Apalutamide_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Apalutamide_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.257621
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0971104
PSD3 pleckstrin and Sec7 domain containing 3 0.0885445
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0875726
PDE10A phosphodiesterase 10A 0.0872027
EFNA5 ephrin-A5 0.0836628
COL5A2 collagen, type V, alpha 2 0.0810819
FN1 fibronectin 1 0.0750506
NALF1 NALCN channel auxiliary factor 1 0.0603251
ASPH aspartate beta-hydroxylase 0.0555452
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.054894
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0539844
CDH13 cadherin 13 0.0524247
DST dystonin 0.04558
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0430549
MAML3 mastermind-like 3 (Drosophila) 0.0412429
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0404005
GDA guanine deaminase 0.0397371
P3H2 prolyl 3-hydroxylase 2 0.0385275
PM20D1 peptidase M20 domain containing 1 0.0384491
SMYD3 SET and MYND domain containing 3 0.0383866
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0379907
PCBP3 poly(rC) binding protein 3 0.0372491
PDLIM5 PDZ and LIM domain 5 0.0352657
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0346555
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0321094
COL4A5 collagen, type IV, alpha 5 0.0299213
NRCAM neuronal cell adhesion molecule 0.0299116
PTPRM protein tyrosine phosphatase, receptor type, M 0.0298158
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.029418
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0292268
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0276664
KYNU kynureninase 0.0271662
PRKN parkin RBR E3 ubiquitin protein ligase 0.0268141
DOCK4 dedicator of cytokinesis 4 0.0264783
COL8A1 collagen, type VIII, alpha 1 0.0256458
FNDC3B fibronectin type III domain containing 3B 0.0252695
TRIO trio Rho guanine nucleotide exchange factor 0.0241372
DOCK5 dedicator of cytokinesis 5 0.0240027
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0237857
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0231351
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0227918
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0221223
TBXT T-box transcription factor T 0.0217379
ADGRD1 adhesion G protein-coupled receptor D1 0.0217352
RAD51B RAD51 paralog B 0.0217108
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0217039
AUTS2 autism susceptibility candidate 2 0.0212752
GRAMD1B GRAM domain containing 1B 0.020538
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0201666
NPAS2 neuronal PAS domain protein 2 0.0198565
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.019615
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0190707
RPH3AL rabphilin 3A-like (without C2 domains) 0.0189592
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 0.0186195
LSAMP limbic system-associated membrane protein 0.0181398
PRELID2 PRELI domain containing 2 0.0174471
ANTXR1 anthrax toxin receptor 1 0.0172705
RTN1 reticulon 1 0.0171954
SMOC1 SPARC related modular calcium binding 1 0.0170276
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0169406
MYOF myoferlin 0.0169318
CHL1 cell adhesion molecule L1-like 0.0168414
COL4A6 collagen, type IV, alpha 6 0.0166916
KIAA0825 KIAA0825 0.0165815
SAMD4A sterile alpha motif domain containing 4A 0.0165403
LIMCH1 LIM and calponin homology domains 1 0.0163475
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0160249
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0155443
CTNND2 catenin (cadherin-associated protein), delta 2 0.0151604
EXT1 exostosin glycosyltransferase 1 0.015006
CTSC cathepsin C 0.0147942
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0147759
GLIS3 GLIS family zinc finger 3 0.014763
PDE7B phosphodiesterase 7B 0.0146341
GPRIN3 GPRIN family member 3 0.0143604
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0142436
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0140632
ATXN1 ataxin 1 0.0139555
TTC28 tetratricopeptide repeat domain 28 0.0133198
SH3KBP1 SH3-domain kinase binding protein 1 0.013308
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.013185
ZEB2 zinc finger E-box binding homeobox 2 0.0131568
EXOC4 exocyst complex component 4 0.0131262
TENM3 teneurin transmembrane protein 3 0.0129035
IGF1R insulin-like growth factor 1 receptor 0.0127639
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0126851
PBX1 pre-B-cell leukemia homeobox 1 0.0125139
CADM2 cell adhesion molecule 2 0.012471
PALLD palladin, cytoskeletal associated protein 0.0124112
NCKAP5 NCK-associated protein 5 0.0123547
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa 0.0123206
MBD5 methyl-CpG binding domain protein 5 0.0121935
BCAS3 breast carcinoma amplified sequence 3 0.011942
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0118236
DENND1A DENN/MADD domain containing 1A 0.0118137
RABGAP1L RAB GTPase activating protein 1-like 0.0117681
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 0.0116804
AOPEP aminopeptidase O (putative) 0.0115386
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0115178

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0761559
TMSB10 thymosin beta 10 -0.0455232
FTL ferritin, light polypeptide -0.0448237
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.043701
VIM vimentin -0.0418154
PTMA prothymosin, alpha -0.0394525
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0358577
RPLP1 ribosomal protein, large, P1 -0.0329133
RPS6 ribosomal protein S6 -0.0322955
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0272684
NDRG1 N-myc downstream regulated 1 -0.0244419
TPT1 tumor protein, translationally-controlled 1 -0.0240202
EIF1 eukaryotic translation initiation factor 1 -0.0234396
RPS19 ribosomal protein S19 -0.0227281
RPL35A ribosomal protein L35a -0.0224368
RPS23 ribosomal protein S23 -0.0223219
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0220628
RPL19 ribosomal protein L19 -0.0216947
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0211128
MT2A metallothionein 2A -0.0208695
RPL12 ribosomal protein L12 -0.0206395
RPS8 ribosomal protein S8 -0.0206312
RPL31 ribosomal protein L31 -0.0205797
HILPDA hypoxia inducible lipid droplet-associated -0.0205136
RPLP0 ribosomal protein, large, P0 -0.0200578
RPS24 ribosomal protein S24 -0.019775
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0197432
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0197068
S100A10 S100 calcium binding protein A10 -0.0193648
RPL23 ribosomal protein L23 -0.0193283
RPL37A ribosomal protein L37a -0.0192185
RPS12 ribosomal protein S12 -0.0189007
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0186765
POTEF POTE ankyrin domain family, member F -0.0186033
S100A6 S100 calcium binding protein A6 -0.0184656
EIF4A1 eukaryotic translation initiation factor 4A1 -0.018072
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.017985
NAP1L1 nucleosome assembly protein 1-like 1 -0.0172947
RPL26 ribosomal protein L26 -0.0167235
B2M beta-2-microglobulin -0.0166166
RPLP2 ribosomal protein, large, P2 -0.0165001
DDIT4 DNA-damage-inducible transcript 4 -0.0160659
PDGFA platelet-derived growth factor alpha polypeptide -0.0158921
WDR45B WD repeat domain 45B -0.0156693
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0156269
VDAC1 voltage-dependent anion channel 1 -0.015149
RPL36 ribosomal protein L36 -0.0146461
RPL9 ribosomal protein L9 -0.0145433
RPS14 ribosomal protein S14 -0.0144753
RPL36A ribosomal protein L36a -0.0144301
RPL7A ribosomal protein L7a -0.0143651
PDIA3 protein disulfide isomerase family A, member 3 -0.0142573
UBC ubiquitin C -0.0142439
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.014111
RTN4 reticulon 4 -0.0140083
HLA-A major histocompatibility complex, class I, A -0.0139323
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.013865
GNAS GNAS complex locus -0.0138101
RPS27 ribosomal protein S27 -0.0134433
RPS29 ribosomal protein S29 -0.0134002
RPS27A ribosomal protein S27a -0.0133202
KMT2E lysine (K)-specific methyltransferase 2E -0.0131887
RPL11 ribosomal protein L11 -0.0131856
RPS21 ribosomal protein S21 -0.0131414
FTH1 ferritin, heavy polypeptide 1 -0.0131161
GARS1 glycyl-tRNA synthetase 1 -0.0129828
GOLGA4 golgin A4 -0.012907
STC1 stanniocalcin 1 -0.0128981
RPL34 ribosomal protein L34 -0.0128896
ACTG1 actin gamma 1 -0.0127841
PFN1 profilin 1 -0.0125116
RPS25 ribosomal protein S25 -0.0124392
RPS3 ribosomal protein S3 -0.0120041
PGK1 phosphoglycerate kinase 1 -0.0116143
YBX1 Y box binding protein 1 -0.0115411
LOC112694756 uncharaterized LOC112694756 -0.0114394
PDIA6 protein disulfide isomerase family A, member 6 -0.0113188
RPL37 ribosomal protein L37 -0.0112871
RPS16 ribosomal protein S16 -0.0111853
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0111232
SPAG9 sperm associated antigen 9 -0.0110685
SEPTIN7 septin 7 -0.011049
RACK1 receptor for activated C kinase 1 -0.0110078
RPL28 ribosomal protein L28 -0.010725
RPS13 ribosomal protein S13 -0.0106118
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0103808
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0103586
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0103122
RPL35 ribosomal protein L35 -0.0102437
NUP58 nucleoporin 58 -0.0102172
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0102083
IER3 immediate early response 3 -0.0101407
PKM pyruvate kinase, muscle -0.0100155
FOSL1 FOS-like antigen 1 -0.00986042
RPL8 ribosomal protein L8 -0.0097857
RPS11 ribosomal protein S11 -0.00973541
RPL13A ribosomal protein L13a -0.00969255
PCBP2 poly(rC) binding protein 2 -0.00957232
ATP5F1E ATP synthase F1 subunit epsilon -0.00945562