Antiphospholipid Syndrome Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A hypersensitivity reaction type II disease that is characterized by recurrent venous or arterial thrombosis and/or fetal losses associated with characteristic elevated levels of antibodies directed against membrane anionic phospholipids (anticardiolipin). (Human Disease Ontology, DOID_2988)
External Link https://www.disgenet.org/browser/0/1/0/C0085278
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Genes

95 genes associated with the disease Antiphospholipid Syndrome in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
ACR acrosin
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13
ADIPOQ adiponectin, C1Q and collagen domain containing
AGER advanced glycosylation end product-specific receptor
AMH anti-Mullerian hormone
ANXA2 annexin A2
ANXA5 annexin A5
ANXA8 annexin A8
ANXA8L1 annexin A8-like 1
APOH apolipoprotein H (beta-2-glycoprotein I)
AQP4 aquaporin 4
ATXN2 ataxin 2
B2M beta-2-microglobulin
CALR calreticulin
CCL2 chemokine (C-C motif) ligand 2
CD1D CD1d molecule
CD36 CD36 molecule (thrombospondin receptor)
CPB2 carboxypeptidase B2 (plasma)
CRP C-reactive protein, pentraxin-related
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL8 chemokine (C-X-C motif) ligand 8
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial
EDN1 endothelin 1
EMD emerin
F10 coagulation factor X
F2 coagulation factor II (thrombin)
F2RL1 coagulation factor II (thrombin) receptor-like 1
F3 coagulation factor III (thromboplastin, tissue factor)
F5 coagulation factor V (proaccelerin, labile factor)
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32)
FGA fibrinogen alpha chain
FOXP3 forkhead box P3
FRMD4A FERM domain containing 4A
GP1BA glycoprotein Ib (platelet), alpha polypeptide
GPI glucose-6-phosphate isomerase
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HMGB1 high mobility group box 1
IDS iduronate 2-sulfatase
IFNG interferon, gamma
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP1 insulin-like growth factor binding protein 1
IL1B interleukin 1, beta
IL21 interleukin 21
KLK3 kallikrein-related peptidase 3
LCT lactase
LGALS9 lectin, galactoside-binding, soluble, 9
LPA lipoprotein, Lp(a)
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
MBL2 mannose-binding lectin (protein C) 2, soluble
MOK MOK protein kinase
MPL MPL proto-oncogene, thrombopoietin receptor
MSN moesin
MTHFR methylenetetrahydrofolate reductase (NAD(P)H)
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYD88 myeloid differentiation primary response 88
NOS3 nitric oxide synthase 3 (endothelial cell)
NR1I2 nuclear receptor subfamily 1, group I, member 2
PC pyruvate carboxylase
PF4 platelet factor 4
PLAT plasminogen activator, tissue
PLG plasminogen
PLSCR1 phospholipid scramblase 1
PON1 paraoxonase 1
PPARG peroxisome proliferator-activated receptor gamma
PROCR protein C receptor, endothelial
PROS1 protein S (alpha)
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
PTPRO protein tyrosine phosphatase, receptor type, O
RAB4A RAB4A, member RAS oncogene family
RO60 Ro60, Y RNA binding protein
S100A10 S100 calcium binding protein A10
SELP selectin P (granule membrane protein 140kDa, antigen CD62)
SELPLG selectin P ligand
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SH2B2 SH2B adaptor protein 2
SH2B3 SH2B adaptor protein 3
SLC52A1 solute carrier family 52 (riboflavin transporter), member 1
SSB Sjogren syndrome antigen B (autoantigen La)
SYCP2L synaptonemal complex protein 2-like
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBD thrombomodulin
TLR4 toll-like receptor 4
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TREX1 three prime repair exonuclease 1
TRIM21 tripartite motif containing 21
TSHR thyroid stimulating hormone receptor
VIM vimentin
VWF von Willebrand factor