244
FGFR1 fibroblast growth factor receptor 1 1.235
BMPR1A bone morphogenetic protein receptor, type IA 1.233
PJA1 praja ring finger 1, E3 ubiquitin protein ligase 1.233
SOSTDC1 sclerostin domain containing 1 1.232
MYO1H myosin IH 1.232
PAX7 paired box 7 1.226
C2CD3 C2 calcium-dependent domain containing 3 1.221
TBX2 T-box 2 1.219
PKP1 plakophilin 1 1.218
PBX2 pre-B-cell leukemia homeobox 2 1.217
LAMB3 laminin, beta 3 1.208
SATB2 SATB homeobox 2 1.207
PITX2 paired-like homeodomain 2 1.196
USP32 ubiquitin specific peptidase 32 1.184
ZBTB40 zinc finger and BTB domain containing 40 1.183
FGFR2 fibroblast growth factor receptor 2 1.182
PTRH2 peptidyl-tRNA hydrolase 2 1.182
TCOF1 Treacher Collins-Franceschetti syndrome 1 1.178
DLX6 distal-less homeobox 6 1.177
ZNF236 zinc finger protein 236 1.176
SUMO1 small ubiquitin-like modifier 1 1.176
NDP Norrie disease (pseudoglioma) 1.168
TMEM31 transmembrane protein 31 1.156
PHF8 PHD finger protein 8 1.153
ZNRF3 zinc and ring finger 3 1.151
WNT9B wingless-type MMTV integration site family, member 9B 1.15
OXT oxytocin/neurophysin I prepropeptide 1.146
WNT3 wingless-type MMTV integration site family, member 3 1.142
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 1.141
MAGEA9B melanoma antigen family A9B 1.134
EVC2 Ellis van Creveld syndrome 2 1.132
WNT11 wingless-type MMTV integration site family, member 11 1.128
EVC Ellis van Creveld protein 1.127
LPAR4 lysophosphatidic acid receptor 4 1.119
MAGEA9 melanoma antigen family A9 1.116
TSHZ1 teashirt zinc finger homeobox 1 1.109
FZD5 frizzled class receptor 5 1.105
ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif, 20 1.104
SEBOX SEBOX homeobox 1.103
LRP6 low density lipoprotein receptor-related protein 6 1.098
PORCN porcupine homolog (Drosophila) 1.093
PLCL1 phospholipase C-like 1 1.091
UTP25 UTP25 small subunit processome component 1.09
KRT5 keratin 5, type II 1.086
SULT6B1 sulfotransferase family, cytosolic, 6B, member 1 1.077
CSRNP2 cysteine-serine-rich nuclear protein 2 1.077
ARHGAP29 Rho GTPase activating protein 29 1.075
FRZB frizzled-related protein 1.073
TMEM26 transmembrane protein 26 1.071
LAMA4 laminin, alpha 4 1.07
FAM149A family with sequence similarity 149, member A 1.07
WNT1 wingless-type MMTV integration site family, member 1 1.069
C9ORF152 chromosome 9 open reading frame 152 1.059
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B 1.059
DUSP21 dual specificity phosphatase 21 1.053
MYH8 myosin, heavy chain 8, skeletal muscle, perinatal 1.047
RNF43 ring finger protein 43 1.045
FOXE1 forkhead box E1 1.042
MAMLD1 mastermind-like domain containing 1 1.042
P3H1 prolyl 3-hydroxylase 1 1.041
GLI3 GLI family zinc finger 3 1.038
DVL1 dishevelled segment polarity protein 1 1.034
ITGA6 integrin, alpha 6 1.032
MSX2 msh homeobox 2 1.029
PTCH1 patched 1 1.027
FGF10 fibroblast growth factor 10 1.024
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.023
URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase 1.022
MOSMO modulator of smoothened 1.016
COL2A1 collagen, type II, alpha 1 1.016
WNT9A wingless-type MMTV integration site family, member 9A 1.015
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 1.009
AVPI1 arginine vasopressin-induced 1 1.008
MEIS2 Meis homeobox 2 1.006
KIF3A kinesin family member 3A 1.005
WNT10B wingless-type MMTV integration site family, member 10B 1.004
FOXF2 forkhead box F2 1.002
LEF1 lymphoid enhancer-binding factor 1 1.002