Apalutamide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Apalutamide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DST dystonin 0.071963
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0689528
DPH6 diphthamine biosynthesis 6 0.0686812
AKAP12 A kinase (PRKA) anchor protein 12 0.0642037
GULP1 GULP, engulfment adaptor PTB domain containing 1 0.0527975
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0464949
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0452519
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0432771
MEIS2 Meis homeobox 2 0.0429766
NRIP1 nuclear receptor interacting protein 1 0.0412757
SOS1 son of sevenless homolog 1 (Drosophila) 0.0403398
ITPRID2 ITPR interacting domain containing 2 0.0387871
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0376733
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0375609
TLE4 transducin-like enhancer of split 4 0.0361981
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0349204
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0346293
ANGPT1 angiopoietin 1 0.0321262
VMP1 vacuole membrane protein 1 0.0314492
FNDC3B fibronectin type III domain containing 3B 0.0287328
NCAM2 neural cell adhesion molecule 2 0.0283083
SYT1 synaptotagmin I 0.0282933
CD36 CD36 molecule (thrombospondin receptor) 0.0280624
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0278336
SMYD3 SET and MYND domain containing 3 0.027543
PHF3 PHD finger protein 3 0.0267309
PTEN phosphatase and tensin homolog 0.0264297
LINGO2 leucine rich repeat and Ig domain containing 2 0.0257257
BCAS3 breast carcinoma amplified sequence 3 0.0251728
ZFC3H1 zinc finger, C3H1-type containing 0.0245333
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0243214
ZBTB20 zinc finger and BTB domain containing 20 0.0242434
HELZ helicase with zinc finger 0.0237609
AUTS2 autism susceptibility candidate 2 0.0237306
ADARB1 adenosine deaminase, RNA-specific, B1 0.0236818
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0235524
YEATS2 YEATS domain containing 2 0.0234988
FAM13A family with sequence similarity 13, member A 0.0233795
UNC5C unc-5 homolog C (C. elegans) 0.0232172
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0226982
ANTXR1 anthrax toxin receptor 1 0.0225242
EPHA3 EPH receptor A3 0.0223349
ADGRG6 adhesion G protein-coupled receptor G6 0.0222177
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0211775
PRKD1 protein kinase D1 0.0210546
MBNL2 muscleblind-like splicing regulator 2 0.0207737
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2 0.0206485
NBEA neurobeachin 0.0199873
PCBP3 poly(rC) binding protein 3 0.0197216
PTPRE protein tyrosine phosphatase, receptor type, E 0.0195287
PELI1 pellino E3 ubiquitin protein ligase 1 0.0194619
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.019383
TRIO trio Rho guanine nucleotide exchange factor 0.0191725
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0191172
PLPP1 phospholipid phosphatase 1 0.0190804
RNF213 ring finger protein 213 0.0189537
NREP neuronal regeneration related protein 0.018937
AHR aryl hydrocarbon receptor 0.0188059
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0188035
ATRNL1 attractin-like 1 0.0186049
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0183461
KDM4C lysine (K)-specific demethylase 4C 0.018105
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0180416
XRN1 5'-3' exoribonuclease 1 0.0180376
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0180295
NAMPT nicotinamide phosphoribosyltransferase 0.0172806
SLC35F5 solute carrier family 35, member F5 0.0169961
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0163905
NEK7 NIMA-related kinase 7 0.0161829
MAP1B microtubule-associated protein 1B 0.0161487
FLT1 fms-related tyrosine kinase 1 0.0161125
XPO1 exportin 1 0.0160508
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0159229
CHD9 chromodomain helicase DNA binding protein 9 0.0158785
RUNX1 runt-related transcription factor 1 0.0156803
GLI3 GLI family zinc finger 3 0.0156592
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0148725
WDFY3 WD repeat and FYVE domain containing 3 0.0147976
CEMIP2 cell migration inducing hyaluronidase 2 0.0147955
GHR growth hormone receptor 0.0147835
PBX1 pre-B-cell leukemia homeobox 1 0.0145819
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0145621
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.014558
CDK19 cyclin-dependent kinase 19 0.0145276
TOX thymocyte selection-associated high mobility group box 0.0143733
NFE2L1 nuclear factor, erythroid 2-like 1 0.0143303
PRRC2B proline-rich coiled-coil 2B 0.0141189
SNX13 sorting nexin 13 0.0140611
LIMCH1 LIM and calponin homology domains 1 0.0139179
AMOTL1 angiomotin like 1 0.0138519
NCOR2 nuclear receptor corepressor 2 0.0138296
MYO9A myosin IXA 0.0137692
MTUS1 microtubule associated tumor suppressor 1 0.0137626
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.013753
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0137426
FAT4 FAT atypical cadherin 4 0.0137355
FMN1 formin 1 0.013499
PSD3 pleckstrin and Sec7 domain containing 3 0.0134916
EFNA5 ephrin-A5 0.0133094
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0132713

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.22497
IGF2 insulin-like growth factor 2 -0.174185
PTMA prothymosin, alpha -0.166338
VIM vimentin -0.146098
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.112168
RPL23 ribosomal protein L23 -0.0969733
RPS6 ribosomal protein S6 -0.0966656
RPL35A ribosomal protein L35a -0.0940379
RPL19 ribosomal protein L19 -0.0905624
ACTG1 actin gamma 1 -0.0893384
TPT1 tumor protein, translationally-controlled 1 -0.0850132
COL1A1 collagen, type I, alpha 1 -0.0786808
RPLP1 ribosomal protein, large, P1 -0.0740762
RPS24 ribosomal protein S24 -0.0733187
TMSB10 thymosin beta 10 -0.0710162
RPL37A ribosomal protein L37a -0.0669089
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0660503
RPL26 ribosomal protein L26 -0.0648655
CRH corticotropin releasing hormone -0.0605386
RPL34 ribosomal protein L34 -0.0583818
RPS12 ribosomal protein S12 -0.0583481
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0565563
EIF1 eukaryotic translation initiation factor 1 -0.0561192
RPS8 ribosomal protein S8 -0.0550338
RPS19 ribosomal protein S19 -0.052054
RPL38 ribosomal protein L38 -0.0497197
RPS3 ribosomal protein S3 -0.0490072
FTL ferritin, light polypeptide -0.0489604
B2M beta-2-microglobulin -0.048634
EXT1 exostosin glycosyltransferase 1 -0.0483535
RPL32 ribosomal protein L32 -0.0460011
GNAS GNAS complex locus -0.0457779
RPL12 ribosomal protein L12 -0.0436279
RPL31 ribosomal protein L31 -0.043298
S100A9 S100 calcium binding protein A9 -0.0426708
RPS25 ribosomal protein S25 -0.0406084
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0404112
RPS14 ribosomal protein S14 -0.039783
RPL36 ribosomal protein L36 -0.0394763
RPLP0 ribosomal protein, large, P0 -0.0377554
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0372111
RPL37 ribosomal protein L37 -0.0370129
RPS17 ribosomal protein S17 -0.0366616
RPL7A ribosomal protein L7a -0.0363693
RPS23 ribosomal protein S23 -0.0359524
RPS27A ribosomal protein S27a -0.0351374
IER3 immediate early response 3 -0.0338517
RPS27 ribosomal protein S27 -0.0336692
RPS16 ribosomal protein S16 -0.0334474
VCL vinculin -0.0328463
PKM pyruvate kinase, muscle -0.0321684
RPS11 ribosomal protein S11 -0.0316861
RPS21 ribosomal protein S21 -0.0316658
VDAC1 voltage-dependent anion channel 1 -0.0308286
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0307262
NALF1 NALCN channel auxiliary factor 1 -0.0303584
RPS29 ribosomal protein S29 -0.0301314
RPL9 ribosomal protein L9 -0.0295644
COL3A1 collagen, type III, alpha 1 -0.0291836
DCAF7 DDB1 and CUL4 associated factor 7 -0.0290917
RPL11 ribosomal protein L11 -0.0288843
RPS13 ribosomal protein S13 -0.0288549
S100A6 S100 calcium binding protein A6 -0.0286368
H3-3B H3.3 histone B -0.0286114
LMNA lamin A/C -0.0284541
RPL30 ribosomal protein L30 -0.0283963
SOX4 SRY (sex determining region Y)-box 4 -0.0283761
RPLP2 ribosomal protein, large, P2 -0.028356
RACK1 receptor for activated C kinase 1 -0.0271586
RPL27 ribosomal protein L27 -0.0270644
KPNB1 karyopherin (importin) beta 1 -0.0267207
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0263531
NAP1L1 nucleosome assembly protein 1-like 1 -0.0263401
RSL1D1 ribosomal L1 domain containing 1 -0.0253886
RPS5 ribosomal protein S5 -0.0253616
CCND1 cyclin D1 -0.0252127
RPL18 ribosomal protein L18 -0.0250166
RPL35 ribosomal protein L35 -0.0249604
RPL8 ribosomal protein L8 -0.02447
RPL28 ribosomal protein L28 -0.0239197
EGR1 early growth response 1 -0.0238051
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0237829
SLC38A2 solute carrier family 38, member 2 -0.02378
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0232598
RAB7A RAB7A, member RAS oncogene family -0.0230263
CBX3 chromobox homolog 3 -0.0230083
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0229599
TBX2 T-box 2 -0.0228515
STC1 stanniocalcin 1 -0.0227254
RPL5 ribosomal protein L5 -0.0226505
RPL7 ribosomal protein L7 -0.0223699
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0222628
ARID4B AT rich interactive domain 4B (RBP1-like) -0.022202
HILPDA hypoxia inducible lipid droplet-associated -0.0216932
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0213466
THSD4 thrombospondin, type I, domain containing 4 -0.0211221
TPI1 triosephosphate isomerase 1 -0.0209716
RPL13A ribosomal protein L13a -0.0208815
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0207488
RAD21 RAD21 homolog (S. pombe) -0.0207452