Apalutamide_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Apalutamide_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.249668
NDRG1 N-myc downstream regulated 1 0.181529
IGFBP3 insulin-like growth factor binding protein 3 0.154866
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.118736
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.114633
ASPH aspartate beta-hydroxylase 0.099957
LDHA lactate dehydrogenase A 0.0867631
APLP2 amyloid beta (A4) precursor-like protein 2 0.0842997
FN1 fibronectin 1 0.0826314
TRIO trio Rho guanine nucleotide exchange factor 0.074719
POTEF POTE ankyrin domain family, member F 0.0708278
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0699851
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0694737
ENO1 enolase 1, (alpha) 0.0694279
IFI27 interferon, alpha-inducible protein 27 0.0632203
ELL2 elongation factor, RNA polymerase II, 2 0.0617198
ANXA2 annexin A2 0.0607799
FAM3C family with sequence similarity 3, member C 0.0604947
EZR ezrin 0.0603831
DSPP dentin sialophosphoprotein 0.0592976
VEGFA vascular endothelial growth factor A 0.0591445
ZFP36L1 ZFP36 ring finger protein-like 1 0.0582981
GRB10 growth factor receptor-bound protein 10 0.0579105
ITCH itchy E3 ubiquitin protein ligase 0.0577577
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0575341
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0544429
MYH9 myosin, heavy chain 9, non-muscle 0.0543967
DSG2 desmoglein 2 0.0537465
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0530586
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.051834
ERRFI1 ERBB receptor feedback inhibitor 1 0.0515893
TMF1 TATA element modulatory factor 1 0.0515052
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0507022
TXNIP thioredoxin interacting protein 0.0506527
LMO7 LIM domain 7 0.0502456
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0500343
UBA6 ubiquitin-like modifier activating enzyme 6 0.0498869
LAMB3 laminin, beta 3 0.0497842
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0484244
MSN moesin 0.0473814
MAP1B microtubule-associated protein 1B 0.0470508
LAMC2 laminin, gamma 2 0.045703
ERBIN erbb2 interacting protein 0.0452886
FTH1 ferritin, heavy polypeptide 1 0.045045
NRIP1 nuclear receptor interacting protein 1 0.0444428
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0428246
HMGA1 high mobility group AT-hook 1 0.0412987
FLNB filamin B, beta 0.0411763
CDCP1 CUB domain containing protein 1 0.0399979
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0398605
IQGAP1 IQ motif containing GTPase activating protein 1 0.0388927
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0387177
ARRDC3 arrestin domain containing 3 0.0384694
SLTM SAFB-like, transcription modulator 0.0380994
CTSB cathepsin B 0.0379927
ESYT2 extended synaptotagmin-like protein 2 0.0367894
PTK2 protein tyrosine kinase 2 0.0367316
PKM pyruvate kinase, muscle 0.0365116
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0362129
MACF1 microtubule-actin crosslinking factor 1 0.0355505
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0354667
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0352086
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0351674
CD44 CD44 molecule (Indian blood group) 0.0351606
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0349792
TPM3 tropomyosin 3 0.0342293
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0339258
OPTN optineurin 0.033903
ARHGAP29 Rho GTPase activating protein 29 0.0337878
FHIT fragile histidine triad 0.0336524
PPARD peroxisome proliferator-activated receptor delta 0.0336325
PCM1 pericentriolar material 1 0.0329884
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0327568
TSC22D2 TSC22 domain family, member 2 0.0324249
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase 0.0321224
DUSP10 dual specificity phosphatase 10 0.0319494
ADAM9 ADAM metallopeptidase domain 9 0.0317923
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0317357
CLDN4 claudin 4 0.031118
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0310954
DTNA dystrobrevin, alpha 0.0309308
FBXO32 F-box protein 32 0.0307782
AKAP9 A kinase (PRKA) anchor protein 9 0.0305308
RIOK3 RIO kinase 3 0.0304969
JUP junction plakoglobin 0.0304689
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0302008
MYO6 myosin VI 0.0301732
SBF2 SET binding factor 2 0.0298741
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0298303
MYO5B myosin VB 0.0298108
MAML2 mastermind-like 2 (Drosophila) 0.029011
MYO10 myosin X 0.0286694
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0284746
ACBD3 acyl-CoA binding domain containing 3 0.028469
EFNA5 ephrin-A5 0.028183
VEZT vezatin, adherens junctions transmembrane protein 0.0280611
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0279647
FNBP1L formin binding protein 1-like 0.0277626
BRD2 bromodomain containing 2 0.0272698
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0270277

decreased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 -0.104993
PTMA prothymosin, alpha -0.097404
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0935801
TMSB10 thymosin beta 10 -0.080449
RPL35A ribosomal protein L35a -0.0652805
GNAS GNAS complex locus -0.0607223
RPL34 ribosomal protein L34 -0.0588824
RPL23 ribosomal protein L23 -0.0559929
SLC38A1 solute carrier family 38, member 1 -0.0529394
TMSB4X thymosin beta 4, X-linked -0.0514737
RPS24 ribosomal protein S24 -0.0458171
RAD21 RAD21 homolog (S. pombe) -0.0421487
RPL9 ribosomal protein L9 -0.0404114
RPL37A ribosomal protein L37a -0.0396513
RPS3 ribosomal protein S3 -0.0387505
RPS8 ribosomal protein S8 -0.0385538
BHLHE40 basic helix-loop-helix family, member e40 -0.0380402
SAMD4A sterile alpha motif domain containing 4A -0.0373832
RPS23 ribosomal protein S23 -0.0365462
GARS1 glycyl-tRNA synthetase 1 -0.0341069
RPS29 ribosomal protein S29 -0.0336481
RPL32 ribosomal protein L32 -0.0332337
PDLIM5 PDZ and LIM domain 5 -0.0328445
RHEB Ras homolog enriched in brain -0.0319221
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0313632
RPS25 ribosomal protein S25 -0.0307717
INTS6 integrator complex subunit 6 -0.0303084
RPLP2 ribosomal protein, large, P2 -0.0297546
RPL30 ribosomal protein L30 -0.0293627
RPS27A ribosomal protein S27a -0.0287672
RPL37 ribosomal protein L37 -0.0283907
RPS19 ribosomal protein S19 -0.028249
HMGB2 high mobility group box 2 -0.0281818
MARCHF6 membrane associated ring-CH-type finger 6 -0.0277603
RPS13 ribosomal protein S13 -0.0274901
TM4SF1 transmembrane 4 L six family member 1 -0.027213
RPL5 ribosomal protein L5 -0.0271917
RPLP0 ribosomal protein, large, P0 -0.0270203
RPL11 ribosomal protein L11 -0.0265983
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.026218
CCND1 cyclin D1 -0.0260912
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0260877
VCL vinculin -0.0259203
RPLP1 ribosomal protein, large, P1 -0.0258795
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0255473
EIF1 eukaryotic translation initiation factor 1 -0.0250465
RPL36 ribosomal protein L36 -0.0249134
NAP1L1 nucleosome assembly protein 1-like 1 -0.0248915
ARHGAP20 Rho GTPase activating protein 20 -0.0246498
RPL19 ribosomal protein L19 -0.0237925
RPL4 ribosomal protein L4 -0.0235336
CANX calnexin -0.0229999
RPS6 ribosomal protein S6 -0.0227737
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0226706
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 -0.0225354
RPL27A ribosomal protein L27a -0.0224333
RPS12 ribosomal protein S12 -0.0222147
GPBP1 GC-rich promoter binding protein 1 -0.0221047
RPS10 ribosomal protein S10 -0.022087
RPS21 ribosomal protein S21 -0.0217008
S100A10 S100 calcium binding protein A10 -0.021673
AHNAK AHNAK nucleoprotein -0.021575
G0S2 G0/G1 switch 2 -0.021328
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0210984
RPL7A ribosomal protein L7a -0.0210823
ZFAND3 zinc finger, AN1-type domain 3 -0.0209156
ARF1 ADP-ribosylation factor 1 -0.0204379
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0201279
RPS16 ribosomal protein S16 -0.0199512
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0199089
RPL6 ribosomal protein L6 -0.0197213
FTL ferritin, light polypeptide -0.0195231
CAVIN1 caveolae associated protein 1 -0.0192848
RPL31 ribosomal protein L31 -0.0192468
RPL12 ribosomal protein L12 -0.0191632
CDK13 cyclin-dependent kinase 13 -0.0191037
NCOA7 nuclear receptor coactivator 7 -0.0190239
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0187494
RPS17 ribosomal protein S17 -0.0186969
RPL38 ribosomal protein L38 -0.0186239
ANKLE2 ankyrin repeat and LEM domain containing 2 -0.0186177
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) -0.0181256
IFRD1 interferon-related developmental regulator 1 -0.0181064
NAMPT nicotinamide phosphoribosyltransferase -0.0180681
TFRC transferrin receptor -0.0180451
PPP1R15B protein phosphatase 1, regulatory subunit 15B -0.0178269
TBCA tubulin folding cofactor A -0.0178108
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0176556
RPL15 ribosomal protein L15 -0.0176391
MSMO1 methylsterol monooxygenase 1 -0.0175421
RPS20 ribosomal protein S20 -0.017535
DEK DEK proto-oncogene -0.0173759
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0173542
PLAU plasminogen activator, urokinase -0.0171355
ISG15 ISG15 ubiquitin-like modifier -0.0170286
RPL8 ribosomal protein L8 -0.0167679
KDM3A lysine (K)-specific demethylase 3A -0.0166574
ANKRD10 ankyrin repeat domain 10 -0.0166433
PEG10 paternally expressed 10 -0.0164493
RTN3 reticulon 3 -0.0164227