Apalutamide_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Apalutamide_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.143262
PABPC1 poly(A) binding protein, cytoplasmic 1 0.108861
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0982974
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0874351
TSC22D2 TSC22 domain family, member 2 0.0791593
DST dystonin 0.0779715
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0742289
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0629097
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.053781
TRIO trio Rho guanine nucleotide exchange factor 0.0526454
GOLGA4 golgin A4 0.0518672
CENPF centromere protein F, 350/400kDa 0.050323
ZEB2 zinc finger E-box binding homeobox 2 0.0498001
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0492502
METAP2 methionyl aminopeptidase 2 0.0479857
PGAP1 post-GPI attachment to proteins 1 0.0451448
SHROOM3 shroom family member 3 0.0443995
SMC3 structural maintenance of chromosomes 3 0.0440294
PDE4D phosphodiesterase 4D, cAMP-specific 0.0437112
ATP5F1B ATP synthase F1 subunit beta 0.0423664
PEG10 paternally expressed 10 0.0421137
SMC4 structural maintenance of chromosomes 4 0.0416725
ZNF608 zinc finger protein 608 0.0414371
TENM3 teneurin transmembrane protein 3 0.0410403
PARD3B par-3 family cell polarity regulator beta 0.0410205
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.0394001
RBM25 RNA binding motif protein 25 0.038967
EVI5 ecotropic viral integration site 5 0.0380203
MED13L mediator complex subunit 13-like 0.0376951
FAM171B family with sequence similarity 171, member B 0.0363185
PUM2 pumilio RNA-binding family member 2 0.0358783
STAG2 stromal antigen 2 0.0357483
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0355689
PUM1 pumilio RNA-binding family member 1 0.0351253
NIPBL Nipped-B homolog (Drosophila) 0.034109
ENAH enabled homolog (Drosophila) 0.0337832
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 0.0336113
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0328995
PDGFC platelet derived growth factor C 0.0321842
WDR43 WD repeat domain 43 0.0320311
PRTG protogenin 0.0313938
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0312081
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0310942
WNK1 WNK lysine deficient protein kinase 1 0.0309103
USP25 ubiquitin specific peptidase 25 0.0305216
TRPS1 trichorhinophalangeal syndrome I 0.0303106
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0301945
CKAP2 cytoskeleton associated protein 2 0.0297103
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0293042
KMT2E lysine (K)-specific methyltransferase 2E 0.0292505
BAZ2A bromodomain adjacent to zinc finger domain, 2A 0.0288278
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0285755
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0282805
ECT2 epithelial cell transforming 2 0.027927
H1-4 H1.4 linker histone, cluster member 0.0278225
BTBD3 BTB (POZ) domain containing 3 0.0275204
MAML2 mastermind-like 2 (Drosophila) 0.0275172
PRRC2C proline-rich coiled-coil 2C 0.027399
PFN1 profilin 1 0.0272502
TRA2B transformer 2 beta homolog (Drosophila) 0.0263816
ANXA1 annexin A1 0.0260043
CABLES1 Cdk5 and Abl enzyme substrate 1 0.025896
NCKAP1 NCK-associated protein 1 0.0258783
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0258025
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0256636
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0254932
DENND4C DENN/MADD domain containing 4C 0.0254224
MIS18BP1 MIS18 binding protein 1 0.0252417
CDC73 cell division cycle 73 0.0249631
RBM33 RNA binding motif protein 33 0.0249257
ZFAND3 zinc finger, AN1-type domain 3 0.024838
CELF2 CUGBP, Elav-like family member 2 0.0248215
MKI67 marker of proliferation Ki-67 0.0243333
ZC3H15 zinc finger CCCH-type containing 15 0.0239872
HMGA2 high mobility group AT-hook 2 0.0239505
AKAP9 A kinase (PRKA) anchor protein 9 0.02388
ANK2 ankyrin 2, neuronal 0.0237001
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 0.0234327
RB1CC1 RB1-inducible coiled-coil 1 0.0233371
PRRC2B proline-rich coiled-coil 2B 0.0231548
JMJD1C jumonji domain containing 1C 0.0229794
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0229652
FAM168A family with sequence similarity 168, member A 0.0228871
ADAM9 ADAM metallopeptidase domain 9 0.0228441
FAM13B family with sequence similarity 13, member B 0.0228381
PRPF8 pre-mRNA processing factor 8 0.0228087
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0226145
ITCH itchy E3 ubiquitin protein ligase 0.0224404
ATF7IP activating transcription factor 7 interacting protein 0.0220718
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0220386
DR1 down-regulator of transcription 1, TBP-binding (negative cofactor 2) 0.0218723
NRXN1 neurexin 1 0.0218625
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0217413
SOS1 son of sevenless homolog 1 (Drosophila) 0.0217076
ACIN1 apoptotic chromatin condensation inducer 1 0.0214901
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0213849
RDX radixin 0.0211849
AHCTF1 AT hook containing transcription factor 1 0.0211589
BSG basigin (Ok blood group) 0.02104
AGTPBP1 ATP/GTP binding protein 1 0.0208894

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.253878
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.169358
PTMA prothymosin, alpha -0.159604
TMSB10 thymosin beta 10 -0.156646
VIM vimentin -0.11727
COL11A1 collagen, type XI, alpha 1 -0.105723
RPS16 ribosomal protein S16 -0.0949731
RPS8 ribosomal protein S8 -0.0846829
GPC3 glypican 3 -0.0841257
RPS27A ribosomal protein S27a -0.082824
UBC ubiquitin C -0.0827433
COL3A1 collagen, type III, alpha 1 -0.0779398
COL1A2 collagen, type I, alpha 2 -0.0728604
ADGRV1 adhesion G protein-coupled receptor V1 -0.0721584
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0635231
PCLO piccolo presynaptic cytomatrix protein -0.0626419
CALR calreticulin -0.0625449
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0620294
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0607754
GNAS GNAS complex locus -0.0604442
TMSB4X thymosin beta 4, X-linked -0.0587099
PCDH9 protocadherin 9 -0.0583497
TPT1 tumor protein, translationally-controlled 1 -0.0577569
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0556309
AHNAK AHNAK nucleoprotein -0.054497
RPLP1 ribosomal protein, large, P1 -0.0529773
RPL31 ribosomal protein L31 -0.0501954
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0498681
PGK1 phosphoglycerate kinase 1 -0.0479105
RPL23 ribosomal protein L23 -0.0477851
B2M beta-2-microglobulin -0.0473593
HMGB2 high mobility group box 2 -0.0470996
APP amyloid beta (A4) precursor protein -0.0469761
KDM3A lysine (K)-specific demethylase 3A -0.0465629
NTM neurotrimin -0.0443198
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0437814
S100A10 S100 calcium binding protein A10 -0.0436135
PDIA4 protein disulfide isomerase family A, member 4 -0.0428576
ENO1 enolase 1, (alpha) -0.0421912
RPS12 ribosomal protein S12 -0.0414453
CALU calumenin -0.0414409
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0398363
LRRC4C leucine rich repeat containing 4C -0.0390449
RFPL4B ret finger protein-like 4B -0.039033
MDK midkine (neurite growth-promoting factor 2) -0.0390261
THBS1 thrombospondin 1 -0.0381569
ACTG1 actin gamma 1 -0.0380681
NPAS3 neuronal PAS domain protein 3 -0.0367855
WSB1 WD repeat and SOCS box containing 1 -0.0367578
FNDC3A fibronectin type III domain containing 3A -0.0364673
CDH19 cadherin 19, type 2 -0.0362882
ANKRD12 ankyrin repeat domain 12 -0.0358774
NEBL nebulette -0.0356405
LOC112694756 uncharaterized LOC112694756 -0.0354832
APOE apolipoprotein E -0.0353906
ISG15 ISG15 ubiquitin-like modifier -0.0352013
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0351826
BRMS1L breast cancer metastasis-suppressor 1-like -0.0347962
RPL35A ribosomal protein L35a -0.0346579
SNX6 sorting nexin 6 -0.0345696
RPS21 ribosomal protein S21 -0.0340135
RPS13 ribosomal protein S13 -0.0333699
RPS25 ribosomal protein S25 -0.0331847
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -0.0331475
EAPP E2F-associated phosphoprotein -0.0331423
RPS3 ribosomal protein S3 -0.0329991
ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4 -0.0329144
CADM2 cell adhesion molecule 2 -0.0328076
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0326772
ADGRL2 adhesion G protein-coupled receptor L2 -0.0325499
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.0320394
TRAK1 trafficking protein, kinesin binding 1 -0.0314034
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.031255
RPL37 ribosomal protein L37 -0.0311621
RPLP2 ribosomal protein, large, P2 -0.0307229
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0306935
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0302806
ATXN1 ataxin 1 -0.0302103
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0298976
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0298714
RPL11 ribosomal protein L11 -0.0295947
UBE2B ubiquitin-conjugating enzyme E2B -0.0291282
TPM4 tropomyosin 4 -0.0288926
RPL26 ribosomal protein L26 -0.028689
SPAG9 sperm associated antigen 9 -0.0286115
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle -0.0282278
RPL36A ribosomal protein L36a -0.0281375
RAB7A RAB7A, member RAS oncogene family -0.027567
HMCN1 hemicentin 1 -0.0274983
RPL34 ribosomal protein L34 -0.0273294
UBE2K ubiquitin-conjugating enzyme E2K -0.0271843
EIF1 eukaryotic translation initiation factor 1 -0.0271484
FST follistatin -0.0271203
RAB2A RAB2A, member RAS oncogene family -0.0269629
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0269476
MYO10 myosin X -0.0269386
TMEM165 transmembrane protein 165 -0.0268349
RPL37A ribosomal protein L37a -0.0267198
RACK1 receptor for activated C kinase 1 -0.0266623
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 -0.0264663