Apalutamide_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Apalutamide perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Apalutamide_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 0.0672515
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0656678
ADAM10 ADAM metallopeptidase domain 10 0.0620757
EZR ezrin 0.052217
PRELID2 PRELI domain containing 2 0.0519349
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0518223
ZNF292 zinc finger protein 292 0.0468353
FLNB filamin B, beta 0.046372
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0447497
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0440675
ZBTB20 zinc finger and BTB domain containing 20 0.039858
POTEF POTE ankyrin domain family, member F 0.0397781
SMYD3 SET and MYND domain containing 3 0.038849
PDE4D phosphodiesterase 4D, cAMP-specific 0.0376993
CCNL1 cyclin L1 0.0359284
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0351108
SOX6 SRY (sex determining region Y)-box 6 0.0339016
RTN4 reticulon 4 0.0337658
EML4 echinoderm microtubule associated protein like 4 0.0333864
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0328092
PCBP2 poly(rC) binding protein 2 0.0326616
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0322246
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0318022
PTK2 protein tyrosine kinase 2 0.0312202
PTBP2 polypyrimidine tract binding protein 2 0.030071
PDGFC platelet derived growth factor C 0.0298709
ECT2 epithelial cell transforming 2 0.0297233
PHIP pleckstrin homology domain interacting protein 0.0296501
SBF2 SET binding factor 2 0.0294306
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0292425
MON2 MON2 homolog (S. cerevisiae) 0.0291205
TBK1 TANK-binding kinase 1 0.0288931
TMEM65 transmembrane protein 65 0.0288041
PICALM phosphatidylinositol binding clathrin assembly protein 0.0267462
NUP58 nucleoporin 58 0.0264093
XPO1 exportin 1 0.026328
NBAS neuroblastoma amplified sequence 0.0261456
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0261032
SFPQ splicing factor proline/glutamine-rich 0.0260611
AKAP9 A kinase (PRKA) anchor protein 9 0.0255934
ADAM9 ADAM metallopeptidase domain 9 0.0252466
HDAC9 histone deacetylase 9 0.0248652
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0243961
SRPK2 SRSF protein kinase 2 0.0242764
BRD2 bromodomain containing 2 0.0237656
UBA6 ubiquitin-like modifier activating enzyme 6 0.0237595
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.023369
INSIG2 insulin induced gene 2 0.0229078
EEF2 eukaryotic translation elongation factor 2 0.0228753
TENT4A terminal nucleotidyltransferase 4A 0.0227788
FNDC3B fibronectin type III domain containing 3B 0.0227519
YAP1 Yes-associated protein 1 0.0226423
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0223671
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0221798
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0221169
JMJD1C jumonji domain containing 1C 0.0220659
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.021712
TBC1D22A TBC1 domain family, member 22A 0.0214865
RBM39 RNA binding motif protein 39 0.0209966
CAMTA1 calmodulin binding transcription activator 1 0.0208985
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0206034
KDM6A lysine (K)-specific demethylase 6A 0.0203597
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0203547
HELZ helicase with zinc finger 0.0202326
TRA2A transformer 2 alpha homolog (Drosophila) 0.0201556
ATXN1 ataxin 1 0.0200117
EIF4B eukaryotic translation initiation factor 4B 0.0199897
TFG TRK-fused gene 0.0199623
DIAPH2 diaphanous-related formin 2 0.019686
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0192044
TBC1D5 TBC1 domain family, member 5 0.0191875
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0186918
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0186622
SPRED2 sprouty-related, EVH1 domain containing 2 0.018653
USP47 ubiquitin specific peptidase 47 0.0185786
PCM1 pericentriolar material 1 0.0185296
ZNF608 zinc finger protein 608 0.0184298
EFNA5 ephrin-A5 0.01838
CDK19 cyclin-dependent kinase 19 0.0183621
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0183314
RNF145 ring finger protein 145 0.0182693
MBNL1 muscleblind-like splicing regulator 1 0.0179477
FAT1 FAT atypical cadherin 1 0.0179309
METTL15 methyltransferase like 15 0.017923
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0178966
KMT2C lysine (K)-specific methyltransferase 2C 0.0178349
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0178007
TRA2B transformer 2 beta homolog (Drosophila) 0.0177789
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.017777
PLPP3 phospholipid phosphatase 3 0.0177701
RPRD1B regulation of nuclear pre-mRNA domain containing 1B 0.0176878
KMT2E lysine (K)-specific methyltransferase 2E 0.0176407
PRRC2C proline-rich coiled-coil 2C 0.0174941
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0172473
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 0.0172023
ZMYM2 zinc finger, MYM-type 2 0.0171962
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0171901
MBNL2 muscleblind-like splicing regulator 2 0.0171411
ECPAS Ecm29 proteasome adaptor and scaffold 0.0171378
FAR1 fatty acyl CoA reductase 1 0.0171178

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.33397
RPS6 ribosomal protein S6 -0.152936
RPS8 ribosomal protein S8 -0.122414
TPT1 tumor protein, translationally-controlled 1 -0.114476
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0990704
TMSB4X thymosin beta 4, X-linked -0.0956593
RPL35A ribosomal protein L35a -0.0815584
RPL12 ribosomal protein L12 -0.0761322
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0758274
RPS3 ribosomal protein S3 -0.0757189
RPL37A ribosomal protein L37a -0.0698711
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0684951
RPLP2 ribosomal protein, large, P2 -0.0681338
RPL34 ribosomal protein L34 -0.066791
RPL26 ribosomal protein L26 -0.0665584
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0665376
RPL31 ribosomal protein L31 -0.0650676
RPS19 ribosomal protein S19 -0.0639554
RPL7A ribosomal protein L7a -0.0607568
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0605159
RPL36 ribosomal protein L36 -0.0584404
ACTG1 actin gamma 1 -0.0577718
RPS23 ribosomal protein S23 -0.0576135
RPL23 ribosomal protein L23 -0.0543801
RPL19 ribosomal protein L19 -0.0542704
AHNAK AHNAK nucleoprotein -0.0532855
FOXP1 forkhead box P1 -0.0519902
BMP10 bone morphogenetic protein 10 -0.0498575
RPS29 ribosomal protein S29 -0.0488809
RPL32 ribosomal protein L32 -0.0444956
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0428155
RPL13A ribosomal protein L13a -0.0423231
RPLP1 ribosomal protein, large, P1 -0.0422728
RPS12 ribosomal protein S12 -0.0418017
RPS27A ribosomal protein S27a -0.0414343
NAP1L1 nucleosome assembly protein 1-like 1 -0.0410934
RPS13 ribosomal protein S13 -0.0406241
RPL9 ribosomal protein L9 -0.0398094
RPL18 ribosomal protein L18 -0.039173
RPS25 ribosomal protein S25 -0.0389516
S100A6 S100 calcium binding protein A6 -0.0377479
RPL37 ribosomal protein L37 -0.0371773
RPL30 ribosomal protein L30 -0.0369801
LOC112694756 uncharaterized LOC112694756 -0.0363102
RPS27 ribosomal protein S27 -0.035825
PDE4B phosphodiesterase 4B, cAMP-specific -0.0358144
RACK1 receptor for activated C kinase 1 -0.0357556
MYL12B myosin, light chain 12B, regulatory -0.035564
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0348075
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0337572
RPS14 ribosomal protein S14 -0.0334735
BMP2K BMP2 inducible kinase -0.0334538
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0332856
RPS21 ribosomal protein S21 -0.0330595
RPL8 ribosomal protein L8 -0.032768
RPS16 ribosomal protein S16 -0.0323693
RPL35 ribosomal protein L35 -0.031991
RPL11 ribosomal protein L11 -0.0318066
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0310418
RPS24 ribosomal protein S24 -0.0302796
VCL vinculin -0.0293445
RPL36A ribosomal protein L36a -0.0292766
EIF1 eukaryotic translation initiation factor 1 -0.0292476
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0289011
DLG1 discs, large homolog 1 (Drosophila) -0.0276493
TBCA tubulin folding cofactor A -0.0272158
RSL1D1 ribosomal L1 domain containing 1 -0.025996
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0257746
HSPH1 heat shock 105kDa/110kDa protein 1 -0.025773
WSB1 WD repeat and SOCS box containing 1 -0.0256621
RPS10 ribosomal protein S10 -0.0255812
RPL7 ribosomal protein L7 -0.0253141
S100A9 S100 calcium binding protein A9 -0.0246391
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0245229
B2M beta-2-microglobulin -0.0242925
RPL27 ribosomal protein L27 -0.0241959
RPL38 ribosomal protein L38 -0.0239694
RPS17 ribosomal protein S17 -0.0236373
RPS2 ribosomal protein S2 -0.0235874
GNAS GNAS complex locus -0.0235609
LOC102724023 ES1 protein homolog, mitochondrial -0.0231792
MYOF myoferlin -0.0229153
RPL10A ribosomal protein L10a -0.0227501
KPNB1 karyopherin (importin) beta 1 -0.0218093
RPLP0 ribosomal protein, large, P0 -0.0217301
HSPB1 heat shock 27kDa protein 1 -0.0217006
MYO5C myosin VC -0.0216151
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.021279
EBNA1BP2 EBNA1 binding protein 2 -0.0212593
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0212414
RPL4 ribosomal protein L4 -0.0209993
SLC38A2 solute carrier family 38, member 2 -0.0208267
SERF2 small EDRK-rich factor 2 -0.0206239
RFC3 replication factor C (activator 1) 3, 38kDa -0.0205178
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0205074
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -0.0200946
RPL27A ribosomal protein L27a -0.020071
CUX1 cut-like homeobox 1 -0.0200079
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0199801
NPAS2 neuronal PAS domain protein 2 -0.0198798