| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Apalutamide perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Apalutamide_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.202312 |
| FN1 | fibronectin 1 | 0.173254 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.130843 |
| GRB10 | growth factor receptor-bound protein 10 | 0.1025 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0781998 |
| GPC6 | glypican 6 | 0.0692057 |
| HMGA2 | high mobility group AT-hook 2 | 0.0679962 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0677388 |
| FAM20C | family with sequence similarity 20, member C | 0.0609863 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0577357 |
| RAI14 | retinoic acid induced 14 | 0.0572122 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0567911 |
| VIM | vimentin | 0.0551985 |
| PCBP2 | poly(rC) binding protein 2 | 0.0543372 |
| TMSB10 | thymosin beta 10 | 0.0538251 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0527322 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0517592 |
| MAP1B | microtubule-associated protein 1B | 0.0511938 |
| LOX | lysyl oxidase | 0.051102 |
| DST | dystonin | 0.0506719 |
| MECOM | MDS1 and EVI1 complex locus | 0.0490038 |
| DDIT3 | DNA-damage-inducible transcript 3 | 0.0490033 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0480485 |
| MEF2A | myocyte enhancer factor 2A | 0.0478681 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.046614 |
| SYT1 | synaptotagmin I | 0.0450563 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0449069 |
| RUNX2 | runt-related transcription factor 2 | 0.0439846 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0428022 |
| ANXA2 | annexin A2 | 0.0424745 |
| DLG1 | discs, large homolog 1 (Drosophila) | 0.041493 |
| ZNF804A | zinc finger protein 804A | 0.0401582 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0378319 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0364918 |
| ARF4 | ADP-ribosylation factor 4 | 0.0348379 |
| RAD51B | RAD51 paralog B | 0.0347446 |
| EGR1 | early growth response 1 | 0.0339482 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0323551 |
| OXR1 | oxidation resistance 1 | 0.0319707 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.0313139 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 0.0312961 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0308741 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0305932 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0305212 |
| ADD3 | adducin 3 (gamma) | 0.0304308 |
| CDK14 | cyclin-dependent kinase 14 | 0.0303033 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0297906 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0297157 |
| LDHA | lactate dehydrogenase A | 0.0288059 |
| DNER | delta/notch-like EGF repeat containing | 0.0284934 |
| RASAL2 | RAS protein activator like 2 | 0.0282526 |
| TMTC1 | transmembrane and tetratricopeptide repeat containing 1 | 0.0279046 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.0276767 |
| MYADM | myeloid-associated differentiation marker | 0.0276208 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.0272789 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0272087 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0261803 |
| NAV1 | neuron navigator 1 | 0.0259429 |
| VMP1 | vacuole membrane protein 1 | 0.025377 |
| FBN1 | fibrillin 1 | 0.0252006 |
| EXOC4 | exocyst complex component 4 | 0.0250357 |
| EXOC6B | exocyst complex component 6B | 0.0250136 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0248091 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.02448 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0240652 |
| CUX1 | cut-like homeobox 1 | 0.0239593 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0237137 |
| THBS1 | thrombospondin 1 | 0.0235922 |
| RNF213 | ring finger protein 213 | 0.0234454 |
| GLCCI1 | glucocorticoid induced 1 | 0.0230694 |
| EHBP1 | EH domain binding protein 1 | 0.0227502 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0223744 |
| ABCA6 | ATP-binding cassette, sub-family A (ABC1), member 6 | 0.0223347 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0220492 |
| CLIC4 | chloride intracellular channel 4 | 0.0218317 |
| BCAT1 | branched chain amino-acid transaminase 1, cytosolic | 0.0212584 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0211581 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0209973 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0208334 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.0203048 |
| ETV6 | ets variant 6 | 0.0202047 |
| FNBP4 | formin binding protein 4 | 0.0199693 |
| ADAMTS14 | ADAM metallopeptidase with thrombospondin type 1 motif, 14 | 0.0195412 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0194848 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0194483 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0193857 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0192468 |
| CDH13 | cadherin 13 | 0.0191958 |
| SUMF1 | sulfatase modifying factor 1 | 0.0190148 |
| OXSR1 | oxidative stress responsive 1 | 0.0190068 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0189851 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0189673 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0186691 |
| PDGFC | platelet derived growth factor C | 0.0185221 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0181629 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.0181226 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0180948 |
| GLIS3 | GLIS family zinc finger 3 | 0.0180498 |
| RAI1 | retinoic acid induced 1 | 0.0180104 |
| KRT19 | keratin 19, type I | 0.0179195 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SMAD3 | SMAD family member 3 | -0.120825 |
| CD44 | CD44 molecule (Indian blood group) | -0.115621 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.113384 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.104161 |
| MT2A | metallothionein 2A | -0.0990649 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0984239 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.09806 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0966642 |
| EFNA5 | ephrin-A5 | -0.0662826 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0623532 |
| NDRG1 | N-myc downstream regulated 1 | -0.0592551 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0587578 |
| STC1 | stanniocalcin 1 | -0.0571599 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.055974 |
| RPS2 | ribosomal protein S2 | -0.0559645 |
| USP34 | ubiquitin specific peptidase 34 | -0.0559033 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0525554 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.051871 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.050761 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0505172 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0498808 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0496289 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0494995 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0461575 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0459185 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0446442 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0439987 |
| GOLGA4 | golgin A4 | -0.0438602 |
| CDCP1 | CUB domain containing protein 1 | -0.0410201 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0408196 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0403653 |
| CANX | calnexin | -0.0396449 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0387038 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.0381496 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0365793 |
| RUNX1 | runt-related transcription factor 1 | -0.036348 |
| TGM2 | transglutaminase 2 | -0.0356436 |
| TMSB4X | thymosin beta 4, X-linked | -0.0344005 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.033655 |
| GFPT2 | glutamine-fructose-6-phosphate transaminase 2 | -0.0323779 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0321057 |
| APP | amyloid beta (A4) precursor protein | -0.0314713 |
| ZNF638 | zinc finger protein 638 | -0.0311004 |
| ECE1 | endothelin converting enzyme 1 | -0.0310412 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.030385 |
| FBXL13 | F-box and leucine-rich repeat protein 13 | -0.0303574 |
| OGA | O-GlcNAcase | -0.030213 |
| MYO6 | myosin VI | -0.0301883 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0301497 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.029939 |
| RPL4 | ribosomal protein L4 | -0.0294268 |
| RPS12 | ribosomal protein S12 | -0.0291721 |
| DUSP5 | dual specificity phosphatase 5 | -0.0291714 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | -0.0289687 |
| EGFR | epidermal growth factor receptor | -0.0288935 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0276751 |
| RPLP1 | ribosomal protein, large, P1 | -0.0274124 |
| UBC | ubiquitin C | -0.0268851 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0268546 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0268148 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0262351 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0260715 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0259926 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0259519 |
| ZC3H12C | zinc finger CCCH-type containing 12C | -0.0258891 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0258031 |
| NAV2 | neuron navigator 2 | -0.0257939 |
| RBM25 | RNA binding motif protein 25 | -0.0255165 |
| RPS24 | ribosomal protein S24 | -0.0251867 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0251205 |
| CHD1L | chromodomain helicase DNA binding protein 1-like | -0.0251093 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.0250747 |
| ANGPTL4 | angiopoietin-like 4 | -0.0248899 |
| MAN2A1 | mannosidase, alpha, class 2A, member 1 | -0.0246464 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0244795 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0243644 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0242126 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0240997 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | -0.0240951 |
| CLTC | clathrin, heavy chain (Hc) | -0.0237313 |
| PCNX1 | pecanex 1 | -0.0236627 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0235158 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0234371 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0234366 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0230913 |
| RPS21 | ribosomal protein S21 | -0.0230076 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0229932 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | -0.0229846 |
| FNBP1 | formin binding protein 1 | -0.0229771 |
| GRAMD1B | GRAM domain containing 1B | -0.0229659 |
| MYO10 | myosin X | -0.0229524 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0227477 |
| AHR | aryl hydrocarbon receptor | -0.0226471 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0226271 |
| RPS6 | ribosomal protein S6 | -0.0225971 |
| RNF24 | ring finger protein 24 | -0.0225203 |
| YBX3 | Y box binding protein 3 | -0.0224475 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0224457 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0224167 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0223398 |
