Apalutamide_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Apalutamide_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0824915
ARHGAP26 Rho GTPase activating protein 26 0.0754729
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.063879
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.058418
BTBD9 BTB (POZ) domain containing 9 0.0582318
EPSTI1 epithelial stromal interaction 1 (breast) 0.0544371
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0527878
NCKAP5 NCK-associated protein 5 0.0502458
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0485705
SPATA13 spermatogenesis associated 13 0.046176
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0449078
LMO7 LIM domain 7 0.0403916
ITGA6 integrin, alpha 6 0.0395904
ATP10B ATPase, class V, type 10B 0.0376736
RUNX1 runt-related transcription factor 1 0.0374
PTBP3 polypyrimidine tract binding protein 3 0.0365026
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0351653
MECOM MDS1 and EVI1 complex locus 0.0334549
PRKCA protein kinase C, alpha 0.033163
FMN1 formin 1 0.0331458
RNF43 ring finger protein 43 0.0330476
ETV6 ets variant 6 0.0323746
MEIS2 Meis homeobox 2 0.0322877
SORBS1 sorbin and SH3 domain containing 1 0.0316966
TC2N tandem C2 domains, nuclear 0.0314037
FAT1 FAT atypical cadherin 1 0.0310959
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0306326
MAN1A1 mannosidase, alpha, class 1A, member 1 0.030559
TSHZ2 teashirt zinc finger homeobox 2 0.0299361
NKD1 naked cuticle homolog 1 (Drosophila) 0.0296992
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0296685
NRIP1 nuclear receptor interacting protein 1 0.0293738
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0292992
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.0291211
MX1 MX dynamin-like GTPase 1 0.0290459
PRELID2 PRELI domain containing 2 0.0287887
PLSCR1 phospholipid scramblase 1 0.0283951
EHF ets homologous factor 0.0280051
MACC1 metastasis associated in colon cancer 1 0.0274329
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0269892
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0269586
PRKCE protein kinase C, epsilon 0.0268308
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0266346
EPHB2 EPH receptor B2 0.0256227
SH3PXD2A SH3 and PX domains 2A 0.0253908
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0252871
STK24 serine/threonine kinase 24 0.0252015
ZBTB20 zinc finger and BTB domain containing 20 0.0246706
DSPP dentin sialophosphoprotein 0.0242561
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0239977
UTRN utrophin 0.0236141
ARHGAP32 Rho GTPase activating protein 32 0.0234717
ALPK1 alpha-kinase 1 0.0234086
BCLAF1 BCL2-associated transcription factor 1 0.0233903
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0233583
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0232809
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0232515
IFNGR1 interferon gamma receptor 1 0.0231416
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0229472
FOXP1 forkhead box P1 0.0226055
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0222736
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0219358
TMEM62 transmembrane protein 62 0.0218507
GMDS GDP-mannose 4,6-dehydratase 0.0214213
PDZD8 PDZ domain containing 8 0.0210505
ADD3 adducin 3 (gamma) 0.0207742
OARD1 O-acyl-ADP-ribose deacylase 1 0.0206426
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit 0.0204236
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.020411
ZMYM2 zinc finger, MYM-type 2 0.0203625
MSI2 musashi RNA-binding protein 2 0.0203599
ETNK1 ethanolamine kinase 1 0.02026
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0198765
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0194357
ABHD2 abhydrolase domain containing 2 0.0191893
PRSS3 protease, serine, 3 0.0191067
ERBIN erbb2 interacting protein 0.0190683
ITGA1 integrin, alpha 1 0.0190272
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0189971
IGF1R insulin-like growth factor 1 receptor 0.0189847
SCAPER S-phase cyclin A-associated protein in the ER 0.0188859
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0187307
LPP LIM domain containing preferred translocation partner in lipoma 0.0182743
AOPEP aminopeptidase O (putative) 0.0182709
CEMIP2 cell migration inducing hyaluronidase 2 0.0181925
CARMIL1 capping protein regulator and myosin 1 linker 1 0.0181705
PHF3 PHD finger protein 3 0.0179279
SERINC5 serine incorporator 5 0.0178201
GOLM2 golgi membrane protein 2 0.0177035
EXOC4 exocyst complex component 4 0.0173219
STK39 serine threonine kinase 39 0.0171361
DGKH diacylglycerol kinase, eta 0.0169922
VMP1 vacuole membrane protein 1 0.0169669
MLPH melanophilin 0.0169658
KIAA1217 KIAA1217 0.0169414
ARGLU1 arginine and glutamate rich 1 0.0168394
PROX1 prospero homeobox 1 0.0167651
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0167242
KLF5 Kruppel-like factor 5 (intestinal) 0.016724
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic 0.0165447

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.200781
PTMA prothymosin, alpha -0.128225
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121273
B2M beta-2-microglobulin -0.11581
LCN2 lipocalin 2 -0.0860387
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0838439
FTL ferritin, light polypeptide -0.081362
RPL35A ribosomal protein L35a -0.075668
EGR1 early growth response 1 -0.0752078
HLA-B major histocompatibility complex, class I, B -0.0717106
ACTG1 actin gamma 1 -0.0709737
LYZ lysozyme -0.0632687
RPL34 ribosomal protein L34 -0.0611511
NDRG1 N-myc downstream regulated 1 -0.0587615
LOC102724023 ES1 protein homolog, mitochondrial -0.0567479
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0554715
PERP PERP, TP53 apoptosis effector -0.0549634
CANX calnexin -0.0521698
RPL23 ribosomal protein L23 -0.0513075
TMSB10 thymosin beta 10 -0.0503551
UBC ubiquitin C -0.0482751
RAB7A RAB7A, member RAS oncogene family -0.0482529
EIF1 eukaryotic translation initiation factor 1 -0.0473
IFI6 interferon, alpha-inducible protein 6 -0.0470491
RPS24 ribosomal protein S24 -0.0460002
AREG amphiregulin -0.0453993
INTS6 integrator complex subunit 6 -0.045011
RPL7L1 ribosomal protein L7-like 1 -0.0450021
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0441578
PKM pyruvate kinase, muscle -0.0432464
MUC20 mucin 20, cell surface associated -0.0421766
GCLC glutamate-cysteine ligase, catalytic subunit -0.0418963
RPLP1 ribosomal protein, large, P1 -0.0415346
RPS6 ribosomal protein S6 -0.0415241
TM4SF1 transmembrane 4 L six family member 1 -0.0409456
RPL31 ribosomal protein L31 -0.0399465
RPL19 ribosomal protein L19 -0.0397163
MT2A metallothionein 2A -0.0359964
HLA-A major histocompatibility complex, class I, A -0.0350291
HLA-E major histocompatibility complex, class I, E -0.0346529
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0346526
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0344893
S100A6 S100 calcium binding protein A6 -0.0344859
RPS25 ribosomal protein S25 -0.0336217
LOC112694756 uncharaterized LOC112694756 -0.0330354
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0328554
IER3 immediate early response 3 -0.0322487
AHI1 Abelson helper integration site 1 -0.0319537
RPS8 ribosomal protein S8 -0.0312419
WSB1 WD repeat and SOCS box containing 1 -0.0312113
MORF4L2 mortality factor 4 like 2 -0.0309866
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0308458
RPL37 ribosomal protein L37 -0.0308294
HM13 histocompatibility (minor) 13 -0.0305472
RPS29 ribosomal protein S29 -0.0304786
S100P S100 calcium binding protein P -0.0303619
JUN jun proto-oncogene -0.0302684
SLC38A1 solute carrier family 38, member 1 -0.0300888
MCL1 myeloid cell leukemia 1 -0.029306
FTH1 ferritin, heavy polypeptide 1 -0.0290832
RPLP0 ribosomal protein, large, P0 -0.0289943
RPL7A ribosomal protein L7a -0.0289486
RPL9 ribosomal protein L9 -0.0288254
IGFBP3 insulin-like growth factor binding protein 3 -0.0288118
SLC38A2 solute carrier family 38, member 2 -0.0286779
PGK1 phosphoglycerate kinase 1 -0.0286709
RPL11 ribosomal protein L11 -0.0286128
RPS27 ribosomal protein S27 -0.0285877
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0282025
KPNB1 karyopherin (importin) beta 1 -0.0281005
RPS16 ribosomal protein S16 -0.0280867
SP100 SP100 nuclear antigen -0.0280506
RPS13 ribosomal protein S13 -0.0274895
RPL26 ribosomal protein L26 -0.0274253
VCL vinculin -0.0271609
HLA-C major histocompatibility complex, class I, C -0.0265849
VDAC1 voltage-dependent anion channel 1 -0.026472
RPLP2 ribosomal protein, large, P2 -0.0262889
PRRC2C proline-rich coiled-coil 2C -0.0260642
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0259918
RACK1 receptor for activated C kinase 1 -0.0258721
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.025868
RPS19 ribosomal protein S19 -0.0257782
UBE2B ubiquitin-conjugating enzyme E2B -0.02576
RPS23 ribosomal protein S23 -0.0257452
RPL37A ribosomal protein L37a -0.0254613
EZR ezrin -0.024518
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0242115
RPS12 ribosomal protein S12 -0.0241825
S100A9 S100 calcium binding protein A9 -0.0240556
SEC31A SEC31 homolog A (S. cerevisiae) -0.0240292
ENO1 enolase 1, (alpha) -0.0239635
C6ORF132 chromosome 6 open reading frame 132 -0.0238713
RPS27A ribosomal protein S27a -0.0236763
PIBF1 progesterone immunomodulatory binding factor 1 -0.0236634
STAU1 staufen double-stranded RNA binding protein 1 -0.0235485
VIM vimentin -0.0233534
RPS3 ribosomal protein S3 -0.0233112
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0232435
H3-3B H3.3 histone B -0.022891