Ankylosis Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description Ankylosis is a arthropathy where there is a stiffness of a joint, the result of injury or disease. The rigidity may be complete or partial and may be due to inflammation of the tendinous or muscular structures outside the joint or of the tissues of the joint itself. (Human Disease Ontology, DOID_227)
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Genes

308 genes co-occuring with the disease Ankylosis in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ANKH ANKH inorganic pyrophosphate transport regulator 3.326
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1 2.859
ALPL alkaline phosphatase, liver/bone/kidney 2.678
TNF tumor necrosis factor 2.573
BMP2 bone morphogenetic protein 2 2.507
IL17A interleukin 17A 2.506
BGLAP bone gamma-carboxyglutamate (gla) protein 2.5
RUNX2 runt-related transcription factor 2 2.479
ACVR1 activin A receptor, type I 2.473
NOG noggin 2.466
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 2.461
CRP C-reactive protein, pentraxin-related 2.46
DKK1 dickkopf WNT signaling pathway inhibitor 1 2.419
SOST sclerostin 2.397
ERAP1 endoplasmic reticulum aminopeptidase 1 2.369
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 2.357
IBSP integrin-binding sialoprotein 2.334
SP7 Sp7 transcription factor 2.274
SPP1 secreted phosphoprotein 1 2.272
IL1B interleukin 1, beta 2.271
GDF5 growth differentiation factor 5 2.238
IL6 interleukin 6 2.232
PHOSPHO1 phosphatase, orphan 1 2.213
ACAN aggrecan 2.196
BMP7 bone morphogenetic protein 7 2.19
ACP5 acid phosphatase 5, tartrate resistant 2.113
DMP1 dentin matrix acidic phosphoprotein 1 2.112
PTH1R parathyroid hormone 1 receptor 2.101
TGFB1 transforming growth factor, beta 1 2.097
BMP4 bone morphogenetic protein 4 2.079
AMBN ameloblastin (enamel matrix protein) 2.066
IL1A interleukin 1, alpha 2.063
CEMP1 cementum protein 1 2.045
IL23R interleukin 23 receptor 2.021
IFNG interferon, gamma 1.977
MSX2 msh homeobox 2 1.964
CD4 CD4 molecule 1.96
MGP matrix Gla protein 1.946
MMP3 matrix metallopeptidase 3 1.945
IL10 interleukin 10 1.919
BMP6 bone morphogenetic protein 6 1.91
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.886
SOX9 SRY (sex determining region Y)-box 9 1.856
HLA-B major histocompatibility complex, class I, B 1.834
PTH parathyroid hormone 1.831
MMP13 matrix metallopeptidase 13 1.828
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.816
IL22 interleukin 22 1.813
FGF2 fibroblast growth factor 2 (basic) 1.812
IHH indian hedgehog 1.772
COL2A1 collagen, type II, alpha 1 1.759
IL4 interleukin 4 1.755
CTSK cathepsin K 1.752
COL1A1 collagen, type I, alpha 1 1.747
ARSJ arylsulfatase family, member J 1.739
COL10A1 collagen, type X, alpha 1 1.732
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.731
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.731
ERAP2 endoplasmic reticulum aminopeptidase 2 1.727
PTPRC protein tyrosine phosphatase, receptor type, C 1.694
FMOD fibromodulin 1.682
CD8A CD8a molecule 1.669
ACTB actin, beta 1.647
PXDNL peroxidasin-like 1.636
FOXP3 forkhead box P3 1.636
PXDN peroxidasin 1.634
PHEX phosphate regulating endopeptidase homolog, X-linked 1.611
IL17F interleukin 17F 1.61
NT5E 5'-nucleotidase, ecto (CD73) 1.607
POSTN periostin, osteoblast specific factor 1.607
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5 1.606
MEPE matrix extracellular phosphoglycoprotein 1.603
FGF9 fibroblast growth factor 9 1.601
AHSG alpha-2-HS-glycoprotein 1.598
ALB albumin 1.59
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.585
IL17RA interleukin 17 receptor A 1.575
PTHLH parathyroid hormone-like hormone 1.57
DSPP dentin sialophosphoprotein 1.567
ASPN asporin 1.566
GDF7 growth differentiation factor 7 1.563
FGF8 fibroblast growth factor 8 (androgen-induced) 1.56
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3 1.557
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.556
COMP cartilage oligomeric matrix protein 1.555
FGF7 fibroblast growth factor 7 1.555
RARG retinoic acid receptor, gamma 1.554
BGN biglycan 1.554
FGFR2 fibroblast growth factor receptor 2 1.544
FGF10 fibroblast growth factor 10 1.543
FGF18 fibroblast growth factor 18 1.543
RPF1 ribosome production factor 1 homolog (S. cerevisiae) 1.543
ANTXR2 anthrax toxin receptor 2 1.54
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 1.536
FGF3 fibroblast growth factor 3 1.532
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.532
MRAP melanocortin 2 receptor accessory protein 1.523
FGF4 fibroblast growth factor 4 1.522
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.522
FGF16 fibroblast growth factor 16 1.519
FGF20 fibroblast growth factor 20 1.516
FGF22 fibroblast growth factor 22 1.514
FGF6 fibroblast growth factor 6 1.512
FGF5 fibroblast growth factor 5 1.511
CSF1 colony stimulating factor 1 (macrophage) 1.508
FGF17 fibroblast growth factor 17 1.507
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.507
SHOX2 short stature homeobox 2 1.505
SCX scleraxis basic helix-loop-helix transcription factor 1.503
AOC3 amine oxidase, copper containing 3 1.502
THY1 Thy-1 cell surface antigen 1.499
FGF23 fibroblast growth factor 23 1.486
IL2 interleukin 2 1.485
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.483
IL23A interleukin 23, alpha subunit p19 1.481
CCL2 chemokine (C-C motif) ligand 2 1.477
IGF1 insulin-like growth factor 1 (somatomedin C) 1.476
MKX mohawk homeobox 1.473
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.469
HACD1 3-hydroxyacyl-CoA dehydratase 1 1.459
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 1.457
CXCL8 chemokine (C-X-C motif) ligand 8 1.454
LRP5 low density lipoprotein receptor-related protein 5 1.446
TYK2 tyrosine kinase 2 1.433
ENG endoglin 1.433
TLR4 toll-like receptor 4 1.427
IL18 interleukin 18 1.424
DCN decorin 1.421
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.419
MMP9 matrix metallopeptidase 9 1.418
FGFR1 fibroblast growth factor receptor 1 1.415
FN1 fibronectin 1 1.402
BMP3 bone morphogenetic protein 3 1.399
MSX1 msh homeobox 1 1.398
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 1.396
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 1.395
COL1A2 collagen, type I, alpha 2 1.39
IL6R interleukin 6 receptor 1.385
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.385
DKK2 dickkopf WNT signaling pathway inhibitor 2 1.385
PAX9 paired box 9 1.38
KIR3DL2 killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 2 1.378
PRTN3 proteinase 3 1.377
CHRD chordin 1.377
JAK1 Janus kinase 1 1.374
PTGER4 prostaglandin E receptor 4 (subtype EP4) 1.369
DKK4 dickkopf WNT signaling pathway inhibitor 4 1.368
KIF21B kinesin family member 21B 1.355
RUNX3 runt-related transcription factor 3 1.348
ZER1 zyg-11 related, cell cycle regulator 1.346
WNT3A wingless-type MMTV integration site family, member 3A 1.344
OSM oncostatin M 1.342
CD80 CD80 molecule 1.341
JAK2 Janus kinase 2 1.341
SMAD5 SMAD family member 5 1.34
CD19 CD19 molecule 1.337
C20ORF203 chromosome 20 open reading frame 203 1.337
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.336
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 1.335
PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 1.331
MMP1 matrix metallopeptidase 1 1.33
CRTAP cartilage associated protein 1.329
BMP5 bone morphogenetic protein 5 1.328
FST follistatin 1.327
CARD9 caspase recruitment domain family, member 9 1.324
HAPLN1 hyaluronan and proteoglycan link protein 1 1.321
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.316
LRP6 low density lipoprotein receptor-related protein 6 1.313
IL7 interleukin 7 1.311
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.31
CD28 CD28 molecule 1.309
CPNE7 copine VII 1.306
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 1.302
SFRP1 secreted frizzled-related protein 1 1.298
TAC1 tachykinin, precursor 1 1.298
CD44 CD44 molecule (Indian blood group) 1.296
ENAM enamelin 1.292
IL1R1 interleukin 1 receptor, type I 1.288
ZFP36 ZFP36 ring finger protein 1.288
WNT5A wingless-type MMTV integration site family, member 5A 1.282
NKX3-2 NK3 homeobox 2 1.276
CD34 CD34 molecule 1.274
KL klotho 1.267
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.263
IL1RN interleukin 1 receptor antagonist 1.26
CCN2 cellular communication network factor 2 1.258
TBX21 T-box 21 1.248
GDF2 growth differentiation factor 2 1.247
PRG4 proteoglycan 4 1.24
FRZB frizzled-related protein 1.239
CD86 CD86 molecule 1.239
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.238
CD68 CD68 molecule 1.237
ZNF658 zinc finger protein 658 1.237
BMPR1B bone morphogenetic protein receptor, type IB 1.236
FGFR3 fibroblast growth factor receptor 3 1.233
TLR2 toll-like receptor 2 1.227
ELN elastin 1.225
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.223
SHOX short stature homeobox 1.218
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.216
IL13 interleukin 13 1.211
CCL3 chemokine (C-C motif) ligand 3 1.208
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.208
JUN jun proto-oncogene 1.205
DLX3 distal-less homeobox 3 1.203
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.201
PECAM1 platelet/endothelial cell adhesion molecule 1 1.198
ODAM odontogenic, ameloblast asssociated 1.195
TBKBP1 TBK1 binding protein 1 1.194
DLX2 distal-less homeobox 2 1.19
BMP1 bone morphogenetic protein 1 1.189
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 1.186
RARB retinoic acid receptor, beta 1.18
HLA-C major histocompatibility complex, class I, C 1.175
PADI4 peptidyl arginine deiminase, type IV 1.175
FGF13 fibroblast growth factor 13 1.174
JAK3 Janus kinase 3 1.165
CXCL12 chemokine (C-X-C motif) ligand 12 1.165
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.162
MMP2 matrix metallopeptidase 2 1.16
BMPR1A bone morphogenetic protein receptor, type IA 1.16
SLC34A3 solute carrier family 34 (type II sodium/phosphate cotransporter), member 3 1.159
WNT10B wingless-type MMTV integration site family, member 10B 1.152
CASR calcium-sensing receptor 1.149
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 1.147
SELL selectin L 1.14
CCR6 chemokine (C-C motif) receptor 6 1.138
B2M beta-2-microglobulin 1.137
SMAD9 SMAD family member 9 1.134
TAGLN transgelin 1.132
MAPK3 mitogen-activated protein kinase 3 1.126
NOD2 nucleotide-binding oligomerization domain containing 2 1.125
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.124
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 1.121
CCRL2 chemokine (C-C motif) receptor-like 2 1.119
FANCL Fanconi anemia, complementation group L 1.117
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 1.116
COL6A1 collagen, type VI, alpha 1 1.111
TUFT1 tuftelin 1 1.111
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 1.11
CYP27B1 cytochrome P450, family 27, subfamily B, polypeptide 1 1.11
SHH sonic hedgehog 1.11
IL1R2 interleukin 1 receptor, type II 1.109
ALPP alkaline phosphatase, placental 1.103
HDAC4 histone deacetylase 4 1.093
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.093
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3 1.09
BARX1 BARX homeobox 1 1.09
SMAD2 SMAD family member 2 1.089
CALCR calcitonin receptor 1.089
FOS FBJ murine osteosarcoma viral oncogene homolog 1.088
PRRX1 paired related homeobox 1 1.083
ZMIZ1 zinc finger, MIZ-type containing 1 1.081
COL11A1 collagen, type XI, alpha 1 1.08
CCK cholecystokinin 1.079
OSCAR osteoclast associated, immunoglobulin-like receptor 1.076
WNT1 wingless-type MMTV integration site family, member 1 1.074
CD69 CD69 molecule 1.07
OMD osteomodulin 1.067
GNAS GNAS complex locus 1.067
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.066
EGF epidermal growth factor 1.065
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.064
IL15 interleukin 15 1.059
IL33 interleukin 33 1.059
SAA1 serum amyloid A1 1.054
CA2 carbonic anhydrase II 1.051
IL17RC interleukin 17 receptor C 1.051
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.051
RGL1 ral guanine nucleotide dissociation stimulator-like 1 1.049
OSTM1 osteopetrosis associated transmembrane protein 1 1.048
AGBL2 ATP/GTP binding protein-like 2 1.048
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.047
IL5 interleukin 5 1.046
AXIN2 axin 2 1.045
INS insulin 1.041
SAA2 serum amyloid A2 1.041
DNAH8 dynein, axonemal, heavy chain 8 1.039
GLI1 GLI family zinc finger 1 1.038
PPARG peroxisome proliferator-activated receptor gamma 1.038
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 1.038
TIMP1 TIMP metallopeptidase inhibitor 1 1.035
ACVR1C activin A receptor, type IC 1.035
GPR25 G protein-coupled receptor 25 1.033
SMAD4 SMAD family member 4 1.033
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.033
C5AR1 complement component 5a receptor 1 1.03
LEP leptin 1.024
ALPI alkaline phosphatase, intestinal 1.022
GREM2 gremlin 2, DAN family BMP antagonist 1.022
CTSS cathepsin S 1.02
ANO6 anoctamin 6 1.02
MCAM melanoma cell adhesion molecule 1.017
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 1.017
LUM lumican 1.014
IL3 interleukin 3 1.013
CCL5 chemokine (C-C motif) ligand 5 1.013
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.013
IL7R interleukin 7 receptor 1.012
PADI2 peptidyl arginine deiminase, type II 1.012
MMP8 matrix metallopeptidase 8 1.009
TYROBP TYRO protein tyrosine kinase binding protein 1.007
CXCL5 chemokine (C-X-C motif) ligand 5 1.005
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.004
CCL7 chemokine (C-C motif) ligand 7 1.004
VCAM1 vascular cell adhesion molecule 1 1.003
CLCN7 chloride channel, voltage-sensitive 7 1.0