| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Apalutamide perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Apalutamide_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.158797 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.103638 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0884771 |
| VIM | vimentin | 0.0690504 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0590426 |
| LDHA | lactate dehydrogenase A | 0.0587625 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0573067 |
| DOCK4 | dedicator of cytokinesis 4 | 0.047293 |
| CMIP | c-Maf inducing protein | 0.0451216 |
| BICC1 | BicC family RNA binding protein 1 | 0.0434498 |
| RAD51B | RAD51 paralog B | 0.0433048 |
| FLNB | filamin B, beta | 0.0418169 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0381132 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0355089 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0352855 |
| KLF6 | Kruppel-like factor 6 | 0.0339929 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | 0.0339238 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0337004 |
| FMNL2 | formin-like 2 | 0.0330691 |
| EFNA5 | ephrin-A5 | 0.0323511 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0298129 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0291114 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.028193 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0280029 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0276105 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.027429 |
| UTRN | utrophin | 0.0268975 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0263164 |
| IGF2 | insulin-like growth factor 2 | 0.0253379 |
| CAVIN1 | caveolae associated protein 1 | 0.0251908 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0251384 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0251199 |
| PYGL | phosphorylase, glycogen, liver | 0.0251025 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | 0.0250165 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0248628 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0242231 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0239544 |
| ANXA2 | annexin A2 | 0.0238805 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0235917 |
| PTK2 | protein tyrosine kinase 2 | 0.0231162 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0229654 |
| NEBL | nebulette | 0.0224779 |
| GLIS3 | GLIS family zinc finger 3 | 0.0216967 |
| ZNF804A | zinc finger protein 804A | 0.0214 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0211555 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.021113 |
| NF1 | neurofibromin 1 | 0.0207038 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0205199 |
| THBS1 | thrombospondin 1 | 0.0200266 |
| EGFR | epidermal growth factor receptor | 0.019495 |
| TPM4 | tropomyosin 4 | 0.0193625 |
| AK1 | adenylate kinase 1 | 0.0191643 |
| PRR16 | proline rich 16 | 0.0190184 |
| VDAC1 | voltage-dependent anion channel 1 | 0.0188517 |
| HMGA2 | high mobility group AT-hook 2 | 0.0188508 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0185184 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0184094 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.018356 |
| ZFHX3 | zinc finger homeobox 3 | 0.0180085 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.017947 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | 0.0178175 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0176077 |
| DST | dystonin | 0.0175914 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.017366 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0173333 |
| SBF2 | SET binding factor 2 | 0.0172473 |
| NAV3 | neuron navigator 3 | 0.0172225 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0172122 |
| OSMR | oncostatin M receptor | 0.0169028 |
| AHNAK | AHNAK nucleoprotein | 0.0166946 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0165857 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0160092 |
| RPS4X | ribosomal protein S4, X-linked | 0.0157603 |
| DCLK2 | doublecortin-like kinase 2 | 0.0157352 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0156966 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0156162 |
| GSK3B | glycogen synthase kinase 3 beta | 0.0153291 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0150075 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.014917 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | 0.0148006 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0147084 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0145506 |
| KYNU | kynureninase | 0.01447 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0141805 |
| VCL | vinculin | 0.0141779 |
| ITSN2 | intersectin 2 | 0.0141289 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0140128 |
| CUX1 | cut-like homeobox 1 | 0.0138602 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0138099 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | 0.0136792 |
| RPL35A | ribosomal protein L35a | 0.0136552 |
| CTBP2 | C-terminal binding protein 2 | 0.0135149 |
| PCED1B | PC-esterase domain containing 1B | 0.0135015 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0134922 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0134289 |
| RAB31 | RAB31, member RAS oncogene family | 0.0134049 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0134047 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0133963 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | 0.013211 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.0131387 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PM20D1 | peptidase M20 domain containing 1 | -0.166953 |
| GRAMD1B | GRAM domain containing 1B | -0.121586 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0833466 |
| RPS2 | ribosomal protein S2 | -0.0719641 |
| RPL19 | ribosomal protein L19 | -0.0714061 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0695821 |
| RTN4 | reticulon 4 | -0.0621067 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0615494 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.0612902 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0603575 |
| FTL | ferritin, light polypeptide | -0.0600717 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0584947 |
| DENND4A | DENN/MADD domain containing 4A | -0.0578907 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0566627 |
| TPM3 | tropomyosin 3 | -0.0559102 |
| KIF5B | kinesin family member 5B | -0.0532703 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0502336 |
| POTEF | POTE ankyrin domain family, member F | -0.0501759 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | -0.05008 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0498871 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0467367 |
| HSPA8 | heat shock 70kDa protein 8 | -0.0466266 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0464173 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0461356 |
| MT2A | metallothionein 2A | -0.0455222 |
| PTMA | prothymosin, alpha | -0.0453901 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0434009 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0426458 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0418504 |
| RPS12 | ribosomal protein S12 | -0.0404296 |
| RBM39 | RNA binding motif protein 39 | -0.0397697 |
| PFDN2 | prefoldin subunit 2 | -0.0390784 |
| RPL4 | ribosomal protein L4 | -0.0377066 |
| RPS25 | ribosomal protein S25 | -0.0375858 |
| BCLAF1 | BCL2-associated transcription factor 1 | -0.0371341 |
| RPL7 | ribosomal protein L7 | -0.0369985 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0369558 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0366679 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0363125 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0347721 |
| MATR3 | matrin 3 | -0.0336363 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0328537 |
| MIS18BP1 | MIS18 binding protein 1 | -0.0325857 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0325091 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0317028 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0309933 |
| RPLP1 | ribosomal protein, large, P1 | -0.030661 |
| YBX3 | Y box binding protein 3 | -0.0300956 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0297353 |
| RPL3 | ribosomal protein L3 | -0.0296435 |
| PAPOLA | poly(A) polymerase alpha | -0.0292446 |
| KHDC4 | KH domain containing 4, pre-mRNA splicing factor | -0.0291591 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0290127 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0286418 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0282987 |
| CLTC | clathrin, heavy chain (Hc) | -0.0281955 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0281263 |
| STAM | signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 | -0.0277472 |
| CCL5 | chemokine (C-C motif) ligand 5 | -0.0273701 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0271139 |
| GOLT1B | golgi transport 1B | -0.0270125 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.026938 |
| SPAG9 | sperm associated antigen 9 | -0.0268863 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0264983 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0263598 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0262615 |
| ZNF207 | zinc finger protein 207 | -0.0262553 |
| BRD2 | bromodomain containing 2 | -0.0262287 |
| SETD5 | SET domain containing 5 | -0.0262256 |
| TPD52 | tumor protein D52 | -0.0261643 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0257953 |
| CCNL1 | cyclin L1 | -0.025473 |
| ZNF292 | zinc finger protein 292 | -0.0254436 |
| UPP1 | uridine phosphorylase 1 | -0.0252548 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0252277 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0251292 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0248064 |
| WWOX | WW domain containing oxidoreductase | -0.02469 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0245921 |
| IER3 | immediate early response 3 | -0.0245398 |
| TFG | TRK-fused gene | -0.0243435 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | -0.0242763 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0241907 |
| UBC | ubiquitin C | -0.0240874 |
| PKM | pyruvate kinase, muscle | -0.0239268 |
| MSN | moesin | -0.0239182 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0238111 |
| RHEB | Ras homolog enriched in brain | -0.0235908 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0235503 |
| QKI | QKI, KH domain containing, RNA binding | -0.0234061 |
| RYBP | RING1 and YY1 binding protein | -0.0229632 |
| JAK1 | Janus kinase 1 | -0.0229255 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0229145 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0228958 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0228143 |
| SRRM1 | serine/arginine repetitive matrix 1 | -0.022803 |
| RPL5 | ribosomal protein L5 | -0.0227118 |
| MRTFA | myocardin related transcription factor A | -0.0226121 |
| BUB3 | BUB3 mitotic checkpoint protein | -0.0224492 |
| HBS1L | HBS1-like translational GTPase | -0.0221731 |
