Apalutamide_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Apalutamide_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.225005
APOB apolipoprotein B 0.144365
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.141759
DSPP dentin sialophosphoprotein 0.11024
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0796365
ERRFI1 ERBB receptor feedback inhibitor 1 0.0778952
SAMD4A sterile alpha motif domain containing 4A 0.0714769
DST dystonin 0.0651762
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0626666
LRMDA leucine rich melanocyte differentiation associated 0.0625995
MAML2 mastermind-like 2 (Drosophila) 0.057224
EHBP1 EH domain binding protein 1 0.0517425
DOCK4 dedicator of cytokinesis 4 0.0497942
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0492683
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0490332
GPC6 glypican 6 0.0485679
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0475825
FAT1 FAT atypical cadherin 1 0.0450585
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0444755
FRMD5 FERM domain containing 5 0.0436629
ELL2 elongation factor, RNA polymerase II, 2 0.0427875
FNDC3B fibronectin type III domain containing 3B 0.0425228
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0424862
RBM39 RNA binding motif protein 39 0.0404475
NKD1 naked cuticle homolog 1 (Drosophila) 0.0397568
ATXN1 ataxin 1 0.0378193
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0364665
VCL vinculin 0.0358171
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0357272
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.035067
MACF1 microtubule-actin crosslinking factor 1 0.0337717
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0335102
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0328742
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0324796
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.032124
SOX5 SRY (sex determining region Y)-box 5 0.0305076
MBNL3 muscleblind-like splicing regulator 3 0.0297971
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0297509
ARHGAP9 Rho GTPase activating protein 9 0.029462
PEG3 paternally expressed 3 0.0294434
SVIL supervillin 0.0292468
JMJD1C jumonji domain containing 1C 0.029039
ZBTB20 zinc finger and BTB domain containing 20 0.0277257
ASPH aspartate beta-hydroxylase 0.0276502
AFDN afadin, adherens junction formation factor 0.0274949
A2M alpha-2-macroglobulin 0.0270332
APLP2 amyloid beta (A4) precursor-like protein 2 0.0268573
DSCAM Down syndrome cell adhesion molecule 0.0267635
ABTB3 ankyrin repeat and BTB domain containing 3 0.0258992
ITGAV integrin, alpha V 0.0257385
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0256687
LCOR ligand dependent nuclear receptor corepressor 0.0256488
CEMIP2 cell migration inducing hyaluronidase 2 0.0253213
TRIM26 tripartite motif containing 26 0.0252497
SESTD1 SEC14 and spectrin domains 1 0.0250499
PTPRM protein tyrosine phosphatase, receptor type, M 0.0250118
RUNX1 runt-related transcription factor 1 0.0241057
MYH9 myosin, heavy chain 9, non-muscle 0.0235447
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0234408
C3 complement component 3 0.0232506
NRIP1 nuclear receptor interacting protein 1 0.0231858
IGF1R insulin-like growth factor 1 receptor 0.0228649
AHR aryl hydrocarbon receptor 0.0228317
LDHA lactate dehydrogenase A 0.0227668
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0224222
CADM1 cell adhesion molecule 1 0.0222223
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0220503
FOXP1 forkhead box P1 0.0215594
CNKSR3 CNKSR family member 3 0.0215566
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0213921
PTCHD4 patched domain containing 4 0.0213782
SMAD3 SMAD family member 3 0.020984
ITGA1 integrin, alpha 1 0.0204987
TNS1 tensin 1 0.0204294
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0204124
TF transferrin 0.0203193
ITGB5 integrin, beta 5 0.0201672
PHF3 PHD finger protein 3 0.0199467
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 0.0198986
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.01989
KIZ kizuna centrosomal protein 0.0197571
ENO1 enolase 1, (alpha) 0.0196867
YAP1 Yes-associated protein 1 0.0195822
EXT1 exostosin glycosyltransferase 1 0.0195541
GMDS GDP-mannose 4,6-dehydratase 0.0195346
GPC3 glypican 3 0.0195314
MTUS1 microtubule associated tumor suppressor 1 0.0195196
MALT1 MALT1 paracaspase 0.0194543
VMP1 vacuole membrane protein 1 0.0194052
BCL2L1 BCL2-like 1 0.0191233
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0189818
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0189765
FAM135A family with sequence similarity 135, member A 0.018925
PARD3 par-3 family cell polarity regulator 0.0188048
EPAS1 endothelial PAS domain protein 1 0.0184585
MBNL2 muscleblind-like splicing regulator 2 0.0183293
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.017807
TRIO trio Rho guanine nucleotide exchange factor 0.0177666
MALRD1 MAM and LDL receptor class A domain containing 1 0.0177609
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0174684

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.234364
MT2A metallothionein 2A -0.100005
TPT1 tumor protein, translationally-controlled 1 -0.0766907
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0668196
APOA2 apolipoprotein A-II -0.0644047
RPL11 ribosomal protein L11 -0.0513879
RPL37A ribosomal protein L37a -0.0511499
RPS6 ribosomal protein S6 -0.0478035
FTL ferritin, light polypeptide -0.0469001
RPL35A ribosomal protein L35a -0.0453008
RPLP1 ribosomal protein, large, P1 -0.0449299
RPS24 ribosomal protein S24 -0.0448325
TMSB10 thymosin beta 10 -0.0431368
RPS19 ribosomal protein S19 -0.0412348
RPS8 ribosomal protein S8 -0.0411995
RPL31 ribosomal protein L31 -0.0376939
RPS27A ribosomal protein S27a -0.0368724
RPL34 ribosomal protein L34 -0.036635
RPLP2 ribosomal protein, large, P2 -0.0365555
AHSG alpha-2-HS-glycoprotein -0.0361063
RPL23 ribosomal protein L23 -0.0357094
RPS12 ribosomal protein S12 -0.0348911
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0340405
RPS13 ribosomal protein S13 -0.0311137
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 -0.0307453
RPS29 ribosomal protein S29 -0.0295884
RPS14 ribosomal protein S14 -0.0292017
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0290413
DDIT4 DNA-damage-inducible transcript 4 -0.0288399
RPS21 ribosomal protein S21 -0.0286321
RPS23 ribosomal protein S23 -0.0276585
RPL9 ribosomal protein L9 -0.0262229
RPS25 ribosomal protein S25 -0.0259439
PTMA prothymosin, alpha -0.0255819
RPLP0 ribosomal protein, large, P0 -0.0251703
CCL20 chemokine (C-C motif) ligand 20 -0.0246183
NDRG1 N-myc downstream regulated 1 -0.0233199
RPL26 ribosomal protein L26 -0.0230023
RPS3 ribosomal protein S3 -0.021053
RPL5 ribosomal protein L5 -0.0210477
RPL12 ribosomal protein L12 -0.0210057
RPL28 ribosomal protein L28 -0.0209751
RPL19 ribosomal protein L19 -0.0208824
APOE apolipoprotein E -0.0208315
RPL32 ribosomal protein L32 -0.0197659
RACK1 receptor for activated C kinase 1 -0.0197019
RPS10 ribosomal protein S10 -0.0195273
RPL37 ribosomal protein L37 -0.0194629
RPS11 ribosomal protein S11 -0.0190925
S100A9 S100 calcium binding protein A9 -0.0188567
IGFBP1 insulin-like growth factor binding protein 1 -0.01876
RPS16 ribosomal protein S16 -0.0184492
RPL36 ribosomal protein L36 -0.0184299
ACTG1 actin gamma 1 -0.0181746
RPL8 ribosomal protein L8 -0.0181004
RPL38 ribosomal protein L38 -0.0179782
RPS5 ribosomal protein S5 -0.0179718
HMGA1 high mobility group AT-hook 1 -0.0179651
ISG15 ISG15 ubiquitin-like modifier -0.0177885
APOA1 apolipoprotein A-I -0.0177533
IER3 immediate early response 3 -0.0176535
RPL27 ribosomal protein L27 -0.0171229
RPL7A ribosomal protein L7a -0.0168724
LOC112694756 uncharaterized LOC112694756 -0.0168428
RPS17 ribosomal protein S17 -0.0162824
CP ceruloplasmin (ferroxidase) -0.0162747
RPL36A ribosomal protein L36a -0.0160652
RPL15 ribosomal protein L15 -0.015301
GNAS GNAS complex locus -0.0149013
RPL10A ribosomal protein L10a -0.0147516
EIF1 eukaryotic translation initiation factor 1 -0.0146996
IFI6 interferon, alpha-inducible protein 6 -0.0145932
RPS27 ribosomal protein S27 -0.0144682
RPL27A ribosomal protein L27a -0.0143876
EGR1 early growth response 1 -0.0140732
GDF15 growth differentiation factor 15 -0.0134503
RPS20 ribosomal protein S20 -0.0130897
RPL30 ribosomal protein L30 -0.0129014
ETFB electron-transfer-flavoprotein, beta polypeptide -0.0128738
B2M beta-2-microglobulin -0.0128571
RPS15 ribosomal protein S15 -0.0128109
S100P S100 calcium binding protein P -0.012722
APOC1 apolipoprotein C-I -0.012592
IL32 interleukin 32 -0.0124158
RPL35 ribosomal protein L35 -0.0123313
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0121055
ATP5F1E ATP synthase F1 subunit epsilon -0.0117364
IFITM1 interferon induced transmembrane protein 1 -0.0116741
VIM vimentin -0.0115738
AMBP alpha-1-microglobulin/bikunin precursor -0.0113216
UQCRB ubiquinol-cytochrome c reductase binding protein -0.011305
IFITM3 interferon induced transmembrane protein 3 -0.0112557
UBC ubiquitin C -0.0110245
CST3 cystatin C -0.0109122
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0105018
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1 -0.0104136
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0103583
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0101672
S100A6 S100 calcium binding protein A6 -0.0101555
H3-3B H3.3 histone B -0.0100339