| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Apalutamide perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Apalutamide_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ASPH | aspartate beta-hydroxylase | 0.180967 |
| EGFR | epidermal growth factor receptor | 0.165256 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.135918 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.113517 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.109147 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.109082 |
| GRAMD1B | GRAM domain containing 1B | 0.105327 |
| TXNRD1 | thioredoxin reductase 1 | 0.101517 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0889828 |
| LDHA | lactate dehydrogenase A | 0.0801765 |
| SMAD3 | SMAD family member 3 | 0.079111 |
| FAM13A | family with sequence similarity 13, member A | 0.074672 |
| LAMC2 | laminin, gamma 2 | 0.0709631 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0707363 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0680027 |
| PTMA | prothymosin, alpha | 0.0666388 |
| MKI67 | marker of proliferation Ki-67 | 0.0649302 |
| ENO1 | enolase 1, (alpha) | 0.0645583 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0612795 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0553301 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0542391 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0516168 |
| RPS3 | ribosomal protein S3 | 0.0500206 |
| CDCP1 | CUB domain containing protein 1 | 0.049004 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | 0.0489822 |
| LAMB3 | laminin, beta 3 | 0.0487525 |
| DSPP | dentin sialophosphoprotein | 0.0484523 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0475412 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0453351 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0446157 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0435831 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0431669 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0431511 |
| ACTG1 | actin gamma 1 | 0.0425154 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0422931 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0421967 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0416457 |
| CES1 | carboxylesterase 1 | 0.0408238 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0397192 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0396425 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | 0.0395807 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0380745 |
| TMEM45B | transmembrane protein 45B | 0.0361876 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0361332 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0356484 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0349222 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0342831 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0334097 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0328664 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0325108 |
| NGLY1 | N-glycanase 1 | 0.0323068 |
| ARRDC3 | arrestin domain containing 3 | 0.0320116 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0315738 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0314337 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0314275 |
| ANXA2 | annexin A2 | 0.0310846 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | 0.0310176 |
| RNF213 | ring finger protein 213 | 0.0308409 |
| EFNA5 | ephrin-A5 | 0.0307202 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0305249 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0302908 |
| RASA2 | RAS p21 protein activator 2 | 0.0289199 |
| RNF145 | ring finger protein 145 | 0.0286786 |
| TLK1 | tousled-like kinase 1 | 0.0284995 |
| H1-0 | H1.0 linker histone | 0.0284319 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0283815 |
| RPL37A | ribosomal protein L37a | 0.0283526 |
| MT2A | metallothionein 2A | 0.0281585 |
| MLKL | mixed lineage kinase domain-like | 0.0281538 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0278483 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.027713 |
| NCKAP1 | NCK-associated protein 1 | 0.0276577 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0269361 |
| SLCO4A1 | solute carrier organic anion transporter family, member 4A1 | 0.0268858 |
| PKM | pyruvate kinase, muscle | 0.0267762 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0267682 |
| SLMAP | sarcolemma associated protein | 0.0267593 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0267462 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0267424 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0266781 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0266126 |
| TPD52 | tumor protein D52 | 0.0265997 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0263704 |
| KRT18 | keratin 18, type I | 0.0258888 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0251671 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0250763 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0250736 |
| RNF149 | ring finger protein 149 | 0.0248262 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0247981 |
| KRT7 | keratin 7, type II | 0.0247349 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0246632 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0245138 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0244441 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0243863 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | 0.0240808 |
| RBM39 | RNA binding motif protein 39 | 0.0240565 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0240104 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0240097 |
| USP3 | ubiquitin specific peptidase 3 | 0.0237384 |
| ATP13A3 | ATPase type 13A3 | 0.0237086 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.187452 |
| EGR1 | early growth response 1 | -0.0990006 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0836537 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0700474 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0599758 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.053485 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0496573 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0463153 |
| INTS6 | integrator complex subunit 6 | -0.0459921 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0456047 |
| JMJD1C | jumonji domain containing 1C | -0.0423593 |
| NABP1 | nucleic acid binding protein 1 | -0.0403196 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0384537 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0379218 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0368335 |
| TJP1 | tight junction protein 1 | -0.0339596 |
| NSUN6 | NOP2/Sun domain family, member 6 | -0.0328037 |
| TMCO3 | transmembrane and coiled-coil domains 3 | -0.0323681 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0319688 |
| FZR1 | fizzy/cell division cycle 20 related 1 (Drosophila) | -0.0302401 |
| CCNL1 | cyclin L1 | -0.029496 |
| SPAG9 | sperm associated antigen 9 | -0.0289066 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0284027 |
| TRAPPC9 | trafficking protein particle complex 9 | -0.0273508 |
| RAP2B | RAP2B, member of RAS oncogene family | -0.0268479 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0264571 |
| OXSR1 | oxidative stress responsive 1 | -0.0255605 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0253053 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | -0.0245259 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0242871 |
| NBEAL1 | neurobeachin-like 1 | -0.0240512 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.022962 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0228033 |
| HOMER1 | homer scaffolding protein 1 | -0.0226238 |
| DTNA | dystrobrevin, alpha | -0.0220704 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0218231 |
| MCL1 | myeloid cell leukemia 1 | -0.0214233 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | -0.0209377 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0206758 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0205495 |
| UBAP1 | ubiquitin associated protein 1 | -0.0204542 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | -0.0202411 |
| OCLN | occludin | -0.0201511 |
| PTEN | phosphatase and tensin homolog | -0.0200347 |
| ABLIM1 | actin binding LIM protein 1 | -0.0200012 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0199287 |
| BMP6 | bone morphogenetic protein 6 | -0.0199273 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0198046 |
| SYAP1 | synapse associated protein 1 | -0.0196835 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0194869 |
| GOSR2 | golgi SNAP receptor complex member 2 | -0.0194815 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0193369 |
| NPC1 | Niemann-Pick disease, type C1 | -0.018889 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.018837 |
| ST14 | suppression of tumorigenicity 14 (colon carcinoma) | -0.0188081 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0186418 |
| ADAM32 | ADAM metallopeptidase domain 32 | -0.018569 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0184304 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0181465 |
| MGAT4C | MGAT4 family, member C | -0.0180454 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.01799 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0179688 |
| MACC1 | metastasis associated in colon cancer 1 | -0.0175668 |
| TMEM184B | transmembrane protein 184B | -0.0175428 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -0.0171031 |
| VCL | vinculin | -0.0170131 |
| C3ORF52 | chromosome 3 open reading frame 52 | -0.0169718 |
| JUN | jun proto-oncogene | -0.0168899 |
| MORF4L2 | mortality factor 4 like 2 | -0.0168761 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | -0.0165778 |
| HDAC9 | histone deacetylase 9 | -0.0164779 |
| VMP1 | vacuole membrane protein 1 | -0.0164164 |
| EYA2 | EYA transcriptional coactivator and phosphatase 2 | -0.0162849 |
| TES | testin LIM domain protein | -0.0158591 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0156807 |
| C6ORF62 | chromosome 6 open reading frame 62 | -0.0155478 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0153929 |
| DHFR | dihydrofolate reductase | -0.0153475 |
| NTN4 | netrin 4 | -0.015099 |
| FRMD4B | FERM domain containing 4B | -0.0150159 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0146837 |
| WNT2B | wingless-type MMTV integration site family, member 2B | -0.0145119 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0144583 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0144173 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | -0.0143763 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.0141875 |
| CDKL5 | cyclin-dependent kinase-like 5 | -0.0141105 |
| EZR | ezrin | -0.0140777 |
| RB1 | retinoblastoma 1 | -0.0136845 |
| SIK3 | SIK family kinase 3 | -0.0136194 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0132599 |
| MYO1E | myosin IE | -0.0132482 |
| NME7 | NME/NM23 family member 7 | -0.013202 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | -0.0130828 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0130232 |
| FAM193A | family with sequence similarity 193, member A | -0.0129737 |
| SCLT1 | sodium channel and clathrin linker 1 | -0.0128703 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0127791 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0126915 |
| MRPS35 | mitochondrial ribosomal protein S35 | -0.0125494 |
