Apalutamide_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Apalutamide_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.206416
TFPI2 tissue factor pathway inhibitor 2 0.0982379
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0951734
RTN4 reticulon 4 0.0802377
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0709307
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0646609
GRAMD1B GRAM domain containing 1B 0.0634476
XPO1 exportin 1 0.0584111
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0528636
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0515184
TRIO trio Rho guanine nucleotide exchange factor 0.0508605
MARCHF4 membrane associated ring-CH-type finger 4 0.0469807
EEF2 eukaryotic translation elongation factor 2 0.0466887
ERRFI1 ERBB receptor feedback inhibitor 1 0.0458034
RUSC2 RUN and SH3 domain containing 2 0.0453496
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0426817
TPM3 tropomyosin 3 0.0416272
MKI67 marker of proliferation Ki-67 0.0415793
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0398179
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0385435
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0382044
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0376363
CSDE1 cold shock domain containing E1, RNA-binding 0.0373394
PUM2 pumilio RNA-binding family member 2 0.0371124
CTTNBP2NL CTTNBP2 N-terminal like 0.0367731
WNK1 WNK lysine deficient protein kinase 1 0.0366667
IPO7 importin 7 0.0365589
NIPBL Nipped-B homolog (Drosophila) 0.0355757
ADAM17 ADAM metallopeptidase domain 17 0.0354106
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0350348
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0348733
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0347785
RNF145 ring finger protein 145 0.0340944
ZFR zinc finger RNA binding protein 0.0339461
NUP153 nucleoporin 153kDa 0.033372
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0332136
SINHCAF SIN3-HDAC complex associated factor 0.0327517
ANXA5 annexin A5 0.0327216
ARID1A AT rich interactive domain 1A (SWI-like) 0.0321362
KCMF1 potassium channel modulatory factor 1 0.0320376
CCNL1 cyclin L1 0.031534
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.031476
ZFAND3 zinc finger, AN1-type domain 3 0.0312796
ADAM9 ADAM metallopeptidase domain 9 0.0309388
BIRC2 baculoviral IAP repeat containing 2 0.0309112
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0309013
PHIP pleckstrin homology domain interacting protein 0.0306216
RASAL2 RAS protein activator like 2 0.0304407
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 0.0295668
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0293302
SFPQ splicing factor proline/glutamine-rich 0.0293258
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0288155
MATR3 matrin 3 0.0283388
TMEM41B transmembrane protein 41B 0.0281562
KDM3A lysine (K)-specific demethylase 3A 0.0278045
LATS2 large tumor suppressor kinase 2 0.0275658
NCAPD2 non-SMC condensin I complex, subunit D2 0.027564
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.027554
CLTC clathrin, heavy chain (Hc) 0.0274138
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0271749
EIF4B eukaryotic translation initiation factor 4B 0.0271529
IL6ST interleukin 6 signal transducer 0.0270977
MED13L mediator complex subunit 13-like 0.0266722
PCBP2 poly(rC) binding protein 2 0.0263429
MAP3K14 mitogen-activated protein kinase kinase kinase 14 0.026254
ERBIN erbb2 interacting protein 0.0259726
TOP2B topoisomerase (DNA) II beta 180kDa 0.0259439
CUL3 cullin 3 0.0257746
OGA O-GlcNAcase 0.025617
TBK1 TANK-binding kinase 1 0.0255855
SPAG9 sperm associated antigen 9 0.0254471
NCKAP1 NCK-associated protein 1 0.0253199
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.025294
RNF169 ring finger protein 169 0.0251913
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0251892
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0251539
COG5 component of oligomeric golgi complex 5 0.0250551
WDR43 WD repeat domain 43 0.0250531
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0250186
SP3 Sp3 transcription factor 0.0248101
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 0.024759
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0245632
PALS1 protein associated with LIN7 1, MAGUK p55 family member 0.0244776
JMJD1C jumonji domain containing 1C 0.0243175
AGFG1 ArfGAP with FG repeats 1 0.0239746
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0237879
MIS18BP1 MIS18 binding protein 1 0.0235605
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.023549
SPRED2 sprouty-related, EVH1 domain containing 2 0.0232974
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0232474
NFE2L2 nuclear factor, erythroid 2-like 2 0.0230628
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0230464
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0230236
CHD1 chromodomain helicase DNA binding protein 1 0.0230137
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0229047
KIF5B kinesin family member 5B 0.0228313
ADAR adenosine deaminase, RNA-specific 0.0226964
CAMKMT calmodulin-lysine N-methyltransferase 0.0226846
EXOC6B exocyst complex component 6B 0.0226474
MSH6 mutS homolog 6 0.02248

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16649
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.163833
TMSB10 thymosin beta 10 -0.108408
PTMA prothymosin, alpha -0.0880344
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0823347
RPS3 ribosomal protein S3 -0.0780922
RPL37A ribosomal protein L37a -0.0776113
AFF3 AF4/FMR2 family, member 3 -0.0662789
RPS8 ribosomal protein S8 -0.0626757
RPL26 ribosomal protein L26 -0.0622475
MCL1 myeloid cell leukemia 1 -0.0607276
RPS29 ribosomal protein S29 -0.0599258
RPL37 ribosomal protein L37 -0.0568067
AKAP12 A kinase (PRKA) anchor protein 12 -0.0567239
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0566849
RPS27 ribosomal protein S27 -0.0560868
MT2A metallothionein 2A -0.0560806
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0560495
HMGA2 high mobility group AT-hook 2 -0.055759
AEBP2 AE binding protein 2 -0.0539877
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0536416
RPS12 ribosomal protein S12 -0.0525536
RPS19 ribosomal protein S19 -0.0521186
RPS21 ribosomal protein S21 -0.0516567
RPL23 ribosomal protein L23 -0.0514813
RPL12 ribosomal protein L12 -0.0513125
ATXN1 ataxin 1 -0.05016
ACTG1 actin gamma 1 -0.048633
RPL35A ribosomal protein L35a -0.0485113
RPL31 ribosomal protein L31 -0.0484445
PRELID2 PRELI domain containing 2 -0.0479289
RYR3 ryanodine receptor 3 -0.0476998
VIM vimentin -0.0467498
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0464932
PRH1 proline-rich protein HaeIII subfamily 1 -0.0453523
RPL36 ribosomal protein L36 -0.0445273
RIMS2 regulating synaptic membrane exocytosis 2 -0.043763
RPS27A ribosomal protein S27a -0.0430379
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0422461
PDE10A phosphodiesterase 10A -0.0419099
TPM2 tropomyosin 2 (beta) -0.0417895
TPT1 tumor protein, translationally-controlled 1 -0.0411582
HLA-B major histocompatibility complex, class I, B -0.0411519
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0410938
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0408741
RPL19 ribosomal protein L19 -0.0402129
RPLP2 ribosomal protein, large, P2 -0.0401299
RPLP1 ribosomal protein, large, P1 -0.0386814
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0385911
RPL11 ribosomal protein L11 -0.038544
INTS6 integrator complex subunit 6 -0.0381259
RPS10 ribosomal protein S10 -0.0371466
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0370287
EGR1 early growth response 1 -0.0369012
EGFR epidermal growth factor receptor -0.0364023
RPL34 ribosomal protein L34 -0.0359751
WNT2B wingless-type MMTV integration site family, member 2B -0.0351346
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0350574
RPL9 ribosomal protein L9 -0.0350065
RPS15 ribosomal protein S15 -0.034332
RPL32 ribosomal protein L32 -0.033923
RPL8 ribosomal protein L8 -0.0338153
PDLIM5 PDZ and LIM domain 5 -0.0329165
THSD4 thrombospondin, type I, domain containing 4 -0.031723
FMNL2 formin-like 2 -0.0311474
RPS23 ribosomal protein S23 -0.0307498
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0293119
CUX1 cut-like homeobox 1 -0.0291403
RPS6 ribosomal protein S6 -0.0286548
RPL27 ribosomal protein L27 -0.0282203
TPI1 triosephosphate isomerase 1 -0.0280043
RPL38 ribosomal protein L38 -0.0279086
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0278382
PYGL phosphorylase, glycogen, liver -0.0277414
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0277286
RPS17 ribosomal protein S17 -0.027567
PATJ PATJ crumbs cell polarity complex component -0.0274308
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0273338
RPL18 ribosomal protein L18 -0.0267796
FTL ferritin, light polypeptide -0.0265921
NPAS2 neuronal PAS domain protein 2 -0.0262512
NEK10 NIMA-related kinase 10 -0.0259365
FNDC3B fibronectin type III domain containing 3B -0.0259251
NCOA7 nuclear receptor coactivator 7 -0.0256331
TAS2R14 taste receptor, type 2, member 14 -0.0255715
WWOX WW domain containing oxidoreductase -0.0249743
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0248414
RAD51B RAD51 paralog B -0.0247823
DOCK1 dedicator of cytokinesis 1 -0.0247294
EIF1 eukaryotic translation initiation factor 1 -0.0246871
RPL7A ribosomal protein L7a -0.0246263
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.024599
RPL5 ribosomal protein L5 -0.0245427
RPL35 ribosomal protein L35 -0.0241382
DENND1A DENN/MADD domain containing 1A -0.0241378
RPL28 ribosomal protein L28 -0.0234716
RNF213 ring finger protein 213 -0.0234576
CALR calreticulin -0.0231492
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.022969
RPS11 ribosomal protein S11 -0.0228598