Aortic Valve Calcification Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description Deposition of calcium salts in the aortic valve. (Human Phenotype Ontology, HP_0004380)
External Link https://www.disgenet.org/browser/0/1/0/C0428791
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Genes

72 genes associated with the disease Aortic Valve Calcification in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACE angiotensin I converting enzyme
AGER advanced glycosylation end product-specific receptor
AHSG alpha-2-HS-glycoprotein
AKT1 v-akt murine thymoma viral oncogene homolog 1
ANXA6 annexin A6
APLN apelin
APOB apolipoprotein B
APOE apolipoprotein E
BSG basigin (Ok blood group)
CCL2 chemokine (C-C motif) ligand 2
CCR2 chemokine (C-C motif) receptor 2
CD40LG CD40 ligand
CD44 CD44 molecule (Indian blood group)
CNN2 calponin 2
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
COX2
CRP C-reactive protein, pentraxin-related
DDIT3 DNA-damage-inducible transcript 3
DPP4 dipeptidyl-peptidase 4
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1
F10 coagulation factor X
FGF23 fibroblast growth factor 23
GATA5 GATA binding protein 5
GBA glucosidase, beta, acid
HDAC6 histone deacetylase 6
HGD homogentisate 1,2-dioxygenase
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGB1 high mobility group box 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
ICAM1 intercellular adhesion molecule 1
IFIH1 interferon induced with helicase C domain 1
IFNA1 interferon, alpha 1
IFNA13 interferon, alpha 13
IL6 interleukin 6
LDLR low density lipoprotein receptor
LMNA lamin A/C
LPA lipoprotein, Lp(a)
LRP5 low density lipoprotein receptor-related protein 5
MEIS2 Meis homeobox 2
METTL3 methyltransferase like 3
MGP matrix Gla protein
MMP9 matrix metallopeptidase 9
MOK MOK protein kinase
NKX2-5 NK2 homeobox 5
NOS3 nitric oxide synthase 3 (endothelial cell)
NOTCH1 notch 1
NPR1 natriuretic peptide receptor 1
NT5E 5'-nucleotidase, ecto (CD73)
PON1 paraoxonase 1
PTH parathyroid hormone
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RUNX2 runt-related transcription factor 2
SELE selectin E
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SMAD6 SMAD family member 6
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STS steroid sulfatase (microsomal), isozyme S
TNF tumor necrosis factor
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TP53 tumor protein p53
TTR transthyretin
TUG1 taurine up-regulated 1 (non-protein coding)
UCMA upper zone of growth plate and cartilage matrix associated
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WNT11 wingless-type MMTV integration site family, member 11