Apalutamide_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

197 genes differentially expressed following the Apalutamide_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.166706
PDE4D phosphodiesterase 4D, cAMP-specific 0.136603
USP34 ubiquitin specific peptidase 34 0.112841
NKD1 naked cuticle homolog 1 (Drosophila) 0.0994203
RPL11 ribosomal protein L11 0.0985968
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0881548
SPTBN1 spectrin, beta, non-erythrocytic 1 0.079306
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0776155
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0768156
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0763247
KMT2E lysine (K)-specific methyltransferase 2E 0.0743608
ENO1 enolase 1, (alpha) 0.0720222
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0712476
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0654917
FN1 fibronectin 1 0.0651016
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0646332
STC1 stanniocalcin 1 0.0626549
SBF2 SET binding factor 2 0.0625635
TXNRD1 thioredoxin reductase 1 0.0624986
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0609399
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0608733
RACK1 receptor for activated C kinase 1 0.0601037
MAML2 mastermind-like 2 (Drosophila) 0.0596653
ZFAND3 zinc finger, AN1-type domain 3 0.0581635
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.055796
DST dystonin 0.0550421
SQSTM1 sequestosome 1 0.0522329
RLF rearranged L-myc fusion 0.0508468
GMDS GDP-mannose 4,6-dehydratase 0.0506724
NAV2 neuron navigator 2 0.0500566
TBC1D22A TBC1 domain family, member 22A 0.0475852
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0472477
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0468325
PTMA prothymosin, alpha 0.0455993
ELL2 elongation factor, RNA polymerase II, 2 0.0437844
PKM pyruvate kinase, muscle 0.0434673
ANKRD17 ankyrin repeat domain 17 0.0430521
IGF2 insulin-like growth factor 2 0.0421716
ERBIN erbb2 interacting protein 0.0410698
JMJD1C jumonji domain containing 1C 0.0409167
RPS24 ribosomal protein S24 0.0403468
RPL7A ribosomal protein L7a 0.0396069
ANKRD12 ankyrin repeat domain 12 0.0349902
FMNL2 formin-like 2 0.0334245
KTN1 kinectin 1 (kinesin receptor) 0.0304588
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0299299
VIM vimentin 0.029502
RPS6 ribosomal protein S6 0.029147
NF1 neurofibromin 1 0.0291427
BABAM2 BRISC and BRCA1 A complex member 2 0.0288153
DSCAM Down syndrome cell adhesion molecule 0.0280182
SRRM2 serine/arginine repetitive matrix 2 0.0272826
RPS12 ribosomal protein S12 0.0268367
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0267204
C3 complement component 3 0.0266947
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0264528
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0261538
SYT1 synaptotagmin I 0.0255131
SNX9 sorting nexin 9 0.0243339
RPS3 ribosomal protein S3 0.0237083
PTPRM protein tyrosine phosphatase, receptor type, M 0.0218688
INHBA inhibin, beta A 0.021524
AHNAK AHNAK nucleoprotein 0.0214585
YBX3 Y box binding protein 3 0.0205136
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0202081
RPLP1 ribosomal protein, large, P1 0.0201466
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha 0.0199295
NALF1 NALCN channel auxiliary factor 1 0.0196996
TNRC6B trinucleotide repeat containing 6B 0.0179827
B2M beta-2-microglobulin 0.0175433
RBM39 RNA binding motif protein 39 0.0175039
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.016565
INTS6 integrator complex subunit 6 0.0161581
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0154706
ZNF638 zinc finger protein 638 0.0151628
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.014035
RPL37A ribosomal protein L37a 0.0140283
RPL12 ribosomal protein L12 0.0139803
ADAM10 ADAM metallopeptidase domain 10 0.0124847
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0123195
MYO9A myosin IXA 0.0122856
RAB7A RAB7A, member RAS oncogene family 0.0116555
ACSL3 acyl-CoA synthetase long-chain family member 3 0.00946784
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.00941176
PIAS1 protein inhibitor of activated STAT, 1 0.00855494
PRRC2C proline-rich coiled-coil 2C 0.00675128
COL6A3 collagen, type VI, alpha 3 0.00543826
FNDC3B fibronectin type III domain containing 3B 0.00488496
RPL37 ribosomal protein L37 0.00398215
MCL1 myeloid cell leukemia 1 0.0028759
MBD5 methyl-CpG binding domain protein 5 0.00251665
DTNA dystrobrevin, alpha 0.00247577
RPS8 ribosomal protein S8 0.00220819
NAMPT nicotinamide phosphoribosyltransferase 0.00184389
AKAP12 A kinase (PRKA) anchor protein 12 0.00175005
TENM3 teneurin transmembrane protein 3 9.20529E-4
HLA-B major histocompatibility complex, class I, B 1.91015E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.206027
MYO1E myosin IE -0.129974
TPT1 tumor protein, translationally-controlled 1 -0.121984
ALCAM activated leukocyte cell adhesion molecule -0.107487
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.103663
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.102969
LAMA4 laminin, alpha 4 -0.100821
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0916622
HMGA2 high mobility group AT-hook 2 -0.0853953
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0832724
FHIT fragile histidine triad -0.0828288
NDRG1 N-myc downstream regulated 1 -0.0819997
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0754622
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0741645
TTC3 tetratricopeptide repeat domain 3 -0.0734869
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0728373
YAP1 Yes-associated protein 1 -0.0721922
ANXA2 annexin A2 -0.071611
SLTM SAFB-like, transcription modulator -0.0712932
EGR1 early growth response 1 -0.0707808
FLNB filamin B, beta -0.0686322
EGFR epidermal growth factor receptor -0.0685591
HDAC9 histone deacetylase 9 -0.0676636
ARHGAP26 Rho GTPase activating protein 26 -0.0655368
RPL15 ribosomal protein L15 -0.0624984
EIF1 eukaryotic translation initiation factor 1 -0.0573618
ZBTB20 zinc finger and BTB domain containing 20 -0.0565786
TPM4 tropomyosin 4 -0.0565364
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0556195
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0545604
MYOF myoferlin -0.054225
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0540194
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0523112
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0516455
CD44 CD44 molecule (Indian blood group) -0.0496128
PDE8A phosphodiesterase 8A -0.0477346
TOP1 topoisomerase (DNA) I -0.0476295
RAD51B RAD51 paralog B -0.0472053
PTK2 protein tyrosine kinase 2 -0.0452867
EXT1 exostosin glycosyltransferase 1 -0.0443958
EFNA5 ephrin-A5 -0.0438443
PRELID2 PRELI domain containing 2 -0.0409853
RPL31 ribosomal protein L31 -0.0403714
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0395525
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0381396
CANX calnexin -0.0370722
FNIP1 folliculin interacting protein 1 -0.0361755
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0351608
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0345102
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0341835
TM9SF3 transmembrane 9 superfamily member 3 -0.0337912
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0328153
PUM2 pumilio RNA-binding family member 2 -0.0324382
ASPH aspartate beta-hydroxylase -0.0318731
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0312555
RAB1A RAB1A, member RAS oncogene family -0.0306865
PARD3 par-3 family cell polarity regulator -0.030224
KMT2C lysine (K)-specific methyltransferase 2C -0.0301398
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0298061
DLG1 discs, large homolog 1 (Drosophila) -0.0292525
MACF1 microtubule-actin crosslinking factor 1 -0.0279468
RPS19 ribosomal protein S19 -0.0273075
HDLBP high density lipoprotein binding protein -0.0272961
BIRC6 baculoviral IAP repeat containing 6 -0.0271221
GPC6 glypican 6 -0.025102
SLC38A2 solute carrier family 38, member 2 -0.0246793
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -0.0228663
MARCHF6 membrane associated ring-CH-type finger 6 -0.0225406
PRKCA protein kinase C, alpha -0.0223312
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0222871
IGFBP3 insulin-like growth factor binding protein 3 -0.0221744
RTN4 reticulon 4 -0.0220913
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0217885
TRIO trio Rho guanine nucleotide exchange factor -0.0200577
CARD16 caspase recruitment domain family, member 16 -0.0195841
MAP4 microtubule-associated protein 4 -0.0193646
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0188121
MYO6 myosin VI -0.0187072
FTL ferritin, light polypeptide -0.0176017
CMIP c-Maf inducing protein -0.0172123
LDHA lactate dehydrogenase A -0.0147961
RUNX1 runt-related transcription factor 1 -0.0136114
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0125167
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0114673
AKAP9 A kinase (PRKA) anchor protein 9 -0.0114429
RPS13 ribosomal protein S13 -0.0111065
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0105696
POTEF POTE ankyrin domain family, member F -0.00919342
TMSB10 thymosin beta 10 -0.00862402
NIPBL Nipped-B homolog (Drosophila) -0.00835057
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00817888
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0080314
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.00797166
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.00623679
TSC22D2 TSC22 domain family, member 2 -0.00505493
VCL vinculin -0.0045514
RABGAP1L RAB GTPase activating protein 1-like -0.00419717
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.00414358
RPL23 ribosomal protein L23 -0.00362564
ACTG1 actin gamma 1 -0.00308384